Rational Alteration of Pharmacokinetics of Chiral Fluorinated and Deuterated Derivatives of Emixustat for Retinal Therapy
出版年份 2021 全文链接
标题
Rational Alteration of Pharmacokinetics of Chiral Fluorinated and Deuterated Derivatives of Emixustat for Retinal Therapy
作者
关键词
-
出版物
JOURNAL OF MEDICINAL CHEMISTRY
Volume 64, Issue 12, Pages 8287-8302
出版商
American Chemical Society (ACS)
发表日期
2021-06-04
DOI
10.1021/acs.jmedchem.1c00279
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Shedding new light on the generation of the visual chromophore
- (2020) Krzysztof Palczewski et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Effects of emixustat hydrochloride in patients with proliferative diabetic retinopathy: a randomized, placebo-controlled phase 2 study
- (2020) Ryo Kubota et al. GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
- Randomised study evaluating the pharmacodynamics of emixustat hydrochloride in subjects with macular atrophy secondary to Stargardt disease
- (2020) Ryo Kubota et al. BRITISH JOURNAL OF OPHTHALMOLOGY
- Oxidative Deamination of Emixustat by Human Vascular Adhesion Protein-1/Semicarbazide-Sensitive Amine Oxidase
- (2019) Michael J. Reid et al. DRUG METABOLISM AND DISPOSITION
- Stereoselective Synthesis of syn-γ-Hydroxynorvaline and Related α-Amino Acids
- (2019) Dominika Valachová et al. SYNTHESIS-STUTTGART
- Pharmacotherapy for metabolic and cellular stress in degenerative retinal diseases
- (2019) Ryo Kubota et al. DRUG DISCOVERY TODAY
- An Expedient Synthesis of CMF-019: (S)-5-Methyl-3-{1-(pentan-3-yl)-2-(thiophen-2-ylmethyl)-1H-benzo[d]imidazole-5-carboxamido}hexanoic acid, a Potent Apelin Receptor (APJ) Agonist
- (2018) Lena Trifonov et al. Medicinal Chemistry
- Emixustat Hydrochloride for Geographic Atrophy Secondary to Age-Related Macular Degeneration
- (2018) Philip J. Rosenfeld et al. OPHTHALMOLOGY
- Validation and reproducibility of an LC–MS/MS method for emixustat and its three deaminated metabolites in human plasma
- (2018) Terry Podoll et al. Bioanalysis
- Rational Tuning of Visual Cycle Modulator Pharmacodynamics
- (2017) Philip D. Kiser et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- MolProbity: More and better reference data for improved all-atom structure validation
- (2017) Christopher J. Williams et al. PROTEIN SCIENCE
- Disposition, profiling and identification of emixustat and its metabolites in humans
- (2017) Michael E. Fitzsimmons et al. XENOBIOTICA
- Decomposition of Intermolecular Interaction Energies within the Local Pair Natural Orbital Coupled Cluster Framework
- (2016) Wolfgang B. Schneider et al. Journal of Chemical Theory and Computation
- Asymmetric Hydrogenation of β-Secondary Amino Ketones Catalyzed by a Ruthenocenyl Phosphino-oxazoline-ruthenium Complex (RuPHOX-Ru): the Synthesis of γ-Secondary Amino Alcohols
- (2015) Jianxia Wang et al. ADVANCED SYNTHESIS & CATALYSIS
- Molecular pharmacodynamics of emixustat in protection against retinal degeneration
- (2015) Jianye Zhang et al. JOURNAL OF CLINICAL INVESTIGATION
- Applications of Fluorine in Medicinal Chemistry
- (2015) Eric P. Gillis et al. JOURNAL OF MEDICINAL CHEMISTRY
- Catalytic mechanism of a retinoid isomerase essential for vertebrate vision
- (2015) Philip D Kiser et al. Nature Chemical Biology
- PHASE II, RANDOMIZED, PLACEBO-CONTROLLED, 90-DAY STUDY OF EMIXUSTAT HYDROCHLORIDE IN GEOGRAPHIC ATROPHY ASSOCIATED WITH DRY AGE-RELATED MACULAR DEGENERATION
- (2015) Pravin U. Dugel et al. RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
- Bioanalysis of emixustat (ACU-4429) in whole blood collected with volumetric absorptive microsampling by LC–MS/MS
- (2015) Zhixin Miao et al. Bioanalysis
