Targeting Sirtuin1 to treat aging-related tissue fibrosis: From prevention to therapy

Formononetin Activates the Nrf2/ARE Signaling Pathway Via Sirt1 to Improve Diabetic Renal Fibrosis

(2021) Kai Zhuang et al.   Frontiers in Pharmacology

Coumestrol mitigates retinal cell inflammation, apoptosis, and oxidative stress in a rat model of diabetic retinopathy via activation of SIRT1

(2021) Yanchao Xu et al.   Aging-US

Sirtuin 1 ameliorates defenestration in hepatic sinusoidal endothelial cells during liver fibrosis via inhibiting stress‐induced premature senescence

(2021) Xiaoying Luo et al.   CELL PROLIFERATION

Sirtuin 1 activated by SRT1460 protects against myocardial ischemia/reperfusion injury

(2021) Shanjun Zhao et al.   CLINICAL HEMORHEOLOGY AND MICROCIRCULATION

SIRT1 and gynecological malignancies (Review)

(2021) Jiayu Chen et al.   ONCOLOGY REPORTS

Cigarette smoke-inactivated SIRT1 promotes autophagy-dependent senescence of alveolar epithelial type 2 cells to induce pulmonary fibrosis

(2021) Yue Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ameliorative role of SIRT1 in peritoneal fibrosis: an in vivo and in vitro study

(2021) Yanhong Guo et al.   Cell and Bioscience

SIRT1 attenuates renal fibrosis by repressing HIF-2α

(2021) Peipei Li et al.   Cell Death Discovery

Age-Associated B Cells

(2020) Michael P. Cancro   Annual Review of Immunology

Cardiac Fibroblast Diversity

(2020) Michelle D. Tallquist   Annual Review of Physiology

The Citrus Flavonoid Naringenin Protects the Myocardium from Ageing-Dependent Dysfunction: Potential Role of SIRT1

(2020) Lara Testai et al.   Oxidative Medicine and Cellular Longevity

Dihydromyricetin alleviates doxorubicin-induced cardiotoxicity by inhibiting NLRP3 inflammasome through activation of SIRT1

(2020) Zhenzhu Sun et al.   BIOCHEMICAL PHARMACOLOGY

Hepatoprotective effects of hydroxysafflor yellow A in D-galactose-treated aging mice

(2020) Fei Min et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Roles of Autophagy in Oxidative Stress

(2020) Hyeong Rok Yun et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

(2020) Fei Zhou et al.   LANCET

Tropisetron protects against brain aging via attenuating oxidative stress, apoptosis and inflammation: The role of SIRT1 signaling

(2020) Atefeh Mirshafa et al.   LIFE SCIENCES

SIRT1 and aging related signaling pathways

(2020) Cui Chen et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Reactive oxygen species (ROS) as pleiotropic physiological signalling agents

(2020) Helmut Sies et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Differential Gender-Dependent Patterns of Cardiac Fibrosis and Fibroblast Phenotypes in Aging Mice

(2020) Angela Achkar et al.   Oxidative Medicine and Cellular Longevity

Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China

(2020) Chaomin Wu et al.   JAMA Internal Medicine

Wnt signaling pathway in aging-related tissue fibrosis and therapies

(2020) He-He Hu et al.   AGEING RESEARCH REVIEWS

Therapeutic Effects of SRT2104 on Lung Injury in Rats with Emphysema via Reduction of Type II Alveolar Epithelial Cell Senescence

(2020) Chao Gu et al.   COPD-Journal of Chronic Obstructive Pulmonary Disease

Bariatric Surgery Provides Long-term Resolution of Nonalcoholic Steatohepatitis and Regression of Fibrosis

(2020) Guillaume Lassailly et al.   GASTROENTEROLOGY

SIRT1 agonism modulates cardiac NLRP3 inflammasome through pyruvate dehydrogenase during ischemia and reperfusion

(2020) Ying Han et al.   Redox Biology

Senescence of Alveolar Type 2 Cells Drives Progressive Pulmonary Fibrosis

(2020) Changfu Yao et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Ginsenoside Rb2 alleviates myocardial ischemia/reperfusion injury in rats through SIRT1 activation

(2020) Yan Xue et al.   JOURNAL OF FOOD SCIENCE

Quercetin alleviates kidney fibrosis by reducing renal tubular epithelial cell senescence through the SIRT1/PINK1/mitophagy axis

(2020) Tao Liu et al.   LIFE SCIENCES

A natural product solution to aging and aging-associated diseases

(2020) Chuanbin Yang et al.   PHARMACOLOGY & THERAPEUTICS

SIRT1-modified human umbilical cord mesenchymal stem cells ameliorate experimental peritoneal fibrosis by inhibiting the TGF-β/Smad3 pathway

