Fluorescence-based tools to probe G-quadruplexes in cell-free and cellular environments

Surface Plasmon Resonance kinetic analysis of the interaction between G-quadruplex nucleic acids and an anti-G-quadruplex monoclonal antibody

(2018) Sara Lago et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

I-motif DNA structures are formed in the nuclei of human cells

(2018) Mahdi Zeraati et al.   Nature Chemistry

Comprehensive Thermodynamic Profiling for the Binding of a G-Quadruplex Selective Indoloquinoline

(2017) Andrea Funke et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Resolving the Ligand-Binding Specificity in c-MYC G-Quadruplex DNA: Absolute Binding Free Energy Calculations and SPR Experiment

(2017) Nanjie Deng et al.   JOURNAL OF PHYSICAL CHEMISTRY B

4n–1 Is a “Sweet Spot” in DNA i-Motif Folding of 2′-Deoxycytidine Homopolymers

(2017) Aaron M. Fleming et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Confined space facilitates G-quadruplex formation

(2017) Prakash Shrestha et al.   Nature Nanotechnology

DNA G-quadruplexes in the human genome: detection, functions and therapeutic potential

(2017) Robert Hänsel-Hertsch et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Identification of multiple genomic DNA sequences which form i-motif structures at neutral pH

(2017) Elisé P. Wright et al.   NUCLEIC ACIDS RESEARCH

Identification of new DNA i-motif binding ligands through a fluorescent intercalator displacement assay

(2017) Qiran Sheng et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Development of a light-up fluorescent probe for HRAS G-quadruplex DNA

(2017) Ming-Qi Wang et al.   TETRAHEDRON LETTERS

Target guided synthesis using DNA nano-templates for selectively assembling a G-quadruplex binding c-MYC inhibitor

(2017) Deepanjan Panda et al.   Nature Communications

Quadruplex nucleic acids as targets for anticancer therapeutics

(2017) Stephen Neidle   Nature Reviews Chemistry

A Simple Molecular Rotor for Defining Nucleoside Environment within a DNA Aptamer–Protein Complex

(2016) Thomas Z. Cservenyi et al.   ACS Chemical Biology

New pyridinium-based fluorescent dyes: A comparison of symmetry and side-group effects on G-Quadruplex DNA binding selectivity and application in live cell imaging

(2016) Yu-Jing Lu et al.   BIOSENSORS & BIOELECTRONICS

Responsive Fluorescent PNA Analogue as a Tool for Detecting G-quadruplex Motifs of Oncogenes and Activity of Toxic Ribosome-Inactivating Proteins

(2016) Pramod M. Sabale et al.   CHEMBIOCHEM

Berberine as a novel light-up i-motif fluorescence ligand and its application in designing molecular logic systems

(2016) Lijun Xu et al.   CHEMICAL COMMUNICATIONS

Visualization of NRAS RNA G-Quadruplex Structures in Cells with an Engineered Fluorogenic Hybridization Probe

(2016) Shuo-Bin Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure and possible function of a G-quadruplex in the long terminal repeat of the proviral HIV-1 genome

(2016) Beatrice De Nicola et al.   NUCLEIC ACIDS RESEARCH

A single molecule study of a fluorescently labeled telomestatin derivative and G-quadruplex interactions

(2016) Parastoo Maleki et al.   NUCLEIC ACIDS RESEARCH

Re-evaluation of G-quadruplex propensity with G4Hunter

(2016) Amina Bedrat et al.   NUCLEIC ACIDS RESEARCH

A bimodal fluorescent and photocytotoxic naphthalene diimide for theranostic applications

(2016) Erica Salvati et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

C-Linked 8-aryl guanine nucleobase adducts: biological outcomes and utility as fluorescent probes

(2016) Richard A. Manderville et al.   Chemical Science

Photophysical properties of push–pull 8-aryl-deoxyguanosine probes within duplex and G-quadruplex structures

(2016) Darian J. M. Blanchard et al.   Journal of Materials Chemistry C

Direct visualization of both DNA and RNA quadruplexes in human cells via an uncommon spectroscopic method

(2016) Aurélien Laguerre et al.   Scientific Reports

Positional Impact of Fluorescently Modified G-Tetrads within Polymorphic Human Telomeric G-Quadruplex Structures

(2015) Michael Sproviero et al.   ACS Chemical Biology

Assessment of selectivity of G-quadruplex ligands via an optimised FRET melting assay

(2015) Aurore De Rache et al.   BIOCHIMIE

Probing structural changes of self assembled i-motif DNA

(2015) Il Joon Lee et al.   CHEMICAL COMMUNICATIONS

Targeting G-quadruplex structures with extrinsic fluorogenic dyes: promising fluorescence sensors

