Discovery of New 4-Indolyl Quinazoline Derivatives as Highly Potent and Orally Bioavailable P-Glycoprotein Inhibitors

Cu(OTf)2-Catalyzed Intramolecular Radical Cascade Reactions for the Diversity-Oriented Synthesis of Quinoline-Annulated Polyheterocyclic Frameworks

(2021) Shuo Yuan et al.   ORGANIC LETTERS

Palladium-Catalyzed Ligand-Free Double Cyclization Reactions for the Synthesis of 3-(1′-Indolyl)-phthalides

(2020) Shuo Yuan et al.   ORGANIC LETTERS

Construction of Biologically Important Biaryl Scaffolds through Direct C–H Bond Activation: Advances and Prospects

(2020) Shuo Yuan et al.   Topics in Current Chemistry

Discovery of (2R)-N-[3-[2-[(3-Methoxy-1-methyl-pyrazol-4-yl)amino]pyrimidin-4-yl]-1H-indol-7-yl]-2-(4-methylpiperazin-1-yl)propenamide (AZD4205) as a Potent and Selective Janus Kinase 1 Inhibitor

(2020) Qibin Su et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Potent Inhibitors against P-Glycoprotein-Mediated Multidrug Resistance Aided by Late-Stage Functionalization of a 2-(4-(Pyridin-2-yl)phenoxy)pyridine Analogue

(2020) Yao Ma et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cryo-EM structures reveal distinct mechanisms of inhibition of the human multidrug transporter ABCB1

(2020) Kamil Nosol et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure-Based Design, Synthesis, and Biological Evaluation of New Triazolo[1,5-a]Pyrimidine Derivatives as Highly Potent and Orally Active ABCB1 Modulators

(2020) Shuai Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Dissecting mechanisms of resistance to targeted drug combination therapy in human colorectal cancer

(2019) Paul A. Clarke et al.   ONCOGENE

A Three-Component Strategy for Benzoselenophene Synthesis under Metal-Free Conditions Using Selenium Powder

(2019) Penghui Ni et al.   ORGANIC LETTERS

Mechanism of allosteric modulation of P-glycoprotein by transport substrates and inhibitors

(2019) Reza Dastvan et al.   SCIENCE

Brønsted acid-promoted ‘on–water’ C(sp3)-H functionalization for the synthesis of isoindolinone/[1,2,4]triazolo[1,5-a]pyrimidine derivatives targeting the SKP2-CKS1 interaction

(2019) Shuo Yuan et al.   CHINESE CHEMICAL LETTERS

Discovery of WS-157 as a highly potent, selective and orally active EGFR inhibitor

(2019) Pengxing He et al.   Acta Pharmaceutica Sinica B

“On‐Water” Palladium‐Catalyzed Tandem Cyclization Reaction for the Synthesis of Biologically Relevant 4‐Arylquinazolines

(2019) Shuo Yuan et al.   CHEMISTRY-A EUROPEAN JOURNAL

Discovery of [1,2,3]triazolo[4,5-d]pyrimidine derivatives as highly potent, selective, and cellularly active USP28 inhibitors

(2019) Zhenzhen Liu et al.   Acta Pharmaceutica Sinica B

Exploration of 1,2,3-triazole-pyrimidine hybrids as potent reversal agents against ABCB1-mediated multidrug resistance

(2018) Bo Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery of 5-Cyano-6-phenylpyrimidin Derivatives Containing an Acylurea Moiety as Orally Bioavailable Reversal Agents against P-Glycoprotein-Mediated Mutidrug Resistance

(2018) Bo Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Meridianin D Analogues Display Antibiofilm Activity against MRSA and Increase Colistin Efficacy in Gram-Negative Bacteria

(2018) William M. Huggins et al.   ACS Medicinal Chemistry Letters

Cancer Stem Cells (CSCs) in Drug Resistance and their Therapeutic Implications in Cancer Treatment

(2018) Lan Thi Hanh Phi et al.   Stem Cells International

Brønsted Acid-Catalyzed Direct C(sp 2 )−H Heteroarylation Enabling the Synthesis of Structurally Diverse Biaryl Derivatives

(2018) Shuo Yuan et al.   ADVANCED SYNTHESIS & CATALYSIS

Discovery of Novel Flavonoid Dimers To Reverse Multidrug Resistance Protein 1 (MRP1, ABCC1) Mediated Drug Resistance in Cancers Using a High Throughput Platform with “Click Chemistry”

(2018) Iris L. K. Wong et al.   JOURNAL OF MEDICINAL CHEMISTRY

Natural alkaloids as P-gp inhibitors for multidrug resistance reversal in cancer

(2017) Prashant Joshi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

9-Deazapurines as Broad-Spectrum Inhibitors of the ABC Transport Proteins P-Glycoprotein, Multidrug Resistance-Associated Protein 1, and Breast Cancer Resistance Protein

(2017) Katja Stefan et al.   JOURNAL OF MEDICINAL CHEMISTRY

NMR-filtered virtual screening leads to non-metal chelating metallo-β-lactamase inhibitors

(2017) Guo-Bo Li et al.   Chemical Science

Cisplatin-enriching cancer stem cells confer multidrug resistance in non-small cell lung cancer via enhancing TRIB1/HDAC activity

(2017) Lihui Wang et al.   Cell Death & Disease

Elacridar, a third-generation ABCB1 inhibitor, overcomes resistance to docetaxel in non-small cell lung cancer

(2017) Haiyang Chen et al.   Oncology Letters

The Cellular Thermal Shift Assay: A Novel Biophysical Assay for In Situ Drug Target Engagement and Mechanistic Biomarker Studies

(2016) Daniel Martinez Molina et al.   Annual Review of Pharmacology and Toxicology

Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade

(2016) Zhaolin Chen et al.   CANCER LETTERS

Design, synthesis, and biological evaluation of novel quinazolinyl-diaryl urea derivatives as potential anticancer agents

(2016) Jia-Nian Chen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Me2AlCl-mediated carboxylation, ethoxycarbonylation, and carbamoylation of indoles

(2016) Koji Nemoto et al.   TETRAHEDRON

Through-Space 1,4-Palladium Migration and 1,2-Aryl Shift: Direct Access to Dibenzo[a,c]carbazoles through a Triple CH Functionalization Cascade

(2015) Samir Kumar Bhunia et al.   CHEMISTRY-A EUROPEAN JOURNAL

The modulation of ABC transporter-mediated multidrug resistance in cancer: A review of the past decade

(2015) Rishil J. Kathawala et al.   DRUG RESISTANCE UPDATES

Modulation of P-glycoprotein efflux pump: induction and activation as a therapeutic strategy

(2015) Renata Silva et al.   PHARMACOLOGY & THERAPEUTICS

Broad targeting of resistance to apoptosis in cancer

(2015) Ramzi M. Mohammad et al.   SEMINARS IN CANCER BIOLOGY

Discovery of a Potent and Selective EGFR Inhibitor (AZD9291) of Both Sensitizing and T790M Resistance Mutations That Spares the Wild Type Form of the Receptor

(2014) M. Raymond V. Finlay et al.   JOURNAL OF MEDICINAL CHEMISTRY

The third-generation P-glycoprotein inhibitor tariquidar may overcome bacterial multidrug resistance by increasing intracellular drug concentration

(2011) I. Leitner et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading

(2009) Oleg Trott et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Modulation of Multidrug Resistance Protein 1 (MRP1/ABCC1)-Mediated Multidrug Resistance by Bivalent Apigenin Homodimers and Their Derivatives

(2009) Iris L. K. Wong et al.   JOURNAL OF MEDICINAL CHEMISTRY

Evaluation of [11C]laniquidar as a tracer of P-glycoprotein: radiosynthesis and biodistribution in rats

(2009) Gert Luurtsema et al.   NUCLEAR MEDICINE AND BIOLOGY

Verapamil Toxicity Dysregulates the Phosphatidylinositol 3-Kinase Pathway

(2008) Laura K. Bechtel et al.   ACADEMIC EMERGENCY MEDICINE

Inhibition of MDR1 Activity in Vitro by a Novel Class of Diltiazem Analogues: Toward New Candidates

(2008) Maurizio Viale et al.   JOURNAL OF MEDICINAL CHEMISTRY

ABC multidrug transporters: structure, function and role in chemoresistance

(2007) Frances J Sharom   PHARMACOGENOMICS