Targeting JAK/STAT signaling pathways in treatment of inflammatory bowel disease

Efficacy of Upadacitinib in a Randomized Trial of Patients With Active Ulcerative Colitis

(2020) William J. Sandborn et al.   GASTROENTEROLOGY

Efficacy and Safety of Upadacitinib in a Randomized Trial of Patients With Crohn’s Disease

(2020) William J. Sandborn et al.   GASTROENTEROLOGY

Interleukin-22 orchestrates a pathological endoplasmic reticulum stress response transcriptional programme in colonic epithelial cells

(2020) Nick Powell et al.   GUT

ECM1 is an essential factor for the determination of M1 macrophage polarization in IBD in response to LPS stimulation

(2020) Yaguang Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CCL2 and CXCL12 Derived from Mesenchymal Stromal Cells Cooperatively Polarize IL-10+ Tissue Macrophages to Mitigate Gut Injury

(2020) Jayeeta Giri et al.   Cell Reports

Protective effects of iridoid glycosides on acute colitis via inhibition of the inflammatory response mediated by the STAT3/NF-кB pathway

(2020) Jiahui Yuan et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Development of Gut-Selective Pan-Janus Kinase Inhibitor TD-1473 for Ulcerative Colitis: A Translational Medicine Programme

(2020) William J Sandborn et al.   Journal of Crohns & Colitis

Potential therapeutic effects of curcumin mediated by JAK/STAT signaling pathway: A review

(2020) Milad Ashrafizadeh et al.   PHYTOTHERAPY RESEARCH

Intervention of oncostatin M-driven mucosal inflammation by berberine exerts therapeutic property in chronic ulcerative colitis

(2020) Heng Li et al.   Cell Death & Disease

Crohn’s disease

(2020) Giulia Roda et al.   Nature Reviews Disease Primers

Small molecule oral targeted therapies in ulcerative colitis

(2020) Uday N Shivaji et al.   Lancet Gastroenterology & Hepatology

Noncanonical STAT3 activity sustains pathogenic Th17 proliferation and cytokine response to antigen

(2020) Catherine H. Poholek et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Real-World Effectiveness and Safety of Tofacitinib in Crohn’s Disease and IBD-U: A Multi-Center Study from the TROPIC consortium

(2020) Marc Fenster et al.   Clinical Gastroenterology and Hepatology

Deconvolution of monocyte responses in inflammatory bowel disease reveals an IL-1 cytokine network that regulates IL-23 in genetic and acquired IL-10 resistance

(2020) Dominik Aschenbrenner et al.   GUT

Dietary Soy Protein Isolate Attenuates Intestinal Immunoglobulin and Mucin Expression in Young Mice Compared with Casein

(2020) Bin Zeng et al.   Nutrients

Resistant Maltodextrin Alleviates Dextran Sulfate Sodium-Induced Intestinal Inflammatory Injury by Increasing Butyric Acid to Inhibit Proinflammatory Cytokine Levels

(2020) Shilan Wang et al.   Biomed Research International

Ulcerative colitis

(2020) Taku Kobayashi et al.   Nature Reviews Disease Primers

Tofacitinib Treatment Safety in Moderate to Severe Ulcerative Colitis: Comparison of Observational Population Cohort Data From the IBM MarketScan® Administrative Claims Database With Tofacitinib Trial Data

(2020) Jeffrey R Curtis et al.   INFLAMMATORY BOWEL DISEASES

Events Within the First Year of Life, but not the Neonatal Period, Affect Risk for Later Development of Inflammatory Bowel Diseases

(2019) Charles N. Bernstein et al.   GASTROENTEROLOGY

Systematic review and meta-analysis: efficacy and safety of oral Janus kinase inhibitors for inflammatory bowel disease

(2019) Christopher Ma et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

YAP Aggravates Inflammatory Bowel Disease by Regulating M1/M2 Macrophage Polarization and Gut Microbial Homeostasis

(2019) Xin Zhou et al.   Cell Reports

Innovations in Oral Therapies for Inflammatory Bowel Disease

(2019) Christopher Ma et al.   DRUGS

Interferon lambda Promotes Paneth Cell Death via STAT1 Signaling in Mice and is Increased in Inflamed Ileal Tissues of Patients with Crohn’s Disease

