Studies on Cycloheptathiophene-3-carboxamide Derivatives as Allosteric HIV-1 Ribonuclease H Inhibitors

(3Z)-3-(2-[4-(aryl)-1,3-thiazol-2-yl]hydrazin-1-ylidene)-2,3-dihydro-1H-indol-2-one derivatives as dual inhibitors of HIV-1 reverse transcriptase

(2015) Rita Meleddu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Structure–Activity Relationship of Pyrrolyl Diketo Acid Derivatives as Dual Inhibitors of HIV-1 Integrase and Reverse Transcriptase Ribonuclease H Domain

(2015) Giuliana Cuzzucoli Crucitti et al.   JOURNAL OF MEDICINAL CHEMISTRY

Anti-HIV Drug Discovery and Development: Current Innovations and Future Trends

(2015) Peng Zhan et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Broad Anti-influenza Hybrid Small Molecule That Potently Disrupts the Interaction of Polymerase Acidic Protein–Basic Protein 1 (PA-PB1) Subunits

(2015) Serena Massari et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design and Synthesis of DiselenoBisBenzamides (DISeBAs) as Nucleocapsid Protein 7 (NCp7) Inhibitors with anti-HIV Activity

(2015) Luca Sancineto et al.   JOURNAL OF MEDICINAL CHEMISTRY

From the traditional Chinese medicine plant Schisandra chinensis new scaffolds effective on HIV-1 reverse transcriptase resistant to non-nucleoside inhibitors

(2015) Lijia Xu et al.   JOURNAL OF MICROBIOLOGY

Identification of Highly Conserved Residues Involved in Inhibition of HIV-1 RNase H Function by Diketo Acid Derivatives

(2014) Angela Corona et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Increase in transmitted resistance to non-nucleoside reverse transcriptase inhibitors among newly diagnosed HIV-1 infections in Europe

(2014) Dineke Frentz et al.   BMC INFECTIOUS DISEASES

Can the ever-promising target HIV reverse transcriptase-associated RNase H become a success story for drug development?

(2014) Angela Corona et al.   Future Virology

Binding free energy based structural dynamics analysis of HIV-1 RT RNase H–inhibitor complexes

(2014) Vasanthanathan Poongavanam et al.   Integrative Biology

Basic Quinolinonyl Diketo Acid Derivatives as Inhibitors of HIV Integrase and their Activity against RNase H Function of Reverse Transcriptase

(2014) Roberta Costi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure of a Dihydroxycoumarin Active-Site Inhibitor in Complex with the RNase H Domain of HIV-1 Reverse Transcriptase and Structure–Activity Analysis of Inhibitor Analogs

(2014) Daniel M. Himmel et al.   JOURNAL OF MOLECULAR BIOLOGY

Patterns of Transmitted HIV Drug Resistance in Europe Vary by Risk Group

(2014) Dineke Frentz et al.   PLoS One

Blocking HIV-1 Replication by Targeting the Tat-Hijacked Transcriptional Machinery

(2013) Serena Massari et al.   CURRENT PHARMACEUTICAL DESIGN

Active site and allosteric inhibitors of the ribonuclease H activity of HIV reverse transcriptase

(2013) Angela Corona et al.   Future Medicinal Chemistry

Detecting Allosteric Sites of HIV-1 Reverse Transcriptase by X-ray Crystallographic Fragment Screening

(2013) Joseph D. Bauman et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structural Investigation of Cycloheptathiophene-3-carboxamide Derivatives Targeting Influenza Virus Polymerase Assembly

(2013) Serena Massari et al.   JOURNAL OF MEDICINAL CHEMISTRY

Exploiting Drug-Resistant Enzymes as Tools To Identify Thienopyrimidinone Inhibitors of Human Immunodeficiency Virus Reverse Transcriptase-Associated Ribonuclease H

(2013) Takashi Masaoka et al.   JOURNAL OF MEDICINAL CHEMISTRY

Complexes of HIV-1 RT, NNRTI and RNA/DNA hybrid reveal a structure compatible with RNA degradation

(2013) Mikalai Lapkouski et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Hypericum hircinumL. components as new single-molecule inhibitors of both HIV-1 reverse transcriptase-associated DNA polymerase and ribonuclease H activities

(2013) Francesca Esposito et al.   Pathogens and Disease

New Anthraquinone Derivatives as Inhibitors of the HIV-1 Reverse Transcriptase-Associated Ribonuclease H Function

(2012) Francesca Esposito et al.   CHEMOTHERAPY

Structural Investigation of the Naphthyridone Scaffold: Identification of a 1,6-Naphthyridone Derivative with Potent and Selective Anti-HIV Activity

(2011) Oriana Tabarrini et al.   ChemMedChem

Alizarine derivatives as new dual inhibitors of the HIV-1 reverse transcriptase-associated DNA polymerase and RNase H activities effective also on the RNase H activity of non-nucleoside resistant reverse transcriptases

(2011) Francesca Esposito et al.   FEBS Journal

Mutagenesis of Human Immunodeficiency Virus Reverse Transcriptase p51 Subunit Defines Residues Contributing to Vinylogous Urea Inhibition of Ribonuclease H Activity

(2011) Suhman Chung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Alternative Binding Sites for Inhibitors of HIV-1 Ribonuclease H Through Comparative Analysis of Virtual Enrichment Studies

(2011) Anthony K. Felts et al.   Journal of Chemical Information and Modeling

Synthesis, Activity, and Structural Analysis of Novel α-Hydroxytropolone Inhibitors of Human Immunodeficiency Virus Reverse Transcriptase-Associated Ribonuclease H

(2011) Suhman Chung et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure-Activity Analysis of Vinylogous Urea Inhibitors of Human Immunodeficiency Virus-Encoded Ribonuclease H

(2010) S. Chung et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Studies of Anti-HIV Transcription Inhibitor Quinolones: Identification of Potent N1-Vinyl Derivatives

(2010) Oriana Tabarrini et al.   ChemMedChem

6-desfluoroquinolones as HIV-1 Tat-mediated transcription inhibitors

(2010) Oriana Tabarrini et al.   Future Medicinal Chemistry

Vinylogous Ureas as a Novel Class of Inhibitors of Reverse Transcriptase-Associated Ribonuclease H Activity

(2008) Michaela Wendeler et al.   ACS Chemical Biology

Tetrazolium-based colorimetric assay for the detection of HIV replication inhibitors: revisited 20 years later

(2008) Christophe Pannecouque et al.   Nature Protocols