CISH constrains the tuft–ILC2 circuit to set epithelial and immune tone

Enteric helminth coinfection enhances host susceptibility to neurotropic flaviviruses via a tuft cell-IL-4 receptor signaling axis

(2021) Pritesh Desai et al.   CELL

Tissue-specific pathways extrude activated ILC2s to disseminate type 2 immunity

(2020) Roberto R. Ricardo-Gonzalez et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Metabolic Reprograming via Deletion of CISH in Human iPSC-Derived NK Cells Promotes In Vivo Persistence and Enhances Anti-tumor Activity

(2020) Huang Zhu et al.   Cell Stem Cell

Distinct functions of tissue-resident and circulating memory Th2 cells in allergic airway disease

(2020) Rod A. Rahimi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Human NK cells: surface receptors, inhibitory checkpoints, and translational applications

(2019) Simona Sivori et al.   Cellular & Molecular Immunology

Neuropeptide CGRP Limits Group 2 Innate Lymphoid Cell Responses and Constrains Type 2 Inflammation

(2019) Hiroyuki Nagashima et al.   IMMUNITY

Salmonella-Driven Polarization of Granuloma Macrophages Antagonizes TNF-Mediated Pathogen Restriction during Persistent Infection

(2019) Trung H.M. Pham et al.   Cell Host & Microbe

A Metabolite-Triggered Tuft Cell-ILC2 Circuit Drives Small Intestinal Remodeling

(2018) Christoph Schneider et al.   CELL

Why Innate Lymphoid Cells?

(2018) Maya E. Kotas et al.   IMMUNITY

Detection of Succinate by Intestinal Tuft Cells Triggers a Type 2 Innate Immune Circuit

(2018) Marija S. Nadjsombati et al.   IMMUNITY

S1P-dependent interorgan trafficking of group 2 innate lymphoid cells supports host defense

(2018) Yuefeng Huang et al.   SCIENCE

β2-adrenergic receptor–mediated negative regulation of group 2 innate lymphoid cell responses

(2018) Saya Moriyama et al.   SCIENCE

Tissue signals imprint ILC2 identity with anticipatory function

(2018) Roberto R. Ricardo-Gonzalez et al.   NATURE IMMUNOLOGY

CISH is a negative regulator of IL-13-induced CCL26 production in lung fibroblasts

(2018) Hideyuki Takeshima et al.   ALLERGOLOGY INTERNATIONAL

A single-cell survey of the small intestinal epithelium

(2017) Adam L. Haber et al.   NATURE

Cholesterol Metabolism in T Cells

(2017) Andreas Bietz et al.   Frontiers in Immunology

Host-Protozoan Interactions Protect from Mucosal Infections through Activation of the Inflammasome

(2016) Aleksey Chudnovskiy et al.   CELL

Intestinal epithelial tuft cells initiate type 2 mucosal immunity to helminth parasites

(2016) François Gerbe et al.   NATURE

CIS is a potent checkpoint in NK cell–mediated tumor immunity

(2016) Rebecca B Delconte et al.   NATURE IMMUNOLOGY

Innate lymphoid cells as regulators of immunity, inflammation and tissue homeostasis

(2016) Christoph S N Klose et al.   NATURE IMMUNOLOGY

Tuft cells, taste-chemosensory cells, orchestrate parasite type 2 immunity in the gut

(2016) M. R. Howitt et al.   SCIENCE

Deciphering the Innate Lymphoid Cell Transcriptional Program

(2016) Cyril Seillet et al.   Cell Reports

Cish actively silences TCR signaling in CD8 + T cells to maintain tumor tolerance

(2015) Douglas C. Palmer et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Novel IL-25 Signaling Pathway through STAT5

(2015) Ling Wu et al.   JOURNAL OF IMMUNOLOGY

Tuft-cell-derived IL-25 regulates an intestinal ILC2–epithelial response circuit

(2015) Jakob von Moltke et al.   NATURE

Type I interferon restricts type 2 immunopathology through the regulation of group 2 innate lymphoid cells

(2015) Claudia U Duerr et al.   NATURE IMMUNOLOGY

Interferon and IL-27 antagonize the function of group 2 innate lymphoid cells and type 2 innate immune responses

(2015) Kazuyo Moro et al.   NATURE IMMUNOLOGY

ILC2s and T cells cooperate to ensure maintenance of M2 macrophages for lung immunity against hookworms

(2015) Tiffany Bouchery et al.   Nature Communications

IL-33-Mediated Protection against Experimental Cerebral Malaria Is Linked to Induction of Type 2 Innate Lymphoid Cells, M2 Macrophages and Regulatory T Cells

(2015) Anne-Gaelle Besnard et al.   PLoS Pathogens

IL-25-responsive, lineage-negative KLRG1hi cells are multipotential ‘inflammatory’ type 2 innate lymphoid cells

(2014) Yuefeng Huang et al.   NATURE IMMUNOLOGY

Genetic Contribution of CISH Promoter Polymorphisms to Susceptibility to Tuberculosis in Chinese Children

(2014) Lin Sun et al.   PLoS One

Metabolic Regulation of T Lymphocytes

(2013) Nancie J. MacIver et al.   Annual Review of Immunology

Salmonella Require the Fatty Acid Regulator PPARδ for the Establishment of a Metabolic Environment Essential for Long-Term Persistence

(2013) Nicholas A. Eisele et al.   Cell Host & Microbe

Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages

(2013) Ari B. Molofsky et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Human Airway Eosinophils Exhibit Preferential Reduction in STAT Signaling Capacity and Increased CISH Expression

(2013) M. E. Burnham et al.   JOURNAL OF IMMUNOLOGY

Type 2 innate lymphoid cells control eosinophil homeostasis

(2013) Jesse C. Nussbaum et al.   NATURE

Sterol regulatory element–binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity

(2013) Yoko Kidani et al.   NATURE IMMUNOLOGY

The signaling suppressor CIS controls proallergic T cell development and allergic airway inflammation

(2013) Xuexian O Yang et al.   NATURE IMMUNOLOGY

The Deubiquitinase A20 Mediates Feedback Inhibition of Interleukin-17 Receptor Signaling

(2013) A. V. Garg et al.   Science Signaling

Lung Natural Helper Cells Are a Critical Source of Th2 Cell-Type Cytokines in Protease Allergen-Induced Airway Inflammation

(2012) Timotheus Y.F. Halim et al.   IMMUNITY

CISH is induced during DC development and regulates DC-mediated CTL activation

(2011) Mohammad Alam Miah et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Association of CISH -292A/T genetic variant with hepatitis B virus infection

(2011) Hoang V. Tong et al.   IMMUNOGENETICS

A conditional knockout resource for the genome-wide study of mouse gene function

(2011) William C. Skarnes et al.   NATURE

Divergent expression patterns of IL-4 and IL-13 define unique functions in allergic immunity

(2011) Hong-Erh Liang et al.   NATURE IMMUNOLOGY

Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus

(2011) Laurel A Monticelli et al.   NATURE IMMUNOLOGY

Alternative Activation of Macrophages: Mechanism and Functions

(2010) Siamon Gordon et al.   IMMUNITY

CISHand Susceptibility to Infectious Diseases

(2010) Chiea C. Khor et al.   NEW ENGLAND JOURNAL OF MEDICINE

Systemically dispersed innate IL-13-expressing cells in type 2 immunity

(2010) A. E. Price et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Immunological Genome Project: networks of gene expression in immune cells

(2008) Tracy S P Heng et al.   NATURE IMMUNOLOGY