Article
Biochemistry & Molecular Biology
Chiao-Juno Chiu, Chien-Chia Liao, Yu-Hsiang Hsu, Bor-Luen Chiang
Summary: Endogenous adult lung SSEA-1(+) cells almost disappear in asthmatic mice, but a unique population of circulating SSEA-1(+) cells is enriched after the challenge phase. These cells play a beneficial role in lung inflammation and structural damage by homing to the lung and inhibiting inflammatory cell infiltration.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Multidisciplinary Sciences
Nicholas N. Jarjour, Kelsey M. Wanhainen, Changwei Peng, Noah V. Gavil, Nicholas J. Maurice, Henrique Borges da Silva, Ryan J. Martinez, Talia S. Dalzell, Matthew A. Huggins, David Masopust, Sara E. Hamilton, Stephen C. Jameson
Summary: Interleukin-15 (IL-15) is a central regulator of memory CD8+ T cells and can stimulate their proliferation and expansion. IL-15 sensitivity is an important feature of memory CD8+ T cell populations, with therapeutic potential.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Allergy
Takao Kobayashi, Koji Iijima, Koji Matsumoto, Jyoti K. Lama, Hirohito Kita
Summary: This study investigated the mechanisms behind the persistent type 2 immunity in chronic airway diseases such as asthma. Mouse models were used to show that CD69+ST2+ TH2 memory cells quickly develop in lung tissue after initial allergen exposure and persist for a prolonged period. The ST2/IL-33 pathway may play a role in the development of immune memory in lung to certain allergens.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Review
Immunology
Marcus Buggert, David A. Price, Laura K. Mackay, Michael R. Betts
Summary: Our current understanding of human memory CD8(+) T cells mainly comes from studies of the intravascular space, but new data challenges some established ideas and suggests the need for conceptual revision. This review provides a brief history of the field and summarizes the biology of circulating and tissue-resident memory CD8(+) T cells, which play a crucial role in immune surveillance. The authors also discuss how future human studies can improve our understanding of CD8(+) T cells and inform the development of better immunotherapies and vaccines.
Article
Allergy
ZhengWang Sun, Ji Hye Kim, Seo Hyeong Kim, Hye Ran Kim, KeLun Zhang, Youdong Pan, Min Kyung Ko, Bo Mi Kim, Howard Chu, Hee Ra Lee, Hye Li Kim, Ji Hyung Kim, Xiujun Fu, Young-Min Hyun, Ki Na Yun, Jin Young Kim, Dong Won Lee, Seung Yong Song, Charles P. Lin, Rachael A. Clark, Kwang Hoon Lee, Thomas S. Kupper, Chang Ook Park
Summary: The study found that CXCR4 and its ligand CXCL12 were significantly upregulated in the skin of humans with AD through global transcriptomic and proteomic analyses. Skin-resident CXCR4(+) NKT cells were enriched and consistently elevated in models of mice with AD, suggesting their potential role in contributing to AD pathogenesis.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Plant Sciences
Soo-Jin Park, Kiram Lee, Min-Ah Kang, Tae-hyoun Kim, Hyun-Jae Jang, Hyung Won Ryu, Sei-Ryang Oh, Hyun-Jun Lee
Summary: The study showed that tilianin attenuates airway inflammation and AHR in a HDM-induced asthma mouse model by inhibiting Th2-mediated inflammation.
Review
Immunology
Weihang Luo, Jindong Hu, Weifang Xu, Jingcheng Dong
Summary: The immune response in the asthmatic respiratory tract is driven by CD4(+) T helper cells, especially Th2 cells. Asthma is a heterogeneous and progressive disease, with different stages of the disease course showing different immune responses. The complex immune networks in the inflammatory airway make it challenging to find a universal treatment for all asthmatics.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Miaomiao Han, Jingyu Ma, Suidong Ouyang, Yanyan Wang, Tingting Zheng, Peishan Lu, Zihan Zheng, Weiheng Zhao, Hongjin Li, Yun Wu, Baohua Zhang, Ran Hu, Kinya Otsu, Xinguang Liu, Ying Wan, Huabin Li, Gonghua Huang
Summary: Dendritic cells (DCs) play a critical role in controlling T helper 2 (Th2) cell-dependent diseases. Our study identifies p38 alpha signaling as a central pathway in DCs that regulates Th2-cell differentiation and function, integrating allergic and parasitic instructive signals with Th2-instructive cytokines from the microenvironment.
CELLULAR & MOLECULAR IMMUNOLOGY
(2022)
Review
Allergy
Ami Aoki, Kiyoshi Hirahara, Masahiro Kiuchi, Toshinori Nakayama
Summary: Eosinophils are multifunctional leukocytes involved in defense, tissue repair, and pathogenesis of allergic diseases. Their granules release various substances that exacerbate inflammation. In type 2 inflammatory diseases, specific T cells regulate eosinophilic inflammation.
