Asprosin, a novel pleiotropic adipokine implicated in fasting and obesity-related cardio-metabolic disease: Comprehensive review of preclinical and clinical evidence

High Serum Asprosin Levels Are Associated with Presence of Metabolic Syndrome

(2021) Tao Hong et al.   International Journal of Endocrinology

Effect of sodium–glucose co-transporter-2 inhibitors on the levels of serum asprosin in patients with newly diagnosed type 2 diabetes mellitus

(2021) Aijun Jiang et al.   Diabetology & Metabolic Syndrome

Asprosin serum levels and glucose homeostasis in children with obesity

(2021) Domenico Corica et al.   CYTOKINE

An MRM-Based Multiplexed Quantification Assay for Human Adipokines and Apolipoproteins

(2020) Laura Krieg et al.   MOLECULES

Increased Serum Circulating Asprosin Levels in Children with Obesity

(2020) Eda Sünnetçi Silistre et al.   PEDIATRICS INTERNATIONAL

Continuous elevation of plasma asprosin in pregnant women complicated with gestational diabetes mellitus: A nested case-control study

(2020) Lieqiang Zhong et al.   PLACENTA

The Asprosin–OLFR734 module regulates appetitive behaviors

(2020) Yang Liu et al.   Cell Discovery

Adipokines as novel biomarkers of cardio-metabolic disorders

(2020) Xin Su et al.   CLINICA CHIMICA ACTA

Serum concentration of asprosin in new-onset type 2 diabetes

(2020) Shakiba Naiemian et al.   Diabetology & Metabolic Syndrome

The Role of Exercise in the Interplay between Myokines, Hepatokines, Osteokines, Adipokines, and Modulation of Inflammation for Energy Substrate Redistribution and Fat Mass Loss: A Review

(2020) Adrian M. Gonzalez-Gil et al.   Nutrients

The role of Asprosin in patients with dilated cardiomyopathy

(2020) Ming-Shien Wen et al.   BMC Cardiovascular Disorders

Assessment of acute aerobic exercise in the morning versus evening on asprosin, spexin, lipocalin-2, and insulin level in overweight/obese versus normal weight adult men

(2020) Halil İbrahim Ceylan et al.   CHRONOBIOLOGY INTERNATIONAL

Combination of asprosin and adiponectin as a novel marker for diagnosing non-alcoholic fatty liver disease

(2020) Fan Ke et al.   CYTOKINE

Newly Discovered Adipokines: Pathophysiological Link Between Obesity and Cardiometabolic Disorders

(2020) Jung A. Kim et al.   Frontiers in Physiology

Expression and purification of asprosin in Pichia pastoris and investigation of its increase glucose uptake activity in skeletal muscle through activation of AMPK

(2020) Yunhua Zhang et al.   ENZYME AND MICROBIAL TECHNOLOGY

The Distinct Effects of Palmitic and Oleic Acid on Pancreatic Beta Cell Function: The Elucidation of Associated Mechanisms and Effector Molecules

(2019) Miruna Nemecz et al.   Frontiers in Pharmacology

The obesity transition: stages of the global epidemic

(2019) Lindsay M Jaacks et al.   Lancet Diabetes & Endocrinology

Saliva and Blood Asprosin Hormone Concentration Associated with Obesity

(2019) Kader Ugur et al.   International Journal of Endocrinology

Obesity: global epidemiology and pathogenesis

(2019) Matthias Blüher   Nature Reviews Endocrinology

Asprosin attenuates insulin signaling pathway through PKCδ‐activated ER stress and inflammation in skeletal muscle

(2019) Tae Woo Jung et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Asprosin impairs insulin secretion in response to glucose and viability through TLR4/JNK-mediated inflammation

(2019) Taeseung Lee et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The serum level of irisin, but not asprosin, is abnormal in polycystic ovary syndrome patients

(2019) Chia Lin Chang et al.   Scientific Reports

OLFR734 Mediates Glucose Metabolism as a Receptor of Asprosin

(2019) Erwei Li et al.   Cell Metabolism

Decreased Circulating Levels of Asprosin in Obese Children

(2019) Wenjun Long et al.   Hormone Research in Paediatrics

The endocrine function of adipose tissues in health and cardiometabolic disease

(2019) Ludger Scheja et al.   Nature Reviews Endocrinology

Asprosin improves the survival of mesenchymal stromal cells in myocardial infarction by inhibiting apoptosis via the activated ERK1/2-SOD2 pathway

(2019) Zhengbin Zhang et al.   LIFE SCIENCES

Sense of Smell as the Central Driver of Pavlovian Appetite Behavior in Mammals

(2019) Leon G. Fine et al.   Frontiers in Physiology

Decreased Blood Asprosin in Hyperglycemic Menopausal Women as a Result of Whole-Body Cryotherapy Regardless of Metabolic Syndrome

(2019) Magdalena Wiecek et al.   Journal of Clinical Medicine

Asprosin in umbilical cord of newborns and maternal blood of gestational diabetes, preeclampsia, severe preeclampsia, intrauterine growth retardation and macrosemic fetus

(2019) Yakup Baykus et al.   PEPTIDES

Increased serum level and impaired response to glucose fluctuation of asprosin is associated with type 2 diabetes mellitus

(2019) Xinyue Zhang et al.   Journal of Diabetes Investigation

The Asprosin-OLFR734 hormonal signaling axis modulates male fertility

(2019) Fangchao Wei et al.   Cell Discovery

Regulation of Hepatic Glucose Production by Transforming Growth Factor Beta 1 via Protein Kinase A

(2018) QUAN PAN et al.   DIABETES

Plasma Asprosin Concentrations Are Increased in Individuals with Glucose Dysregulation and Correlated with Insulin Resistance and First-Phase Insulin Secretion

(2018) Yuren Wang et al.   MEDIATORS OF INFLAMMATION

Mechanisms of NAFLD development and therapeutic strategies

(2018) Scott L. Friedman et al.   NATURE MEDICINE

The epidemiology of obesity

(2018) Yu Chung Chooi et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Serum asprosin levels and bariatric surgery outcomes in obese adults

(2018) Chao-Yung Wang et al.   INTERNATIONAL JOURNAL OF OBESITY

Plasma Asprosin Levels Are Associated with Glucose Metabolism, Lipid, and Sex Hormone Profiles in Females with Metabolic-Related Diseases

(2018) Xing Li et al.   MEDIATORS OF INFLAMMATION

Acute Anaerobic Exercise Affects the Secretion of Asprosin, Irisin, and Other Cytokines – A Comparison Between Sexes

(2018) Magdalena Wiecek et al.   Frontiers in Physiology

Skeletal muscle inflammation and insulin resistance in obesity

(2017) Huaizhu Wu et al.   JOURNAL OF CLINICAL INVESTIGATION

Adiponectin improves insulin sensitivity via activation of autophagic flux

(2017) Penny Ahlstrom et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Asprosin is a centrally acting orexigenic hormone

(2017) Clemens Duerrschmid et al.   NATURE MEDICINE

A consensus statement for the clinical use of the renal sodium-glucose co-transporter-2 inhibitor dapagliflozin in patients with type 2 diabetes mellitus

(2017) A. Avogaro et al.   Expert Review of Clinical Pharmacology

Circulating asprosin concentrations are increased in type 2 diabetes mellitus and independently associated with fasting glucose and triglyceride

(2017) Lei Zhang et al.   CLINICA CHIMICA ACTA

Asprosin, a Fasting-Induced Glucogenic Protein Hormone

(2016) Chase Romere et al.   CELL

The Pathogenesis of Polycystic Ovary Syndrome (PCOS): The Hypothesis of PCOS as Functional Ovarian Hyperandrogenism Revisited

(2016) Robert L. Rosenfield et al.   ENDOCRINE REVIEWS

The Adipokine-Cardiovascular-Lifestyle Network

(2016) Jeffrey I. Mechanick et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Expression of FBN1 during adipogenesis: Relevance to the lipodystrophy phenotype in Marfan syndrome and related conditions

(2016) Margaret R. Davis et al.   MOLECULAR GENETICS AND METABOLISM

Adipose Tissue Remodeling: Its Role in Energy Metabolism and Metabolic Disorders

(2016) Sung Sik Choe et al.   Frontiers in Endocrinology

Role of PKCδ in Insulin Sensitivity and Skeletal Muscle Metabolism

(2015) Mengyao Li et al.   DIABETES

Body Composition, Lipid Profile, Adipokine Concentration, and Antioxidant Capacity Changes during Interventions to Treat Overweight with Exercise Programme and Whole-Body Cryostimulation

(2015) Anna Lubkowska et al.   Oxidative Medicine and Cellular Longevity

Neonatal progeroid variant of Marfan syndrome with congenital lipodystrophy results from mutations at the 3′ end of FBN1 gene

(2014) Adeline Jacquinet et al.   European Journal of Medical Genetics

Low Concentrations of Metformin Suppress Glucose Production in Hepatocytes through AMP-activated Protein Kinase (AMPK)

(2014) Jia Cao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exercise Induced Adipokine Changes and the Metabolic Syndrome

(2014) Saeid Golbidi et al.   Journal of Diabetes Research

Adipokines in gestational diabetes

(2014) Mathias Fasshauer et al.   Lancet Diabetes & Endocrinology

Severe congenital lipodystrophy and a progeroid appearance: Mutation in the penultimate exon ofFBN1causing a recognizable phenotype

(2013) Toshiki Takenouchi et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Whole-body cryostimulation as an effective method of reducing low-grade inflammation in obese men

(2013) Ewa Ziemann et al.   Journal of Physiological Sciences

Increased systemic and adipose tissue inflammation differentiates obese women with T2DM from obese women with normal glucose tolerance

(2013) Lianne van Beek et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Further evidence for a marfanoid syndrome with neonatal progeroid features and severe generalized lipodystrophy due to frameshift mutations near the 3′ end of the FBN1 gene

(2011) Jack Goldblatt et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Marfan syndrome with neonatal progeroid syndrome-like lipodystrophy associated with a novel frameshift mutation at the 3′ terminus of the FBN1-gene

(2010) Luitgard M. Graul-Neumann et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Dilated cardiomyopathy

(2010) John Lynn Jefferies et al.   LANCET

Fatty liver and lipotoxicity

(2009) Michael Trauner et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The pathogenesis of diabetic nephropathy

(2008) Suma Dronavalli et al.   Nature clinical practice. Endocrinology & metabolism