Revisiting the tumorigenesis timeline with a data-driven generative model

Mutated clones are the new normal

(2019) Cristian Tomasetti   SCIENCE

RNA sequence analysis reveals macroscopic somatic clonal expansion across normal tissues

(2019) Keren Yizhak et al.   SCIENCE

Cell division rates decrease with age, providing a potential explanation for the age-dependent deceleration in cancer incidence

(2019) Cristian Tomasetti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Timing the Landmark Events in the Evolution of Clear Cell Renal Cell Cancer: TRACERx Renal

(2018) Thomas J. Mitchell et al.   CELL

Quantification of subclonal selection in cancer from bulk sequencing data

(2018) Marc J. Williams et al.   NATURE GENETICS

Somatic mutant clones colonize the human esophagus with age

(2018) Iñigo Martincorena et al.   SCIENCE

Role of stem-cell divisions in cancer risk

(2017) Cristian Tomasetti et al.   NATURE

Understanding TERT Promoter Mutations: A Common Path to Immortality

(2016) R. J. A. Bell et al.   MOLECULAR CANCER RESEARCH

Variation in cancer risk among tissues can be explained by the number of stem cell divisions

(2015) C. Tomasetti et al.   SCIENCE

Only three driver gene mutations are required for the development of lung and colorectal cancers

(2014) Cristian Tomasetti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lessons from the Cancer Genome

(2013) Levi A. Garraway et al.   CELL

Half or more of the somatic mutations in cancers of self-renewing tissues originate prior to tumor initiation

(2013) C. Tomasetti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Defining Stem Cell Dynamics in Models of Intestinal Tumor Initiation

(2013) L. Vermeulen et al.   SCIENCE

Cancer Genome Landscapes

(2013) B. Vogelstein et al.   SCIENCE

2564 resected periampullary adenocarcinomas at a single institution: trends over three decades

(2013) Jin He et al.   HPB

Cancer Risks forMLH1andMSH2Mutation Carriers

(2012) James G. Dowty et al.   HUMAN MUTATION

Comprehensive molecular characterization of human colon and rectal cancer

(2012)   NATURE

Predicting clonal self-renewal and extinction of hematopoietic stem cells

(2011) H. B. Sieburg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hereditary and Familial Colon Cancer

(2010) Kory W. Jasperson et al.   GASTROENTEROLOGY

Role of symmetric and asymmetric division of stem cells in developing drug resistance

(2010) C. Tomasetti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Accumulation of driver and passenger mutations during tumor progression

(2010) I. Bozic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Calculation of Risk of Colorectal and Endometrial Cancer Among Patients With Lynch Syndrome

(2009) Elena Stoffel et al.   GASTROENTEROLOGY

Cancer and non-cancer effects in Japanese atomic bomb survivors

(2009) M P Little   JOURNAL OF RADIOLOGICAL PROTECTION

The cancer genome

(2009) Michael R. Stratton et al.   NATURE

Evolution of resistance and progression to disease during clonal expansion of cancer

(2009) Richard Durrett et al.   THEORETICAL POPULATION BIOLOGY

Pancreatic Cancer

(2008) Anirban Maitra et al.   Annual Review of Pathology-Mechanisms of Disease

Comparative lesion sequencing provides insights into tumor evolution

(2008) S. Jones et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA