Cooperative DNA binding mediated by KicGAS/ORF52 oligomerization allows inhibition of DNA-induced phase separation and activation of cGAS

cGAS phase separation inhibits TREX1-mediated DNA degradation and enhances cytosolic DNA sensing

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Viral tegument proteins restrict cGAS-DNA phase separation to mediate immune evasion

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Structural Insights into STING Signaling

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Conserved strategies for pathogen evasion of cGAS–STING immunity

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Viral and metazoan poxins are cGAMP-specific nucleases that restrict cGAS–STING signalling

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Mechanism of DNA-Induced Phase Separation for Transcriptional Repressor VRN1

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Regulation of cGAS- and RLR-mediated immunity to nucleic acids

(2019) Andrea Ablasser et al.   NATURE IMMUNOLOGY

Human Cytomegalovirus Protein UL31 Inhibits DNA Sensing of cGAS to Mediate Immune Evasion

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The cGAS–cGAMP–STING pathway connects DNA damage to inflammation, senescence, and cancer

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DNA-induced liquid phase condensation of cGAS activates innate immune signaling

(2018) Mingjian Du et al.   SCIENCE

Species-Specific Deamidation of cGAS by Herpes Simplex Virus UL37 Protein Facilitates Viral Replication

(2018) Junjie Zhang et al.   Cell Host & Microbe

Controllable protein phase separation and modular recruitment to form responsive membraneless organelles

(2018) Benjamin S. Schuster et al.   Nature Communications

cGAS and STING: At the intersection of DNA and RNA virus-sensing networks

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Cryo-EM Structures of MDA5-dsRNA Filaments at Different Stages of ATP Hydrolysis

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Innate immunosensing of DNA in cellular senescence

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HEXIM1 and NEAT1 Long Non-coding RNA Form a Multi-subunit Complex that Regulates DNA-Mediated Innate Immune Response

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cGAS surveillance of micronuclei links genome instability to innate immunity

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cGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein–DNA ladders

(2017) Liudmila Andreeva et al.   NATURE

Liquid droplet formation by HP1α suggests a role for phase separation in heterochromatin

(2017) Adam G. Larson et al.   NATURE

HIV-associated malignancies in sub-Saharan Africa

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The cGAS-STING Defense Pathway and Its Counteraction by Viruses

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Structural basis for concerted recruitment and activation of IRF-3 by innate immune adaptor proteins

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Cytoplasmic isoforms of Kaposi sarcoma herpesvirus LANA recruit and antagonize the innate immune DNA sensor cGAS

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Inhibition of cGAS DNA Sensing by a Herpesvirus Virion Protein

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VP22 core domain from Herpes simplex virus 1 reveals a surprising structural conservation in both the Alpha- and Gammaherpesvirinae subfamilies

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Formation and Maturation of Phase-Separated Liquid Droplets by RNA-Binding Proteins

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Modulation of the cGAS-STING DNA sensing pathway by gammaherpesviruses

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Cytosolic RNA:DNA hybrids activate the cGAS–STING axis

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The Influenza A Virus Protein NS1 Displays Structural Polymorphism

(2014) B. Carrillo et al.   JOURNAL OF VIROLOGY

The Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation Loop

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Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase

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Cyclic GMP-AMP Synthase Is Activated by Double-Stranded DNA-Induced Oligomerization

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Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity

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Pivotal Roles of cGAS-cGAMP Signaling in Antiviral Defense and Immune Adjuvant Effects

(2013) X.-D. Li et al.   SCIENCE

Structural Basis for dsRNA Recognition, Filament Formation, and Antiviral Signal Activation by MDA5

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Critical Role of an Antiviral Stress Granule Containing RIG-I and PKR in Viral Detection and Innate Immunity

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Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

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Structural Basis for the Activation of Innate Immune Pattern-Recognition Receptor RIG-I by Viral RNA

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Structural Insights into RNA Recognition by RIG-I

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Ebolavirus VP35 uses a bimodal strategy to bind dsRNA for innate immune suppression

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