Ginsenoside Rg3 attenuates angiotensin II-induced myocardial hypertrophy through repressing NLRP3 inflammasome and oxidative stress via modulating SIRT1/NF-κB pathway

MiR-200a-3p Aggravates DOX-Induced Cardiotoxicity by Targeting PEG3 Through SIRT1/NF-κB Signal Pathway

(2021) Qinghua Fu et al.   Cardiovascular Toxicology

Dual Role of Triptolide in Interrupting the NLRP3 Inflammasome Pathway to Attenuate Cardiac Fibrosis

(2019) Xi-Chun Pan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

ERK: A Key Player in the Pathophysiology of Cardiac Hypertrophy

(2019) Simona Gallo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Melatonin differentially regulates pathological and physiological cardiac hypertrophy: Crucial role of circadian nuclear receptor RORα signaling

(2019) Longwei Xu et al.   JOURNAL OF PINEAL RESEARCH

Ginsenoside Rg3 suppresses the NLRP3 inflammasome activation through inhibition of its assembly

(2019) Yuhua Shi et al.   FASEB JOURNAL

Ginsenoside Rg3-loaded, reactive oxygen species-responsive polymeric nanoparticles for alleviating myocardial ischemia-reperfusion injury

(2019) Lan Li et al.   JOURNAL OF CONTROLLED RELEASE

Ginsenoside-Rb2 and 20(S)-Ginsenoside-Rg3 from Korean Red Ginseng Prevent Rotavirus Infection in Newborn Mice

(2018) Hui Yang et al.   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

Gallic acid improves cardiac dysfunction and fibrosis in pressure overload-induced heart failure

(2018) Li Jin et al.   Scientific Reports

Effects of Ginsenoside Rg3 on fatigue resistance and SIRT1 in aged rats

(2018) Qi-Yu Yang et al.   TOXICOLOGY

A new role for the ginsenoside RG3 in antiaging via mitochondria function in ultraviolet-irradiated human dermal fibroblasts

(2018) Hyunji Lee et al.   Journal of Ginseng Research

Ginsenoside Rd contributes the attenuation of cardiac hypertrophy in vivo and in vitro

(2018) Ningning Zhang et al.   BIOMEDICINE & PHARMACOTHERAPY

Salvianolate reduces atrial fibrillation through suppressing atrial interstitial fibrosis by inhibiting TGF-β1/Smad2/3 and TXNIP/NLRP3 inflammasome signaling pathways in post-MI rats

(2018) Huiliang Qiu et al.   PHYTOMEDICINE

Anticancer effects of ginsenoside Rg3 (Review)

(2017) Mengyao Sun et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Suppressive Effect of Ginsenoside Rg3 against Lipopolysaccharide-Induced Depression-Like Behavior and Neuroinflammation in Mice

(2017) An Kang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

A Review of the Molecular Mechanisms Underlying the Development and Progression of Cardiac Remodeling

(2017) Leonardo Schirone et al.   Oxidative Medicine and Cellular Longevity

Ginsenoside Rg3 inhibits the senescence of prostate stromal cells through down-regulation of interleukin 8 expression

(2017) Yanfei Peng et al.   Oncotarget

Roles of ginsenosides in inflammasome activation

(2017) Young-Su Yi   Journal of Ginseng Research

Ginsenoside Rg3 Improves Cardiac Function after Myocardial Ischemia/Reperfusion via Attenuating Apoptosis and Inflammation

(2016) Li-ping Zhang et al.   Evidence-based Complementary and Alternative Medicine

Netrin-1 prevents the development of cardiac hypertrophy and heart failure

(2016) NAN WANG et al.   Molecular Medicine Reports

Pathophysiology of cardiac hypertrophy and heart failure: signaling pathways and novel therapeutic targets

(2015) Yow Keat Tham et al.   ARCHIVES OF TOXICOLOGY

Ginsenoside Rg3 regulates S-nitrosylation of the NLRP3 inflammasome via suppression of iNOS

(2015) Sung-Jin Yoon et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

SIRT1 reduction causes renal and retinal injury in diabetes through endothelin 1 and transforming growth factor β1

(2015) Rokhsana Mortuza et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Ginsenoside Rg3 antagonizes adriamycin-induced cardiotoxicity by improving endothelial dysfunction from oxidative stress via upregulating the Nrf2-ARE pathway through the activation of akt

(2015) Xiaoying Wang et al.   PHYTOMEDICINE

Puerarin inhibits angiotensin II-induced cardiac hypertrophy via the redox-sensitive ERK1/2, p38 and NF-κB pathways

(2014) Gang Chen et al.   ACTA PHARMACOLOGICA SINICA

Regulation of Akt Signaling by Sirtuins

(2014) Vinodkumar B. Pillai et al.   CIRCULATION RESEARCH

Antagonistic crosstalk between NF-κB and SIRT1 in the regulation of inflammation and metabolic disorders

(2013) Anu Kauppinen et al.   CELLULAR SIGNALLING

Tetramethylpyrazine inhibits angiotensin II-induced cardiomyocyte hypertrophy and tumor necrosis factor-α secretion through an NF-κB-dependent mechanism

(2013) LIANGZHU YU et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

The Ginsenoside Rg1 Prevents Transverse Aortic Constriction–Induced Left Ventricular Hypertrophy and Cardiac Dysfunction by Inhibiting Fibrosis and Enhancing Angiogenesis

(2013) Yao-Jun Zhang et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Interrelationship Between Cardiac Hypertrophy, Heart Failure, and Chronic Kidney Disease

(2011) Jeffrey G. Dickhout et al.   CIRCULATION RESEARCH

Sirt1 acts in association with PPAR  to protect the heart from hypertrophy, metabolic dysregulation, and inflammation

(2010) A. Planavila et al.   CARDIOVASCULAR RESEARCH