(2015) Achikanath C. Bhasikuttan et al.   CHEMICAL COMMUNICATIONS

Visualization of RNA-Quadruplexes in Live Cells

(2015) Aurélien Laguerre et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Conformation-sensitive nucleoside analogues as topology-specific fluorescence turn-on probes for DNA and RNA G-quadruplexes

(2015) Arun A. Tanpure et al.   NUCLEIC ACIDS RESEARCH

Loop flexibility in human telomeric quadruplex small-molecule complexes

(2015) Gavin W. Collie et al.   NUCLEIC ACIDS RESEARCH

G-quadruplexes and their regulatory roles in biology

(2015) Daniela Rhodes et al.   NUCLEIC ACIDS RESEARCH

The tale of RNA G-quadruplex

(2015) Prachi Agarwala et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

The interactions between a small molecule and G-quadruplexes are visualized by fluorescence lifetime imaging microscopy

(2015) Arun Shivalingam et al.   Nature Communications

In-Cell NMR and EPR Spectroscopy of Biomacromolecules

(2014) Robert Hänsel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Morphological Effects of G-Quadruplex Stabilization Using a Small Molecule in Zebrafish

(2014) Tani Agarwal et al.   BIOCHEMISTRY

i-Motif DNA: Structure, stability and targeting with ligands

(2014) Henry A. Day et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Small-molecule quadruplex-targeted drug discovery

(2014) Stephan A. Ohnmacht et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis, Photophysical Properties and Incorporation of a Highly Emissive and Environment-Sensitive Uridine Analogue Based on the Lucifer Chromophore

(2014) Arun A. Tanpure et al.   CHEMBIOCHEM

Harnessing G-tetrad scaffolds within G-quadruplex forming aptamers for fluorescence detection strategies

(2014) Michael Sproviero et al.   CHEMICAL COMMUNICATIONS

G-Quadruplex Structures and Their Interaction Diversity with Ligands

(2014) Sulin Zhang et al.   ChemMedChem

N-methylmesoporphyrin IX fluorescence as a reporter of strand orientation in guanine quadruplexes

(2014) Navin C. Sabharwal et al.   FEBS Journal

A Twice-As-Smart Synthetic G-Quartet: PyroTASQ Is Both a Smart Quadruplex Ligand and a Smart Fluorescent Probe

(2014) Aurélien Laguerre et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Transcriptional Complex Between the BCL2 i-Motif and hnRNP LL Is a Molecular Switch for Control of Gene Expression That Can Be Modulated by Small Molecules

(2014) Hyun-Jin Kang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Topology of a DNA G-Quadruplex Structure Formed in the HIV-1 Promoter: A Potential Target for Anti-HIV Drug Development

(2014) Samir Amrane et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Major G-Quadruplex Formed in the Human BCL-2 Proximal Promoter Adopts a Parallel Structure with a 13-nt Loop in K+ Solution

(2014) Prashansa Agrawal et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A base-modified PNA–graphene oxide platform as a turn-on fluorescence sensor for the detection of human telomeric repeats

(2014) Pramod M. Sabale et al.   Nanoscale

Selective recognition of parallel and anti-parallel thrombin-binding aptamer G-quadruplexes by different fluorescent dyes

(2014) Dan Zhao et al.   NUCLEIC ACIDS RESEARCH

Molecular population dynamics of DNA structures in a bcl-2 promoter sequence is regulated by small molecules and the transcription factor hnRNP LL

(2014) Yunxi Cui et al.   NUCLEIC ACIDS RESEARCH

Fundamental aspects of the nucleic acid i-motif structures

(2014) S. Benabou et al.   RSC Advances

Fluorescent-Ligand-Mediated Screening of G-Quadruplex Structures Using a DNA Microarray

(2013) Keisuke Iida et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Fluorescence Enhancement upon G-Quadruplex Folding: Synthesis, Structure, and Biophysical Characterization of a Dansyl/Cyclodextrin-Tagged Thrombin Binding Aptamer

(2013) Stefano De Tito et al.   BIOCONJUGATE CHEMISTRY

Fluorescent Probes for G-Quadruplex Structures

(2013) Balayeshwanth R. Vummidi et al.   CHEMBIOCHEM

Fluorescent Nucleoside Analogs: Probes for Investigating Nucleic Acid Structure and Function

(2013) Arun A. Tanpure et al.   ISRAEL JOURNAL OF CHEMISTRY

Fluorescent probe for visualizing guanine-quadruplex DNA by fluorescence lifetime imaging microscopy

(2013) Ting-Yuan Tseng et al.   JOURNAL OF BIOMEDICAL OPTICS

A Dynamic G-Quadruplex Region Regulates the HIV-1 Long Terminal Repeat Promoter

(2013) Rosalba Perrone et al.   JOURNAL OF MEDICINAL CHEMISTRY

Environment-Responsive Fluorescent Nucleoside Analogue Probe for Studying Oligonucleotide Dynamics in a Model Cell-like Compartment

(2013) Maroti G. Pawar et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Targeting Human Telomeric Higher-Order DNA: Dimeric G-Quadruplex Units Serve as Preferred Binding Site

(2013) Chuanqi Zhao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Visualization and selective chemical targeting of RNA G-quadruplex structures in the cytoplasm of human cells

(2013) Giulia Biffi et al.   Nature Chemistry

Quantitative visualization of DNA G-quadruplex structures in human cells

(2013) Giulia Biffi et al.   Nature Chemistry

Detection of G-quadruplex DNA in mammalian cells

(2013) A. Henderson et al.   NUCLEIC ACIDS RESEARCH

Polyethylene glycol binding alters human telomere G-quadruplex structure by conformational selection

(2013) Robert Buscaglia et al.   NUCLEIC ACIDS RESEARCH

In-cell optical imaging of exogenous G-quadruplex DNA by fluorogenic ligands

(2013) Ting-Yuan Tseng et al.   NUCLEIC ACIDS RESEARCH

Reversible Conformational Switching of i-Motif DNA Studied by Fluorescence Spectroscopy

(2013) Jungkweon Choi et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Electronic tuning of fluorescent 8-aryl-guanine probes for monitoring DNA duplex–quadruplex exchange

(2013) Michael Sproviero et al.   Chemical Science

When secondary comes first – The importance of non-canonical DNA structures

(2012) Natalie Saini et al.   BIOCHIMIE

Fluorescence imaging of potassium ions in living cells using a fluorescent probe based on a thrombin binding aptamer–peptide conjugate

(2012) Keiichi Ohtsuka et al.   CHEMICAL COMMUNICATIONS

C8-Heteroaryl-2′-deoxyguanosine Adducts as Conformational Fluorescent Probes in the NarI Recognition Sequence

(2012) Katherine M. Rankin et al.   JOURNAL OF ORGANIC CHEMISTRY

Human Telomere Sequence DNA in Water-Free and High-Viscosity Solvents: G-Quadruplex Folding Governed by Kramers Rate Theory

(2012) Ford M. Lannan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Major G-Quadruplex Formed in the Human Platelet-Derived Growth Factor Receptor β Promoter Adopts a Novel Broken-Strand Structure in K+ Solution

(2012) Yuwei Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Thioflavin T as an Efficient Inducer and Selective Fluorescent Sensor for the Human Telomeric G-Quadruplex DNA

(2012) Jyotirmayee Mohanty et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Circular dichroism and guanine quadruplexes

(2012) Michaela Vorlíčková et al.   METHODS

Structure, function and targeting of human telomere RNA

(2012) Yan Xu et al.   METHODS

NMR spectroscopy of G-quadruplexes

(2012) Michael Adrian et al.   METHODS

Small-molecule–induced DNA damage identifies alternative DNA structures in human genes

(2012) Raphaël Rodriguez et al.   Nature Chemical Biology

Contribution of the first K-homology domain of poly(C)-binding protein 1 to its affinity and specificity for C-rich oligonucleotides

(2012) Y. M. K. Yoga et al.   NUCLEIC ACIDS RESEARCH

Quadruplex formation as a molecular switch to turn on intrinsically fluorescent nucleotide analogs

(2012) John Johnson et al.   NUCLEIC ACIDS RESEARCH

5'-UTR RNA G-quadruplexes: translation regulation and targeting

(2012) A. Bugaut et al.   NUCLEIC ACIDS RESEARCH

8-Vinylguanine Nucleo Amino Acid: A Fluorescent PNA Building Block

(2012) Stefan Müllar et al.   ORGANIC LETTERS

Insights into the biomedical effects of carboxylated single-wall carbon nanotubes on telomerase and telomeres

(2012) Yong Chen et al.   Nature Communications

8-Vinyl-2′-deoxyguanosine as a Fluorescent 2′-Deoxyguanosine Mimic for Investigating DNA Hybridization and Topology

(2011) André Nadler et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Heterogeneous Nuclear Ribonucleoprotein K and Nucleolin as Transcriptional Activators of the Vascular Endothelial Growth Factor Promoter through Interaction with Secondary DNA Structures

(2011) Diana J. Uribe et al.   BIOCHEMISTRY

Fluorescence Properties of 8-(2-Pyridyl)guanine “2PyG” as Compared to 2-Aminopurine in DNA

(2011) Anaëlle Dumas et al.   CHEMBIOCHEM

Conformational changes of non-B DNA

(2011) Jungkweon Choi et al.   CHEMICAL SOCIETY REVIEWS

The application of DNA and RNA G-quadruplexes to therapeutic medicines

(2011) Gavin W. Collie et al.   CHEMICAL SOCIETY REVIEWS

A Microenvironment-Sensitive Fluorescent Pyrimidine Ribonucleoside Analogue: Synthesis, Enzymatic Incorporation, and Fluorescence Detection of a DNA Abasic Site

(2011) Arun A. Tanpure et al.   CHEMISTRY-A EUROPEAN JOURNAL

Structure of Human Telomeric DNA in Crowded Solution

(2011) Brahim Heddi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?

