The pancreatic cancer genome revisited

Evaluating the utility of tumour mutational signatures for identifying hereditary colorectal cancer and polyposis syndrome carriers

(2021) Peter Georgeson et al.   GUT

Randomized, Multicenter, Phase II Trial of Gemcitabine and Cisplatin With or Without Veliparib in Patients With Pancreas Adenocarcinoma and a Germline BRCA/PALB2 Mutation

(2020) Eileen M. O’Reilly et al.   JOURNAL OF CLINICAL ONCOLOGY

Overall survival in patients with pancreatic cancer receiving matched therapies following molecular profiling: a retrospective analysis of the Know Your Tumor registry trial

(2020) Michael J Pishvaian et al.   LANCET ONCOLOGY

Analyses of non-coding somatic drivers in 2,658 cancer whole genomes

(2020) Esther Rheinbay et al.   NATURE

Pan-cancer analysis of whole genomes

(2020)   NATURE

The repertoire of mutational signatures in human cancer

(2020) Ludmil B. Alexandrov et al.   NATURE

Transcription phenotypes of pancreatic cancer are driven by genomic events during tumor evolution

(2020) Michelle Chan-Seng-Yue et al.   NATURE GENETICS

Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing

(2020) Isidro Cortés-Ciriano et al.   NATURE GENETICS

Role of oncogenic KRAS in the diagnosis, prognosis and treatment of pancreatic cancer

(2020) Louis Buscail et al.   Nature Reviews Gastroenterology & Hepatology

Combined burden and functional impact tests for cancer driver discovery using DriverPower

(2020) Shimin Shuai et al.   Nature Communications

Pattern of invasion in human pancreatic cancer organoids is associated with loss of SMAD4 and clinical outcome

(2020) Wenjie Huang et al.   CANCER RESEARCH

Senescence-Induced Vascular Remodeling Creates Therapeutic Vulnerabilities in Pancreas Cancer

(2020) Marcus Ruscetti et al.   CELL

GATA6 Expression Distinguishes Classical and Basal-like Subtypes in Advanced Pancreatic Cancer

(2020) Grainne M. O'Kane et al.   CLINICAL CANCER RESEARCH

Carcinogenesis of Pancreatic Ductal Adenocarcinoma

(2020) Peter Storz et al.   GASTROENTEROLOGY

Genetic and clinical correlates of entosis in pancreatic ductal adenocarcinoma

(2020) Akimasa Hayashi et al.   MODERN PATHOLOGY

The Evolutionary Origins of Recurrent Pancreatic Cancer

(2020) Hitomi Sakamoto et al.   Cancer Discovery

Squamous trans-differentiation of pancreatic cancer cells promotes stromal inflammation

(2020) Tim DD Somerville et al.   eLife

Chronic Pancreatitis and the Development of Pancreatic Cancer

(2020) Hemanth K. Kandikattu et al.   Endocrine Metabolic & Immune Disorders-Drug Targets

Multidisciplinary standards of care and recent progress in pancreatic ductal adenocarcinoma

(2020) Aaron J. Grossberg et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Oncogene-induced senescence limits the progression of pancreatic neoplasia through production of Activin A

(2020) Yajie Zhao et al.   CANCER RESEARCH

Basal‐like and classical cells coexist in pancreatic cancer revealed by single‐cell analysis on biopsy‐derived pancreatic cancer organoids from the classical subtype

(2020) Natalia Juiz et al.   FASEB JOURNAL

Alternative splicing and cancer: insights, opportunities, and challenges from an expanding view of the transcriptome

(2020) Sara Cherry et al.   GENES & DEVELOPMENT

Emerging mechanisms of cell competition

(2020) Nicholas E. Baker   NATURE REVIEWS GENETICS

Medullary Pancreatic Carcinoma Due to Somatic POLE Mutation

(2020) Valentyna Kryklyva et al.   PANCREAS

Pancreatic cancers suppress negative feedback of glucose transport to reprogram chromatin for metastasis

(2020) Matthew E. Bechard et al.   Nature Communications

Intraductal transplantation models of human pancreatic ductal adenocarcinoma reveal progressive transition of molecular subtypes

(2020) Koji Miyabayashi et al.   Cancer Discovery

The genetic factors of bilaterian evolution

(2020) Peter Heger et al.   eLife

Establishment of a pancreatic adenocarcinoma molecular gradient (PAMG) that predicts the clinical outcome of pancreatic cancer

