Article
Biochemistry & Molecular Biology
Lingmiao Wen, Wei Xiong, Guihua Wei, Liudai Zhang, Yanjun Liu, Tinglan Zhang, Alvin Altamirano, Qiaozhi Yin, Tiane Zhang, Zhiyong Yan
Summary: Growing evidence suggests a link between gut microbiota and atherosclerosis (AS). This study established an AS rat model through long-term high-fat diet feeding. Pathological and microbiota changes in the rat's ileum and colon were examined, and correlations between AS and gut microbiota were analyzed. The study found varying degrees of pathological damage and microbiota disturbance in the ileum and colon of AS rats. This article contributes to the understanding of the relationship between gut microbiota in different gut segments and AS and provides new approaches to gut microbiota intervention for AS treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Minchun Zhang, Jie Chen, Minglan Yang, Cheng Qian, Yu Liu, Yicheng Qi, Rilu Feng, Mei Yang, Wei Liu, Jing Ma
Summary: This study investigated the effects of lower doses of sucralose on fecal microbiota in obesity and found that 0.54 mM and 0.78 mM sucralose can affect beneficial bacteria. Different dosages of sucralose may alter the compositions of fecal microbiota.
FRONTIERS IN NUTRITION
(2021)
Article
Endocrinology & Metabolism
Feiyu Cai, Aihemaitijiang Yusufu, Kai Liu, Wenjiao Chen, Ruomei Zhao, Yanshi Liu, Yi Liu
Summary: The study evaluated the difference in bone regeneration between rats under high-fat diets (HFD) and low-fat diets (LFD) by monitoring the process of bone regeneration in distraction osteogenesis (DO) model animals. The results showed that HFD resulted in elevated blood lipids, increased adipose differentiation at the bone marrow level, and delayed bone regeneration.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Yuan Dang, Chunxiang Ma, Kexin Chen, Yiding Chen, Mingshan Jiang, Kehan Hu, Lili Li, Zhen Zeng, Hu Zhang
Summary: The interactions among diet, intestinal immunity, and microbiota in inflammatory bowel disease (IBD) are complex and contradictory. Increasing research has provided insights into this field. A high-fat diet (HFD) disrupts intestinal immune balance by impairing the intestinal barrier, influencing immune cells, and altering the gut microbiota. Conversely, a rational diet is believed to maintain intestinal immunity by regulating gut microbiota. This review emphasizes the crucial contributions of an HFD to the gut immune system and microbiota.
Article
Nutrition & Dietetics
Yukako Okazaki, Tetsuyuki Katayama
Summary: It was found that fermentable nondigestible carbohydrates had an effect on colonic alkaline phosphatase activity and gene expression in rats, and this effect was influenced by the quality of dietary fats. Adding fructo-oligosaccharides to a high-fat diet increased colonic ALP activity and gene expression, while there was no effect in a low-fat diet. The addition of fructo-oligosaccharides to a high-fat diet also led to changes in fecal mucins and gut microbiota composition.
NUTRITION RESEARCH
(2023)
Article
Immunology
Rong Tan, Huiwei Dong, Zhengshan Chen, Min Jin, Jing Yin, Haibei Li, Danyang Shi, Yifan Shao, Huaran Wang, Tianjiao Chen, Dong Yang, Junwen Li
Summary: Unhealthy dietary habits are associated with increased incidence of chronic diseases, with high-fat and high-fructose diets leading to reduced defecation volume, increased levels of pro-inflammatory cytokines and IgG in serum, inflammatory cell infiltration in intestinal tissue, changes in microbial composition, alterations in microbial metabolites, and potential causes of constipation and inflammation.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ornella Selmin, Andreas J. Papoutsis, Sabine Hazan, Christopher Smith, Nick Greenfield, Micah G. Donovan, Spencer N. Wren, Thomas C. Doetschman, Justin M. Snider, Ashley J. Snider, Sherry H-H Chow, Donato F. Romagnolo
Summary: This study compared the effects of a typical Western diet and a soybean oil-rich n-6HFD on gut inflammation and microbiome using a mouse model. The results showed that n-6HFD induced colonic inflammation and altered gut bacterial composition, promoting the growth of proinflammatory bacteria.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Food Science & Technology
Yafang Ma, Kai Shan, Zixin Huang, Di Zhao, Miao Zhang, Weixin Ke, Chunbao Li
Summary: High-fat diet alters colonic bile acid composition and impairs colonic barrier function. Secondary bile acids, especially isomerized derivatives, may play a protective role in maintaining colonic barrier function.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Food Science & Technology
Bernat Miralles-Perez, Maria Rosa Nogues, Vanessa Sanchez-Martos, Angels Fortuno-Mar, Sara Ramos-Romero, Josep L. Torres, Julia Ponomarenko, Susana Amezqueta, Xiang Zhang, Marta Romeu
Summary: The present study found that increasing consumption of inulin promoted high dominance of certain bacterial genera in feces while reducing richness and diversity. Additionally, inulin decreased cardiometabolic risk factors, eicosanoid levels in the liver, and oxidative stress in blood.
Article
Multidisciplinary Sciences
Jihyun Kim, Jiyoung Moon, Chul-Hong Park, Jisu Lee, Helia Cheng, Z. Elizabeth Floyd, Ji Suk Chang
Summary: Selective ablation of NT-PGC-1α in mice led to a lean phenotype under high-fat diet conditions, with more pronounced effects in females. This was primarily due to reduced dietary fat intake. Additionally, female NT-PGC-1α (-/-) mice showed decreased feed efficiency, increased fecal fat excretion, and decreased uptake of fatty acids by enterocytes and adipocytes under high-fat diet conditions.
SCIENTIFIC REPORTS
(2021)
Article
Nutrition & Dietetics
Thomas A. Aloysius, Veronika Tillander, Matteo Pedrelli, Simon N. Dankel, Rolf K. Berge, Bodil Bjorndal
Summary: Rest raw materials from chicken, such as chicken protein hydrolysate (CPH) and chicken oil (CO), have beneficial effects on health by reducing cholesterol levels and increasing fatty acid oxidation.
Article
Nutrition & Dietetics
Ilenia Martinelli, Seyed Khosrow Tayebati, Proshanta Roy, Maria Vittoria Micioni Di Bonaventura, Michele Moruzzi, Carlo Cifani, Francesco Amenta, Daniele Tomassoni
Summary: This study investigates the potential involvement of cholinergic markers in brain alterations associated with obesity induced by a high-fat diet. The results reveal changes in the expression and activity of cholinergic markers in obese rats, suggesting a link between obesity and cerebral injuries.
Article
Environmental Sciences
Anouar Feriani, Mariano Bizzarri, Meriam Tir, Nouf Aldawood, Hussah Alobaid, Mohamed Salah Allagui, Waleed Dahmash, Nizar Tlili, Kais Mnafgui, Saleh Alwasel, Abdel Halim Harrath
Summary: The study revealed that a high-fat diet and permethrin treatment can induce cardiotoxicity, increase cardiovascular disease risk, and promote heart failure and fibrosis in rats. Changes in blood lipid levels, cardiac damage, inflammation, and fibrosis were observed as a result of HFD and PER exposure.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Pharmacology & Pharmacy