(2020) Yanhong Guo et al.   Stem Cell Research & Therapy

Hydroxysafflor Yellow A Exerts Anti-Inflammatory Effects Mediated by SIRT1 in Lipopolysaccharide-Induced Microglia Activation

(2020) Xiude Qin et al.   Frontiers in Pharmacology

SIRT1/SIRT3 Modulates Redox Homeostasis during Ischemia/Reperfusion in the Aging Heart

(2020) Jingwen Zhang et al.   Antioxidants

Aging in COVID-19: Vulnerability, immunity and intervention

(2020) Yiyin Chen et al.   AGEING RESEARCH REVIEWS

Propofol reduces renal ischemia/reperfusion-induced acute lung injury by stimulating sirtuin 1 and inhibiting pyroptosis

(2020) Zhaohui Liu et al.   Aging-US

Hesperetin, a SIRT1 activator, inhibits hepatic inflammation via AMPK/CREB pathway

(2020) Si-wei Wang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Association between vision and hearing impairment and successful aging over five years

(2020) Bamini Gopinath et al.   MATURITAS

Latest progress on the molecular mechanisms of idiopathic pulmonary fibrosis

(2020) Yue Fang et al.   MOLECULAR BIOLOGY REPORTS

Naringenin alleviates nonalcoholic steatohepatitis in middle-aged Apoe−/−mice: role of SIRT1

(2020) Yi Qiao Hua et al.   PHYTOMEDICINE

Isoliquiritigenin prevents hyperglycemia-induced renal injuries by inhibiting inflammation and oxidative stress via SIRT1-dependent mechanism

(2020) Xiaozhong Huang et al.   Cell Death & Disease

Polysulfide-mediated sulfhydration of SIRT1 prevents diabetic nephropathy by suppressing phosphorylation and acetylation of p65 NF-κB and STAT3

(2020) Hai-Jian Sun et al.   Redox Biology

Air Pollution—An Overlooked Risk Factor for Idiopathic Pulmonary Fibrosis

(2020) Sebastian Majewski et al.   Journal of Clinical Medicine

Peroxisome proliferator-activated receptors in the pathogenesis and therapies of liver fibrosis

(2020) Xin Han et al.   PHARMACOLOGY & THERAPEUTICS

Sirt1-hypoxia-inducible factor-1α interaction is a key mediator of tubulointerstitial damage in the aged kidney

(2019) Dong Ryeol Ryu et al.   AGING CELL

Sirtuins and FoxOs in osteoporosis and osteoarthritis

(2019) Maria Almeida et al.   BONE

The protective effect of oleanolic acid on NMDA-induced MLE-12 cells apoptosis and lung injury in mice by activating SIRT1 and reducing NF-κB acetylation

(2019) Xiang-Ping Peng et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

MHY2233 Attenuates Replicative Cellular Senescence in Human Endothelial Progenitor Cells via SIRT1 Signaling

(2019) Shreekrishna Lamichane et al.   Oxidative Medicine and Cellular Longevity

Sirt1 ameliorates monosodium urate crystal–induced inflammation by altering macrophage polarization via the PI3K/Akt/STAT6 pathway

(2019) Lei Liu et al.   RHEUMATOLOGY

Body composition changes in diabetes and aging

(2019) Mohammed E. Al-Sofiani et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

From discoveries in ageing research to therapeutics for healthy ageing

(2019) Judith Campisi et al.   NATURE

EX527, a Sirt-1 inhibitor, induces apoptosis in glioma via activating the p53 signaling pathway

(2019) Tianpeng Wang et al.   ANTI-CANCER DRUGS

CGRP derived from cardiac fibroblasts is an endogenous suppressor of cardiac fibrosis

(2019) Wenqun Li et al.   CARDIOVASCULAR RESEARCH

Chronic Kidney Disease Diagnosis and Management

(2019) Teresa K. Chen et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Replication Stress at Telomeric and Mitochondrial DNA: Common Origins and Consequences on Ageing

(2019) Pauline Billard et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Intracellular sensing of viral genomes and viral evasion

(2019) Hyun-Cheol Lee et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Oxymatrine exerts organ- and tissue-protective effects by regulating inflammation, oxidative stress, apoptosis, and fibrosis: From bench to bedside

(2019) Xu Lan et al.   PHARMACOLOGICAL RESEARCH

Sirtuin 1 activation attenuates cardiac fibrosis in a rodent pressure overload model by modifying Smad2/3 transactivation

(2018) Antoinette Bugyei-Twum et al.   CARDIOVASCULAR RESEARCH

Effects of Resveratrol and other Polyphenols on Sirt1: Relevance to Brain Function During Aging

(2018) F. Sarubbo et al.   Current Neuropharmacology

Rutin, a quercetin glycoside, alleviates acute endotoxemic kidney injury in C57BL/6 mice via suppression of inflammation and up-regulation of antioxidants and SIRT1

