A loss-of-function variant in SUV39H2 identified in autism-spectrum disorder causes altered H3K9 trimethylation and dysregulation of protocadherin β-cluster genes in the developing brain
出版年份 2021 全文链接
标题
A loss-of-function variant in SUV39H2 identified in autism-spectrum disorder causes altered H3K9 trimethylation and dysregulation of protocadherin β-cluster genes in the developing brain
作者
关键词
-
出版物
MOLECULAR PSYCHIATRY
Volume -, Issue -, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2021-07-15
DOI
10.1038/s41380-021-01199-7
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Role of an Atypical Cadherin Gene, Cdh23 in Prepulse Inhibition, and Implication of CDH23 in Schizophrenia
- (2021) Shabeesh Balan et al. SCHIZOPHRENIA BULLETIN
- IntelliCage as a tool for measuring mouse behavior – 20 years perspective
- (2020) Anna Kiryk et al. BEHAVIOURAL BRAIN RESEARCH
- Wiring the Brain by Clustered Protocadherin Neural Codes
- (2020) Qiang Wu et al. Neuroscience Bulletin
- The role of clustered protocadherins in neurodevelopment and neuropsychiatric diseases
- (2020) Erin Flaherty et al. CURRENT OPINION IN GENETICS & DEVELOPMENT
- Peroxisome proliferator-activated receptor α as a novel therapeutic target for schizophrenia
- (2020) Yuina Wada et al. EBioMedicine
- Cerebellar Dysfunction in Autism Spectrum Disorders: Deriving Mechanistic Insights from an Internal Model Framework
- (2020) Elyza Kelly et al. NEUROSCIENCE
- Structural Insights into Stimulation of Ash1L's H3K36 Methyltransferase Activity through Mrg15 Binding
- (2019) Peini Hou et al. STRUCTURE
- A Synaptic Perspective of Fragile X Syndrome and Autism Spectrum Disorders
- (2019) Claudia Bagni et al. NEURON
- Emerging connections between cerebellar development, behaviour and complex brain disorders
- (2019) Aaron Sathyanesan et al. NATURE REVIEWS NEUROSCIENCE
- Identification of common genetic risk variants for autism spectrum disorder
- (2019) Jakob Grove et al. NATURE GENETICS
- Impaired neurodevelopmental pathways in autism spectrum disorder: a review of signaling mechanisms and crosstalk
- (2019) Santosh Kumar et al. Journal of Neurodevelopmental Disorders
- Gene expression across mammalian organ development
- (2019) Margarida Cardoso-Moreira et al. NATURE
- Investigation of betaine as a novel psychotherapeutic for schizophrenia
- (2019) Tetsuo Ohnishi et al. EBioMedicine
- Inherited and De Novo Genetic Risk for Autism Impacts Shared Networks
- (2019) Elizabeth K. Ruzzo et al. CELL
- Getting to the Cores of Autism
- (2019) Lilia M. Iakoucheva et al. CELL
- Molecular and anatomical organization of the dorsal raphe nucleus
- (2019) Kee Wui Huang et al. eLife
- Increased H3K9 methylation and impaired expression of Protocadherins are associated with the cognitive dysfunctions of the Kleefstra syndrome
- (2018) Giovanni Iacono et al. NUCLEIC ACIDS RESEARCH
- The methyltransferase SETDB1 regulates a large neuron-specific topological chromatin domain
- (2017) Yan Jiang et al. NATURE GENETICS
- Impact of nucleic acid and methylated H3K9 binding activities of Suv39h1 on its heterochromatin assembly
- (2017) Atsuko Shirai et al. eLife
- CTCF binding landscape in jawless fish with reference to Hox cluster evolution
- (2017) Mitsutaka Kadota et al. Scientific Reports
- A structured assessment of motor function and behavior in patients with Kleefstra syndrome
- (2016) Susanne Schmidt et al. European Journal of Medical Genetics
- Genome-wide changes in lncRNA, splicing and regional gene expression patterns in autism
- (2016) Neelroop N. Parikshak et al. NATURE
- Lessons learned from studying syndromic autism spectrum disorders
- (2016) Yehezkel Sztainberg et al. NATURE NEUROSCIENCE
- Cognitive deficits in single App knock-in mouse models
- (2016) Akira Masuda et al. NEUROBIOLOGY OF LEARNING AND MEMORY
- Dynamic behavior of the post-SET loop region of NSD1: Implications for histone binding and drug development
- (2016) Sarah E. Graham et al. PROTEIN SCIENCE
- A Subset of Autism-Associated Genes Regulate the Structural Stability of Neurons
- (2016) Yu-Chih Lin et al. Frontiers in Cellular Neuroscience
- Wiz binds active promoters and CTCF-binding sites and is required for normal behaviour in the mouse
- (2016) Luke Isbel et al. eLife
- Distinct and Cooperative Functions for the Protocadherin-α, -β and -γ Clusters in Neuronal Survival and Axon Targeting
- (2016) Sonoko Hasegawa et al. Frontiers in Molecular Neuroscience
- Euchromatin histone methyltransferase 1 regulates cortical neuronal network development
- (2016) Marijn Bart Martens et al. Scientific Reports
- Recent Advances in Autism Research as Reflected in DSM-5 Criteria for Autism Spectrum Disorder
- (2015) Catherine Lord et al. Annual Review of Clinical Psychology
- Two Loops Undergoing Concerted Dynamics Regulate the Activity of the ASH1L Histone Methyltransferase
- (2015) David S. Rogawski et al. BIOCHEMISTRY
- Activity and specificity of the human SUV39H2 protein lysine methyltransferase
- (2015) Maren Kirstin Schuhmacher et al. Biochimica et Biophysica Acta-Gene Regulatory Mechanisms
- Alternative splicing regulates the expression of G9A and SUV39H2 methyltransferases, and dramatically changes SUV39H2 functions
- (2015) Oriane Mauger et al. NUCLEIC ACIDS RESEARCH
- Single-Cell Identity Generated by Combinatorial Homophilic Interactions between α, β, and γ Protocadherins
- (2014) Chan Aye Thu et al. CELL
- Synaptic, transcriptional and chromatin genes disrupted in autism
- (2014) Silvia De Rubeis et al. NATURE
- Exon resequencing of H3K9 methyltransferase complex genes, EHMT1, EHTM2 and WIZ, in Japanese autism subjects
- (2014) Shabeesh Balan et al. Molecular Autism
- Reduced behavioral flexibility in autism spectrum disorders.
- (2013) Anna-Maria D'Cruz et al. NEUROPSYCHOLOGY
- Sequencing Chromosomal Abnormalities Reveals Neurodevelopmental Loci that Confer Risk across Diagnostic Boundaries
- (2012) Michael E. Talkowski et al. CELL
- Consensus Paper: Pathological Role of the Cerebellum in Autism
- (2012) S. Hossein Fatemi et al. CEREBELLUM
- Hippocampal dysfunction in the Euchromatin histone methyltransferase 1 heterozygous knockout mouse model for Kleefstra syndrome
- (2012) M. C. M. Balemans et al. HUMAN MOLECULAR GENETICS
- Protocadherins mediate dendritic self-avoidance in the mammalian nervous system
- (2012) Julie L. Lefebvre et al. NATURE
- Histone methylation: a dynamic mark in health, disease and inheritance
- (2012) Eric L. Greer et al. NATURE REVIEWS GENETICS
- Single-neuron diversity generated by Protocadherin-β cluster in mouse central and peripheral nervous systems
- (2012) Keizo Hirano et al. Frontiers in Molecular Neuroscience
- Automated test of behavioral flexibility in mice using a behavioral sequencing task in IntelliCage
- (2011) Toshihiro Endo et al. BEHAVIOURAL BRAIN RESEARCH
- The protocadherins, PCDHB1 and PCDH7, are regulated by MeCP2 in neuronal cells and brain tissues: implication for pathogenesis of Rett syndrome
- (2011) Kunio Miyake et al. BMC NEUROSCIENCE
- Specificity Analysis-Based Identification of New Methylation Targets of the SET7/9 Protein Lysine Methyltransferase
- (2011) Arunkumar Dhayalan et al. CHEMISTRY & BIOLOGY
- The Structure of NSD1 Reveals an Autoregulatory Mechanism Underlying Histone H3K36 Methylation
- (2011) Qi Qiao et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Identification of the Cluster Control Region for the Protocadherin-β Genes Located beyond the Protocadherin-γ Cluster
- (2011) Shinnichi Yokota et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Etiological heterogeneity in autism spectrum disorders: More than 100 genetic and genomic disorders and still counting
- (2010) Catalina Betancur BRAIN RESEARCH
- Behavioral flexibility in a mouse model of developmental cerebellar Purkinje cell loss
- (2010) Price E. Dickson et al. NEUROBIOLOGY OF LEARNING AND MEMORY
- Structural Biology of Human H3K9 Methyltransferases
- (2010) Hong Wu et al. PLoS One
- Reduced exploration, increased anxiety, and altered social behavior: Autistic-like features of euchromatin histone methyltransferase 1 heterozygous knockout mice
- (2009) Monique C.M. Balemans et al. BEHAVIOURAL BRAIN RESEARCH
- Further clinical and molecular delineation of the 9q subtelomeric deletion syndrome supports a major contribution of EHMT1 haploinsufficiency to the core phenotype
- (2009) T Kleefstra et al. JOURNAL OF MEDICAL GENETICS
- Control of Cognition and Adaptive Behavior by the GLP/G9a Epigenetic Suppressor Complex
- (2009) Anne Schaefer et al. NEURON
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started