(2019) Claudia Günther et al.   GASTROENTEROLOGY

Evaluating STAT5 Phosphorylation as a Mean to Assess T Cell Proliferation

(2019) Michael Bitar et al.   Frontiers in Immunology

Anti-Inflammatory Mechanisms of Koreanaside A, a Lignan Isolated from the Flower of Forsythia koreana, against LPS-Induced Macrophage Activation and DSS-Induced Colitis Mice: The Crucial Role of AP-1, NF-κB, and JAK/STAT Signaling

(2019) Kim et al.   Cells

Resveratrol attenuates intestinal injury in irradiated rats via PI3K/Akt/mTOR signaling pathway

(2019) Rasha R. Radwan et al.   ENVIRONMENTAL TOXICOLOGY

Limonin ameliorates ulcerative colitis by regulating STAT3/miR-214 signaling pathway

(2019) Shijia Liu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Lonicerae japonicae flos and Lonicerae flos: a systematic review of ethnopharmacology, phytochemistry and pharmacology

(2019) Yuke Li et al.   PHYTOCHEMISTRY REVIEWS

T cell–derived interferon-γ programs stem cell death in immune-mediated intestinal damage

(2019) S. Takashima et al.   Science Immunology

Janus kinase inhibitors for the treatment of inflammatory bowel diseases: developments from phase I and phase II clinical trials

(2018) Ferdinando D’Amico et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Berberine inhibits macrophage M1 polarization via AKT1/SOCS1/NF-κB signaling pathway to protect against DSS-induced colitis

(2018) Yunxin Liu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Critical role of ROCK2 activity in facilitating mucosal CD4 + T cell activation in inflammatory bowel disease

(2018) Wenjing Yang et al.   JOURNAL OF AUTOIMMUNITY

Peficitinib, an Oral Janus Kinase Inhibitor, in Moderate-to-severe Ulcerative Colitis: Results From a Randomised, Phase 2 Study

(2018) Bruce E Sands et al.   Journal of Crohns & Colitis

SOCS1 and SOCS3 Target IRF7 Degradation To Suppress TLR7-Mediated Type I IFN Production of Human Plasmacytoid Dendritic Cells

(2018) Chun-Feng Yu et al.   JOURNAL OF IMMUNOLOGY

Partial enteral nutrition increases intestinal sIgA levels in mice undergoing parenteral nutrition in a dose-dependent manner

(2018) Haifeng Sun et al.   International Journal of Surgery

JAK/STAT-1 Signaling Is Required for Reserve Intestinal Stem Cell Activation during Intestinal Regeneration Following Acute Inflammation

(2018) Camilla A. Richmond et al.   Stem Cell Reports

TGF-β Control of Adaptive Immune Tolerance: A Break From Treg Cells

(2018) Ming Liu et al.   BIOESSAYS

Interferon gamma decreases intestinal epithelial aquaporin 3 expression through downregulation of constitutive transcription

(2018) Michael A. Peplowski et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Elucidation of the Intestinal Absorption Mechanism of Loganin in the Human Intestinal Caco-2 Cell Model

(2018) Renjie Xu et al.   Evidence-based Complementary and Alternative Medicine

Microbiota-Induced TNF-like Ligand 1A Drives Group 3 Innate Lymphoid Cell-Mediated Barrier Protection and Intestinal T Cell Activation during Colitis

(2018) Jim G. Castellanos et al.   IMMUNITY

JAK/STAT signaling in regulation of innate lymphoid cells: The gods before the guardians

(2018) Helena Stabile et al.   IMMUNOLOGICAL REVIEWS

Multiple Cytokine Profiling: A New Model to Predict Response to Tumor Necrosis Factor Antagonists in Ulcerative Colitis Patients

(2018) Igor Vladimirovich Obraztsov et al.   INFLAMMATORY BOWEL DISEASES

The Pathogenesis of Extraintestinal Manifestations: Implications for IBD research, diagnosis and therapy

(2018) C R H Hedin et al.   Journal of Crohns & Colitis

Butyrate Produced by Commensal Bacteria Down-Regulates Indolamine 2,3-Dioxygenase 1 (IDO-1) Expression via a Dual Mechanism in Human Intestinal Epithelial Cells

(2018) Camille Martin-Gallausiaux et al.   Frontiers in Immunology

IL-22 Increases Permeability of Intestinal Epithelial Tight Junctions by Enhancing Claudin-2 Expression

(2017) Yaya Wang et al.   JOURNAL OF IMMUNOLOGY

m6A mRNA methylation controls T cell homeostasis by targeting the IL-7/STAT5/SOCS pathways

