Article
Food Science & Technology
Reham I. Alagal, Nora A. AlFaris, Ghedeir M. Alshammari, Jozaa Z. ALTamimi, Lujain A. AlMousa, Mohammed Abdo Yahya
Summary: This study demonstrates that kaempferol protects the structure and function of the kidneys in doxorubicin-treated rats by upregulating and activating SIRT1, thereby alleviating doxorubicin-induced nephropathy.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Review
Nutrition & Dietetics
Laura Felgus-Lavefve, Luke Howard, Sean H. Adams, Jamie Baum
Summary: This review examines the anti-inflammatory and antioxidant effects of blueberry phytochemicals in vitro and discusses their relevance to disease and health. It also explores the mechanisms by which different components of blueberries modulate cellular pathways.
ADVANCES IN NUTRITION
(2022)
Article
Pharmacology & Pharmacy
Zhenmao Jia, Panxia Wang, Yuansheng Xu, Guodong Feng, Quan Wang, Xiangjun He, Yan Song, Peiqing Liu, Jianwen Chen
Summary: In this study, LH011 was found to have a therapeutic effect on ulcerative colitis (UC). It inhibited the expression of inflammatory cytokines and enhanced the antioxidant capacity. Mechanistically, LH011 exerted its effects by regulating the TLR4/NF-κB and Nrf2/Keap1/HO-1 signaling pathways.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Agriculture, Multidisciplinary
Ivan Cruz-Chamorro, Guillermo Santos-Sanchez, Carlotta Bollati, Martina Bartolomei, Jianqiang Li, Anna Arnoldi, Carmen Lammi
Summary: In this study, the anti-inflammatory and immunomodulatory properties of H2 and H3 were molecularly characterized, and it was found that these peptides can reduce inflammatory responses and oxidative stress markers by modulating the NF-kappa B and iNOS pathways, suggesting their potential therapeutic value.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Immunology
Haihua Zhang, Jing Wang, Wuying Lang, Hongli Liu, Zhiqiang Zhang, Tonglei Wu, Hongqiang Li, Liya Bai, Qiumei Shi
Summary: This study found that albiflorin can inhibit methotrexate-induced enteritis, reduce inflammation, and exert its effects through inhibiting the NF-kappa B/NLRP3 pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Cell Biology
Gong-Rak Lee, Hye In Lee, Narae Kim, Jiae Lee, Minjeong Kwon, Ye Hee Kang, Hyeong Ju Song, Chang-Yeol Yeo, Woojin Jeong
Summary: This study investigated the role of LC8 in nonalcoholic steatohepatitis (NASH) and explored its potential mechanism. The results showed that LC8 can alleviate NASH induced by an MCD diet by inhibiting NF-kappa B and reducing oxidative stress. Therefore, enhancing intracellular LC8 could be a potential therapeutic strategy for NASH.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Food Science & Technology
Dan Li, Zhi Li, Caiyi Qiu, Bo Peng, Yan Zhang, Hongwen Sun, Shuo Wang
Summary: This study investigated the hepatotoxicity of 2-amino-3-methylimidazole[4,5-f] quinoline (IQ) in zebrafish models and found that IQ exposure led to significant increases in liver enzymes, oxidative stress, and inflammation levels, while decreasing antioxidant levels. The study also revealed the pathological changes in zebrafish liver tissue induced by IQ exposure and elucidated the underlying molecular mechanisms involved in IQ-induced liver damage.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Sergio Davinelli, Luciano Saso, Floriana D'Angeli, Vittorio Calabrese, Mariano Intrieri, Giovanni Scapagnini
Summary: This article reviews the potential molecular mechanisms by which astaxanthin (AST) regulates the transcription factors Nrf2 and NF-κB, which are involved in oxidative stress and inflammation. Additionally, it summarizes the current clinical studies elucidating how AST alleviates the etiopathogenesis of oxidative stress and inflammation.
Article
Biochemistry & Molecular Biology
Tong-Juan Tang, Xiang Wang, Liang Wang, Ming Chen, Jing Cheng, Meng-Yu Zuo, Jin-Fan Gu, Rui Ding, Peng Zhou, Jin-Ling Huang
Summary: Liquiritin, the main ingredient of licorice, has antioxidant and anti-inflammatory properties and can alleviate oxidative stress and inflammation in cardiomyocytes by regulating the AMPK/SIRT1/NF-κB signaling pathway.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Environmental Sciences
Yuming Zhang, Zhen Zhang, Jun Wang, Xiajing Zhang, Jing Zhao, Ning Bai, Annamalai Vijayalakshmi, Qifan Huo
Summary: Scutellarin protects rats from cerebral ischemic injury by inhibiting the inflammatory process through the nuclear factor kappa-B p65 and p38 mitogen-activated protein kinase signaling pathway.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Food Science & Technology
Le-Feng Wang, Wen-Juan Li, Xian-Yi Zhang, Yi-Chi Zhang, Guang-Feng Chen, Xing-Yu Zhou, Dong-Mei Xv, Qiong Wu
Summary: Resveratrol has been shown to protect against age-related heart injury in mice by reducing oxidative stress and inflammation through the Notch/NF-kappa B pathway. Furthermore, it improves cardiac function by protecting the intestine.
