Rethinking embryology in vitro: A synergy between engineering, data science and theory

Gastrointestinal tract modeling using organoids engineered with cellular and microbiota niches

(2020) Sungjin Min et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

In vitro characterization of the human segmentation clock

(2020) Margarete Diaz-Cuadros et al.   NATURE

Single-cell and spatial transcriptomics reveal somitogenesis in gastruloids

(2020) Susanne C. van den Brink et al.   NATURE

Polymer Hydrogels to Guide Organotypic and Organoid Cultures

(2020) Valentina Magno et al.   ADVANCED FUNCTIONAL MATERIALS

Once upon a dish: engineering multicellular systems

(2020) Kristina Haase et al.   DEVELOPMENT

Development of a scalable co-culture system for gut anaerobes and human colon epithelium

(2020) Nobuo Sasaki et al.   GASTROENTEROLOGY

High-throughput screening of human induced pluripotent stem cell-derived brain organoids

(2020) Madel Durens et al.   JOURNAL OF NEUROSCIENCE METHODS

Recapitulating the human segmentation clock with pluripotent stem cells

(2020) Mitsuhiro Matsuda et al.   NATURE

Machine learning analysis of whole mouse brain vasculature

(2020) Mihail Ivilinov Todorov et al.   NATURE METHODS

Inferring spatial and signaling relationships between cells from single cell transcriptomic data

(2020) Zixuan Cang et al.   Nature Communications

Label-free redox imaging of patient-derived organoids using selective plane illumination microscopy

(2020) Peter F. Favreau et al.   Biomedical Optics Express

Zebrafish embryonic explants undergo genetically encoded self-assembly

(2020) Alexandra Schauer et al.   eLife

Nodal and planar cell polarity signaling cooperate to regulate zebrafish convergence and extension gastrulation movements

(2020) Margot LK Williams et al.   eLife

Naive Pluripotent Stem Cells Exhibit Phenotypic Variability that Is Driven by Genetic Variation

(2020) Daniel Ortmann et al.   Cell Stem Cell

Axis Specification in Zebrafish Is Robust to Cell Mixing and Reveals a Regulation of Pattern Formation by Morphogenesis

(2020) Timothy Fulton et al.   CURRENT BIOLOGY

Maturation of human intestinal organoids in vitro facilitates colonization by commensal lactobacilli by reinforcing the mucus layer

(2020) Ye Seul Son et al.   FASEB JOURNAL

An in vitro model of early anteroposterior organization during human development

(2020) Naomi Moris et al.   NATURE

Organoid technology in female reproductive biomedicine

(2020) Heidar Heidari-Khoei et al.   Reproductive Biology and Endocrinology

Convolutional Neural Networks Can Predict Retinal Differentiation in Retinal Organoids

(2020) Evgenii Kegeles et al.   Frontiers in Cellular Neuroscience

Developmental potential of aneuploid human embryos cultured beyond implantation

(2020) Marta N. Shahbazi et al.   Nature Communications

Automated spheroid generation, drug application and efficacy screening using a deep learning classification: a feasibility study

(2020) Leo Benning et al.   Scientific Reports

High-throughput automated organoid culture via stem-cell aggregation in microcavity arrays

(2020) Nathalie Brandenberg et al.   Nature Biomedical Engineering

Using optogenetics to tackle systems-level questions of multicellular morphogenesis

(2020) Jonas Hartmann et al.   CURRENT OPINION IN CELL BIOLOGY

Pluripotent stem cell models of early mammalian development

(2020) Peter Baillie-Benson et al.   CURRENT OPINION IN CELL BIOLOGY

Phenotypic landscape of intestinal organoid regeneration

(2020) Ilya Lukonin et al.   NATURE

Recapitulating macro-scale tissue self-organization through organoid bioprinting

(2020) Jonathan A. Brassard et al.   NATURE MATERIALS

OrganoidTracker: Efficient cell tracking using machine learning and manual error correction

(2020) Rutger N. U. Kok et al.   PLoS One

Mouse embryonic stem cells self-organize into trunk-like structures with neural tube and somites

