Soluble angiotensin‐converting enzyme 2 is transiently elevated in COVID‐19 and correlates with specific inflammatory and endothelial markers

Kinins and Chymase: The Forgotten Components of the Renin angiotensin system and their implications in COVID-19 Disease

(2021) Zaid Abassi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Plasma ACE2 activity is persistently elevated following SARS-CoV-2 infection: implications for COVID-19 pathogenesis and consequences

(2021) Sheila K. Patel et al.   EUROPEAN RESPIRATORY JOURNAL

A novel ACE2 isoform is expressed in human respiratory epithelia and is upregulated in response to interferons and RNA respiratory virus infection

(2021) Cornelia Blume et al.   NATURE GENETICS

Angiotensin-Converting Enzyme 2 (ACE2) Elevation in Severe COVID-19

(2021) Roman Reindl-Schwaighofer et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury

(2020) Yingxia Liu et al.   Science China-Life Sciences

Hypertension, the renin–angiotensin system, and the risk of lower respiratory tract infections and lung injury: implications for COVID-19

(2020) Reinhold Kreutz et al.   CARDIOVASCULAR RESEARCH

COVID-19 and the cardiovascular system: implications for risk assessment, diagnosis, and treatment options

(2020) Tomasz J Guzik et al.   CARDIOVASCULAR RESEARCH

SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues

(2020) Carly G.K. Ziegler et al.   CELL

Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2

(2020) Vanessa Monteil et al.   CELL

Angiotensin Converting Enzyme 2: A Double-Edged Sword

(2020) Kaiming Wang et al.   CIRCULATION

Angiotensin-Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System

(2020) Mahmoud Gheblawi et al.   CIRCULATION RESEARCH

Circulating plasma concentrations of angiotensin-converting enzyme 2 in men and women with heart failure and effects of renin–angiotensin–aldosterone inhibitors

(2020) Iziah E Sama et al.   EUROPEAN HEART JOURNAL

Blood flow restriction exercise stimulates mobilization of hematopoietic stem/progenitor cells and increases the circulating ACE2 levels in healthy adults

(2020) Shrinidh Joshi et al.   JOURNAL OF APPLIED PHYSIOLOGY

Angiotensin‐converting enzyme‐2 ( ACE2 ), SARS‐CoV ‐2 and pathophysiology of coronavirus disease 2019 ( COVID ‐19)

(2020) Arno R. Bourgonje et al.   JOURNAL OF PATHOLOGY

Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19

(2020) Maximilian Ackermann et al.   NEW ENGLAND JOURNAL OF MEDICINE

Increasing host cellular receptor—angiotensin‐converting enzyme 2 expression by coronavirus may facilitate 2019‐nCoV (or SARS‐CoV‐2) infection

(2020) Meng‐Wei Zhuang et al.   JOURNAL OF MEDICAL VIROLOGY

Platelets Can Associate with SARS-Cov-2 RNA and Are Hyperactivated in COVID-19

(2020) Younes Zaid et al.   CIRCULATION RESEARCH

Angiotensin-converting enzyme 2 (ACE2) levels in relation to risk factors for COVID-19 in two large cohorts of patients with atrial fibrillation

(2020) Lars Wallentin et al.   EUROPEAN HEART JOURNAL

SARS-CoV-2 binds platelet ACE2 to enhance thrombosis in COVID-19

(2020) Si Zhang et al.   Journal of Hematology & Oncology

Coronavirus disease 2019 is associated with low circulating plasma levels of angiotensin 1 and angiotensin 1,7

(2020) Brandon M. Henry et al.   JOURNAL OF MEDICAL VIROLOGY

ACE2, COVID-19 Infection, Inflammation, and Coagulopathy: Missing Pieces in the Puzzle

(2020) Zaid Abassi et al.   Frontiers in Physiology

Circulating Markers of Neutrophil Extracellular Traps Are of Prognostic Value in Patients With COVID-19

(2020) Henry Ng et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Patients With COVID-19 Have Elevated Levels of Circulating Extracellular Vesicle Tissue Factor Activity That Is Associated With Severity and Mortality

(2020) Axel Rosell et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

A Dynamic Variation of Pulmonary ACE2 Is Required to Modulate Neutrophilic Inflammation in Response to Pseudomonas aeruginosa Lung Infection in Mice

(2019) Chhinder P. Sodhi et al.   JOURNAL OF IMMUNOLOGY

Attenuation of pulmonary ACE2 activity impairs inactivation of des-Arg9 bradykinin/BKB1R axis and facilitates LPS-induced neutrophil infiltration

(2018) Chhinder P. Sodhi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Angiotensin-converting enzyme in innate and adaptive immunity

(2018) Kenneth E. Bernstein et al.   Nature Reviews Nephrology

Serum angiotensin-converting enzyme 2 concentration and angiotensin-(1–7) concentration in patients with acute heart failure patients requiring emergency hospitalization

(2016) Shinji Hisatake et al.   HEART AND VESSELS

Pulmonary Angiotensin-Converting Enzyme 2 (ACE2) and Inflammatory Lung Disease

(2016) Hongpeng Jia   SHOCK

Angiotensin-converting enzyme 2 and angiotensin 1–7: novel therapeutic targets

(2014) Fan Jiang et al.   Nature Reviews Cardiology

Angiotensin II induced proteolytic cleavage of myocardial ACE2 is mediated by TACE/ADAM-17: A positive feedback mechanism in the RAS

(2013) Vaibhav B. Patel et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Angiotensin-Converting Enzyme 2: The First Decade

(2011) Nicola E. Clarke et al.   International Journal of Hypertension

Trilogy of ACE2: A peptidase in the renin–angiotensin system, a SARS receptor, and a partner for amino acid transporters

(2010) Keiji Kuba et al.   PHARMACOLOGY & THERAPEUTICS

Ectodomain shedding of angiotensin converting enzyme 2 in human airway epithelia

(2009) Hong Peng Jia et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Differential Downregulation of ACE2 by the Spike Proteins of Severe Acute Respiratory Syndrome Coronavirus and Human Coronavirus NL63

(2009) I. Glowacka et al.   JOURNAL OF VIROLOGY

Angiotensin-converting enzyme 2 catalytic activity in human plasma is masked by an endogenous inhibitor

(2008) Rebecca A. Lew et al.   EXPERIMENTAL PHYSIOLOGY

Detection of Soluble Angiotensin-Converting Enzyme 2 in Heart Failure

(2008) Slava Epelman et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Modulation of TNF- -converting enzyme by the spike protein of SARS-CoV and ACE2 induces TNF-  production and facilitates viral entry

(2008) S. Haga et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA