The anti-apoptotic Bcl-2 family protein A1/Bfl-1 regulates neutrophil survival and homeostasis and is controlled via PI3K and JAK/STAT signaling

G-CSF and GM-CSF in Neutropenia

(2015) Hrishikesh M. Mehta et al.   JOURNAL OF IMMUNOLOGY

Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax)

(2015) J D Leverson et al.   Cell Death & Disease

IFN-γ regulates survival and function of tumor-induced CD11b+Gr-1highmyeloid derived suppressor cells by modulating the anti-apoptotic molecule Bcl2a1

(2014) José Medina-Echeverz et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Selective JAK inhibitors in development for rheumatoid arthritis

(2014) Peter Norman   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Characterisation of a novel A1-specific monoclonal antibody

(2014) M J Lang et al.   Cell Death & Disease

JAK Inhibitors: Treatment Efficacy and Safety Profile in Patients with Psoriasis

(2014) Leeyen Hsu et al.   Journal of Immunology Research

Mcl-1 Ubiquitination: Unique Regulation of an Essential Survival Protein

(2014) Barbara Mojsa et al.   Cells

Survival and differentiation defects contribute to neutropenia in glucose-6-phosphatase-β (G6PC3) deficiency in a model of mouse neutrophil granulocyte differentiation

(2013) S Gautam et al.   CELL DEATH AND DIFFERENTIATION

Resolution of inflammation: an integrated view

(2013) Almudena Ortega-Gómez et al.   EMBO Molecular Medicine

A Novel Small-Molecule Inhibitor of Mcl-1 Blocks Pancreatic Cancer Growth In Vitro and In Vivo

(2013) F. Abulwerdi et al.   MOLECULAR CANCER THERAPEUTICS

Identification of C/EBPβ Target Genes in ALK+ Anaplastic Large Cell Lymphoma (ALCL) by Gene Expression Profiling and Chromatin Immunoprecipitation

(2013) Irina Bonzheim et al.   PLoS One

Roscovitine-induced Apoptosis in Neutrophils and Neutrophil Progenitors Is Regulated by the Bcl-2-Family Members Bim, Puma, Noxa and Mcl-1

(2013) Sanjivan Gautam et al.   PLoS One

JAK inhibition in the myeloproliferative neoplasms: lessons learned from the bench and bedside

(2013) J. Gotlib   Hematology-American Society of Hematology Education Program

Targeting antiapoptotic A1/Bfl-1 by in vivo RNAi reveals multiple roles in leukocyte development in mice

(2012) E. Ottina et al.   BLOOD

A1/Bfl-1 in leukocyte development and cell death

(2012) Eleonora Ottina et al.   EXPERIMENTAL CELL RESEARCH

Francisella tularensis Alters Human Neutrophil Gene Expression: Insights into the Molecular Basis of Delayed Neutrophil Apoptosis

(2012) Justin T. Schwartz et al.   Journal of Innate Immunity

Infection of neutrophil granulocytes with Leishmania major activates ERK 1/2 and modulates multiple apoptotic pathways to inhibit apoptosis

(2012) Arup Sarkar et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

Molecular analysis of neutrophil spontaneous apoptosis reveals a strong role for the pro-apoptotic BH3-only protein Noxa

(2011) S Kirschnek et al.   CELL DEATH AND DIFFERENTIATION

In vivo functional analysis and genetic modification of in vitro-derived mouse neutrophils

(2011) Jacqueline U. McDonald et al.   FASEB JOURNAL

JAK2 V617F-Dependent Upregulation of PU.1 Expression in the Peripheral Blood of Myeloproliferative Neoplasm Patients

(2011) Tamotsu Irino et al.   PLoS One

The anti-apoptotic gene BCL2A1 is a novel transcriptional target of PU.1

(2010) M Jenal et al.   LEUKEMIA

Phagocytosis of Apoptotic Cells by Neutrophil Granulocytes: Diminished Proinflammatory Neutrophil Functions in the Presence of Apoptotic Cells

(2009) Lars Esmann et al.   JOURNAL OF IMMUNOLOGY

Apoptosis Is Essential for Neutrophil Functional Shutdown and Determines Tissue Damage in Experimental Pneumococcal Meningitis

(2009) Uwe Koedel et al.   PLoS Pathogens

Selective roles for antiapoptotic MCL-1 during granulocyte development and macrophage effector function

(2008) D. A. Steimer et al.   BLOOD

Constitutive neutrophil apoptosis: Mechanisms and regulation

(2007) Hongbo R. Luo et al.   AMERICAN JOURNAL OF HEMATOLOGY

The dual effects of TNF  on neutrophil apoptosis are mediated via differential effects on expression of Mcl-1 and Bfl-1

(2007) A. Cross et al.   BLOOD