Nazia Begum, Kandavalli Manipriya, B. Veeresh
Summary: This study developed a new animal model by combining a high-fat diet with letrozole to better simulate polycystic ovary syndrome (PCOS). Compared to the letrozole-only model, this new model can better demonstrate metabolic anomalies observed in PCOS.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Petra Bakovic, Maja Kesic, Darko Kolaric, Jasminka Stefulj, Lipa Cicin-Sain
Summary: Maintaining energy balance is vital to prevent obesity and metabolic disorders, and serotonin plays a crucial role in regulating energy homeostasis. Animals with constitutionally low serotonin activity showed increased susceptibility to harmful effects of a high-energy diet, such as weight gain and insulin resistance, while those with constitutionally high serotonin activity appeared to be protected from major metabolic disturbances. These findings suggest that understanding the role of serotonin in metabolically healthy obesity may provide insights into human health.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Yongshou Yang, Akane Iwamoto, Thanutchaporn Kumrungsee, Yukako Okazaki, Manabu Kuroda, Shotaro Yamaguchi, Norihisa Kato
NUTRITION RESEARCH
(2017)
Article
Food Science & Technology
Wanwanut Limpimwong, Thanutchapom Kumrungsee, Norihisa Kato, Noriyuki Yanaka, Masubon Thongngam
JOURNAL OF FUNCTIONAL FOODS
(2017)
Article
Medicine, Research & Experimental
Sofya Suidasari, Shinji Uragami, Noriyuki Yanaka, Norihisa Kato
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2017)
Article
Medicine, Research & Experimental
Akiko Kimoto, Hanae Izu, Churan Fu, Sofya Suidasari, Norihisa Kato
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2017)
Article
Nutrition & Dietetics
Dwi Eva Nirmagustina, Yongshou Yang, Thanutchaporn Kumrungsee, Noriyuki Yanaka, Norihisa Kato
JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY
(2018)
Article
Nutrition & Dietetics
Tsuyoshi Kameda, Hideyuki Aoki, Yongshou Yang, Dwi Eva Nirmagustina, Akane Iwamoto, Thanutchaporn Kumrungsee, Norihisa Kato, Noriyuki Yanaka
JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Thanutchaporn Kumrungsee, Dwi Eva Nirmagustina, Takeshi Arima, Kai Onishi, Kanako Sato, Norihisa Kato, Noriyuki Yanaka
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2019)
Article
Biochemistry & Molecular Biology
Yongshou Yang, Thanutchaporn Kumrungse, Manabu Kurod, Shotaro Yamaguchi, Norihisa Kato
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
(2019)
Article
Nutrition & Dietetics
Yongshou Yang, Kan Takahara, Thanutchaporn Kumrungsee, Akiko Kimoto, Fumio Shimamoto, Norihisa Kato
JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY
(2019)
Article
Nutrition & Dietetics
Churan Fu, Yongshou Yang, Thanutchaporn Kumrungsee, Akiko Kimoto, Hanae Izu, Norihisa Kato
JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY
(2020)
Review
Nutrition & Dietetics
Thanutchaporn Kumrungsee, Peipei Zhang, Noriyuki Yanaka, Takashi Suda, Norihisa Kato
Summary: While overt vitamin B6 deficiency is rare, marginal deficiency is common and associated with an increased risk of inflammation-related diseases. Vitamin B6 treatment can increase certain substances in the heart and suppress the formation of inflammasomes, potentially serving as a cardioprotective mechanism.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Article
Food Science & Technology
Dwi Eva Nirmagustina, Abdelkrim Khedara, Djamila Benouchenne, Karima Boubekri, Yongshou Yang, Saya Suidasari, Thanutchaporn Kumrungsee, Norihisa Kato
FOOD SCIENCE AND TECHNOLOGY RESEARCH
(2019)
Article
Medicine, Research & Experimental
Masahiro Yamaguchi, Yongshou Yang, Misaki Ando, Thanutchaporn Kumrungsee, Norihisa Kato, Yukako Okazaki
BIOMEDICAL REPORTS
(2018)
Article
Biochemistry & Molecular Biology
Yongshou Yang, Dwi Eva Nirmagustina, Thanutchaporn Kumrungsee, Yukako Okazaki, Hiroyuki Tomotake, Norihisa Kato
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
(2017)
Article
Nutrition & Dietetics
Sofya Suidasari, Jan Stautemas, Shinji Uragami, Noriyuki Yanaka, Wim Derave, Norihisa Kato
FRONTIERS IN NUTRITION
(2016)