(2020) Rémy Nicolle et al.   EBioMedicine

KRASG12C Inhibition with Sotorasib in Advanced Solid Tumors

(2020) David S. Hong et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mammalian SWI/SNF Chromatin Remodeling Complexes: Emerging Mechanisms and Therapeutic Strategies

(2020) Richard C. Centore et al.   TRENDS IN GENETICS

Genetic characterization of pancreatic cancer patients and prediction of carrier status of germline pathogenic variants in cancer-predisposing genes

(2020) Keijiro Mizukami et al.   EBioMedicine

RBM10, a New Regulator of p53

(2020) Ji Hoon Jung et al.   Cells

Molecular subtypes of pancreatic cancer

(2019) Eric A. Collisson et al.   Nature Reviews Gastroenterology & Hepatology

UTX Mutations in Human Cancer

(2019) Lu Wang et al.   CANCER CELL

Integration of Genomic and Transcriptional Features in Pancreatic Cancer Reveals Increased Cell Cycle Progression in Metastases

(2019) Ashton A. Connor et al.   CANCER CELL

Human epidermal growth factor receptor 2-positive digestive tumors

(2019) Anna D. Wagner et al.   CURRENT OPINION IN ONCOLOGY

ATDC is required for the initiation of KRAS-induced pancreatic tumorigenesis

(2019) Lidong Wang et al.   GENES & DEVELOPMENT

Quality and quantity control of gene expression by nonsense-mediated mRNA decay

(2019) Tatsuaki Kurosaki et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Oncogenic KRAS Reduces Expression of FGF21 in Acinar Cells to Promote Pancreatic Tumorigenesis in Mice on a High-Fat Diet

(2019) Yongde Luo et al.   GASTROENTEROLOGY

Maintenance Olaparib for Germline BRCA-Mutated Metastatic Pancreatic Cancer

(2019) Talia Golan et al.   NEW ENGLAND JOURNAL OF MEDICINE

CHASMplus Reveals the Scope of Somatic Missense Mutations Driving Human Cancers

(2019) Collin Tokheim et al.   Cell Systems

Guiding pancreatic cyst management

(2019) Conor A. Bradley   Nature Reviews Gastroenterology & Hepatology

Tumour response to TRK inhibition in a patient with pancreatic adenocarcinoma harbouring an NTRK gene fusion

(2019) E M O’Reilly et al.   ANNALS OF ONCOLOGY

Disease-Causing Mutations in SF3B1 Alter Splicing by Disrupting Interaction with SUGP1

(2019) Jian Zhang et al.   MOLECULAR CELL

Emerging epigenomic landscapes of pancreatic cancer in the era of precision medicine

(2019) Gwen Lomberk et al.   Nature Communications

Revisiting the tumorigenesis timeline with a data-driven generative model

(2019) Kamel Lahouel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hereditary Pancreatitis in the United States: Survival and Rates of Pancreatic Cancer

(2018) Celeste A. Shelton et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Exploiting methionine restriction for cancer treatment

(2018) Sushma Chaturvedi et al.   BIOCHEMICAL PHARMACOLOGY

Loss of KDM6A Activates Super-Enhancers to Induce Gender-Specific Squamous-like Pancreatic Cancer and Confers Sensitivity to BET Inhibitors

(2018) Jaclyn Andricovich et al.   CANCER CELL

Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor

(2018) Matthew R. Janes et al.   CELL

Evaluating Mismatch Repair Deficiency in Pancreatic Adenocarcinoma: Challenges and Recommendations

(2018) Zishuo I. Hu et al.   CLINICAL CANCER RESEARCH

Near-tetraploid cancer cells show chromosome instability triggered by replication stress and exhibit enhanced invasiveness

(2018) Darawalee Wangsa et al.   FASEB JOURNAL

Cell of origin affects tumour development and phenotype in pancreatic ductal adenocarcinoma

(2018) Alex Y L Lee et al.   GUT

Prospective Evaluation of Germline Alterations in Patients With Exocrine Pancreatic Neoplasms

(2018) Maeve A Lowery et al.   JNCI-Journal of the National Cancer Institute

Genome doubling shapes the evolution and prognosis of advanced cancers

(2018) Craig M. Bielski et al.   NATURE GENETICS

Contextual determinants of TGFβ action in development, immunity and cancer

(2018) Charles J. David et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mutations in the pancreatic secretory enzymesCPA1andCPB1are associated with pancreatic cancer

(2018) Koji Tamura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endoreplication: The Good, the Bad, and the Ugly