(2017) Hua-Bing Li et al.   NATURE

Current and emerging therapeutic targets for IBD

(2017) Markus F. Neurath   Nature Reviews Gastroenterology & Hepatology

Luteolin suppresses the JAK/STAT pathway in a cellular model of intestinal inflammation

(2017) Carla Nunes et al.   Food & Function

Protective effect of curcumin on TNBS-induced intestinal inflammation is mediated through the JAK/STAT pathway

(2016) Xingxing Zhang et al.   BMC Complementary and Alternative Medicine

HHX-5, a derivative of sesquiterpene from Chinese agarwood, suppresses innate and adaptive immunity via inhibiting STAT signaling pathways

(2016) Zhixiang Zhu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The anti-apoptotic Bcl-2 family protein A1/Bfl-1 regulates neutrophil survival and homeostasis and is controlled via PI3K and JAK/STAT signaling

(2016) J Vier et al.   Cell Death & Disease

Spectrum-Effect Relationships Between Chemical Fingerprints and Antibacterial Effects of Lonicerae Japonicae Flos and Lonicerae Flos Base on UPLC and Microcalorimetry

(2016) Zhilong Shi et al.   Frontiers in Pharmacology

Curcumin Suppressed Activation of Dendritic Cells via JAK/STAT/SOCS Signal in Mice with Experimental Colitis

(2016) Hai-Mei Zhao et al.   Frontiers in Pharmacology

Anti-inflammatory and Anti-oxidative Activities of Paeonol and Its Metabolites Through Blocking MAPK/ERK/p38 Signaling Pathway

(2015) Xin Jin et al.   INFLAMMATION

Allicin Alleviates Inflammation of Trinitrobenzenesulfonic Acid-Induced Rats and Suppresses P38 and JNK Pathways in Caco-2 Cells

(2015) Chen Li et al.   MEDIATORS OF INFLAMMATION

Allicin Alleviates Dextran Sodium Sulfate- (DSS-) Induced Ulcerative Colitis in BALB/c Mice

(2015) Ashok Kumar Pandurangan et al.   Oxidative Medicine and Cellular Longevity

Contribution of the IL-17/IL-23 axis to the pathogenesis of inflammatory bowel disease

(2015) Cristina-Sorina Cătană et al.   WORLD JOURNAL OF GASTROENTEROLOGY

A novel cyclic helix B peptide inhibits dendritic cell maturation during amelioration of acute kidney graft rejection through Jak-2/STAT3/SOCS1

(2015) C Yang et al.   Cell Death & Disease

Activated STAT5 Confers Resistance to Intestinal Injury by Increasing Intestinal Stem Cell Proliferation and Regeneration

(2015) Shila Gilbert et al.   Stem Cell Reports

Interferon-γ Suppresses Intestinal Epithelial Aquaporin-1 Expression via Janus Kinase and STAT3 Activation

(2015) Michael S. Dicay et al.   PLoS One

Update on Janus Kinase Antagonists in Inflammatory Bowel Disease

(2014) Brigid S. Boland et al.   GASTROENTEROLOGY CLINICS OF NORTH AMERICA

Innate immune regulation by STAT-mediated transcriptional mechanisms

(2014) Haiyan S. Li et al.   IMMUNOLOGICAL REVIEWS

Resveratrol Modulates Cytokine-Induced JAK/STAT Activation More Efficiently than 5-Aminosalicylic Acid: An In Vitro Approach

(2014) Diana Serra et al.   PLoS One

Control of inflammation by integration of environmental cues by regulatory T cells

(2013) Ashutosh Chaudhry et al.   JOURNAL OF CLINICAL INVESTIGATION

The signal transducers STAT5 and STAT3 control expression of Id2 and E2-2 during dendritic cell development

(2012) H. S. Li et al.   BLOOD

Enterocyte STAT5 promotes mucosal wound healing via suppression of myosin light chain kinase-mediated loss of barrier function and inflammation

(2012) Shila Gilbert et al.   EMBO Molecular Medicine

The role of neutrophils during intestinal inflammation

(2012) B M Fournier et al.   Mucosal Immunology

STAT1 and pathogens, not a friendly relationship

(2010) Imen Najjar et al.   BIOCHIMIE

Intratumoral T cell infiltration, MHC class I and STAT1 as biomarkers of good prognosis in colorectal cancer

(2010) J. A. D. Simpson et al.   GUT