Article
Chemistry, Physical
Boyang Sun, Sanjana Ghosh, Xuedan He, Wei-Chiao Huang, Breandan Quinn, Meiling Tian, Dushyant Jahagirdar, Moustafa T. Mabrouk, Joaquin Ortega, Yumiao Zhang, Shuai Shao, Jonathan F. Lovell
Summary: This study explores the potential of photodynamic therapy (PDT) combined with chemotherapy for tumor ablation. Liposomes loaded with a photosensitizer and a potent anti-cancer drug were successfully developed and demonstrated effective tumor ablation in in vivo experiments. This liposome delivery system shows versatility and potential for achieving enhanced tumor treatment.
Article
Agriculture, Multidisciplinary
Tiantian Xu, Jingwen Zhang, Risheng Jin, Rong Cheng, Xiaonan Wang, Chuanxun Yuan, Changsheng Gan
Summary: The study found that co-encapsulated liposomes have higher antioxidant activity and bioavailability compared to single loaded liposomes, especially in potential applications in functional foods.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2022)
Review
Chemistry, Applied
Changhoon Chai, Jinhyung Park
Summary: This review examines the structure, components, stability, and applicability of liposomes, and discusses different preparation methods. Emphasis is placed on the role of phospholipids and liposome modulators in achieving desired structure and size. The potential of liposomes to enhance food value through encapsulation and delivery of functional substances is also discussed. The importance of research on lecithin properties and modulators that improve liposome stability is highlighted. The need for cost-effective and rapid preparation methods to improve the marketability of food liposomes and promote their use in foods is identified.
Article
Biochemistry & Molecular Biology
Przemyslaw Jurczak, Kosma Szutkowski, Slawomir Lach, Stefan Jurga, Paulina Czaplewska, Aneta Szymanska, Igor Zhukov
Summary: Studying the mechanisms behind amyloid-based diseases can help identify future treatment targets, but the complexity and interactions of proteins responsible for fibril formation make it a challenging and time-consuming task. Human cystatin C, a cysteine-protease inhibitor, tends to form fibrils under certain stimuli, potentially regulated by cellular components with the cell membrane playing a key role in the oligomerization pathway. The use of phospholipid liposomes as membrane mimetics provides a promising alternative for studying protein-mimetic interactions.
Article
Multidisciplinary Sciences
Long-Fang Tu, Tian-Ze Zhang, Yang -Fan Zhou, Qing-Qing Zhou, Hai-Biao Gong, Lei Liang, Lin-Na Hai, Nan-Xin You, Yang Su, Yong-Jun Chen, Xu-Kai Mo, Chang-Zheng Shi, Liang-Ping Luo, Wan-Yang Sun, Wen -Jun Duan, Hiroshi Kurihara, Yi-Fang Li, Rong-Rong He
Summary: The deficiency of GPX4 leads to motor neuron loss in ALS mice, while overexpression of GPX4 promotes the maintenance and function of neurons. This highlights the importance of GPX4 in maintaining phospholipid redox homeostasis in the spinal cord and suggests GPX4 as a potential therapeutic target for ALS treatment.
JOURNAL OF ADVANCED RESEARCH
(2023)
Article
Food Science & Technology
Wahyudiono, Jiayang He, Xin Hu, Siti Machmudah, Keiji Yasuda, Seiichi Takami, Hideki Kanda, Motonobu Goto
Summary: Curcumin-loaded liposomes were prepared using a supercritical carbon dioxide (SCCO2)-ultrasound environment system. The operating conditions influenced the size of liposome products and the encapsulation efficiency of curcumin. This innovative method does not require organic solvents and is practical for generating liposomes.
Article
Biophysics
Cristina Pavan, Matthew J. Sydor, Chiara Bellomo, Riccardo Leinardi, Stefania Canana, Rebekah L. Kendall, Erica Rebba, Marta Corno, Piero Ugliengo, Lorenzo Mino, Andrij Holian, Francesco Turci
Summary: This study identifies and proposes the molecular recognition mechanism between membrane epitopes and nearly free silanols (NFS) as a novel explanation for the unique activity of inhaled crystalline silica. The results demonstrate that NFS content is the primary determinant of membrane disruption, leading to red blood cell lysis and changes in lipid order. These findings provide insights for the safer design of materials and potential treatments.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Medicine, Research & Experimental
Wei He, Yawei Du, Tao Wang, Ji Wang, Lei Cheng, Xinsong Li
Summary: A novel anticancer drug carrier based on dARTPC encapsulated with Ir was developed, showing high encapsulation efficiency and controllable drug loading. In vitro experiments demonstrated that dARTPC-based liposomes can effectively release DHA and Ir in a weakly acidic environment, exhibiting significant antitumor activity. In vivo studies revealed that Ir encapsulated with dARTPC exhibited a high tumor inhibition rate with minimal toxicity.