- Visual Cycle Modulation as an Approach toward Preservation of Retinal Integrity
- (2015) Claes Bavik et al. PLoS One
- Analysis of Carotenoid Isomerase Activity in a Prototypical Carotenoid Cleavage Enzyme, Apocarotenoid Oxygenase (ACO)
- (2014) Xuewu Sui et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Natural triple excitations in local coupled cluster calculations with pair natural orbitals
- (2013) Christoph Riplinger et al. JOURNAL OF CHEMICAL PHYSICS
- An efficient and near linear scaling pair natural orbital based local coupled cluster method
- (2013) Christoph Riplinger et al. JOURNAL OF CHEMICAL PHYSICS
- Using Deuterium in Drug Discovery: Leaving the Label in the Drug
- (2013) Thomas G. Gant JOURNAL OF MEDICINAL CHEMISTRY
- An evaluation of substituent effects on aromatic edge-to-face interactions and CF–π versus CH–π interactions using an imino torsion balance model
- (2013) W. Brian Jennings et al. ORGANIC & BIOMOLECULAR CHEMISTRY
- PHASE 1, DOSE-RANGING STUDY OF EMIXUSTAT HYDROCHLORIDE (ACU-4429), A NOVEL VISUAL CYCLE MODULATOR, IN HEALTHY VOLUNTEERS
- (2013) Ryo Kubota et al. RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
- Long-Range Corrected Hybrid Density Functionals with Improved Dispersion Corrections
- (2012) You-Sheng Lin et al. Journal of Chemical Theory and Computation
- Structure of RPE65 isomerase in a lipidic matrix reveals roles for phospholipids and iron in catalysis
- (2012) P. D. Kiser et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- REFMAC5 for the refinement of macromolecular crystal structures
- (2011) Garib N. Murshudov et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Reaction of Vascular Adhesion Protein-1 (VAP-1) with Primary Amines
- (2011) Dominic P. H. M. Heuts et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Sponge Transgenic Mouse Model Reveals Important Roles for the MicroRNA-183 (miR-183)/96/182 Cluster in Postmitotic Photoreceptors of the Retina
- (2011) Qubo Zhu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Effect of the damping function in dispersion corrected density functional theory
- (2011) Stefan Grimme et al. JOURNAL OF COMPUTATIONAL CHEMISTRY
- Primary amines protect against retinal degeneration in mouse models of retinopathies
- (2011) Akiko Maeda et al. Nature Chemical Biology
- The bisretinoids of retinal pigment epithelium
- (2011) Janet R. Sparrow et al. PROGRESS IN RETINAL AND EYE RESEARCH
- SAFETY AND EFFECT ON ROD FUNCTION OF ACU-4429, A NOVEL SMALL-MOLECULE VISUAL CYCLE MODULATOR
- (2011) Ryo Kubota et al. RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
- A New Generation of Crystallographic Validation Tools for the Protein Data Bank
- (2011) Randy J. Read et al. STRUCTURE
- Integration, scaling, space-group assignment and post-refinement
- (2010) Wolfgang Kabsch ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Features and development ofCoot
- (2010) P. Emsley et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Importance of Membrane Structural Integrity for RPE65 Retinoid Isomerization Activity
- (2010) Marcin Golczak et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Revealing Noncovalent Interactions
- (2010) Erin R. Johnson et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- The first example of a crystallization-induced asymmetric transformation (CIAT) in the Mannich reaction
- (2010) Pavol Jakubec et al. TETRAHEDRON-ASYMMETRY
- RPE65, Visual Cycle Retinol Isomerase, Is Not Inherently 11-cis-specific
- (2009) T. Michael Redmond et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Cl-π interactions in protein-ligand complexes
- (2008) Yumi N. Imai et al. PROTEIN SCIENCE
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now