Role of Human Leukocyte Antigen System as A Predictive Biomarker for Checkpoint-Based Immunotherapy in Cancer Patients

The future of cancer immunotherapy: microenvironment-targeting combinations

(2020) Yonina R. Murciano-Goroff et al.   CELL RESEARCH

HDAC inhibitors overcome immunotherapy resistance in B-cell lymphoma

(2020) Xiaoguang Wang et al.   Protein & Cell

Antigen Cross-Presentation by Macrophages

(2020) Elke M. Muntjewerff et al.   Frontiers in Immunology

Molecular and Genetic Characterization of MHC Deficiency Identifies EZH2 as Therapeutic Target for Enhancing Immune Recognition

(2019) Daisuke Ennishi et al.   Cancer Discovery

Immunoepigenetics Combination Therapies: An Overview of the Role of HDACs in Cancer Immunotherapy

(2019) Debarati Banik et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Current Landscape of Immune Checkpoint Inhibition for Solid Malignancies

(2019) Emily Z. Keung et al.   Surgical Oncology Clinics of North America

Systemic Interferon-γ Increases MHC Class I Expression and T-cell Infiltration in Cold Tumors: Results of a Phase 0 Clinical Trial

(2019) Shihong Zhang et al.   Cancer Immunology Research

Histone-deacetylase inhibition sensitizes PD1 blockade-resistant B-cell lymphomas

(2019) Xiaoguang Wang et al.   Cancer Immunology Research

A role for both HLA-F and HLA-G in reproduction and during pregnancy?

(2019) Gry Persson et al.   HUMAN IMMUNOLOGY

Cancer immune escape: MHC expression in primary tumours versus metastases

(2019) Federico Garrido et al.   IMMUNOLOGY

MHC class I dysfunction of glioma stem cells escapes from CTL-mediated immune response via activation of Wnt/β-catenin signaling pathway

(2019) Wei Yang et al.   ONCOGENE

Establishment and characterization of a mouse tumor cell line with irreversible downregulation of MHC class I molecules

(2019) Karolina Lhotakova et al.   ONCOLOGY REPORTS

Humanized Mice as an Effective Evaluation System for Peptide Vaccines and Immune Checkpoint Inhibitors

(2019) Yoshie Kametani et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Epigenetic modifiers as new immunomodulatory therapies in solid tumours

(2018) S Aspeslagh et al.   ANNALS OF ONCOLOGY

Mechanisms of resistance to immune checkpoint inhibitors

(2018) Russell W Jenkins et al.   BRITISH JOURNAL OF CANCER

Defective HLA class I antigen processing machinery in cancer

(2018) Lei Cai et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Major Histocompatibility Complex Class II and Programmed Death Ligand 1 Expression Predict Outcome After Programmed Death 1 Blockade in Classic Hodgkin Lymphoma

(2018) Margaretha G.M. Roemer et al.   JOURNAL OF CLINICAL ONCOLOGY

MHC proteins confer differential sensitivity to CTLA-4 and PD-1 blockade in untreated metastatic melanoma

(2018) Scott J. Rodig et al.   Science Translational Medicine

DNA methyltransferase inhibition upregulates MHC-I to potentiate cytotoxic T lymphocyte responses in breast cancer

(2018) Na Luo et al.   Nature Communications

Current Concepts of Antigen Cross-Presentation

(2018) Maria Embgenbroich et al.   Frontiers in Immunology

Interferon-Gamma at the Crossroads of Tumor Immune Surveillance or Evasion

(2018) Flávia Castro et al.   Frontiers in Immunology

Inhibition of MEK with trametinib enhances the efficacy of anti-PD-L1 inhibitor by regulating anti-tumor immunity in head and neck squamous cell carcinoma

(2018) Seong-Ho Kang et al.   OncoImmunology

Biological Consequences of Major Histocompatibility Class-II Expression by Tumor Cells in Cancer

(2018) Margaret L Axelrod et al.   CLINICAL CANCER RESEARCH

CD8+ cytotoxic T lymphocytes in cancer immunotherapy: A review

(2018) Bagher Farhood et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Sequences of 95 humanMHChaplotypes reveal extreme coding variation in genes other than highly polymorphicHLA class IandII

(2017) Paul J. Norman et al.   GENOME RESEARCH

The regulatory network behind MHC class I expression

(2017) Marlieke L.M. Jongsma et al.   MOLECULAR IMMUNOLOGY

Expression of the MHC class II in triple-negative breast cancer is associated with tumor-infiltrating lymphocytes and interferon signaling