(2018) Zhiqiang Shu et al.   TRENDS IN CELL BIOLOGY

NRG1 Fusions in KRAS Wild-type Pancreatic Cancer

(2018) Christoph Heining et al.   Cancer Discovery

Prospective Evaluation of Germline Alterations in Patients With Exocrine Pancreatic Neoplasms

(2018) Maeve A Lowery et al.   JNCI-Journal of the National Cancer Institute

Cancerization of the Pancreatic Ducts

(2018) Danielle Hutchings et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Evolutionary routes and KRAS dosage define pancreatic cancer phenotypes

(2018) Sebastian Mueller et al.   NATURE

Precancerous neoplastic cells can move through the pancreatic ductal system

(2018) Alvin P. Makohon-Moore et al.   NATURE

Minimal functional driver gene heterogeneity among untreated metastases

(2018) Johannes G. Reiter et al.   SCIENCE

FOLFIRINOX or Gemcitabine as Adjuvant Therapy for Pancreatic Cancer

(2018) Thierry Conroy et al.   NEW ENGLAND JOURNAL OF MEDICINE

Somatic mutant clones colonize the human esophagus with age

(2018) Iñigo Martincorena et al.   SCIENCE

TP63-Mediated Enhancer Reprogramming Drives the Squamous Subtype of Pancreatic Ductal Adenocarcinoma

(2018) Tim D.D. Somerville et al.   Cell Reports

Hypermutation In Pancreatic Cancer

(2017) Jeremy L. Humphris et al.   GASTROENTEROLOGY

Deleterious Germline Mutations in Patients With Apparently Sporadic Pancreatic Adenocarcinoma

(2017) Koji Shindo et al.   JOURNAL OF CLINICAL ONCOLOGY

Genetic analyses of isolated high-grade pancreatic intraepithelial neoplasia (HG-PanIN) reveal paucity of alterations in TP53 and SMAD4

(2017) Waki Hosoda et al.   JOURNAL OF PATHOLOGY

Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer

(2017) Vinod P. Balachandran et al.   NATURE

A neoantigen fitness model predicts tumour response to checkpoint blockade immunotherapy

(2017) Marta Łuksza et al.   NATURE

Recurrent noncoding regulatory mutations in pancreatic ductal adenocarcinoma

(2017) Michael E Feigin et al.   NATURE GENETICS

Limited heterogeneity of known driver gene mutations among the metastases of individual patients with pancreatic cancer

(2017) Alvin P Makohon-Moore et al.   NATURE GENETICS

Epigenomic reprogramming during pancreatic cancer progression links anabolic glucose metabolism to distant metastasis

(2017) Oliver G McDonald et al.   NATURE GENETICS

Pancreatic carcinogenesis — several small steps or one giant leap?

(2017) Johannes G. Reiter et al.   Nature Reviews Gastroenterology & Hepatology

The evolutionary significance of polyploidy

(2017) Yves Van de Peer et al.   NATURE REVIEWS GENETICS

Mechanisms of action and regulation of ATP-dependent chromatin-remodelling complexes

(2017) Cedric R. Clapier et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Prevalence and Clinicopathological Characteristics of High-Grade Pancreatic Intraepithelial Neoplasia

(2017) Yoko Matsuda et al.   PANCREAS

MicroRNA regulation of K-Ras in pancreatic cancer and opportunities for therapeutic intervention

(2017) Saswati Karmakar et al.   SEMINARS IN CANCER BIOLOGY

Familial pancreatic cancer: Concept, management and issues

(2017) Hiroyuki Matsubayashi et al.   WORLD JOURNAL OF GASTROENTEROLOGY

KRAS: The Critical Driver and Therapeutic Target for Pancreatic Cancer

(2017) Andrew M. Waters et al.   Cold Spring Harbor Perspectives in Medicine

Chronic pancreatitis

(2017) Jorg Kleeff et al.   Nature Reviews Disease Primers

Association of Distinct Mutational Signatures With Correlates of Increased Immune Activity in Pancreatic Ductal Adenocarcinoma

(2017) Ashton A. Connor et al.   JAMA Oncology

Mutant KRAS Enhances Tumor Cell Fitness by Upregulating Stress Granules

(2016) Elda Grabocka et al.   CELL

A renewed model of pancreatic cancer evolution based on genomic rearrangement patterns

(2016) Faiyaz Notta et al.   NATURE

Genomic analyses identify molecular subtypes of pancreatic cancer

(2016) Peter Bailey et al.   NATURE

Influence of Body Mass Index and Albumin on Perioperative Morbidity and Clinical Outcomes in Resected Pancreatic Adenocarcinoma

(2016) Andrew Hendifar et al.   PLoS One

Evaluating the evaluation of cancer driver genes

(2016) Collin J. Tokheim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Allele-specific inhibitors inactivate mutant KRAS G12C by a trapping mechanism

(2016) P. Lito et al.   SCIENCE

MTAP Deletions in Cancer Create Vulnerability to Targeting of the MAT2A/PRMT5/RIOK1 Axis

(2016) Katya Marjon et al.   Cell Reports

MLL3/MLL4/COMPASS Family on Epigenetic Regulation of Enhancer Function and Cancer

(2016) Christie C. Sze et al.   Cold Spring Harbor Perspectives in Medicine

Control of Wnt Receptor Turnover by R-spondin-ZNRF3/RNF43 Signaling Module and Its Dysregulation in Cancer

(2016) Huai-Xiang Hao et al.   Cancers

A Revised Classification System and Recommendations From the Baltimore Consensus Meeting for Neoplastic Precursor Lesions in the Pancreas

(2015) Olca Basturk et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

RUNX3 Controls a Metastatic Switch in Pancreatic Ductal Adenocarcinoma

(2015) Martin C. Whittle et al.   CELL

Entosis: Cell-in-Cell Formation that Kills Through Entotic Cell Death

(2015) O. Florey et al.   CURRENT MOLECULAR MEDICINE

A Combination of Molecular Markers and Clinical Features Improve the Classification of Pancreatic Cysts

(2015) Simeon Springer et al.   GASTROENTEROLOGY

Whole genomes redefine the mutational landscape of pancreatic cancer

(2015) Nicola Waddell et al.   NATURE

Virtual microdissection identifies distinct tumor- and stroma-specific subtypes of pancreatic ductal adenocarcinoma

(2015) Richard A Moffitt et al.   NATURE GENETICS

PD-1 Blockade in Tumors with Mismatch-Repair Deficiency

(2015) Dung T. Le et al.   NEW ENGLAND JOURNAL OF MEDICINE

High burden and pervasive positive selection of somatic mutations in normal human skin

(2015) I. Martincorena et al.   SCIENCE

Whole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets

(2015) Agnieszka K. Witkiewicz et al.   Nature Communications

IL35-Producing B Cells Promote the Development of Pancreatic Neoplasia

(2015) Y. Pylayeva-Gupta et al.   Cancer Discovery

Whole Genome Sequencing Defines the Genetic Heterogeneity of Familial Pancreatic Cancer

(2015) N. J. Roberts et al.   Cancer Discovery

Mammary Stem Cell Self-Renewal Is Regulated by Slit2/Robo1 Signaling through SNAI1 and mINSC

(2015) Mimmi S. Ballard et al.   Cell Reports

GNAS Spectrum of Disorders

(2015) Serap Turan et al.   Current Osteoporosis Reports

Oncogenic Kras Activates a Hematopoietic-to-Epithelial IL-17 Signaling Axis in Preinvasive Pancreatic Neoplasia

(2014) Florencia McAllister et al.   CANCER CELL

Stromal reengineering to treat pancreas cancer

(2014) I. M. Stromnes et al.   CARCINOGENESIS

Nicotine Promotes Initiation and Progression of KRAS-Induced Pancreatic Cancer via Gata6-Dependent Dedifferentiation of Acinar Cells in Mice

(2014) Patrick C. Hermann et al.   GASTROENTEROLOGY

Homozygous deletion of the activin A receptor, type IB gene is associated with an aggressive cancer phenotype in pancreatic cancer

(2014) Yosuke Togashi et al.   Molecular Cancer

Mechanisms underlying mutational signatures in human cancers

(2014) Thomas Helleday et al.   NATURE REVIEWS GENETICS

Lessons from the Cancer Genome

(2013) Levi A. Garraway et al.   CELL

Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells

(2013) Cosimo Commisso et al.   NATURE

Signatures of mutational processes in human cancer

(2013) Ludmil B. Alexandrov et al.   NATURE

Increased Survival in Pancreatic Cancer with nab-Paclitaxel plus Gemcitabine

(2013) Daniel D. Von Hoff et al.   NEW ENGLAND JOURNAL OF MEDICINE

Evolution and dynamics of pancreatic cancer progression

(2013) S Yachida et al.   ONCOGENE

Half or more of the somatic mutations in cancers of self-renewing tissues originate prior to tumor initiation

