Autophagy-dependent cell death – where, how and why a cell eats itself to death

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Renal ischemia/reperfusion-induced mitophagy protects against renal dysfunction via Drp1-dependent-pathway

(2018) Nan Li et al.   EXPERIMENTAL CELL RESEARCH

Bcl-2/E1B-19KD-Interacting Protein 3/Light Chain 3 Interaction Induces Mitophagy in Spinal Cord Injury in Rats Both In Vivo and In Vitro

(2018) Datang Yu et al.   JOURNAL OF NEUROTRAUMA

Inhibition of Peroxynitrite-Induced Mitophagy Activation Attenuates Cerebral Ischemia-Reperfusion Injury

(2018) Jinghan Feng et al.   MOLECULAR NEUROBIOLOGY

Resveratrol attenuates oxidative damage through activating mitophagy in an in vitro model of Alzheimer’s disease

(2018) Hui Wang et al.   TOXICOLOGY LETTERS

AMBRA1-Mediated Mitophagy Counteracts Oxidative Stress and Apoptosis Induced by Neurotoxicity in Human Neuroblastoma SH-SY5Y Cells

(2018) Anthea Di Rita et al.   Frontiers in Cellular Neuroscience

Non-canonical activation of DAPK2 by AMPK constitutes a new pathway linking metabolic stress to autophagy

(2018) Ruth Shiloh et al.   Nature Communications

Alterations in the properties of the cell membrane due to glycosphingolipid accumulation in a model of Gaucher disease

(2018) Gyula Batta et al.   Scientific Reports

Phosphorylation of p62 by AMP-activated protein kinase mediates autophagic cell death in adult hippocampal neural stem cells

(2017) Shinwon Ha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery of a Small-Molecule Bromodomain-Containing Protein 4 (BRD4) Inhibitor That Induces AMP-Activated Protein Kinase-Modulated Autophagy-Associated Cell Death in Breast Cancer

(2017) Liang Ouyang et al.   JOURNAL OF MEDICINAL CHEMISTRY

The emerging role of autophagic-lysosomal dysfunction in Gaucher disease and Parkinson's disease

(2017) KerriJ Kinghorn et al.   Neural Regeneration Research

Recent progress in autophagic lysosome reformation

(2017) Yang Chen et al.   TRAFFIC

PP2A mediates apoptosis or autophagic cell death in multiple myeloma cell lines

(2017) Hang Zhou et al.   Oncotarget

Kaempferol induces autophagic cell death of hepatocellular carcinoma cells via activating AMPK signaling

(2017) Bing Han et al.   Oncotarget

Thalidezine, a novel AMPK activator, eliminates apoptosis-resistant cancer cells through energy-mediated autophagic cell death

(2017) Betty Yuen Kwan Law et al.   Oncotarget

Mammalian Autophagy: How Does It Work?

(2016) Carla F. Bento et al.   Annual Review of Biochemistry

Neuroprotection by selective neuronal deletion of Atg7 in neonatal brain injury

(2016) Cuicui Xie et al.   Autophagy

Autophagy promotes ferroptosis by degradation of ferritin

(2016) Wen Hou et al.   Autophagy

The intricate regulation and complex functions of the Class III phosphoinositide 3-kinase Vps34

(2016) J. M. Backer   BIOCHEMICAL JOURNAL

Ferroptosis is an autophagic cell death process

(2016) Minghui Gao et al.   CELL RESEARCH

The Autophagy Machinery Controls Cell Death Switching between Apoptosis and Necroptosis

(2016) Megan L. Goodall et al.   DEVELOPMENTAL CELL

Cul3-KLHL20 Ubiquitin Ligase Governs the Turnover of ULK1 and VPS34 Complexes to Control Autophagy Termination

(2016) Chin-Chih Liu et al.   MOLECULAR CELL

Cabazitaxel-induced autophagy via the PI3K/Akt/mTOR pathway contributes to A549 cell death

(2016) Ruichao Huo et al.   Molecular Medicine Reports

From the Cover: Ethylmercury-Induced Oxidative and Endoplasmic Reticulum Stress-Mediated Autophagic Cell Death: Involvement of Autophagosome–Lysosome Fusion Arrest

(2016) Ji-Yoon Choi et al.   TOXICOLOGICAL SCIENCES

Mediation of Autophagic Cell Death by Type 3 Ryanodine Receptor (RyR3) in Adult Hippocampal Neural Stem Cells

(2016) Kyung Min Chung et al.   Frontiers in Cellular Neuroscience

Lapatinib induces autophagic cell death and differentiation in acute myeloblastic leukemia

(2016) Huey-Lan Huang et al.   OncoTargets and Therapy

Differentiation inducing factor 3 mediates its anti-leukemic effect through ROS-dependent DRP1-mediated mitochondrial fission and induction of caspase-independent cell death

(2016) Alix Dubois et al.   Oncotarget

Zanthoxylum fruit extract from Japanese pepper promotes autophagic cell death in cancer cells

(2016) Reo Nozaki et al.   Oncotarget

Ceramide activates lysosomal cathepsin B and cathepsin D to attenuate autophagy and induces ER stress to suppress myeloid-derived suppressor cells

(2016) Feiyan Liu et al.   Oncotarget

Sirt3-mediated mitophagy protects tumor cells against apoptosis under hypoxia

(2016) Aimin Qiao et al.   Oncotarget

Valosin-containing protein is a key mediator between autophagic cell death and apoptosis in adult hippocampal neural stem cells following insulin withdrawal

(2016) Bo Kyoung Yeo et al.   Molecular Brain

Dual Targeting of the Autophagic Regulatory Circuitry in Gliomas with Repurposed Drugs Elicits Cell-Lethal Autophagy and Therapeutic Benefit

(2015) Ksenya Shchors et al.   CANCER CELL

Distinct requirements of Autophagy-related genes in programmed cell death

(2015) T Xu et al.   CELL DEATH AND DIFFERENTIATION

Ral GTPase and the exocyst regulate autophagy in a tissue-specific manner

(2015) K. Tracy et al.   EMBO REPORTS

Autosis occurs in the liver of patients with severe anorexia nervosa

(2015) Marouane Kheloufi et al.   HEPATOLOGY

Secreted Cyclic Di-GMP Induces Stalk Cell Differentiation in the Eukaryote Dictyostelium discoideum

(2015) Zhi-hui Chen et al.   JOURNAL OF BACTERIOLOGY

The kinase Jnk2 promotes stress-induced mitophagy by targeting the small mitochondrial form of the tumor suppressor ARF for degradation

(2015) Qiao Zhang et al.   NATURE IMMUNOLOGY

Cell death by autophagy: emerging molecular mechanisms and implications for cancer therapy

(2015) S Fulda et al.   ONCOGENE

Regulation of autophagic cell death by glycogen synthase kinase-3β in adult hippocampal neural stem cells following insulin withdrawal

(2015) Shinwon Ha et al.   Molecular Brain

Mitochondrially localized ERK2 regulates mitophagy and autophagic cell stress

(2014) Ruben K. Dagda et al.   Autophagy

Neuronal injury in rat model of permanent focal cerebral ischemia is associated with activation of autophagic and lysosomal pathways

(2014) Ya-Dan Wen et al.   Autophagy

Hypoxia induces autophagic cell death in apoptosis-competent cells through a mechanism involving BNIP3

(2014) Meghan B. Azad et al.   Autophagy

Involvement of autophagy in hypoxic-excitotoxic neuronal death

(2014) Vanessa Ginet et al.   Autophagy

Cardiac glycoside ouabain induces autophagic cell death in non-small cell lung cancer cells via a JNK-dependent decrease of Bcl-2

(2014) Annalisa Trenti et al.   BIOCHEMICAL PHARMACOLOGY

DAPK2 is a novel regulator of mTORC1 activity and autophagy

(2014) Y Ber et al.   CELL DEATH AND DIFFERENTIATION

Short Mitochondrial ARF Triggers Parkin/PINK1-dependent Mitophagy

(2014) Karl Grenier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ecdysone-Induced Receptor Tyrosine Phosphatase PTP52F Regulates Drosophila Midgut Histolysis by Enhancement of Autophagy and Apoptosis

(2014) A. Santhanam et al.   MOLECULAR AND CELLULAR BIOLOGY

mTOR and autophagy: A dynamic relationship governed by nutrients and energy

(2014) E.A. Dunlop et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

A conserved domain in exon 2 coding for the human and murine ARF tumor suppressor protein is required for autophagy induction

(2013) Anna Budina-Kolomets et al.   Autophagy

M98K-OPTN induces transferrin receptor degradation and RAB12-mediated autophagic death in retinal ganglion cells

(2013) Kapil Sirohi et al.   Autophagy

Control of Autophagic Cell Death by Caspase-10 in Multiple Myeloma

(2013) Laurence Lamy et al.   CANCER CELL

4-Hydroxytamoxifen Induces Autophagic Death through K-Ras Degradation

(2013) L. Kohli et al.   CANCER RESEARCH

Differential Regulation of Distinct Vps34 Complexes by AMPK in Nutrient Stress and Autophagy

(2013) Joungmok Kim et al.   CELL

Obatoclax (GX15-070) triggers necroptosis by promoting the assembly of the necrosome on autophagosomal membranes

(2013) F Basit et al.   CELL DEATH AND DIFFERENTIATION

Autophagy variation within a cell population determines cell fate through selective degradation of Fap-1

(2013) Jacob M. Gump et al.   NATURE CELL BIOLOGY

Uba1 functions in Atg7- and Atg3-independent autophagy

(2013) Tsun-Kai Chang et al.   NATURE CELL BIOLOGY

Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway

(2013) Wei-jia Wang et al.   Nature Chemical Biology

A JNK-mediated autophagy pathway that triggers c-IAP degradation and necroptosis for anticancer chemotherapy

(2013) W He et al.   ONCOGENE

Autosis is a Na+,K+-ATPase-regulated form of cell death triggered by autophagy-inducing peptides, starvation, and hypoxia-ischemia

(2013) Y. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impairment of lysosomal integrity by B10, a glycosylated derivative of betulinic acid, leads to lysosomal cell death and converts autophagy into a detrimental process

(2012) P Gonzalez et al.   CELL DEATH AND DIFFERENTIATION

Autophagosomal Membrane Serves as Platform for Intracellular Death-inducing Signaling Complex (iDISC)-mediated Caspase-8 Activation and Apoptosis

(2012) Megan M. Young et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ablation of ceramide synthase 2 strongly affects biophysical properties of membranes

(2012) Liana C. Silva et al.   JOURNAL OF LIPID RESEARCH

Emerging functions of the VCP/p97 AAA-ATPase in the ubiquitin system

(2012) Hemmo Meyer et al.   NATURE CELL BIOLOGY

Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy

(2012) R David Sentelle et al.   Nature Chemical Biology

The Role of Atg Proteins in Autophagosome Formation

(2011) Noboru Mizushima et al.   Annual Review of Cell and Developmental Biology

Atg1 allows second-signaled autophagic cell death in Dictyostelium

(2011) Marie-Françoise Luciani et al.   Autophagy

Autophagic cell death: Loch Ness monster or endangered species?

(2011) Han-Ming Shen et al.   Autophagy

Role of Autophagy in Cancer Prevention

(2011) Hsin-Yi Chen et al.   Cancer Prevention Research

RalB and the Exocyst Mediate the Cellular Starvation Response by Direct Activation of Autophagosome Assembly

(2011) Brian O. Bodemann et al.   CELL

Proteasome inhibition can induce an autophagy-dependent apical activation of caspase-8

(2011) M A Laussmann et al.   CELL DEATH AND DIFFERENTIATION

Cell death by autophagy: facts and apparent artefacts

(2011) D Denton et al.   CELL DEATH AND DIFFERENTIATION

Role of AMPK-mTOR-Ulk1/2 in the Regulation of Autophagy: Cross Talk, Shortcuts, and Feedbacks

(2011) S. Alers et al.   MOLECULAR AND CELLULAR BIOLOGY

A second signal for autophagic cell death?

(2010) Corinne Giusti et al.   Autophagy

Autophagic degradation of dBruce controls DNA fragmentation in nurse cells during lateDrosophila melanogasteroogenesis

(2010) Ioannis P. Nezis et al.   JOURNAL OF CELL BIOLOGY

Activation of autophagy during cell death requires the engulfment receptor Draper

(2010) Christina K. McPhee et al.   NATURE

Autophagy in mammalian development and differentiation

(2010) Noboru Mizushima et al.   NATURE CELL BIOLOGY

RNA interference-mediated downregulation of Beclin1 attenuates cerebral ischemic injury in rats

(2009) Yong-qiu Zheng et al.   ACTA PHARMACOLOGICA SINICA

Postischemic treatment of neonatal cerebral ischemia should target autophagy

(2009) Julien Puyal et al.   ANNALS OF NEUROLOGY

Regulation Mechanisms and Signaling Pathways of Autophagy

(2009) Congcong He et al.   Annual Review of Genetics

Cullin3-Based Polyubiquitination and p62-Dependent Aggregation of Caspase-8 Mediate Extrinsic Apoptosis Signaling

(2009) Zhaoyu Jin et al.   CELL

Autophagy, Not Apoptosis, Is Essential for Midgut Cell Death in Drosophila

(2009) Donna Denton et al.   CURRENT BIOLOGY

DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy

(2009) Einat Zalckvar et al.   EMBO REPORTS

Valosin-containing protein (VCP) is required for autophagy and is disrupted in VCP disease

(2009) Jeong-Sun Ju et al.   JOURNAL OF CELL BIOLOGY

Inhibition of Autophagy Prevents Hippocampal Pyramidal Neuron Death after Hypoxic-Ischemic Injury

(2008) Masato Koike et al.   AMERICAN JOURNAL OF PATHOLOGY

Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents

(2008) Michael Degtyarev et al.   JOURNAL OF CELL BIOLOGY

Autophagic Death of Adult Hippocampal Neural Stem Cells Following Insulin Withdrawal

(2008) Seong-Woon Yu et al.   STEM CELLS