(2017) In Ah Park et al.   PLoS One

Patient HLA class I genotype influences cancer response to checkpoint blockade immunotherapy

(2017) Diego Chowell et al.   SCIENCE

Acquired IFNγ resistance impairs anti-tumor immunity and gives rise to T-cell-resistant melanoma lesions

(2017) Antje Sucker et al.   Nature Communications

Impaired HLA Class I Antigen Processing and Presentation as a Mechanism of Acquired Resistance to Immune Checkpoint Inhibitors in Lung Cancer

(2017) Scott Gettinger et al.   Cancer Discovery

Immunomodulatory and antitumor effects of type I interferons and their application in cancer therapy

(2017) Ruan F.V. Medrano et al.   Oncotarget

Identification of a novel PD-L1 positive solid tumor transplantable in HLA-A*0201/DRB1*0101 transgenic mice

(2017) Laurie Rangan et al.   Oncotarget

Upregulation of HLA Class I Expression on Tumor Cells by the Anti-EGFR Antibody Nimotuzumab

(2017) Greta Garrido et al.   Frontiers in Pharmacology

Major Histocompatibility Complex (MHC) Class I and MHC Class II Proteins: Conformational Plasticity in Antigen Presentation

(2017) Marek Wieczorek et al.   Frontiers in Immunology

HLA class II antigen-processing pathway in tumors: Molecular defects and clinical relevance

(2017) Barbara Seliger et al.   OncoImmunology

Epigenetic priming restores the HLA class-I antigen processing machinery expression in Merkel cell carcinoma

(2017) Cathrin Ritter et al.   Scientific Reports

Biomarkers associated with checkpoint inhibitors

(2016) G. Manson et al.   ANNALS OF ONCOLOGY

Antitumor Effect of Programmed Death-1 (PD-1) Blockade in Humanized the NOG-MHC Double Knockout Mouse

(2016) Tadashi Ashizawa et al.   CLINICAL CANCER RESEARCH

The urgent need to recover MHC class I in cancers for effective immunotherapy

(2016) Federico Garrido et al.   CURRENT OPINION IN IMMUNOLOGY

Turning tumour cells into antigen presenting cells: The next step to improve cancer immunotherapy?

(2016) Marie de Charette et al.   EUROPEAN JOURNAL OF CANCER

Resistance Mechanisms to Immune-Checkpoint Blockade in Cancer: Tumor-Intrinsic and -Extrinsic Factors

(2016) Jonathan M. Pitt et al.   IMMUNITY

Antitumor Activity of BRAF Inhibitor and IFNα Combination in BRAF-Mutant Melanoma

(2016) Francesco Sabbatino et al.   JNCI-Journal of the National Cancer Institute

Predictive biomarkers for checkpoint inhibitor-based immunotherapy

(2016) Geoffrey T Gibney et al.   LANCET ONCOLOGY

Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma

(2016) Jesse M. Zaretsky et al.   NEW ENGLAND JOURNAL OF MEDICINE

Immunological and clinical significance of HLA class I antigen processing machinery component defects in malignant cells

(2016) Fernando Concha-Benavente et al.   ORAL ONCOLOGY

NLRC5/MHC class I transactivator is a target for immune evasion in cancer

(2016) Sayuri Yoshihama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Present Yourself! By MHC Class I and MHC Class II Molecules

(2016) Kenneth L. Rock et al.   TRENDS IN IMMUNOLOGY

NLRC5 shields T lymphocytes from NK-cell-mediated elimination under inflammatory conditions

(2016) Kristina Ludigs et al.   Nature Communications

Melanoma-specific MHC-II expression represents a tumour-autonomous phenotype and predicts response to anti-PD-1/PD-L1 therapy

(2016) Douglas B. Johnson et al.   Nature Communications

Antitumor Activity of BRAF Inhibitor and IFNα Combination in BRAF-Mutant Melanoma

(2016) Francesco Sabbatino et al.   JNCI-Journal of the National Cancer Institute

Expression of the MHC Class II Pathway in Triple-Negative Breast Cancer Tumor Cells Is Associated with a Good Prognosis and Infiltrating Lymphocytes

(2016) A. Forero et al.   Cancer Immunology Research

Kinase Regulation of Human MHC Class I Molecule Expression on Cancer Cells

(2016) E. J. Brea et al.   Cancer Immunology Research

Broadening Specificity and Enhancing Cytotoxicity of Adoptive T Cells for Nasopharyngeal Carcinoma Immunotherapy