ALLERGOLOGY INTERNATIONAL
(2021)
Article
Allergy
Komal Agrawal, Li Ching Ong, Susan Monkley, Kristofer Thorn, Elisabeth Israelsson, Engin Baturcam, Cassie Rist, Karin Schon, Sophia Blake, Bjorn Magnusson, James Cartwright, Suman Mitra, Abilash Ravi, Nazanin Zounemat-Kermani, Jayendra Kumar Krishnaswamy, Nils Y. Lycke, Ulf Gehrmann, Johan Mattsson
Summary: Patients with asthma experience reduced ability to clear respiratory viral infections due to changes in gene expression in nasal and lung epithelial cells. These changes interfere with the development of lung resident memory T cells, which may contribute to the increased susceptibility of patients with asthma to viral exacerbations.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Immunology
Nianyu Li, Zhuqing Li, Fang Fang, Chendi Zhu, Wenzhe Zhang, Yueshuang Lu, Rongrong Zhang, Pinxin Si, Yuehong Bian, Yingying Qin, Xue Jiao
Summary: This study identifies two distinct macrophage populations in the mouse ovary and investigates their heterogeneity, maintenance, and role in ovarian homeostasis and physiology. The findings highlight the importance of tissue-resident macrophages in regulating ovarian function.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Demi Brownlie, Marlena Scharenberg, Jeff E. Mold, Joanna Hard, Eliisa Kekalainen, Marcus Buggert, Son Nguyen, Jennifer N. Wilson, Mamdoh Al-Ameri, Hans-Gustaf Ljunggren, Nicole Marquardt, Jakob Michaelsson
Summary: Recent studies have shown the existence of tissue-resident adaptive-like NK cells in the human lung and blood, which differ from traditional NK cells and exhibit enhanced cytotoxicity towards tumor cells. These cells may represent a novel strategy for targeted therapies against solid tumors.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Immunology
Curtis J. Pritzl, Mark A. Daniels, Emma Teixeiro
Summary: CD8 positive, tissue resident memory T cells are a specialized subset of T cells that provide critical protection against tumors and pathogen re-infection. The development and maintenance of these cells involve a myriad of signals, including tissue-derived signals and antigenic/pro-inflammatory cytokines. Recent research suggests additional roles for antigenic and pro-inflammatory signals in the establishment of resident memory T cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Rut Mora-Buch, Shannon K. Bromley
Summary: Resident memory CD8(+) T cells provide rapid local protection and control tumor growth, but dysregulation may contribute to autoimmune diseases. Intrinsic mechanisms and extrinsic stimuli regulate T-RM differentiation and response.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Cell Biology
Anoushka Ashok Kumar Samat, Jolijn van der Geest, Sebastiaan J. Vastert, Jorg van Loosdregt, Femke van Wijk
Summary: The article summarizes the role of tissue-resident memory T cells (T-RM) in chronic inflammatory diseases, highlighting the presence of T-RM in both non-lymphoid tissue and circulation, and their potential significance in disease progression and treatment.
Article
Respiratory System
David C. Adams, Alyssa J. Miller, Matthew B. Applegate, Josalyn L. Cho, Daniel L. Hamilos, Alex Chee, Jasmin A. Holz, Margit V. Szabari, Lida P. Hariri, R. Scott Harris, Jason W. Griffith, Andrew D. Luster, Benjamin D. Medoff, Melissa J. Suter
Article
Cell Biology
Jeffrey Lian, Aleksandra J. Ozga, Caroline L. Sokol, Andrew D. Luster
Article
Microbiology
Yahui Guo, Shinji Kasahara, Anupam Jhingran, Nicholas L. Tosini, Bing Zhai, Mariano A. Aufiero, Kathleen A. M. Mills, Mergim Gjonbalaj, Vanessa Espinosa, Amariliz Rivera, Andrew D. Luster, Tobias M. Hohl
CELL HOST & MICROBE
(2020)
Editorial Material
Immunology
Rod A. Rahimi, Andrew D. Luster
TRENDS IN IMMUNOLOGY
(2020)
Article
Oncology
Dexter P. Mendoza, Puja Kohli, John W. Nance, Ramandeep Singh, Josalyn Cho, Jason Griffith, R. Scott Harris, Vanessa J. Kelly, Andrew D. Luster, Benjamin Medoff, Subba R. Digumarthy
ANNALS OF TRANSLATIONAL MEDICINE
(2020)
Article
Immunology
Lucas D. Faustino, Jason W. Griffith, Rod A. Rahimi, Keshav Nepal, Daniel L. Hamilos, Josalyn L. Cho, Benjamin D. Medoff, James J. Moon, Dario A. A. Vignali, Andrew D. Luster
Article
Cell Biology
Shannon K. Bromley, Hasan Akbaba, Vinidhra Mani, Rut Mora-Buch, Alexandra Y. Chasse, Andrea Sama, Andrew D. Luster
Article
Cell Biology
Benedict D. Michael, Laura Bricio-Moreno, Elizabeth W. Sorensen, Yoshishige Miyabe, Jeffrey Lian, Tom Solomon, Evelyn A. Kurt-Jones, Andrew D. Luster
Meeting Abstract
Critical Care Medicine
J. Alladina, T. Kooistra, R. A. Rahimi, D. Hamilos, A. Luster, B. D. Medoff, J. L. Cho
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2020)
Meeting Abstract
Critical Care Medicine
R. A. Rahimi, K. Nepal, A. D. Luster
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2020)
Meeting Abstract
Rheumatology
Mazen Nasrallah, Molly Thomas, Kasidet Manakongtreecheep, Daniel Zlotoff, Aleigha Lawless, Hellen Giang, Sara Schoenfeld, Ryan Sullivan, Genevieve Boland, Kerry Reynolds, Minna Kohler, Andrew Luster, Alexandra-Chloe Villani
ARTHRITIS & RHEUMATOLOGY
(2019)
Meeting Abstract
Critical Care Medicine
J. Griffith, L. Faustino, A. Luster
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2019)
Meeting Abstract
Critical Care Medicine
J. Alladina, R. A. Rahimi, J. W. Griffith, K. M. Discipio, D. L. Hamilos, A. D. Luster, B. D. Medoff, J. L. Cho
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2019)
Article
Medicine, Research & Experimental
Njabulo Ngwenyama, Ane M. Salvador, Francisco Velazquez, Tania Nevers, Alexander Levy, Mark Aronovitz, Andrew D. Luster, Gordon S. Huggins, Pilar Alcaide