(2018) Mohammad-Reza Khajevand-Khazaei et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Pioglitazone attenuates aging-related disorders in aged apolipoprotein E deficient mice

(2018) Dan Shen et al.   EXPERIMENTAL GERONTOLOGY

Administration of nicotinamide riboside prevents oxidative stress and organ injury in sepsis

(2018) Guangliang Hong et al.   FREE RADICAL BIOLOGY AND MEDICINE

Resolvin D1 Promotes SIRT1 Expression to Counteract the Activation of STAT3 and NF-κB in Mice with Septic-Associated Lung Injury

(2018) Yuzhen Zhuo et al.   INFLAMMATION

Cudratricusxanthone A attenuates sepsis-induced liver injury via SIRT1 signaling

(2018) Yuri Lee et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Melatonin prevents Drp1-mediated mitochondrial fission in diabetic hearts through SIRT1-PGC1α pathway

(2018) Mingge Ding et al.   JOURNAL OF PINEAL RESEARCH

Cellular and molecular mechanisms of kidney fibrosis

(2018) Sonja Djudjaj et al.   MOLECULAR ASPECTS OF MEDICINE

Organ and tissue fibrosis: Molecular signals, cellular mechanisms and translational implications

(2018) Ralf Weiskirchen et al.   MOLECULAR ASPECTS OF MEDICINE

Liver fibrosis

(2018) M. Merve Aydin et al.   Turkish Journal of Gastroenterology

Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases

(2018) Ana Luisa Cardoso et al.   AGEING RESEARCH REVIEWS

Long-Term l-Serine Administration Reduces Food Intake and Improves Oxidative Stress and Sirt1/NFκB Signaling in the Hypothalamus of Aging Mice

(2018) Xihong Zhou et al.   Frontiers in Endocrinology

Role and mechanism of ROS scavengers in alleviating NLRP3-mediated inflammation

(2018) Takami Sho et al.   BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY

Protective effect of astaxanthin against contrast-induced acute kidney injury via SIRT1-p53 pathway in rats

(2018) Dongmei Gao et al.   INTERNATIONAL UROLOGY AND NEPHROLOGY

Melatonin protects against sepsis-induced cardiac dysfunction by regulating apoptosis and autophagy via activation of SIRT1 in mice

(2018) Wen-xuan Zhang et al.   LIFE SCIENCES

SIRT1 is required for mitochondrial biogenesis reprogramming in hypoxic human pulmonary arteriolar smooth muscle cells

(2017) Pengyun Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

The Sirt1 activator, SRT1720, attenuates renal fibrosis by inhibiting CTGF and oxidative stress

(2017) Yunzhuo Ren et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Fibroblast-specific TGF-β–Smad2/3 signaling underlies cardiac fibrosis

(2017) Hadi Khalil et al.   JOURNAL OF CLINICAL INVESTIGATION

Aging aggravates alcoholic liver injury and fibrosis in mice by downregulating sirtuin 1 expression

(2017) Teresa Ramirez et al.   JOURNAL OF HEPATOLOGY

Nicotinamide Mononucleotide, an NAD + Precursor, Rescues Age-Associated Susceptibility to AKI in a Sirtuin 1–Dependent Manner

(2017) Yi Guan et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Salvianolic acid B protects against chronic alcoholic liver injury via SIRT1-mediated inhibition of CRP and ChREBP in rats

(2017) Ning Zhang et al.   TOXICOLOGY LETTERS

Key role of liver sinusoidal endothelial cells in liver fibrosis

(2017) Mingxing Xu et al.   BioScience Trends

Lifestyle Modulators of Neuroplasticity: How Physical Activity, Mental Engagement, and Diet Promote Cognitive Health during Aging

(2017) Cristy Phillips   NEURAL PLASTICITY

Salidroside ameliorates sepsis-induced acute lung injury and mortality via downregulating NF-κB and HMGB1 pathways through the upregulation of SIRT1

(2017) Kuo-Cheng Lan et al.   Scientific Reports

Aging increases the susceptibility of hepatic inflammation, liver fibrosis and aging in response to high-fat diet in mice

(2016) In Hee Kim et al.   AGE

Epigenetic Mechanisms of Longevity and Aging

(2016) Payel Sen et al.   CELL

New Developments on the Treatment of Liver Fibrosis

(2016) Yukinori Koyama et al.   DIGESTIVE DISEASES

Defective sirtuin-1 increases IL-4 expression through acetylation of GATA-3 in patients with severe asthma

(2016) Thomas Colley et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Oxidative stress and metabolic disorders: Pathogenesis and therapeutic strategies

(2016) Vibha Rani et al.   LIFE SCIENCES

Regulation of SIRT1 in aging: Roles in mitochondrial function and biogenesis

(2016) Yujia Yuan et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Carnosic acid alleviates chronic alcoholic liver injury by regulating the SIRT1/ChREBP and SIRT1/p66shc pathways in rats