(2016) D. A. Fae et al.   Cancer Immunology Research

Characteristics of HLA-E Restricted T-Cell Responses and Their Role in Infectious Diseases

(2016) Simone A. Joosten et al.   Journal of Immunology Research

Immune-Modulation by Epidermal Growth Factor Receptor Inhibitors: Implication on Anti-Tumor Immunity in Lung Cancer

(2016) Jin S. Im et al.   PLoS One

Predictive biomarkers in PD-1/PD-L1 checkpoint blockade immunotherapy

(2015) Xiangjiao Meng et al.   CANCER TREATMENT REVIEWS

RAS/MAPK Activation Is Associated with Reduced Tumor-Infiltrating Lymphocytes in Triple-Negative Breast Cancer: Therapeutic Cooperation Between MEK and PD-1/PD-L1 Immune Checkpoint Inhibitors

(2015) S. Loi et al.   CLINICAL CANCER RESEARCH

Epigenetic regulation of differentialHLA-Aallelic expression levels

(2015) Veron Ramsuran et al.   HUMAN MOLECULAR GENETICS

Multiple Structural and Epigenetic Defects in the Human Leukocyte Antigen Class I Antigen Presentation Pathway in a Recurrent Metastatic Melanoma Following Immunotherapy

(2015) Chien-Chung Chang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting histone deacetylase 6 mediates a dual anti-melanoma effect: Enhanced antitumor immunity and impaired cell proliferation

(2015) K.V. Woan et al.   Molecular Oncology

Releasing the Brakes on Cancer Immunotherapy

(2015) Antoni Ribas   NEW ENGLAND JOURNAL OF MEDICINE

Improved antitumor activity of immunotherapy with BRAF and MEK inhibitors in BRAF V600E melanoma

(2015) Siwen Hu-Lieskovan et al.   Science Translational Medicine

Neoepitopes of Cancers: Looking Back, Looking Ahead

(2015) P. K. Srivastava   Cancer Immunology Research

Alternative Antigen Processing for MHC Class I: Multiple Roads Lead to Rome

(2015) Cláudia C. Oliveira et al.   Frontiers in Immunology

Epigenetic regulations in the IFNγ signalling pathway: IFNγ-mediated MHC class I upregulation on tumour cells is associated with DNA demethylation of antigen-presenting machinery genes

(2015) Veronika Vlková et al.   Oncotarget

Adenovirus expressing β2-microglobulin recovers HLA class I expression and antitumor immunity by increasing T-cell recognition

(2014) A B del Campo et al.   CANCER GENE THERAPY

Cisplatin-Induced Antitumor Immunomodulation: A Review of Preclinical and Clinical Evidence

(2014) A. R. de Biasi et al.   CLINICAL CANCER RESEARCH

Generation of MHC class I diversity in primary tumors and selection of the malignant phenotype

(2014) Federico Garrido et al.   INTERNATIONAL JOURNAL OF CANCER

Major Histocompatibility Complex Genomics and Human Disease

(2013) John Trowsdale et al.   Annual Review of Genomics and Human Genetics

Pathways of Antigen Processing

(2013) Janice S. Blum et al.   Annual Review of Immunology

miR-9 modulates the expression of interferon-regulated genes and MHC class I molecules in human nasopharyngeal carcinoma cells

(2013) Fei Gao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Immunogenicity of Murine Solid Tumor Models as a Defining Feature of In Vivo Behavior and Response to Immunotherapy

(2013) Melissa G. Lechner et al.   JOURNAL OF IMMUNOTHERAPY

MHC Class I Antigen Processing and Presenting Machinery: Organization, Function, and Defects in Tumor Cells

(2013) P. Leone et al.   JNCI-Journal of the National Cancer Institute

Vemurafenib enhances MHC induction inBRAFV600Ehomozygous melanoma cells

(2013) Bishu Sapkota et al.   OncoImmunology

Implication of the β2-microglobulin gene in the generation of tumor escape phenotypes

(2012) Monica Bernal et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

NK cell MHC class I specific receptors (KIR): from biology to clinical intervention

(2012) Ariane Thielens et al.   CURRENT OPINION IN IMMUNOLOGY

Regulation of Class I Major Histocompatibility Complex (MHC) by Nucleotide-binding Domain, Leucine-rich Repeat-containing (NLR) Proteins

(2012) Gregory R. Robbins et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Peptide-Receptive Transition State of MHC Class I Molecules: Insight from Structure and Molecular Dynamics

(2012) M. G. Mage et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Impaired MHC Class I Expression in Mice Deficient for Nlrc5/Class I Transactivator