(2020) Jesse V. Veenvliet et al.   SCIENCE

ya||a: GPU-Powered Spheroid Models for Mesenchyme and Epithelium

(2019) Philipp Germann et al.   Cell Systems

Engineering Microfluidic Organoid-on-a-Chip Platforms

(2019) Fang Yu et al.   Micromachines

Agent-based modeling of morphogenetic systems: Advantages and challenges

(2019) Chad M. Glen et al.   PLoS Computational Biology

Theory of mechanochemical patterning in biphasic biological tissues

(2019) Pierre Recho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Understanding the Mechanobiology of Early Mammalian Development through Bioengineered Models

(2019) Stefano Vianello et al.   DEVELOPMENTAL CELL

A wave of WNT signaling balanced by secreted inhibitors controls primitive streak formation in micropattern colonies of human embryonic stem cells

(2019) Iain Martyn et al.   DEVELOPMENT

Bioinspired Hydrogels for 3D Organoid Culture

(2019) Delphine Blondel et al.   CHIMIA

Grow with the Flow: When Morphogenesis Meets Microfluidics

(2019) Pinak Samal et al.   ADVANCED MATERIALS

Figure 1 Theory Meets Figure 2 Experiments in the Study of Gene Expression

(2019) Rob Phillips et al.   Annual Review of Biophysics

Self-organization and symmetry breaking in intestinal organoid development

(2019) Denise Serra et al.   NATURE

High-resolution 3D imaging of fixed and cleared organoids

(2019) Johanna F. Dekkers et al.   Nature Protocols

Comprehensive Integration of Single-Cell Data

(2019) Tim Stuart et al.   CELL

Mechanochemical Feedback Loops in Development and Disease

(2019) Edouard Hannezo et al.   CELL

Engineering Stem Cell Self-organization to Build Better Organoids

(2019) Jonathan A. Brassard et al.   Cell Stem Cell

Disease modelling in human organoids

(2019) Madeline A. Lancaster et al.   Disease Models & Mechanisms

Modelling fluid deformable surfaces with an emphasis on biological interfaces

(2019) Alejandro Torres-Sánchez et al.   JOURNAL OF FLUID MECHANICS

Engineered signaling centers for the spatially controlled patterning of human pluripotent stem cells

(2019) Andrea Manfrin et al.   NATURE METHODS

Organoids by design

(2019) Takanori Takebe et al.   SCIENCE

Self-organization of stem cells into embryos: A window on early mammalian development

(2019) Marta N. Shahbazi et al.   SCIENCE

An Air Bubble-Isolating Rotating Wall Vessel Bioreactor for Improved Spheroid/Organoid Formation

(2019) Michael Alexander Phelan et al.   TISSUE ENGINEERING PART C-METHODS

Optogenetics in the Era of Cerebral Organoids

(2019) Zahra Shiri et al.   TRENDS IN BIOTECHNOLOGY

Morphophenotypic classification of tumor organoids as an indicator of drug exposure and penetration potential

(2019) Aleksandra Karolak et al.   PLoS Computational Biology

Prediction and control of symmetry breaking in embryoid bodies by environment and signal integration

(2019) Naor Sagy et al.   DEVELOPMENT

Controlled modelling of human epiblast and amnion development using stem cells

(2019) Yi Zheng et al.   NATURE

ilastik: interactive machine learning for (bio)image analysis

(2019) Stuart Berg et al.   NATURE METHODS

Fast 3-D Imaging of Brain Organoids With a New Single-Objective Planar-Illumination Two-Photon Microscope

(2019) Irina Rakotoson et al.   Frontiers in Neuroanatomy

Mathematical Models of Organoid Cultures

(2019) Sandra Montes-Olivas et al.   Frontiers in Genetics

Data-driven modeling and learning in science and engineering

(2019) Francisco J. Montáns et al.   COMPTES RENDUS MECANIQUE

Gene expression cartography

(2019) Mor Nitzan et al.   NATURE

OrgaQuant: Human Intestinal Organoid Localization and Quantification Using Deep Convolutional Neural Networks

