Human primary retinal cells as an in-vitro model for investigating defective signalling caused by OPTN mutants associated with glaucoma

A Robust Model System for Retinal Hypoxia: Live Imaging of Calcium Dynamics and Gene Expression Studies in Primary Human Mixed Retinal Culture

(2020) Shahna Shahulhameed et al.   Frontiers in Neuroscience

Spatiotemporal Control of ULK1 Activation by NDP52 and TBK1 during Selective Autophagy

(2019) Jose Norberto S. Vargas et al.   MOLECULAR CELL

661W Photoreceptor Cell Line as a Cell Model for Studying Retinal Ciliopathies

(2019) Gabrielle Wheway et al.   Frontiers in Genetics

Autophagy-dependent cell death – where, how and why a cell eats itself to death

(2018) Shani Bialik et al.   JOURNAL OF CELL SCIENCE

Recent advances in genetically modified animal models of glaucoma and their roles in drug repositioning

(2018) Chikako Harada et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

ALS-Associated E478G Mutation in Human OPTN (Optineurin) Promotes Inflammation and Induces Neuronal Cell Death

(2018) Zhengzhao Liu et al.   Frontiers in Immunology

Optineurin promotes autophagosome formation by recruiting the autophagy-related Atg12-5-16L1 complex to phagophores containing the Wipi2 protein

(2017) Megha Bansal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

661W is a retinal ganglion precursor-like cell line in which glaucoma-associated optineurin mutants induce cell death selectively

(2017) Zuberwasim Sayyad et al.   Scientific Reports

Effects of optineurin mutants on SH-SY5Y cell survival

(2016) Min Zhu et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Significance of optineurin mutations in glaucoma and other diseases

(2016) Yuriko Minegishi et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Glia–neuron interactions in the mammalian retina

(2016) Elena Vecino et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Stepwise Differentiation of Retinal Ganglion Cells from Human Pluripotent Stem Cells Enables Analysis of Glaucomatous Neurodegeneration

(2016) Sarah K. Ohlemacher et al.   STEM CELLS

Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets

(2015) Evan Z. Macosko et al.   CELL

Visual impairment in an optineurin mouse model of primary open-angle glaucoma

(2015) Henry C. Tseng et al.   NEUROBIOLOGY OF AGING

Allogeneic Transplantation of Müller-Derived Retinal Ganglion Cells Improves Retinal Function in a Feline Model of Ganglion Cell Depletion

(2015) Silke Becker et al.   Stem Cells Translational Medicine

A Glaucoma-Associated Variant of Optineurin, M98K, Activates Tbk1 to Enhance Autophagosome Formation and Retinal Cell Death Dependent on Ser177 Phosphorylation of Optineurin

(2015) Kapil Sirohi et al.   PLoS One

Müller glial cell reprogramming and retina regeneration

(2014) Daniel Goldman   NATURE REVIEWS NEUROSCIENCE

Global Prevalence of Glaucoma and Projections of Glaucoma Burden through 2040

(2014) Yih-Chung Tham et al.   OPHTHALMOLOGY

E50K-OPTN-Induced Retinal Cell Death Involves the Rab GTPase-Activating Protein, TBC1D17 Mediated Block in Autophagy

(2014) Madhavi Latha Somaraju Chalasani et al.   PLoS One

TBK1Gene Duplication and Normal-Tension Glaucoma

(2014) Robert Ritch et al.   JAMA Ophthalmology

M98K-OPTN induces transferrin receptor degradation and RAB12-mediated autophagic death in retinal ganglion cells

(2013) Kapil Sirohi et al.   Autophagy

Enhanced optineurin E50K–TBK1 interaction evokes protein insolubility and initiates familial primary open-angle glaucoma

(2013) Yuriko Minegishi et al.   HUMAN MOLECULAR GENETICS

An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice

(2013) Shannon M Reilly et al.   NATURE MEDICINE

Optic neuropathies: characteristic features and mechanisms of retinal ganglion cell loss

(2013) Yuyi You et al.   REVIEWS IN THE NEUROSCIENCES

Human Müller Glia with Stem Cell Characteristics Differentiate into Retinal Ganglion Cell (RGC) Precursors In Vitro and Partially Restore RGC Function In Vivo Following Transplantation

(2012) Shweta Singhal et al.   Stem Cells Translational Medicine

Molecular genetics in glaucoma

(2011) Yutao Liu et al.   EXPERIMENTAL EYE RESEARCH

The molecular basis of retinal ganglion cell death in glaucoma

(2011) Mohammadali Almasieh et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Phosphorylation of the Autophagy Receptor Optineurin Restricts Salmonella Growth

(2011) P. Wild et al.   SCIENCE

Overexpression of optineurin E50K disrupts Rab8 interaction and leads to a progressive retinal degeneration in mice

(2010) Zai-Long Chi et al.   HUMAN MOLECULAR GENETICS

Mutations of optineurin in amyotrophic lateral sclerosis

(2010) Hirofumi Maruyama et al.   NATURE

In vitro differentiation of retinal ganglion-like cells from embryonic stem cell derived neural progenitors

(2009) Balusamy Jagatha et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Rodent models of glaucoma

(2009) Thomas V. Johnson et al.   BRAIN RESEARCH BULLETIN

Enhanced binding of TBK1 by an optineurin mutant that causes a familial form of primary open angle glaucoma

(2008) Simon Morton et al.   FEBS LETTERS