Regulation of redox signaling in HIF‐1‐dependent tumor angiogenesis

The NFIB‐ERO1A axis promotes breast cancer metastatic colonization of disseminated tumour cells

(2021) Federica Zilli et al.   EMBO Molecular Medicine

The ER stress response mediator ERO1 triggers cancer metastasis by favoring the angiogenic switch in hypoxic conditions

(2021) Ersilia Varone et al.   ONCOGENE

Endoplasmic reticulum oxidoreductase 1 alpha modulates prostate cancer hallmarks

(2021) Julian Cornelius et al.   Translational Andrology and Urology

A closer look into NADPH oxidase inhibitors: Validation and insight into their mechanism of action

(2020) Joana Reis et al.   Redox Biology

Use of Computational Biochemistry for Elucidating Molecular Mechanisms of Nitric Oxide Synthase

(2019) Emmanuelle Bignon et al.   Computational and Structural Biotechnology Journal

Targeting the functional interplay between endoplasmic reticulum oxidoreductin-1α and protein disulfide isomerase suppresses the progression of cervical cancer

(2019) Yini Zhang et al.   EBioMedicine

Inhibition of the FAD containing ER oxidoreductin 1 (Ero1) protein by EN-460 as a strategy for treatment of multiple myeloma

(2019) Karen E. Hayes et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Ascorbic Acid Route to the Endoplasmic Reticulum: Function and Role in Disease

(2019) Diego Pozzer et al.   ANTIOXIDANTS & REDOX SIGNALING

Endoplasmic reticulum resident oxidase ERO1-Lalpha promotes hepatocellular carcinoma metastasis and angiogenesis through the S1PR1/STAT3/VEGF-A pathway

(2018) Shikun Yang et al.   Cell Death & Disease

Nitric oxide synthase inhibitors 1400W and L-NIO inhibit angiogenesis pathway of colorectal cancer

(2018) Yanfeng Gao et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Cancer-associated fibroblasts enact field cancerization by promoting extratumoral oxidative stress

(2017) Jeremy Soon Kiat Chan et al.   Cell Death & Disease

Cancer-associated oxidoreductase ERO1-α drives the production of VEGF via oxidative protein folding and regulating the mRNA level

(2016) Tsutomu Tanaka et al.   BRITISH JOURNAL OF CANCER

NRF2 Intensifies Host Defense Systems to Prevent Lung Carcinogenesis, but After Tumor Initiation Accelerates Malignant Cell Growth

(2016) H. Satoh et al.   CANCER RESEARCH

Targeted redox inhibition of protein phosphatase 1 by Nox4 regulates eIF2 -mediated stress signaling

(2016) C. X. Santos et al.   EMBO JOURNAL

Mitochondrial generation of superoxide and hydrogen peroxide as the source of mitochondrial redox signaling

(2016) Martin D. Brand   FREE RADICAL BIOLOGY AND MEDICINE

The NADPH Oxidase Nox4 mediates tumour angiogenesis

(2015) V. Helfinger et al.   Acta Physiologica

Ascorbic acid and ascorbate-2-phosphate decrease HIF activity and malignant properties of human melanoma cells

(2015) Sarah L. Miles et al.   BMC CANCER

ERO1: A protein disulfide oxidase and H2O2 producer

(2015) Ester Zito   FREE RADICAL BIOLOGY AND MEDICINE

β-adrenergic receptor antagonists inhibit vasculogenesis of embryonic stem cells by downregulation of nitric oxide generation and interference with VEGF signalling

(2014) Fatemeh Sharifpanah et al.   CELL AND TISSUE RESEARCH

Ascorbate as a Co-Factor for Fe- and 2-Oxoglutarate Dependent Dioxygenases: Physiological Activity in Tumor Growth and Progression

(2014) Caroline Kuiper et al.   Frontiers in Oncology

BAY 87-2243, a highly potent and selective inhibitor of hypoxia-induced gene activation has antitumor activities by inhibition of mitochondrial complex I

(2013) Peter Ellinghaus et al.   Cancer Medicine

PRDX4, an Endoplasmic Reticulum-Localized Peroxiredoxin at the Crossroads Between Enzymatic Oxidative Protein Folding and Nonenzymatic Protein Oxidation

(2012) Ester Zito   ANTIOXIDANTS & REDOX SIGNALING

Nitric oxide produced by cytochrome c oxidase helps stabilize HIF-1α in hypoxic mammalian cells

(2012) Kerri A. Ball et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Unfolded Protein Response Induces the Angiogenic Switch in Human Tumor Cells through the PERK/ATF4 Pathway

(2012) Y. Wang et al.   CANCER RESEARCH

Hypoxia-Inducible Factors in Physiology and Medicine

(2012) Gregg L. Semenza   CELL

Nox4 Is a Protective Reactive Oxygen Species Generating Vascular NADPH Oxidase

(2012) Katrin Schröder et al.   CIRCULATION RESEARCH

Arylsulfonamide KCN1 Inhibits In Vivo Glioma Growth and Interferes with HIF Signaling by Disrupting HIF-1  Interaction with Cofactors p300/CBP

(2012) S. Yin et al.   CLINICAL CANCER RESEARCH

Ascorbate supplementation inhibits growth and metastasis of B16FO melanoma and 4T1 breast cancer cells in vitamin C-deficient mice

(2012) JOHN CHA et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Endoplasmic Reticulum Thiol Oxidase Deficiency Leads to Ascorbic Acid Depletion and Noncanonical Scurvy in Mice

(2012) Ester Zito et al.   MOLECULAR CELL

NADPH Oxidase 4 Promotes Endothelial Angiogenesis Through Endothelial Nitric Oxide Synthase Activation

(2011) Siobhan M. Craige et al.   CIRCULATION

Tying the knot: The cystine signature and molecular-recognition processes of the vascular endothelial growth factor family of angiogenic cytokines

(2011) Shalini Iyer et al.   FEBS Journal

Studies on the Reaction of Nitric Oxide with the Hypoxia-Inducible Factor Prolyl Hydroxylase Domain 2 (EGLN1)

(2011) Rasheduzzaman Chowdhury et al.   JOURNAL OF MOLECULAR BIOLOGY

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

Constitutive NADPH-Dependent Electron Transferase Activity of the Nox4 Dehydrogenase Domain

(2010) Yukio Nisimoto et al.   BIOCHEMISTRY

The role of tumour-derived iNOS in tumour progression and angiogenesis

(2010) V Kostourou et al.   BRITISH JOURNAL OF CANCER

Nrf2-deficiency creates a responsive microenvironment for metastasis to the lung

(2010) Hironori Satoh et al.   CARCINOGENESIS

NO to Breast: When, Why and Why Not?

(2010) Shehla Pervin et al.   CURRENT PHARMACEUTICAL DESIGN

Disulphide production by Ero1α–PDI relay is rapid and effectively regulated

(2010) Christian Appenzeller-Herzog et al.   EMBO JOURNAL

Crystal structures of human Ero1α reveal the mechanisms of regulated and targeted oxidation of PDI

(2010) Kenji Inaba et al.   EMBO JOURNAL

Oxidative stress promotes myofibroblast differentiation and tumour spreading

(2010) Aurore Toullec et al.   EMBO Molecular Medicine

Terpestacin Inhibits Tumor Angiogenesis by Targeting UQCRB of Mitochondrial Complex III and Suppressing Hypoxia-induced Reactive Oxygen Species Production and Cellular Oxygen Sensing

(2010) Hye Jin Jung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Small Molecule Inhibitor of Endoplasmic Reticulum Oxidation 1 (ERO1) with Selectively Reversible Thiol Reactivity

(2010) Jaime D. Blais et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ERO1-β, a pancreas-specific disulfide oxidase, promotes insulin biogenesis and glucose homeostasis

(2010) Ester Zito et al.   JOURNAL OF CELL BIOLOGY

S-Nitrosylation of β-Catenin by eNOS-Derived NO Promotes VEGF-Induced Endothelial Cell Permeability

(2010) Sébastien Thibeault et al.   MOLECULAR CELL

Oxidative Protein Folding by an Endoplasmic Reticulum-Localized Peroxiredoxin

(2010) Ester Zito et al.   MOLECULAR CELL

Mitochondrial reactive oxygen species regulate hypoxic signaling

(2009) Robert B Hamanaka et al.   CURRENT OPINION IN CELL BIOLOGY

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Reactive oxygen species and angiogenesis: NADPH oxidase as target for cancer therapy

(2008) Masuko Ushio-Fukai et al.   CANCER LETTERS

Molecular mechanisms for the activity of PX-478, an antitumor inhibitor of the hypoxia-inducible factor-1 

(2008) M. Y. Koh et al.   MOLECULAR CANCER THERAPEUTICS

Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway

(2008) William G. Kaelin et al.   MOLECULAR CELL

Stromal gene expression predicts clinical outcome in breast cancer

(2008) Greg Finak et al.   NATURE MEDICINE

ROS-Generating Mitochondrial DNA Mutations Can Regulate Tumor Cell Metastasis

(2008) K. Ishikawa et al.   SCIENCE