MOLECULAR PHARMACEUTICS
(2021)
Article
Food Science & Technology
Wenyang Tao, Xingqian Ye, Yanping Cao
Summary: The study found that all-trans-beta-carotene undergoes degradation during oral, gastro, and intestinal digestion, with the most significant degradation occurring during intestinal digestion. Isomerization was observed during oral digestion, and different degradation products with various functional groups were identified.
FOOD SCIENCE AND HUMAN WELLNESS
(2021)
Article
Agriculture, Multidisciplinary
Hang-Zhi Zhu, Shan Jiang, Jun-Jie Wu, Xue-Rong Zhou, Peng-Yang Liu, Feng-Hong Huang, Xia Wan
Summary: This study successfully engineered Yarrowia lipolytica to produce high levels of 3S,3'S-astaxanthin, providing potential for industrial production and laying the foundation for a sustainable biorefinery platform.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Engineering, Chemical
Martin P. Walsh, Rohan Tikekar, Nitin Nitin, Steven Wrenn
Summary: This study investigates the effectiveness of high-frequency ultrasound-induced microbubble cavitation on bacterial inactivation using liposomal bilayers as a model for bacterial cell membranes. The addition of a positive charge on micmbubbles increased their proximity to liposomes, but dampened microbubble's oscillation. Microstreaming from stable cavitation at 3.3 MHz led to approximately 19% mixing of phospholipids, while inertial cavitation at 1.0 MHz increased this mixing to 50%.
JOURNAL OF FOOD ENGINEERING
(2021)
Article
Biochemistry & Molecular Biology
Deepika Regmi, Fengyun Shen, Aleksander Stanic, Majedul Islam, Deguo Du
Summary: Misfolding and aggregation of cellular prion protein (PrPc) is a major molecular process involved in the pathogenesis of prion diseases. The aggregation of PrP(106-128) depends on concentration, pH, preformed amyloid seeds, and the lipid composition and rigidity of liposomes.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2023)
Article
Agronomy
Asheber K. Mengesha, Dereje Getahun, Setegn Gebeyehu, Anthony Roland Brouwer
Summary: The incorporation of orange-fleshed sweet potato puree into wheat flour bread and teff flour injera can increase the beta-carotene content of the products. This study determined the optimal proportion of orange-fleshed sweet potato puree in the blends and evaluated their nutritional content, sensory acceptability, and profitability. The results showed that bread and injera with 30% orange-fleshed sweet potato puree had the highest beta-carotene content and sensory acceptability. These findings suggest that this blend is recommended for commercial production and consumption, especially for individuals at risk of vitamin A deficiency.
Article
Infectious Diseases
Steven Meier, Zachary M. Ridgway, Angela L. Picciano, Gregory A. Caputo
Summary: Antimicrobial resistance is a major threat to global health. Antimicrobial peptides have emerged as a promising option for the development of new antimicrobial compounds. This study found that the length of the peptide is correlated with its antimicrobial efficacy, and there is also a correlation between peptide length and the hydrophobic thickness of the bilayer, suggesting that hydrophobic mismatch may contribute to the loss of efficacy in shorter peptides.
Article
Biochemistry & Molecular Biology
Sevde Puza, Shima Asfia, Ralf Seemann, Jean-Baptiste Fleury
Summary: Lipid droplets (LD) locate in the endoplasmic reticulum membrane and play important roles in biological functions. A protein called ADRP surrounds LDs along with phospholipid monolayers and is involved in storing neutral lipids. This article focuses on the influence of ADRP on the 3D shape of LDs embedded in bilayers and the diffusion of phospholipids on LD surfaces. The study shows that ADRP significantly affects the 3D structure of LDs. Rating: 9/10.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Chemical
Aureliano Agostinho Dias Meirelles, Ana Leticia Rodrigues Costa, Mariano Michelon, Juliane Vigano, Marcio S. Carvalho, Rosiane Lopes Cunha
Summary: The study evaluated the use of glass microfluidic devices to produce emulsion-filled alginate microgels and investigated the effect of process variables on microgels size and polydispersity. Monodisperse particle size distribution of the microgels was observed, with size influenced by the viscosity of the O/W emulsion and the phases flow rates. These results demonstrate the potential of microfluidic processes for encapsulating lipophilic compounds in microgels.