FOOD SCIENCE & NUTRITION
(2023)
Article
Nutrition & Dietetics
Yongfeng Zhang, Jie Hao, Zijian Liu, Zhige Li, Lirong Teng, Di Wang
Summary: This study investigated the regulatory effects of Inonotus hispidus (IH) on lipid metabolism in mice fed a high-fat diet (HFD). The results showed that IH could reverse the pathological state of the liver and fat, decrease the levels of LDL-C, TC, TG, and LEP, and increase the level of HDL-C in serum. Additionally, IH improved liver damage and modulated the gut microbiota. IH regulated the Nrf2/NF-κB signaling pathway and oxidative stress. These findings provide experimental evidence for the potential use of IH in obesity treatment.
Article
Orthopedics
Peng Zhang, Yesheng Jin, Wei Xia, Xiaotong Wang, Zhiqiang Zhou
Summary: This study found that the active ingredient PHI from Forsythiae Fructus can alleviate IL-1 beta-induced inflammation cytokines and ECM degradation by activating Nrf2 and inhibiting the NF-kappa B pathway. This provides a biological rationale for the use of PHI as a potential candidate for OA treatment.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2023)
Review
Biochemistry & Molecular Biology
Vineeta Chattree, Kamana Singh, Kanishk Singh, Aayush Goel, Amritaparna Maity, Asif Lone
Summary: SARS-CoV-2 infection, causing COVID-19, poses a significant global health risk. Studies have shown that epigallocatechin-3-gallate and melatonin can regulate the expression of pro-inflammatory genes, potentially reducing the detrimental effects on the immune system.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Ziyang Sun, Juehong Li, Gang Luo, Weixuan Liu, Yunwei He, Feiyan Wang, Yun Qian, Cunyi Fan
Summary: This study reveals that metformin can effectively attenuate trauma-induced heterotopic ossification by mitigating macrophage inflammatory responses through inhibiting NF-kappa B signaling via SIRT1-dependent mechanisms. These findings provide novel insights for future therapeutic investigations in trauma-related diseases.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Fisheries
P. Arechavala-Lopez, C. Diaz-Gil, J. L. Saraiva, D. Moranta, M. F. Castanheira, S. Nunez-Velazquez, S. Ledesma-Corvi, M. R. Mora-Ruiz, A. Grau
AQUACULTURE REPORTS
(2019)
Article
Nutrition & Dietetics
Margarita R. Ramis, Fiorella Sarubbo, Silvia Tejada, Manuel Jimenez, Susana Esteban, Antoni Miralles, David Moranta
Article
Food Science & Technology
G. Annunziata, M. Jimenez-Garcia, X. Capo, D. Moranta, A. Arnone, G. C. Tenore, A. Sureda, S. Tejada
FOOD AND CHEMICAL TOXICOLOGY
(2020)
Article
Nutrition & Dietetics
Giuseppe Annunziata, Manuel Jimenez-Garcia, Silvia Tejada, David Moranta, Angela Arnone, Roberto Ciampaglia, Gian Carlo Tenore, Antoni Sureda, Ettore Novellino, Xavier Capo
Article
Multidisciplinary Sciences
P. Arechavala-Lopez, J. C. Caballero-Froilan, M. Jimenez-Garcia, X. Capo, S. Tejada, J. L. Saraiva, A. Sureda, D. Moranta
SCIENTIFIC REPORTS
(2020)
Article
Nutrition & Dietetics
Margarita R. Ramis, Fiorella Sarubbo, David Moranta, Silvia Tejada, Jeronia Llado, Antoni Miralles, Susana Esteban
Summary: Long-term intake of a diet rich in polyphenols has been shown to improve memory and learning, restore brain neurotransmitters and important proteins levels, and have a positive impact on brain health.
Article
Biochemistry & Molecular Biology
Margarita R. Ramis, Fiorella Sarubbo, David Moranta, Silvia Tejada, Jeronia Llado, Antoni Miralles, Susana Esteban
Summary: The study found that physical activity in elderly rats can improve age-related memory and learning deficits, correlating with the restoration of brain neurotransmitters and SIRT1 protein levels. The combination of the antioxidant catechin with exercise can further enhance monoaminergic pathways, beneficial for brain health.
Review
Cell Biology
Fiorella Sarubbo, Virve Cavallucci, Giovambattista Pani
Summary: Adult neurogenesis plays a crucial role in brain repair and plasticity, with the gut microbiota and natural dietary compounds potentially influencing neural stem cell activities. Understanding these interactions could have implications for combating neurodegeneration and brain ageing.