(2019) Timothy Kassis et al.   Scientific Reports

Dissecting the dynamics of signaling events in the BMP, WNT, and NODAL cascade during self-organized fate patterning in human gastruloids

(2019) Sapna Chhabra et al.   PLOS BIOLOGY

Exposure-based assessment of chemical teratogenicity using morphogenetic aggregates of human embryonic stem cells

(2019) Yusuke Marikawa et al.   REPRODUCTIVE TOXICOLOGY

Multi-scale imaging and analysis identify pan-embryo cell dynamics of germlayer formation in zebrafish

(2019) Gopi Shah et al.   Nature Communications

Modulation of Phase Shift between Wnt and Notch Signaling Oscillations Controls Mesoderm Segmentation

(2018) Katharina F. Sonnen et al.   CELL

In Silico Labeling: Predicting Fluorescent Labels in Unlabeled Images

(2018) Eric M. Christiansen et al.   CELL

High-Throughput Screening Enhances Kidney Organoid Differentiation from Human Pluripotent Stem Cells and Enables Automated Multidimensional Phenotyping

(2018) Stefan M. Czerniecki et al.   Cell Stem Cell

Single-Cell Transcriptomics Meets Lineage Tracing

(2018) Lennart Kester et al.   Cell Stem Cell

Linking stem cell function and growth pattern of intestinal organoids

(2018) Torsten Thalheim et al.   DEVELOPMENTAL BIOLOGY

The Strength of Mechanical Forces Determines the Differentiation of Alveolar Epithelial Cells

(2018) Jiao Li et al.   DEVELOPMENTAL CELL

Blastocyst-like structures generated solely from stem cells

(2018) Nicolas C. Rivron et al.   NATURE

Self-assembly of embryonic and two extra-embryonic stem cell types into gastrulating embryo-like structures

(2018) Berna Sozen et al.   NATURE CELL BIOLOGY

Imaging organoids: a bright future ahead

(2018) Anne C Rios et al.   NATURE METHODS

Generation of human brain region–specific organoids using a miniaturized spinning bioreactor

(2018) Xuyu Qian et al.   Nature Protocols

Hydrodynamic theory of active matter

(2018) Frank Jülicher et al.   REPORTS ON PROGRESS IN PHYSICS

Single-cell reconstruction of developmental trajectories during zebrafish embryogenesis

(2018) Jeffrey A. Farrell et al.   SCIENCE

Single-cell mapping of gene expression landscapes and lineage in the zebrafish embryo

(2018) Daniel E. Wagner et al.   SCIENCE

Combining Turing and 3D vertex models reproduces autonomous multicellular morphogenesis with undulation, tubulation, and branching

(2018) Satoru Okuda et al.   Scientific Reports

Automated brightfield morphometry of 3D organoid populations by OrganoSeg

(2018) Michael A. Borten et al.   Scientific Reports

Use of bioreactors for culturing human retinal organoids improves photoreceptor yields

(2018) Patrick Ovando-Roche et al.   Stem Cell Research & Therapy

Organoid and Enteroid Modeling of Salmonella Infection

(2018) Yuebang Yin et al.   Frontiers in Cellular and Infection Microbiology

A Simple Bioreactor-Based Method to Generate Kidney Organoids from Pluripotent Stem Cells

(2018) Aneta Przepiorski et al.   Stem Cell Reports

Effects of 3D culturing conditions on the transcriptomic profile of stem-cell-derived neurons

(2018) Halil Tekin et al.   Nature Biomedical Engineering

Organoids for Drug Discovery and Personalized Medicine

(2018) Toshio Takahashi   Annual Review of Pharmacology and Toxicology

RNA velocity of single cells

(2018) Gioele La Manno et al.   NATURE

Progress and potential in organoid research

(2018) Giuliana Rossi et al.   NATURE REVIEWS GENETICS

Ex vivo live cell tracking in kidney organoids using light sheet fluorescence microscopy