(2016) Lili Gao et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds

(2016) Michael S. Bonkowski et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Upregulation of SIRT1-AMPK by thymoquinone in hepatic stellate cells ameliorates liver injury

(2016) Yong Yang et al.   TOXICOLOGY LETTERS

Trimetazidine prevents macrophage-mediated septic myocardial dysfunction via activation of the histone deacetylase sirtuin 1

(2015) Jing Chen et al.   BRITISH JOURNAL OF PHARMACOLOGY

Combined effect of genetic background and gender in a mouse model of bleomycin-induced skin fibrosis

(2015) Nadira Ruzehaji et al.   ARTHRITIS RESEARCH & THERAPY

Natural and Sun-Induced Aging of Human Skin

(2015) L. Rittie et al.   Cold Spring Harbor Perspectives in Medicine

The SIRT1 activator SRT1720 reverses vascular endothelial dysfunction, excessive superoxide production, and inflammation with aging in mice

(2014) Lindsey B. Gano et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Inflammation, ageing and chronic disease

(2014) Graham Pawelec et al.   CURRENT OPINION IN IMMUNOLOGY

Sirtuin inhibitors as anticancer agents

(2014) Jing Hu et al.   Future Medicinal Chemistry

Transplantation of SIRT1-engineered aged mesenchymal stem cells improves cardiac function in a rat myocardial infarction model

(2014) Xianbao Liu et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

NAD+ and sirtuins in aging and disease

(2014) Shin-ichiro Imai et al.   TRENDS IN CELL BIOLOGY

SIRT1 and other sirtuins in metabolism

(2014) Hung-Chun Chang et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The SIRT1 Activator SRT1720 Extends Lifespan and Improves Health of Mice Fed a Standard Diet

(2014) Sarah J. Mitchell et al.   Cell Reports

Liver diseases and aging: friends or foes?

(2013) Fareeba Sheedfar et al.   AGING CELL

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging

(2013) Ana P. Gomes et al.   CELL

The pathogenesis of cardiac fibrosis

(2013) Ping Kong et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Antagonistic crosstalk between NF-κB and SIRT1 in the regulation of inflammation and metabolic disorders

(2013) Anu Kauppinen et al.   CELLULAR SIGNALLING

Oxidative stress and vascular inflammation in aging

(2013) Mariam El Assar et al.   FREE RADICAL BIOLOGY AND MEDICINE

Endothelial Sirtuin 1 Deficiency Perpetrates Nephrosclerosis through Downregulation of Matrix Metalloproteinase-14: Relevance to Fibrosis of Vascular Senescence

(2013) R. Vasko et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Age-induced hair greying - the multiple effects of oxidative stress

(2013) M. Seiberg   INTERNATIONAL JOURNAL OF COSMETIC SCIENCE

SIRT1 Is Required for AMPK Activation and the Beneficial Effects of Resveratrol on Mitochondrial Function

(2012) Nathan L. Price et al.   Cell Metabolism

Sirtuins in cognitive ageing and Alzheimerʼs disease

(2012) Nady Braidy et al.   CURRENT OPINION IN PSYCHIATRY

Seven sirtuins for seven deadly diseases ofaging

(2012) Brian J. Morris   FREE RADICAL BIOLOGY AND MEDICINE

Age-Associated Molecular Changes in the Kidney in Aged Mice

(2012) Ji Hee Lim et al.   Oxidative Medicine and Cellular Longevity

Age-Related Changes in Pharmacokinetics

(2011) Shaojun Shi et al.   CURRENT DRUG METABOLISM

The reduction of SIRT1 in livers of old mice leads to impaired body homeostasis and to inhibition of liver proliferation

(2011) Jingling Jin et al.   HEPATOLOGY

SIRT1 is required for long-term growth of human mesenchymal stem cells

(2011) Hong-Feng Yuan et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Mammalian Sirtuins: Biological Insights and Disease Relevance

(2010) Marcia C. Haigis et al.   Annual Review of Pathology-Mechanisms of Disease

SIRT1 and p53, effect on cancer, senescence and beyond

(2010) Jingjie Yi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Aging and Arterial Stiffness

(2010) Hae-Young Lee et al.   CIRCULATION JOURNAL

Sirt1 activation protects the mouse renal medulla from oxidative injury

(2010) Wenjuan He et al.   JOURNAL OF CLINICAL INVESTIGATION

Mesenchymal Stem Cells Promote Matrix Metalloproteinase Secretion by Cardiac Fibroblasts and Reduce Cardiac Ventricular Fibrosis After Myocardial Infarction

(2009) C��line Mias et al.   STEM CELLS

Radical-free biology of oxidative stress

(2008) Dean P. Jones   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY