Norstictic Acid Is a Selective Allosteric Transcriptional Regulator

Structure of the transcription coactivator SAGA

(2020) Haibo Wang et al.   NATURE

Heterogeneity at the invasion front of triple negative breast cancer cells

(2020) Koh Meng Aw Yong et al.   Scientific Reports

Yes-associated protein and transcriptional coactivator with PDZ-binding motif as new targets in cardiovascular diseases

(2020) Yue Yu et al.   PHARMACOLOGICAL RESEARCH

Unexpected specificity within dynamic transcriptional protein–protein complexes

(2020) Matthew J. Henley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting Dynamic ATP-Binding Site Features Allows Discrimination between Highly Homologous Protein Kinases

(2019) Sujata Chakraborty et al.   ACS Chemical Biology

Conformational plasticity of the intracellular cavity of GPCR−G-protein complexes leads to G-protein promiscuity and selectivity

(2019) Manbir Sandhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cryptic pocket formation underlies allosteric modulator selectivity at muscarinic GPCRs

(2019) Scott A. Hollingsworth et al.   Nature Communications

A Pliable Mediator Acts as a Functional Rather Than an Architectural Bridge between Promoters and Enhancers

(2019) Laila El Khattabi et al.   CELL

Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1 Alpha as a Novel Target for Bipolar Disorder and Other Neuropsychiatric Disorders

(2018) Andrew A. Nierenberg et al.   BIOLOGICAL PSYCHIATRY

Inhibitors of protein–protein interactions (PPIs): an analysis of scaffold choices and buried surface area

(2018) Xu Ran et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Modulating the masters: chemical tools to dissect CBP and p300 function

(2018) Meghan E Breen et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Transcriptional profiles of different states of cancer stem cells in triple-negative breast cancer

(2018) Mingshan Liu et al.   Molecular Cancer

Coactivator condensation at super-enhancers links phase separation and gene control

(2018) Benjamin R. Sabari et al.   SCIENCE

Conservation of coactivator engagement mechanism enables small-molecule allosteric modulators

(2018) Andrew R. Henderson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantitative conformational profiling of kinase inhibitors reveals origins of selectivity for Aurora kinase activation states

(2018) Eric W. Lake et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting biomolecules with reversible covalent chemistry

(2016) Anupam Bandyopadhyay et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Targeting transcription is no longer a quixotic quest

(2015) Anna K Mapp et al.   Nature Chemical Biology

Characterization of ERM transactivation domain binding to the ACID/PTOV domain of the Mediator subunit MED25

(2015) Isabelle Landrieu et al.   NUCLEIC ACIDS RESEARCH

The cellular thermal shift assay for evaluating drug target interactions in cells

(2014) Rozbeh Jafari et al.   Nature Protocols

Molecular mechanisms of ETS transcription factor-mediated tumorigenesis

(2013) Adwitiya Kar et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Role for Human Mediator Subunit MED25 in Recruitment of Mediator to Promoters by Endoplasmic Reticulum Stress-responsive Transcription Factor ATF6α

(2013) Dotan Sela et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Mediator complex subunit MED25 is targeted by the N-terminal transactivation domain of the PEA3 group members

(2013) Alexis Verger et al.   NUCLEIC ACIDS RESEARCH

Molecular recognition by the KIX domain and its role in gene regulation

(2013) J. K. Thakur et al.   NUCLEIC ACIDS RESEARCH

ETV4 promotes metastasis in response to activation of PI3-kinase and Ras signaling in a mouse model of advanced prostate cancer

(2013) A. Aytes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay

(2013) D. M. Molina et al.   SCIENCE

Strategies for the Selective Regulation of Kinases with Allosteric Modulators: Exploiting Exclusive Structural Features

(2012) Zhizhou Fang et al.   ACS Chemical Biology

Sekikaic Acid and Lobaric Acid Target a Dynamic Interface of the Coactivator CBP/p300

(2012) Chinmay Y. Majmudar et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A structural perspective on Mediator function

(2012) Laurent Larivière et al.   CURRENT OPINION IN CELL BIOLOGY

Steroid receptor coactivator-3 as a potential molecular target for cancer therapy

(2012) Jean Ching-Yi Tien et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Overexpression of ETV4 is oncogenic in prostate cells through promotion of both cell proliferation and epithelial to mesenchymal transition

(2012) A Pellecchia et al.   Oncogenesis

Caught in the Act: Covalent Cross-Linking Captures Activator–Coactivator Interactionsin Vivo

(2011) Malathy Krishnamurthy et al.   ACS Chemical Biology

Structure and VP16 binding of the Mediator Med25 activator interaction domain

(2011) Erika Vojnic et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Steroid Receptor Coactivator (SRC) Family: Masters of Systems Biology

(2010) Brian York et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NMR structure of the human Mediator MED25 ACID domain

(2010) François Bontems et al.   JOURNAL OF STRUCTURAL BIOLOGY