(2018) Marie Held et al.   PLoS One

In Toto Imaging and Reconstruction of Post-Implantation Mouse Development at the Single-Cell Level

(2018) Katie McDole et al.   CELL

Comparative Analysis and Refinement of Human PSC-Derived Kidney Organoid Differentiation with Single-Cell Transcriptomics

(2018) Haojia Wu et al.   Cell Stem Cell

Cell parts to complex processes, from the bottom up

(2018) Matthew Good et al.   NATURE

Multi-axial self-organization properties of mouse embryonic stem cells into gastruloids

(2018) Leonardo Beccari et al.   NATURE

Trophoblast organoids as a model for maternal–fetal interactions during human placentation

(2018) Margherita Y. Turco et al.   NATURE

Content-aware image restoration: pushing the limits of fluorescence microscopy

(2018) Martin Weigert et al.   NATURE METHODS

Evaluation of variability in human kidney organoids

(2018) Belinda Phipson et al.   NATURE METHODS

Self-organized shape dynamics of active surfaces

(2018) Alexander Mietke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microbiome interactions shape host fitness

(2018) Alison L. Gould et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Strain-triggered mechanical feedback in self-organizing optic-cup morphogenesis

(2018) S. Okuda et al.   Science Advances

A mathematical model to investigate the key drivers of the biogeography of the colon microbiota

(2018) Simon Labarthe et al.   JOURNAL OF THEORETICAL BIOLOGY

High-throughput single-cell transcriptomics on organoids

(2018) Agnieska Brazovskaja et al.   CURRENT OPINION IN BIOTECHNOLOGY

Mechanosensing by the nucleus: From pathways to scaling relationships

(2017) Sangkyun Cho et al.   JOURNAL OF CELL BIOLOGY

“What I cannot create, I do not understand”

(2017) Michael Way   JOURNAL OF CELL SCIENCE

Multicut brings automated neurite segmentation closer to human performance

(2017) Thorsten Beier et al.   NATURE METHODS

Vertex models: from cell mechanics to tissue morphogenesis

(2017) Silvanus Alt et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Assembly of embryonic and extraembryonic stem cells to mimic embryogenesis in vitro

(2017) Sarah Ellys Harrison et al.   SCIENCE

A genome-wide screen identifies YAP/WBP2 interplay conferring growth advantage on human epidermal stem cells

(2017) Gernot Walko et al.   Nature Communications

A pluripotent stem cell-based model for post-implantation human amniotic sac development

(2017) Yue Shao et al.   Nature Communications

Comprehensive high-throughput image analysis for therapeutic efficacy of architecturally complex heterotypic organoids

(2017) Anne-Laure Bulin et al.   Scientific Reports

Discovering sparse transcription factor codes for cell states and state transitions during development

(2017) Leon A Furchtgott et al.   eLife

Deep learning microscopy

(2017) Yair Rivenson et al.   Optica

A 3-dimensional mathematical model of microbial proliferation that generates the characteristic cumulative relative abundance distributions in gut microbiomes

(2017) Lena Takayasu et al.   PLoS One

Beyond Turing: mechanochemical pattern formation in biological tissues

(2016) Moritz Mercker et al.   Biology Direct

Genome, transcriptome and proteome: the rise of omics data and their integration in biomedical sciences

(2016) Claudia Manzoni et al.   BRIEFINGS IN BIOINFORMATICS

Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure

(2016) Xuyu Qian et al.   CELL

Microcavity arrays as an in vitro model system of the bone marrow niche for hematopoietic stem cells

(2016) Patrick Wuchter et al.   CELL AND TISSUE RESEARCH

Midbrain-like Organoids from Human Pluripotent Stem Cells Contain Functional Dopaminergic and Neuromelanin-Producing Neurons

(2016) Junghyun Jo et al.   Cell Stem Cell

Engineering Stem Cell Organoids

(2016) Xiaolei Yin et al.   Cell Stem Cell

Derivation of a robust mouse mammary organoid system for studying tissue dynamics

