Conformational plasticity of the intracellular cavity of GPCR−G-protein complexes leads to G-protein promiscuity and selectivity
出版年份 2019 全文链接
标题
Conformational plasticity of the intracellular cavity of GPCR−G-protein complexes leads to G-protein promiscuity and selectivity
作者
关键词
-
出版物
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume -, Issue -, Pages 201820944
出版商
Proceedings of the National Academy of Sciences
发表日期
2019-05-29
DOI
10.1073/pnas.1820944116
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Structure of a Signaling Cannabinoid Receptor 1-G Protein Complex
- (2019) Kaavya Krishna Kumar et al. CELL
- Dynamic Role of the G Protein in Stabilizing the Active State of the Adenosine A2A Receptor
- (2019) Sangbae Lee et al. STRUCTURE
- Subcellular Organization of GPCR Signaling
- (2018) Kelsie Eichel et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Cryo-EM structure of human rhodopsin bound to an inhibitory G protein
- (2018) Yanyong Kang et al. NATURE
- Structure of the adenosine-bound human adenosine A1 receptor–Gi complex
- (2018) Christopher J. Draper-Joyce et al. NATURE
- Cryo-EM structure of the serotonin 5-HT1B receptor coupled to heterotrimeric Go
- (2018) Javier García-Nafría et al. NATURE
- Structure of the µ-opioid receptor–Gi protein complex
- (2018) Antoine Koehl et al. NATURE
- Translating biased signaling in the ghrelin receptor system into differential in vivo functions
- (2018) Franziska Mende et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Functional selectivity profiling of the angiotensin II type 1 receptor using pathway-wide BRET signaling sensors
- (2018) Yoon Namkung et al. Science Signaling
- Selectivity determinants of GPCR–G-protein binding
- (2017) Tilman Flock et al. NATURE
- Single-molecule analysis of ligand efficacy in β2AR–G-protein activation
- (2017) G. Glenn Gregorio et al. NATURE
- Priming GPCR signaling through the synergistic effect of two G proteins
- (2017) Tejas M. Gupte et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structural Elements in the Gαsand GαqC Termini That Mediate Selective G Protein-coupled Receptor (GPCR) Signaling
- (2016) Ansley Semack et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Quantifying biased signaling in GPCRs using BRET-based biosensors
- (2016) Yoon Namkung et al. METHODS
- Erratum: Structure of the adenosine A2A receptor bound to an engineered G protein
- (2016) Byron Carpenter et al. NATURE
- Allosteric coupling from G protein to the agonist-binding pocket in GPCRs
- (2016) Brian T. DeVree et al. NATURE
- Structural Insights into the Dynamic Process of β 2 -Adrenergic Receptor Signaling
- (2015) Aashish Manglik et al. CELL
- Universal allosteric mechanism for Gα activation by GPCRs
- (2015) Tilman Flock et al. NATURE
- Distinct profiles of functional discrimination among G proteins determine the actions of G protein–coupled receptors
- (2015) Ikuo Masuho et al. Science Signaling
- Distinct profiles of functional discrimination among G proteins determine the actions of G protein–coupled receptors
- (2015) Ikuo Masuho et al. Science Signaling
- Differences in Allosteric Communication Pipelines in the Inactive and Active States of a GPCR
- (2014) Supriyo Bhattacharya et al. BIOPHYSICAL JOURNAL
- A Conserved Phenylalanine as a Relay between the α5 Helix and the GDP Binding Region of Heterotrimeric GiProtein α Subunit
- (2014) Ali I. Kaya et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Position of Transmembrane Helix 6 Determines Receptor G Protein Coupling Specificity
- (2014) Alexander S. Rose et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- The Dynamic Process of β2-Adrenergic Receptor Activation
- (2013) Rie Nygaard et al. CELL
- Detection of G Protein-selective G Protein-coupled Receptor (GPCR) Conformations in Live Cells
- (2013) Rabia U. Malik et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Role of Ligands on the Equilibria Between Functional States of a G Protein-Coupled Receptor
- (2013) Tae Hun Kim et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Impedance Responses Reveal β2-Adrenergic Receptor Signaling Pluridimensionality and Allow Classification of Ligands with Distinct Signaling Profiles
- (2012) Wayne Stallaert et al. PLoS One
- The Role of Conformational Ensembles in Ligand Recognition in G-Protein Coupled Receptors
- (2011) Michiel J. M. Niesen et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Conformational changes in the G protein Gs induced by the β2 adrenergic receptor
- (2011) Ka Young Chung et al. NATURE
- Crystal structure of the β2 adrenergic receptor–Gs protein complex
- (2011) Søren G. F. Rasmussen et al. NATURE
- Systematic control of protein interaction using a modular ER/K -helix linker
- (2011) S. Sivaramakrishnan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- NWChem: A comprehensive and scalable open-source solution for large scale molecular simulations
- (2010) M. Valiev et al. COMPUTER PHYSICS COMMUNICATIONS
- The role of conformational ensembles of seven transmembrane receptors in functional selectivity
- (2010) Nagarajan Vaidehi et al. CURRENT OPINION IN PHARMACOLOGY
- Functional Selectivity and Biased Receptor Signaling
- (2010) T. Kenakin JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Computational Mapping of the Conformational Transitions in Agonist Selective Pathways of a G-Protein Coupled Receptor
- (2010) Supriyo Bhattacharya et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started