(2012) A. Biswas et al.   JOURNAL OF IMMUNOLOGY

NLRC5 Cooperates with the RFX Transcription Factor Complex To Induce MHC Class I Gene Expression

(2012) T. B. Meissner et al.   JOURNAL OF IMMUNOLOGY

Chemotherapeutics and Radiation Stimulate MHC Class I Expression through Elevated Interferon-beta Signaling in Breast Cancer Cells

(2012) Shan Wan et al.   PLoS One

Into the Intracellular Logistics of Cross-Presentation

(2012) Jacques Neefjes et al.   Frontiers in Immunology

Epothilone B enhances Class I HLA and HLA-A2 surface molecule expression in ovarian cancer cells

(2011) Ilenia Pellicciotta et al.   GYNECOLOGIC ONCOLOGY

Methylation of the promoter of human leukocyte antigen class I in human esophageal squamous cell carcinoma and its histopathological characteristics

(2011) Sun Qifeng et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

NLRC5: a newly discovered MHC class I transactivator (CITA)

(2011) Torsten B. Meissner et al.   MICROBES AND INFECTION

Conformation of peptides bound to the transporter associated with antigen processing (TAP)

(2011) M. Herget et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression Regulation of Major Histocompatibility Complex Class I and Class II Encoding Genes

(2011) Peter J. van den Elsen   Frontiers in Immunology

Ontogenesis of rat immune system: Proteasome expression in different cell populations of the developing thymus

(2010) Victoria I. Melnikova et al.   CELLULAR IMMUNOLOGY

Frequent loss of heterozygosity in the β2-microglobulin region of chromosome 15 in primary human tumors

(2010) Isabel Maleno et al.   IMMUNOGENETICS

“Hard” and “soft” lesions underlying the HLA class I alterations in cancer cells: Implications for immunotherapy

(2010) Federico Garrido et al.   INTERNATIONAL JOURNAL OF CANCER

ABC proteins in antigen translocation and viral inhibition

(2010) David Parcej et al.   Nature Chemical Biology

Downregulation of HLA Class I Molecules in Primary Oral Squamous Cell Carcinomas and Cell Lines

(2009) Qiusha Tang et al.   ARCHIVES OF MEDICAL RESEARCH

The peptide-loading complex – antigen translocation and MHC class I loading

(2009) Christian Schölz et al.   BIOLOGICAL CHEMISTRY

Relationship between HLA class I antigen processing machinery component expression and the clinicopathologic characteristics of bladder carcinomas

(2009) Helen P. Cathro et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Down-regulation of proteasomal subunit MB1 is an independent predictor of improved survival in ovarian cancer

(2009) Ninke Leffers et al.   GYNECOLOGIC ONCOLOGY

Molecular Mechanisms of IFN-γ to Up-Regulate MHC Class I Antigen Processing and Presentation

(2009) Fang Zhou   INTERNATIONAL REVIEWS OF IMMUNOLOGY

MUTYH-associated polyposis carcinomas frequently lose HLA class I expression-a common event amongst DNA-repair-deficient colorectal cancers

(2009) Noel FCC de Miranda et al.   JOURNAL OF PATHOLOGY

In situ analysis of the antigen-processing machinery in acute myeloid leukaemic blasts by tissue microarray

(2009) S Hoves et al.   LEUKEMIA

Efficient Recovery of HLA Class I Expression in Human Tumor Cells After Beta2-Microglobulin Gene Transfer Using Adenoviral Vector: Implications for Cancer Immunotherapy

(2009) A. B. del Campo et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Increased HLA-DMB Expression in the Tumor Epithelium Is Associated with Increased CTL Infiltration and Improved Prognosis in Advanced-Stage Serous Ovarian Cancer

(2008) M. J. Callahan et al.   CLINICAL CANCER RESEARCH

The quality control of MHC class I peptide loading

(2008) Pamela A Wearsch et al.   CURRENT OPINION IN CELL BIOLOGY

HLA-G–dependent suppressor cells: Diverse by nature, function, and significance

(2008) Edgardo D. Carosella et al.   HUMAN IMMUNOLOGY

Control of peripheral T-cell tolerance and autoimmunity via the CTLA-4 and PD-1 pathways

(2008) Brian T. Fife et al.   IMMUNOLOGICAL REVIEWS

HLA antigen changes in malignant cells: epigenetic mechanisms and biologic significance

(2008) M Campoli et al.   ONCOGENE

MHC class I assembly: out and about

(2008) Malini Raghavan et al.   TRENDS IN IMMUNOLOGY