(2016) Paul R. Jamieson et al.   DEVELOPMENT

A Balance between Secreted Inhibitors and Edge Sensing Controls Gastruloid Self-Organization

(2016) Fred Etoc et al.   DEVELOPMENTAL CELL

Spatial Transcriptome for the Molecular Annotation of Lineage Fates and Cell Identity in Mid-gastrula Mouse Embryo

(2016) Guangdun Peng et al.   DEVELOPMENTAL CELL

Organoids: A historical perspective of thinking in three dimensions

(2016) Marina Simian et al.   JOURNAL OF CELL BIOLOGY

3D high throughput screening and profiling of embryoid bodies in thermoformed microwell plates

(2016) E. J. Vrij et al.   LAB ON A CHIP

High-throughput imaging: Focusing in on drug discovery in 3D

(2016) Linfeng Li et al.   METHODS

Wishbone identifies bifurcating developmental trajectories from single-cell data

(2016) Manu Setty et al.   NATURE BIOTECHNOLOGY

Laser capture microscopy coupled with Smart-seq2 for precise spatial transcriptomic profiling

(2016) Susanne Nichterwitz et al.   Nature Communications

From Discrete to Continuum Models of Three-Dimensional Deformations in Epithelial Sheets

(2015) Nebojsa Murisic et al.   BIOPHYSICAL JOURNAL

Bending Gradients: How the Intestinal Stem Cell Gets Its Home

(2015) Amy E. Shyer et al.   CELL

Development of the anterior-posterior axis is a self-organizing process in the absence of maternal cues in the mouse embryo

(2015) Ivan Bedzhov et al.   CELL RESEARCH

Deep learning

(2015) Yann LeCun et al.   NATURE

Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis

(2015) Minoru Takasato et al.   NATURE

Local and tissue-scale forces drive oriented junction growth during tissue extension

(2015) Claudio Collinet et al.   NATURE CELL BIOLOGY

Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture

(2015) Anca M Paşca et al.   NATURE METHODS

Theory in Biology: Figure 1 or Figure 7?

(2015) Rob Phillips   TRENDS IN CELL BIOLOGY

The Notch and Wnt pathways regulate stemness and differentiation in human fallopian tube organoids

(2015) Mirjana Kessler et al.   Nature Communications

Modelling kidney disease with CRISPR-mutant kidney organoids derived from human pluripotent epiblast spheroids

(2015) Benjamin S. Freedman et al.   Nature Communications

A versatile pipeline for the multi-scale digital reconstruction and quantitative analysis of 3D tissue architecture

(2015) Hernán Morales-Navarrete et al.   eLife

Simulating tissue mechanics with agent-based models: concepts, perspectives and some novel results

(2015) P. Van Liedekerke et al.   Computational Particle Mechanics

Liquid-Liquid Phase Separation in Biology

(2014) Anthony A. Hyman et al.   Annual Review of Cell and Developmental Biology

Vertex dynamics simulations of viscosity-dependent deformation during tissue morphogenesis

(2014) Satoru Okuda et al.   Biomechanics and Modeling in Mechanobiology

Models in biology: ‘accurate descriptions of our pathetic thinking’

(2014) Jeremy Gunawardena   BMC BIOLOGY

Data integration in the era of omics: current and future challenges

(2014) David Gomez-Cabrero et al.   BMC Systems Biology

Symmetry breaking, germ layer specification and axial organisation in aggregates of mouse embryonic stem cells

(2014) S. C. van den Brink et al.   DEVELOPMENT

Encoding of Temporal Signals by the TGF-β Pathway and Implications for Embryonic Patterning

(2014) Benoit Sorre et al.   DEVELOPMENTAL CELL

Microfluidic organs-on-chips

(2014) Sangeeta N Bhatia et al.   NATURE BIOTECHNOLOGY

A method to recapitulate early embryonic spatial patterning in human embryonic stem cells

(2014) Aryeh Warmflash et al.   NATURE METHODS

Efficient Bayesian-based multiview deconvolution

(2014) Stephan Preibisch et al.   NATURE METHODS

Organogenesis in a dish: Modeling development and disease using organoid technologies

