Towards Profiling of the G-Quadruplex Targeting Drugs in the Living Human Cells Using NMR Spectroscopy
出版年份 2021 全文链接
标题
Towards Profiling of the G-Quadruplex Targeting Drugs in the Living Human Cells Using NMR Spectroscopy
作者
关键词
-
出版物
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 22, Issue 11, Pages 6042
出版商
MDPI AG
发表日期
2021-06-03
DOI
10.3390/ijms22116042
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Thermal and pH stabilities of i‐DNA: confronting in vitro experiments with models and in‐cell NMR data
- (2021) Mingpan Cheng et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Monitoring Protein-Ligand Interactions in Human Cells by Real-Time Quantitative In-Cell NMR using a High Cell Density Bioreactor
- (2021) Letizia Barbieri et al. Jove-Journal of Visualized Experiments
- Drug Screening in Human Cells by NMR Spectroscopy Allows the Early Assessment of Drug Potency
- (2020) Enrico Luchinat et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Topologies of G-quadruplex: Biological functions and regulation by ligands
- (2020) Yue Ma et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Reduction Resistant and Rigid Nitroxide Spin-Labels for DNA and RNA
- (2020) Haraldur Y. Juliusson et al. JOURNAL OF ORGANIC CHEMISTRY
- The regulation and functions of DNA and RNA G-quadruplexes
- (2020) Dhaval Varshney et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Real-Time Quantitative In-Cell NMR: Ligand Binding and Protein Oxidation Monitored in Human Cells Using Multivariate Curve Resolution
- (2020) Enrico Luchinat et al. ANALYTICAL CHEMISTRY
- Intracellular Binding/Unbinding Kinetics of Approved Drugs to Carbonic Anhydrase II Observed by in-Cell NMR
- (2020) Enrico Luchinat et al. ACS Chemical Biology
- In‐cell NMR of functional riboswitch aptamers in eukaryotic cells
- (2020) P. Broft et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Compaction of RNA Duplexes in the Cell
- (2020) Alberto Collauto et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Hybrid-type and two-tetrad antiparallel telomere DNA G-quadruplex structures in living human cells
- (2019) Hong-Liang Bao et al. NUCLEIC ACIDS RESEARCH
- NMR solution and X-ray crystal structures of a DNA molecule containing both right- and left-handed parallel-stranded G-quadruplexes
- (2019) Fernaldo Richtia Winnerdy et al. NUCLEIC ACIDS RESEARCH
- Monitoring DNA–Ligand Interactions in Living Human Cells Using NMR Spectroscopy
- (2019) Michaela Krafcikova et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Evaluation of the Stability of DNA i-Motifs in the Nuclei of Living Mammalian Cells
- (2018) Simon Dzatko et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Crowding, Entropic Forces, and Confinement: Crucial Factors for Structures and Functions in the Cell Nucleus
- (2018) R. Hancock BIOCHEMISTRY-MOSCOW
- Advances in the cellular structural biology of nucleic acids
- (2018) Ilektra-Chara Giassa et al. FEBS LETTERS
- Investigation of higher-order RNA G-quadruplex structures in vitro and in living cells by 19F NMR spectroscopy
- (2018) Hong-Liang Bao et al. Nature Protocols
- The first successful observation of in-cell NMR signals of DNA and RNA in living human cells
- (2018) Yudai Yamaoki et al. PHYSICAL CHEMISTRY CHEMICAL PHYSICS
- Fluorescence-based tools to probe G-quadruplexes in cell-free and cellular environments
- (2018) Sudeshna Manna et al. RSC Advances
- A Dual-App Nucleoside Probe Provides Structural Insights into the Human Telomeric Overhang in Live Cells
- (2018) Sudeshna Manna et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- High-resolution three-dimensional NMR structure of theKRASproto-oncogene promoter reveals key features of a G-quadruplex involved in transcriptional regulation
- (2017) Abdelaziz Kerkour et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Model studies of the effects of intracellular crowding on nucleic acid interactions
- (2017) Shu-ichi Nakano et al. Molecular BioSystems
- Characterization of human telomere RNA G-quadruplex structures in vitro and in living cells using 19F NMR spectroscopy
- (2017) Hong-Liang Bao et al. NUCLEIC ACIDS RESEARCH
- Structure, properties, and biological relevance of the DNA and RNA G-quadruplexes: Overview 50 years after their discovery
- (2016) N. G. Dolinnaya et al. BIOCHEMISTRY-MOSCOW
- Comparative study of affinity and selectivity of ligands targeting abasic and mismatch sites in DNA using a fluorescence-melting assay
- (2016) Naoko Kotera et al. BIOCHIMIE