JOURNAL OF FOOD ENGINEERING
(2022)
Article
Chemistry, Multidisciplinary
Rosilene Andrea Welter, Harrson Silva Santana, Bruna Gregatti Carvalho, Natalia Melani, Michael Oelgemoller, Lucimara Gaziola de la Torre, Osvaldir Pereira Taranto
Summary: A double immobilisation technique was developed to improve the enzymatic activity of CALB and address difficulties in lipase-catalysed reactions. The first immobilisation involved adsorption of CALB onto a TiO2 nanoparticle surface, resulting in increased enzymatic activity. The second immobilisation used calcium alginate microbeads to trap CALB(TiO2), providing high enzymatic activity and stability with easier recovery. This study presents a promising approach for enzyme immobilisation in industrial applications.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2022)
Article
Nanoscience & Nanotechnology
Joao Victor Melo Amaral, Lucimara Gaziola de la Torre, Savio Souza Venancio Vianna
Summary: A new strategy to stimulate vorticity by chaotic advection in microchannels has been investigated, and it was found that the narrowing of the microchannel, flattening of the bumps, and lateral feeding in the conical chamber can enhance vorticity.
MICROFLUIDICS AND NANOFLUIDICS
(2022)
Article
Acoustics
Ugur Soysal, Pedro N. Azevedo, Flavien Bureau, Alexandre Aubry, Marcio S. Carvalho, Amanda C. S. N. Pessoa, Lucimara G. De La Torre, Olivier Couture, Arnaud Tourin, Mathias Fink, Patrick Tabeling
Summary: The study successfully generated freeze-dried monodisperse microbubbles using microfluidic technology and preserved their performance through a novel retrieval technique. This work solves the storage and transportation challenges of highly monodisperse bubbles and may lead to new clinical non-invasive measurement methods.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2022)
Article
Chemistry, Physical
Rosilene A. Welter, Harrson Santana, Lucimara G. de la Torre, Mark Robertson, Osvaldir Pereira Taranto, Michael Oelgemoeller
Summary: Methyl oleate, a fatty acid methyl ester, was successfully produced through photoesterification of oleic acid using TO and UVA light. The main operational conditions of the reaction were evaluated and optimized. The study proposed a photoesterification mechanism and described the reaction using the Langmuir-Hinshelwood kinetic model. Thermodynamic results indicated the importance of operational conditions in supplying energy and increasing reactant miscibility.
Article
Biophysics
Ismail Es, Antonio A. Malfatti-Gasperini, Lucimara Gaziola de la Torre
Summary: Our study investigated the manufacturing of lipid-based nanotherapeutics with stealth properties for siRNA delivery. The results showed that lipid nanocarriers had a bigger particle diameter and surface charge compared to lipoplexes. The inclusion of PEG-lipid resulted in an increase in the surface charge of lipoplexes, while a significant decrease was observed in the surface charge of lipid nanocarriers. Different structural assemblies were identified for lipoplex and lipid nanocarriers using Synchrotron SAXS.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Review
Pharmacology & Pharmacy
Marcel Franco Mougenot, Vanessa Sousa Pereira, Ana Leticia Rodrigues Costa, Marcelo Lancellotti, Marimelia Aparecida Porcionatto, Juliano Coelho da Silveira, Lucimara Gaziola de la Torre
Summary: Biomimetic nanovesicles have emerged as a promising strategy for drug and gene delivery systems, combining the advantages of biological vesicles with the controllability of synthetic systems. This article focuses on tracking the research progress in biomimetic nanovesicles applied in drug and gene delivery systems, as well as vaccines applications, describing the different sources of natural vesicles, the technical perspectives on obtaining them, and the possibility of their hybridization with synthetic liposomes.
Article
Chemistry, Applied
Cristhian Rafael Lopes Francisco, Tatiana Porto Santos, Rosiane Lopes Cunha
Summary: Conjugation of lupin protein with grape seed extract improved the stabilization of oil-in-water emulsions. Both nano and micro particles of the conjugates were able to stabilize the emulsions, with micro particles showing better stability and gel-like behavior. The dominant stabilizing mechanism of the conjugates was Pickering-type, but other mechanisms may also be involved.
FOOD HYDROCOLLOIDS
(2023)
Article
Chemistry, Multidisciplinary
Ariel A. C. Toledo Hijo, Aureliano A. D. Meirelles, Guilherme J. Maximo, Rosiane L. Cunha, Marcelo Cristianini, Thiago S. . Leite, Jorge F. B. Pereira, Antonio J. A. Meirelles
Summary: This article presents a strategy to obtain highly stable emulsions using ionic liquid (IL) technology, with ILs derived from fatty acids and choline as an example. These ILs exhibited high emulsifier ability and antimicrobial effectiveness at low concentrations, leading to improved shelf life of emulsions.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2022)
Article
Engineering, Chemical
Rosilene Andrea Welter, Harrson Silva Santana, Lucimara Gaziola de la Torre, Mark C. Barnes, Osvaldir Pereira Taranto, Michael Oelgemoeller
Summary: Biodiesel is a large-scale eco-friendly substitute and additive to fossil fuels. Traditional methods of production have several disadvantages, leading to the exploration of alternative feedstocks, catalysts, and operational conditions. This review analyzes current biodiesel technologies and improvement strategies.
CHEMBIOENG REVIEWS
(2023)
Article
Tropical Medicine
Aline Garnevi-Favero, Karina Nascimento-da Silva, Willian Rodrigues-Ribeiro, Caroline Marcantonio-Ferreira, Patricia Sartorelli, Leonardo Cardili, Rita de Cassia-Sinigaglia, Joice Naiara Bertaglia-Pereira, Marcelo Aparecido-da Silva, Wagner Vilegas, Marcelo Jose Dias-Silva, Ana Paula Ribeiro-Paiotti
Summary: The study evaluated the effects of M. caesalpiniifolia pre-formulation on colitis model, and found that the pre-formulation can alleviate the symptoms and intestinal inflammation of colitis, but cannot repair the damage to the intestinal barrier.
Article
Engineering, Chemical
Larissa Ribas Fonseca, Matheus Augusto Silva Santos, Tatiana Porto Santos, Rosiane Lopes Cunha
Summary: Sunflower waxes were used as stabilizers to prepare W/O HIPEs emulsions with a high volume fraction of water dispersed phase and sunflower oil continuous phase. It was found that 0.5% of sunflower wax could stabilize the emulsion, while at least 1.0% of hydrolyzed sunflower wax was required for the same stabilization effect. Increasing wax concentration reduced droplet size, and emulsions structured with sunflower wax showed better kinetic stability for 60 days of storage.
JOURNAL OF FOOD ENGINEERING
(2023)
Article
Chemistry, Applied
Cristhian Rafael Lopes Francisco, Marluci Palazzolli Silva, Fernando Divino Oliveira Jr, Tatiana Porto Santos, Rosiane Lopes Cunha
Summary: Plant-based high internal phase oil-in-water emulsions (HIPEs) show promise as fat replacers. Conjugation of plant proteins with phenolic compounds and moderate heat treatment can improve the viscoelastic properties of HIPEs. This study demonstrated that the conjugation of lupin protein with grape seed extract and heat treatment enhanced the viscosity and storage modulus of HIPEs.
JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY
(2023)
Review
Food Science & Technology
Jhonatan Rafael de Oliveira Bianchi, Lucimara Gaziola de la Torre, Ana Leticia Rodrigues Costa
Summary: Microfluidic technology is a powerful tool used in various fields, including chemistry, physics, biology, and engineering. Droplet-based microfluidics, utilizing food-grade emulsions, allows for the development of diverse delivery systems and precise control over droplet size, shape, and dispersity. This review highlights recent advances in droplet-based microfluidic processes using food-grade emulsions to create simple and complex delivery systems.
Article
Chemistry, Multidisciplinary
Bruna Gregatti Carvalho, Aya Nakayama, Hiromi Miwa, Sang Won Han, Lucimara Gaziola de la Torre, Dino Di Carlo, Junmin Lee, Han-Jun Kim, Ali Khademhosseini, Natan Roberto de Barros
Summary: A novel mRNA-releasing matrix based on GelMA microporous annealed particle scaffolds is reported. The sustained release of mRNA complexes achieves indirect intracellular delivery, while direct intracellular delivery is achieved by cell adhesion on the mRNA-releasing scaffolds. This hybrid system demonstrates efficient protein expression, offering potential for mRNA-releasing biomaterials in tissue engineering.