(2014) M. A. Lancaster et al.   SCIENCE

3D niche microarrays for systems-level analyses of cell fate

(2014) A. Ranga et al.   Nature Communications

3D Reconstitution of the Patterned Neural Tube from Embryonic Stem Cells

(2014) Andrea Meinhardt et al.   Stem Cell Reports

Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis

(2013) Meritxell Huch et al.   EMBO JOURNAL

In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration

(2013) Meritxell Huch et al.   NATURE

Vascularized and functional human liver from an iPSC-derived organ bud transplant

(2013) Takanori Takebe et al.   NATURE

Cerebral organoids model human brain development and microcephaly

(2013) Madeline A. Lancaster et al.   NATURE

Single-chromosome transcriptional profiling reveals chromosomal gene expression regulation

(2013) Marshall J Levesque et al.   NATURE METHODS

Theory of epithelial sheet morphology in three dimensions

(2013) E. Hannezo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hydrodynamics of soft active matter

(2013) M. C. Marchetti et al.   REVIEWS OF MODERN PHYSICS

Chaste: An Open Source C++ Library for Computational Physiology and Biology

(2013) Gary R. Mirams et al.   PLoS Computational Biology

On the biomechanics of stem cell niche formation in the gut - modelling growing organoids

(2012) Peter Buske et al.   FEBS Journal

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Cell polarity: mechanochemical patterning

(2012) Nathan W. Goehring et al.   TRENDS IN CELL BIOLOGY

Self-organizing optic-cup morphogenesis in three-dimensional culture

(2011) Mototsugu Eiraku et al.   NATURE

Turing's next steps: the mechanochemical basis of morphogenesis

(2011) Jonathon Howard et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Polarization of PAR Proteins by Advective Triggering of a Pattern-Forming System

(2011) N. W. Goehring et al.   SCIENCE

Stochastic Mechanisms of Cell Fate Specification that Yield Random or Robust Outcomes

(2010) Robert J. Johnston et al.   Annual Review of Cell and Developmental Biology

Mathematical Modeling: Bridging the Gap between Concept and Realization in Synthetic Biology

(2010) Yuting Zheng et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Variability in gene expression underlies incomplete penetrance

(2010) Arjun Raj et al.   NATURE

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

Organ printing: Tissue spheroids as building blocks

(2009) Vladimir Mironov et al.   BIOMATERIALS

Chaste: A test-driven approach to software development for biological modelling

(2009) Joe Pitt-Francis et al.   COMPUTER PHYSICS COMMUNICATIONS

Stem cells, signals and vertebrate body axis extension

(2009) V. Wilson et al.   DEVELOPMENT

Microfluidic platform for controlling the differentiation of embryoid bodies

(2009) Wai-To Fung et al.   LAB ON A CHIP

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

mRNA-Seq whole-transcriptome analysis of a single cell

(2009) Fuchou Tang et al.   NATURE METHODS

Biology under construction: in vitro reconstitution of cellular function

(2009) Allen P. Liu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Scoring diverse cellular morphologies in image-based screens with iterative feedback and machine learning

(2009) Thouis R. Jones et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bioimage informatics: a new area of engineering biology

(2008) Hanchuan Peng   BIOINFORMATICS

Self-Organized Formation of Polarized Cortical Tissues from ESCs and Its Active Manipulation by Extrinsic Signals

(2008) Mototsugu Eiraku et al.   Cell Stem Cell

Wnt Signaling Mediates Self-Organization and Axis Formation in Embryoid Bodies

(2008) Derk ten Berge et al.   Cell Stem Cell

Stochastic neuronal cell fate choices

(2008) Robert J Johnston et al.   CURRENT OPINION IN NEUROBIOLOGY

Self-organization in cell biology: a brief history

(2008) Eric Karsenti   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Reconstruction of Zebrafish Early Embryonic Development by Scanned Light Sheet Microscopy

(2008) P. J. Keller et al.   SCIENCE