- Telomere targeting with a novel G-quadruplex-interactive ligand BRACO-19 induces T-loop disassembly and telomerase displacement in human glioblastoma cells
- (2016) Guangtong Zhou et al. Oncotarget
- G-quadruplex DNA and ligand interaction in living cells using NMR spectroscopy
- (2015) Gilmar F. Salgado et al. Chemical Science
- In-Cell NMR and EPR Spectroscopy of Biomacromolecules
- (2014) Robert Hänsel et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- G-quadruplex conformation and dynamics are determined by loop length and sequence
- (2014) Ramreddy Tippana et al. NUCLEIC ACIDS RESEARCH
- Dynamics and stability of polymorphic human telomeric G-quadruplex under tension
- (2014) Huijuan You et al. NUCLEIC ACIDS RESEARCH
- Solution Structure of a G-quadruplex Bound to the Bisquinolinium Compound Phen-DC3
- (2013) Wan Jun Chung et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Structural characterization of quadruplex DNA with in-cell EPR approaches
- (2013) Isabelle T. Holder et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Effects of Molecular Crowding on the Structures, Interactions, and Functions of Nucleic Acids
- (2013) Shu-ichi Nakano et al. CHEMICAL REVIEWS
- High-Resolution Insight into G-Overhang Architecture
- (2013) Robert Hänsel et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Structure-Based DNA-Targeting Strategies with Small Molecule Ligands for Drug Discovery
- (2013) Jia Sheng et al. MEDICINAL RESEARCH REVIEWS
- Structure of the human telomere in Na+ solution: an antiparallel (2+2) G-quadruplex scaffold reveals additional diversity
- (2013) Kah Wai Lim et al. NUCLEIC ACIDS RESEARCH
- A Gel-Encapsulated Bioreactor System for NMR Studies of Protein-Protein Interactions in Living Mammalian Cells
- (2012) Satoshi Kubo et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- State-of-the-Art Methodologies for the Discovery and Characterization of DNA G-Quadruplex Binders
- (2012) Bruno Pagano et al. CURRENT PHARMACEUTICAL DESIGN
- Circular dichroism and guanine quadruplexes
- (2012) Michaela Vorlíčková et al. METHODS
- Site-directed spin-labeling of nucleotides and the use of in-cell EPR to determine long-range distances in a biologically relevant environment
- (2012) Mykhailo Azarkh et al. Nature Protocols
- Towards characterization of DNA structure under physiological conditions in vivo at the single-molecule level using single-pair FRET
- (2012) Tomáš Fessl et al. NUCLEIC ACIDS RESEARCH
- Interaction of human telomeric DNA with N- methyl mesoporphyrin IX
- (2012) John M. Nicoludis et al. NUCLEIC ACIDS RESEARCH
- Long-Range Distance Measurements on Nucleic Acids in Cells by Pulsed EPR Spectroscopy
- (2011) Ivan Krstić et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Targeting DNA
- (2011) J.B. Chaires et al. BIOCHIMIE
- Long-Range Distance Determination in a DNA Model System inside Xenopus laevis Oocytes by In-Cell Spin-Label EPR
- (2011) Mykhailo Azarkh et al. CHEMBIOCHEM
- Methods for investigating G-quadruplex DNA/ligand interactions
- (2011) Pierre Murat et al. CHEMICAL SOCIETY REVIEWS
- NMR Cross-Correlated Relaxation Rates Reveal Ion Coordination Sites in DNA
- (2011) Radovan Fiala et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- The parallel G-quadruplex structure of vertebrate telomeric repeat sequences is not the preferred folding topology under physiological conditions
- (2011) Robert Hänsel et al. NUCLEIC ACIDS RESEARCH
- False Positives in the Early Stages of Drug Discovery
- (2010) R. Sink et al. CURRENT MEDICINAL CHEMISTRY
- Genetic instability triggered by G-quadruplex interacting Phen-DC compounds in Saccharomyces cerevisiae
- (2010) Aurèle Piazza et al. NUCLEIC ACIDS RESEARCH
- Formation of a G-quadruplex at the BCL2 major breakpoint region of the t(14;18) translocation in follicular lymphoma
- (2010) Mridula Nambiar et al. NUCLEIC ACIDS RESEARCH
- Structure-based drug design: From nucleic acid to membrane protein targets
- (2009) Magdalena M. Dailey et al. EXPERIMENTAL AND MOLECULAR PATHOLOGY
- A bioreactor for in-cell protein NMR
- (2009) Naima G. Sharaf et al. JOURNAL OF MAGNETIC RESONANCE
- Evaluation of Parameters Critical for Observing Nucleic Acids Inside LivingXenopus laevisOocytes by In-Cell NMR Spectroscopy
- (2009) Robert Hänsel et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Polymorphism of human telomeric quadruplex structures
- (2008) Jixun Dai et al. BIOCHIMIE
- PlasmodiumTelomeric Sequences: Structure, Stability and Quadruplex Targeting by Small Compounds
- (2008) Anne De Cian et al. CHEMBIOCHEM
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started