(2013) C. Tomasetti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer Genome Landscapes

(2013) B. Vogelstein et al.   SCIENCE

Clinical and molecular characterization of HER2 amplified-pancreatic cancer

(2013) Angela Chou et al.   Genome Medicine

Identification of Sox9-Dependent Acinar-to-Ductal Reprogramming as the Principal Mechanism for Initiation of Pancreatic Ductal Adenocarcinoma

(2012) Janel L. Kopp et al.   CANCER CELL

KrasG12D-Induced IKK2/β/NF-κB Activation by IL-1α and p62 Feedforward Loops Is Required for Development of Pancreatic Ductal Adenocarcinoma

(2012) Jianhua Ling et al.   CANCER CELL

EGF Receptor Is Required for KRAS-Induced Pancreatic Tumorigenesis

(2012) Christine M. Ardito et al.   CANCER CELL

MYC on the Path to Cancer

(2012) Chi V. Dang   CELL

Clinical Significance of the Genetic Landscape of Pancreatic Cancer and Implications for Identification of Potential Long-term Survivors

(2012) S. Yachida et al.   CLINICAL CANCER RESEARCH

Presence of Somatic Mutations in Most Early-Stage Pancreatic Intraepithelial Neoplasia

(2012) Mitsuro Kanda et al.   GASTROENTEROLOGY

An NF-κB pathway–mediated positive feedback loop amplifies Ras activity to pathological levels in mice

(2012) Jaroslaw Daniluk et al.   JOURNAL OF CLINICAL INVESTIGATION

Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes

(2012) Andrew V. Biankin et al.   NATURE

ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner

(2012) Huai-Xiang Hao et al.   NATURE

Convergent structural alterations define SWItch/Sucrose NonFermentable (SWI/SNF) chromatin remodeler as a central tumor suppressive complex in pancreatic cancer

(2012) A. H. Shain et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development

(2011) Philip J. Stephens et al.   CELL

APOBEC3A can activate the DNA damage response and cause cell-cycle arrest

(2011) Sébastien Landry et al.   EMBO REPORTS

Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapy

(2011) Eric A Collisson et al.   NATURE MEDICINE

Cystic precursors to invasive pancreatic cancer

(2011) Hanno Matthaei et al.   Nature Reviews Gastroenterology & Hepatology

Somatic hypermutation of human mitochondrial and nuclear DNA by APOBEC3 cytidine deaminases, a pathway for DNA catabolism

(2011) R. Suspene et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways

(2011) J. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ATM Mutations in Patients with Hereditary Pancreatic Cancer

(2011) Nicholas J. Roberts et al.   Cancer Discovery

Repressive LTR Nucleosome Positioning by the BAF Complex Is Required for HIV Latency

(2011) Haleh Rafati et al.   PLOS BIOLOGY

Frequent genomic copy number gain and overexpression of GATA-6 in pancreatic carcinoma

(2010) Baojin Fu et al.   CANCER BIOLOGY & THERAPY

Distant metastasis occurs late during the genetic evolution of pancreatic cancer

(2010) Shinichi Yachida et al.   NATURE

Accumulation of driver and passenger mutations during tumor progression

(2010) I. Bozic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cigarette Smoking and Pancreatic Cancer: A Pooled Analysis From the Pancreatic Cancer Cohort Consortium

(2009) S. M. Lynch et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

KRAS2 Mutations in Human Pancreatic Acinar-Ductal Metaplastic Lesions Are Limited to Those with PanIN: Implications for the Human Pancreatic Cancer Cell of Origin

(2009) C. Shi et al.   MOLECULAR CANCER RESEARCH

Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer

(2009) J. P. Morton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Trp53 Deletion Stimulates the Formation of Metastatic Pancreatic Tumors

(2008) Jennifer P. Morton et al.   AMERICAN JOURNAL OF PATHOLOGY

TGFβ in Cancer

(2008) Joan Massagué   CELL

Tobacco and the risk of pancreatic cancer: a review and meta-analysis

(2008) Simona Iodice et al.   LANGENBECKS ARCHIVES OF SURGERY

Wound repair and regeneration

(2008) Geoffrey C. Gurtner et al.   NATURE

McCune-Albright syndrome

(2008) Claudia E Dumitrescu et al.   Orphanet Journal of Rare Diseases

Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses

(2008) S. Jones et al.   SCIENCE