(2011) Shankar Balasubramanian et al.   NATURE REVIEWS DRUG DISCOVERY

Highly fluorescent guanosine mimics for folding and energy transfer studies

(2011) Anaëlle Dumas et al.   NUCLEIC ACIDS RESEARCH

c-MYC promoter G-quadruplex formed at the 5′-end of NHE III 1 element: insights into biological relevance and parallel-stranded G-quadruplex stability

(2011) Raveendra I. Mathad et al.   NUCLEIC ACIDS RESEARCH

Synthesis, Photophysical Characterization, and Enzymatic Incorporation of a Microenvironment-Sensitive Fluorescent Uridine Analog

(2011) Maroti G. Pawar et al.   ORGANIC LETTERS

Interaction of Metal Complexes with G-Quadruplex DNA

(2010) Savvas N. Georgiades et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Fluorescent Analogs of Biomolecular Building Blocks: Design, Properties, and Applications

(2010) Renatus W. Sinkeldam et al.   CHEMICAL REVIEWS

Emissive Nucleosides as Molecular Rotors

(2010) Renatus W. Sinkeldam et al.   CHEMPHYSCHEM

Making sense of G-quadruplex and i-motif functions in oncogene promoters

(2010) Tracy A. Brooks et al.   FEBS Journal

Structure, location and interactions of G-quadruplexes

(2010) Julian L. Huppert   FEBS Journal

Cation-Mediated Energy Transfer in G-Quadruplexes Revealed by an Internal Fluorescent Probe

(2010) Anaëlle Dumas et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Hydration Is a Major Determinant of the G-Quadruplex Stability and Conformation of the Human Telomere 3′ Sequence of d(AG3(TTAG3)3)

(2010) M. Clarke Miller et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Small-molecule-mediated G-quadruplex isolation from human cells

(2010) Sebastian Müller et al.   Nature Chemistry

How long is too long? Effects of loop size on G-quadruplex stability

(2010) Aurore Guédin et al.   NUCLEIC ACIDS RESEARCH

Telomeric repeat-containing RNA structure in living cells

(2010) Y. Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of a K+-Induced Conformational Switch in a Human Telomeric DNA Oligonucleotide Using 2-Aminopurine Fluorescence

(2009) Robert D. Gray et al.   BIOCHEMISTRY

Anticancer Activity of CX-3543: A Direct Inhibitor of rRNA Biogenesis

(2009) D. Drygin et al.   CANCER RESEARCH

Applications of Isothermal Titration Calorimetry in Biophysical Studies of G-quadruplexes

(2009) Bruno Pagano et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Differential Biophysical Behavior of Human Telomeric RNA and DNA Quadruplex

(2009) Amit Arora et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Reduced or Diminished Stabilization of the Telomere G-Quadruplex and Inhibition of Telomerase by Small Chemical Ligands under Molecular Crowding Condition

(2009) Zhao Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure of Propeller-Type Parallel-Stranded RNA G-Quadruplexes, Formed by Human Telomeric RNA Sequences in K+Solution

(2009) Herry Martadinata et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Circular dichroism and conformational polymorphism of DNA

(2009) J. Kypr et al.   NUCLEIC ACIDS RESEARCH

G-quadruplex structures: in vivo evidence and function

(2009) Hans J. Lipps et al.   TRENDS IN CELL BIOLOGY

RNA in motion

(2008) Kathleen B Hall   CURRENT OPINION IN CHEMICAL BIOLOGY

RNA dynamics: it is about time

(2008) Hashim M Al-Hashimi et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

G-Quadruplex Formation by Human Telomeric Repeats-Containing RNA in Na+Solution

(2008) Yan Xu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Telomerase recruitment by the telomere end binding protein-β facilitates G-quadruplex DNA unfolding in ciliates

(2008) Katrin Paeschke et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Intramolecularly folded G-quadruplex and i-motif structures in the proximal promoter of the vascular endothelial growth factor gene

(2008) K. Guo et al.   NUCLEIC ACIDS RESEARCH

A novel G-quadruplex-forming GGA repeat region in the c-myb promoter is a critical regulator of promoter activity

(2008) SunMi L. Palumbo et al.   NUCLEIC ACIDS RESEARCH