Heat-dependent opening of TRPV1 in the presence of capsaicin

Mapping temperature-dependent conformational change in the voltage-sensing domain of an engineered heat-activated K+ channel

(2021) Hongbo Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extracellular cap domain is an essential component of the TRPV1 gating mechanism

(2021) Kirill D. Nadezhdin et al.   Nature Communications

The Sensory Coding of Warm Perception

(2020) Ricardo Paricio-Montesinos et al.   NEURON

A paradigm of thermal adaptation in penguins and elephants by tuning cold activation in TRPM8

(2020) Shilong Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evidence that the TRPV1 S1-S4 membrane domain contributes to thermosensing

(2020) Minjoo Kim et al.   Nature Communications

Regulatory switch at the cytoplasmic interface controls TRPV channel gating

(2019) Lejla Zubcevic et al.   eLife

Heat sensing involves a TR i Plet of ion channels

(2019) Joris Vriens et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Contribution of the Ankyrin Repeat Domain of TRPV1 as a Thermal Module

(2019) Ernesto Ladrón-de-Guevara et al.   BIOPHYSICAL JOURNAL

The role of π-helices in TRP channel gating

(2019) Lejla Zubcevic et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Structural basis of temperature sensation by the TRP channel TRPV3

(2019) Appu K. Singh et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Irreversible temperature gating in trpv1 sheds light on channel activation

(2018) Ana Sánchez-Moreno et al.   eLife

New tools for automated high-resolution cryo-EM structure determination in RELION-3

(2018) Jasenko Zivanov et al.   eLife

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination

(2017) Ali Punjani et al.   NATURE METHODS

Heat activation is intrinsic to the pore domain of TRPV1

(2017) Feng Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the cold- and menthol-sensing ion channel TRPM8

(2017) Ying Yin et al.   SCIENCE

Conformational dynamics in TRPV1 channels reported by an encoded coumarin amino acid

(2017) Ximena Steinberg et al.   eLife

Gctf: Real-time CTF determination and correction

(2016) Kai Zhang   JOURNAL OF STRUCTURAL BIOLOGY

TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action

(2016) Yuan Gao et al.   NATURE

Structural insights into the mechanism of activation of the TRPV1 channel by a membrane-bound tarantula toxin

(2016) Chanhyung Bae et al.   eLife

An external sodium ion binding site controls allosteric gating in TRPV1 channels

(2016) Andres Jara-Oseguera et al.   eLife

Capsaicin Interaction with TRPV1 Channels in a Lipid Bilayer: Molecular Dynamics Simulation

(2015) Sonya M. Hanson et al.   BIOPHYSICAL JOURNAL

Location, Partitioning Behavior, and Interaction of Capsaicin with Lipid Bilayer Membrane: Study Using Its Intrinsic Fluorescence

(2015) Jitendriya Swain et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Binding of Capsaicin to the TRPV1 Ion Channel

(2015) Leonardo Darré et al.   MOLECULAR PHARMACEUTICS

Structural mechanism underlying capsaicin binding and activation of the TRPV1 ion channel

(2015) Fan Yang et al.   Nature Chemical Biology

Understanding TRPV1 activation by ligands: Insights from the binding modes of capsaicin and resiniferatoxin

(2015) Khaled Elokely et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Molecular Framework for Temperature-Dependent Gating of Ion Channels

(2014) Sandipan Chowdhury et al.   CELL

Screening and large-scale expression of membrane proteins in mammalian cells for structural studies

(2014) April Goehring et al.   Nature Protocols

TRPV1 structures in distinct conformations reveal activation mechanisms

(2013) Erhu Cao et al.   NATURE

Structure of the TRPV1 ion channel determined by electron cryo-microscopy

(2013) Maofu Liao et al.   NATURE

Single Residues in the Outer Pore of TRPV1 and TRPV3 Have Temperature-Dependent Conformations

(2013) Sung Eun Kim et al.   PLoS One

The thermo-TRP ion channel family: properties and therapeutic implications

(2011) Laura Vay et al.   BRITISH JOURNAL OF PHARMACOLOGY

Modulation of TRPA1 thermal sensitivity enables sensory discrimination in Drosophila

(2011) Kyeongjin Kang et al.   NATURE

A thermodynamic framework for understanding temperature sensing by transient receptor potential (TRP) channels

(2011) D. E. Clapham et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modular thermal sensors in temperature-gated transient receptor potential (TRP) channels

(2011) J. Yao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Kinetic and Energetic Analysis of Thermally Activated TRPV1 Channels

(2010) Jing Yao et al.   BIOPHYSICAL JOURNAL

Temperature-induced opening of TRPV1 ion channel is stabilized by the pore domain

(2010) Jörg Grandl et al.   NATURE NEUROSCIENCE

Thermosensitive TRP channel pore turret is part of the temperature activation pathway

(2010) F. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Structural determinants of gating in the TRPV1 channel

(2009) Héctor Salazar et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY