Review
Oncology
Jing Yu, Yamin Zhang, Huiyong Zhu
Summary: This study summarizes the current knowledge about the roles and mechanisms of different cell competition interactions between host normal cells and transformed cells involved in mammalian tumor development. These interactions play important roles in different phases of tumor progression, and understanding their molecular mechanisms can provide novel ideas for cancer prevention and treatment.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Cell Biology
Keisuke Kuromiya, Kana Aoki, Kojiro Ishibashi, Moe Yotabun, Miho Sekai, Nobuyuki Tanimura, Sayuri Iijima, Susumu Ishikawa, Tomoko Kamasaki, Yuki Akieda, Tohru Ishitani, Takashi Hayashi, Satoshi Toda, Koji Yokoyama, Chol Gyu Lee, Ippei Usami, Haruki Inoue, Ichigaku Takigawa, Estelle Gauquelin, Kaoru Sugimura, Naoya Hino, Yasuyuki Fujita
Summary: In vertebrates, normal cells neighboring transformed cells can enhance cell competition and accelerate the apical extrusion of transformed cells through calcium sparks and phosphorylation of AHNAK2.
Article
Physics, Multidisciplinary
Yoav G. Pollack, Philip Bittihn, Ramin Golestanian
Summary: Competition between different species or cell types depends on the regulation of growth, proliferation, and degradation processes in a limited space. It is found that the by-products of maintaining homeostasis can significantly impact the outcome of cell competition. Interfaces play a critical role in enabling active cells to exploit local growth opportunities.
NEW JOURNAL OF PHYSICS
(2022)
Article
Multidisciplinary Sciences
Nanase Igarashi, Kenichi Miyata, Tze Mun Loo, Masatomo Chiba, Aki Hanyu, Mika Nishio, Hiroko Kawasaki, Hao Zheng, Shinya Toyokuni, Shunsuke Kon, Keiji Moriyama, Yasuyuki Fujita, Akiko Takahashi
Summary: Cellular senescence inhibits the elimination of oncogenic cells through HGF signaling, suggesting its role in cancer development during aging.
NATURE COMMUNICATIONS
(2022)
Article
Cell Biology
Zhiqiang Xiao, Shanshan Wang, Yixia Tian, Wenkai Lv, Hao Sheng, Mingjie Zhan, Qiongxiao Huang, Zhanpeng Zhang, Leqing Zhu, Chuyun Zhu, Hui Zhong, Qiong Wen, Zonghua Liu, Jingyi Tan, Yan Xu, Meixiang Yang, Yumei Liu, Richard A. Flavell, Quanli Yang, Guangchao Cao, Zhinan Yin
Summary: The study finds that m6A methylation regulates the functional specification of γδ T17 and γδ T1 cells by preventing the formation of endogenous double-stranded RNAs and promoting the degradation of Stat1 transcripts. METTL3-mediated m6A methylation orchestrates mRNA stability and double-stranded RNA contents, equilibrating γδ T1 and γδ T17 cells.
Article
Gastroenterology & Hepatology
Wataru Hirose, Makoto Horiuchi, Donghan Li, Ikuko N. Motoike, Lin Zhang, Hafumi Nishi, Yusuke Taniyama, Takashi Kamei, Mikiko Suzuki, Kengo Kinoshita, Fumiki Katsuoka, Keiko Taguchi, Masayuki Yamamoto
Summary: A model of coexisting NRF2-activated and KEAP1-normal cells was established in the esophageal epithelium using Keap1 conditional knockout mice. NRF2-activated cells are selectively eliminated through cell competition, but loser NRF2-activated cells leave a memory for the remaining winner KEAP1-normal cells.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Review
Gastroenterology & Hepatology
Anne R. Meyer, Monica E. Brown, Patrick S. McGrath, Peter J. Dempsey
Summary: The ability of intestinal epithelial cells to revert to a stem cell state is an important physiological response to regenerate the intestinal epithelium after mucosal injury. Activation of signaling networks involved in maintaining the stem cell niche promotes cellular plasticity and regeneration. Further research is needed to determine the contribution of each cell type and signaling pathway in the multicellular cooperation to restore the intestinal epithelium.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Cell Biology
Ana Krotenberg Garcia, Arianna Fumagalli, Huy Quang Le, Rene Jackstadt, Tamsin Rosemary Margaret Lannagan, Owen J. Sansom, Jacco van Rheenen, Saskia J. E. Suijkerbuijk
Summary: Competitive cell interactions between cancer cells and wild-type cells lead to the active elimination of normal cells and promotion of cancer cell proliferation. This process is driven by cell-state change in wild-type cells and activation of JNK signaling, ultimately resulting in the out-competition of normal cells by cancer cells.
Article
Environmental Sciences
Xiangrui Wang, Wen-Xiong Wang
Summary: This study demonstrated that Cu2O microparticles were rapidly dissolved to copper ions inside cells, followed by lysosome-mediated exocytosis. Smaller microparticles had a lower uptake rate but dissolved more quickly, leading to faster exocytosis activation. The rapid release of copper ions resulted in immediate toxic effects, mainly through necrosis, while glutathione buffering ability alleviated copper toxicity. The turnover of intracellular copper was much faster at sublethal exposure levels, but the labile copper(I) concentration only increased by a maximum of 2 times. Tolerance to copper-based nanoparticles depended on their ability to discharge released copper ions.
ENVIRONMENTAL POLLUTION
(2022)
Article
Gastroenterology & Hepatology
Xingyuan Xu, Longyun Ye, Qi Zhang, Hang Shen, Shanshan Li, Xiaoyu Zhang, Mao Ye, Tingbo Liang
Summary: The study revealed that ILC2s were highly enriched in human HCC and significantly correlated with tumor recurrence, progression-free survival, and overall survival in patients. The HCC-associated ILC2s were identified as an immune regulatory cell type that promotes tumor development, suggesting potential new treatments for HCC by targeting these cells.
Article
Cell Biology
Xiaoli Sun, Yajie Ni, Qingmiao Lu, Yan Liang, Mengru Gu, Xian Xue, Chunsun Dai
Summary: Cell-cell interaction between hepatocytes and Kupffer cells is crucial for liver homeostasis. The activation of mTORC1 in immune-mediated hepatitis affects the cell-cell interaction between Kupffer cells and hepatocytes, leading to Kupffer cell death and aggravated liver injury.
CELL DEATH & DISEASE
(2022)
Article
Biology
Deepti Prasad, Katharina Illek, Friedericke Fischer, Katrin Holstein, Anne-Kathrin Classen
Summary: This article investigates the tissue-intrinsic defense mechanisms against aberrant cells. The study finds that in Drosophila imaginal discs, clones of cells with inappropriate cell fate programs induce bilateral JNK activation to drive interface cell apoptosis. This unique 'interface surveillance' mechanism eliminates cells with inappropriate developmental fate but normal cellular fitness.
Article
Veterinary Sciences
Yung-Tien Tien, Haji Akbar, Keith William Jarosinski
Summary: Marek's disease virus (MDV) can establish latency in chicken T lymphocytes and may lead to T cell transformation and cancer. Temperature treatment is an efficient technique to induce MDV reactivation without punitive effects on cell viability seen with chemical treatment.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Biology
Hao Lu, Hua Yan, Xiaoyu Li, Yuan Xing, Yumeng Ye, Siao Jiang, Luyu Ma, Jie Ping, Hongyan Zuo, Yanhui Hao, Chao Yu, Yang Li, Gangqiao Zhou, Yiming Lu
Summary: This study used single-cell RNA sequencing to map the dynamic landscape of the intestinal cellular microenvironment during radiation-induced intestine injury and regeneration. The findings revealed heterogeneity in the radiosensitivity of different cell types in the intestine and identified dynamic patterns of intestinal stem cells and immune cells during the injury and regeneration process. The study also highlighted important cellular communication and immune modulation mechanisms involved in the response to radiation.
COMMUNICATIONS BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Tabata M. Bohlen, Daniella G. de Paula, Pryscila D. S. Teixeira, Naira da Silva Mansano, Guilherme Andrade Alves, Jose Donato Jr, Renata Frazao
Summary: This study used Cre-Loxp technology to ablate Socs3 expression in kisspeptin cells and evaluated the sexual maturation, energy homeostasis features, and fertility of Kiss1/Socs3-KO mice. The results showed that although Kiss1 mRNA expression was significantly reduced in the hypothalamus of KO mice, their sexual maturation and fertility remained unaffected, and body weight gain, leptin sensitivity, and glucose homeostasis were similar to control mice. Interestingly, Kiss1/Socs3-KO mice were partially protected against LPS-induced body weight loss, suggesting that kisspeptin cells can modulate energy metabolism in mice in certain situations.
Review
Developmental Biology
Cheng Shi, Pengfei Jiao, Zhiyi Chen, Lan Ma, Siyue Yao
Summary: This review discusses the molecular etiology of congenital craniofacial abnormalities, with a focus on the role and mechanism of noncoding RNAs in regulating craniofacial development. Aberrant expression of noncoding RNAs has been implicated in the pathogenesis of craniofacial abnormalities, providing potential therapeutic targets.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Hideru Togashi, Steven Ray Davis, Makoto Sato
Summary: Tile patterns, regulated by cell adhesion molecules, are regular arrangements of cells that play important functional roles in multicellular organisms. The physical constraints and cell adhesion regulate both cell shape and tissue morphogenesis.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Armen Khanbabei, Lina Segura, Cynthia Petrossian, Aaron Lemus, Ithan Cano, Courtney Frazier, Armen Halajyan, Donnie Ca, Mariano Loza-Coll
Summary: This article investigates the genetic regulatory mechanisms of Drosophila intestinal stem cells. The study found that most target genes co-regulated by Esg and STAT show a consistent gene expression pattern. However, manipulating these validated targets in vivo rarely replicated the effects of manipulating Esg and STAT, suggesting the presence of complex genetic interactions among the downstream targets of these two master regulator genes.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Bayley J. Waters, Zoe R. Birman, Matthew R. Wagner, Julia Lemanski, Barak Blum
Summary: Researchers found that conditional deletion of Robo2 in adult mice led to a significant loss of islet architecture without affecting beta cell identity or function, suggesting that Robo2 plays a role in actively maintaining adult islet architecture. Understanding the factors required for islet architecture maintenance is crucial for developing future diabetes therapies.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Rhiannon Clements, Tyler Smith, Luke Cowart, Jennifer Zhumi, Alan Sherrod, Aidan Cahill, Ginger L. Hunter
Summary: Cell protrusions play a crucial role in regulating cell activities during development. By studying the regulation mechanism in fruit fly sensory bristle patterning, it was found that Myosin XV is essential for the dynamics of signaling filopodia and promotes long-range Notch signaling.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Margaret Keating, Ryan Hagle, Daniel Osorio-Mendez, Anjelica Rodriguez-Parks, Sarah I. Almutawa, Junsu Kang
Summary: Knock-in reporter (KI) animals are essential for studying gene expression in biomedical research. This study developed a new strategy using minicircle technology and a minimal promoter to enhance knock-in events and establish stable KI transgenic reporter lines. The study also highlighted the importance of selecting the proper KI line due to potential inappropriate influence of genome editing on reporter gene expression.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Christian Altbuerger, Meta Rath, Daniel Armbruster, Wolfgang Driever
Summary: This study reveals that Neurog1 and Olig2 transcription factors have differential requirements for the development of dopaminergic neurons, and they integrate local patterning signals and Notch neurogenic selection signaling to specify the progenitor population and initiate neurogenesis and differentiation.
DEVELOPMENTAL BIOLOGY
(2024)