Article
Food Science & Technology
Yonghong Ye, Songyan Zheng, Yuanxing Wang
Summary: In this study, the changes of aroma components in Gannan navel orange during growth were systematically studied using HS-SPME-GC-MS. Key aroma components and markers were identified. These findings contribute to a better understanding of the dynamic variation of aroma compounds during navel orange growth and have potential for industrial applications.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Jia Xu, Yayuan Zhang, Mengke Zhang, Xinlin Wei, Yiming Zhou
Summary: This study evaluated the effects of glucosamine selenium on summer-autumn tea, showing that it can enhance nutritional quality, improve sensory characteristics, and increase plant adaptation to environmental changes and abiotic stresses.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Yuanming Chu, Zhaoyang Ding, Jing Xie
Summary: This study investigated the use of ice glazing containing D-sodium erythorbate (DSE) and vacuum packaging to maintain the quality of large yellow croaker during frozen storage. The results showed that vacuum packaging effectively inhibited ice crystal growth and minimized water loss, while the combination of vacuum packaging and 0.3% DSE-infused ice glazing maintained freshness indicators at low levels throughout the 300-day storage period. This combination was considered the most effective in preserving the quality of the fish.
FOOD RESEARCH INTERNATIONAL
(2024)
Review
Food Science & Technology
Md. Ashikur Rahman, Shirin Akter, Md. Ashrafudoulla, Md. Anamul Hasan Chowdhury, A. G. M. Sofi Uddin Mahamud, Si Hong Park, Sang-Do Ha
Summary: This comprehensive review aims to provide insights into the mechanisms and key factors influencing biofilm formation by A. hydrophila in the food industry. It explores the molecular processes involved in various stages of biofilm formation and investigates the impact of intrinsic factors and environmental conditions on biofilm architecture and resilience. The article also highlights the potential of bibliometric analysis in conceptualizing the research landscape and identifying knowledge gaps in A. hydrophila biofilm research.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Chujing Wang, Wenni Tian, Zengliu Song, Qun Wang, Yong Cao, Jie Xiao
Summary: Solid lipid ratio in emulsions has significant effects on colloidal stability, mucus permeability, and bioavailability in vivo. Higher solid lipid ratio improves intestinal stability but reduces mucus permeability.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Dacai Zhong, Liping Kang, Juan Liu, Xiang Li, Li Zhou, Luqi Huang, Zidong Qiu
Summary: In this study, a novel online extraction electrospray ionization mass spectrometry method was developed to comprehensively characterize complex foods. Meanwhile, a characteristic marker screening method and chemometrics modeling were used for the accurate authentication of highly-similar foods. This research has significant implications for ensuring food quality and safety.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Qiannan Zhao, Jinyi Yang, Jiahui Li, Lei Zhang, Xiaohai Yan, Tianli Yue, Yahong Yuan
Summary: This study investigated the transport and hypoglycemic effects of phenolics in mulberry leaves using an in vitro digestion model. The results showed that digested phenolics had higher absorbability and could inhibit glucose digestion and absorption. Phenolics also regulated glucose metabolism. Luteoforol and p-coumaric acid were found to be the primary phenolics strongly correlated with the hypoglycemic ability of mulberry leaves.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Yanyun Cao, Qingling Wang, Jinou Lin, Yin-Yi Ding, Jianzhong Han
Summary: This study investigated the effects of gallic acid (GA) and epigallocatechin gallate (EGCG) at different ratios on the gel properties of calcium induced-whey protein emulsion gel. It was found that GA and EGCG could promote gel formation, increase gel strength, and delay the release of emulsified oil droplets.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Monique Martins Strieder, Vitor Lacerda Sanches, Mauricio Ariel Rostagno
Summary: This study proposed an integrated and automated procedure for extracting, separating, and quantifying bioactive compounds from coffee co-products. By optimizing the extraction, separation, and analysis method, real-time analysis was achieved. The results suggest that coupling different techniques can efficiently extract, separate, and analyze phenolic compounds, providing an integrated method to produce high-added value ingredients for various applications.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Kyu Sang Sim, Hyoyoung Kim, Suel Hye Hur, Tae Woong Na, Ji Hye Lee, Ho Jin Kim
Summary: Geographical origin plays a crucial role in determining the quality and safety of agricultural products. In this study, ICP analysis was used to determine the inorganic elemental content of onions and identify their geographical origin. Chemometric methods were applied to analyze the ICP results, and the accuracy of distinguishing between Korean and Chinese onions was found to be excellent. The findings suggest that this method can be beneficial for identifying agricultural products.
FOOD RESEARCH INTERNATIONAL
(2024)
