The Distinct Effects of Palmitic and Oleic Acid on Pancreatic Beta Cell Function: The Elucidation of Associated Mechanisms and Effector Molecules

Oxidative Stress in Pancreatic Beta Cell Regeneration

(2017) Jingjing Wang et al.   Oxidative Medicine and Cellular Longevity

Fatty acids stimulate insulin secretion from human pancreatic islets at fasting glucose concentrations via mitochondria-dependent and -independent mechanisms

(2016) Jing Cen et al.   Nutrition & Metabolism

Inhibition of NAPDH Oxidase 2 (NOX2) Prevents Oxidative Stress and Mitochondrial Abnormalities Caused by Saturated Fat in Cardiomyocytes

(2016) Leroy C. Joseph et al.   PLoS One

Palmitate promotes autophagy and apoptosis through ROS-dependent JNK and p38 MAPK

(2015) Jing Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Phosphorylation of caveolin-1 on tyrosine-14 induced by ROS enhances palmitate-induced death of beta-pancreatic cells

(2015) Sergio Wehinger et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Antagonism Between Saturated and Unsaturated Fatty Acids in ROS Mediated Lipotoxicity in Rat Insulin-Producing Cells

(2015) Wiebke Gehrmann et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Effect of NAD on PARP-mediated insulin sensitivity in oleic acid treated hepatocytes

(2015) Jing Pang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Oxidative and endoplasmic reticulum stress in β-cell dysfunction in diabetes

(2015) Sumaira Z Hasnain et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Palmitate induces ER calcium depletion and apoptosis in mouse podocytes subsequent to mitochondrial oxidative stress

(2015) S Xu et al.   Cell Death & Disease

Measurement of DCF fluorescence as a measure of reactive oxygen species in murine islets of Langerhans

(2014) Xue Wang et al.   Analytical Methods

Lipotoxicity in the Pancreatic Beta Cell: Not Just Survival and Function, but Proliferation as Well?

(2014) Rohit B. Sharma et al.   Current Diabetes Reports

Disruption of Protein-Tyrosine Phosphatase 1B Expression in the Pancreas Affects β-Cell Function

(2014) Siming Liu et al.   ENDOCRINOLOGY

KDEL-Retained Antigen in B Lymphocytes Induces a Proinflammatory Response: A Possible Role for Endoplasmic Reticulum Stress in Adaptive T Cell Immunity

(2014) M. C. Wheeler et al.   JOURNAL OF IMMUNOLOGY

Enhanced synthesis of saturated phospholipids is associated with ER stress and lipotoxicity in palmitate treated hepatic cells

(2014) Alexandra K. Leamy et al.   JOURNAL OF LIPID RESEARCH

Glycemic control in diabetes is restored by therapeutic manipulation of cytokines that regulate beta cell stress

(2014) Sumaira Z Hasnain et al.   NATURE MEDICINE

Matrix Metalloproteinase 2 Contributes to Pancreatic Beta Cell Injury Induced by Oxidative Stress

(2014) Chongxiao Liu et al.   PLoS One

Novel insights into pancreatic β-cell glucolipotoxicity from real-time functional analysis of mitochondrial energy metabolism in INS-1E insulinoma cells

(2013) Jonathan Barlow et al.   BIOCHEMICAL JOURNAL

Effects of lipotoxicity on a novel insulin-secreting human pancreatic β-cell line, 1.1B4

(2013) Srividya Vasu et al.   BIOLOGICAL CHEMISTRY

Free Fatty Acids Inhibit Protein Tyrosine Phosphatase 1B and Activate Akt

(2013) Eisuke Shibata et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

NADPH oxidase inhibition prevents beta cell dysfunction induced by prolonged elevation of oleate in rodents

(2013) K. Koulajian et al.   DIABETOLOGIA

C/EBP Homologous Protein-induced Macrophage Apoptosis Protects Mice from Steatohepatitis

(2013) Harmeet Malhi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protective Effects of Oleic Acid Against Palmitic Acid-Induced Apoptosis in Pancreatic AR42J Cells and Its Mechanisms

(2013) Joung Hoon Ahn et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Role of p53 in the cellular response following oleic acid accumulation in Chang liver cells

(2013) Eun-Jung Park et al.   TOXICOLOGY LETTERS

Palmitate induces reactive oxygen species production and β-cell dysfunction by activating nicotinamide adenine dinucleotide phosphate oxidase through Src signaling

(2013) Yuichi Sato et al.   Journal of Diabetes Investigation

The interplay between endoplasmic reticulum stress and inflammation

(2012) Sumaira Z Hasnain et al.   IMMUNOLOGY AND CELL BIOLOGY

Differential impact of oleate, palmitate, and adipokines on expression of NF-κB target genes in human vascular smooth muscle cells

(2012) Daniela Lamers et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Redox Homeostasis in Pancreatic Cells

(2012) Petr Ježek et al.   Oxidative Medicine and Cellular Longevity

Protein Tyrosine Phosphatase 1B Deficiency Potentiates PERK/eIF2α Signaling in Brown Adipocytes

(2012) Ahmed Bettaieb et al.   PLoS One

A lipidomic screen of palmitate-treated MIN6 β-cells links sphingolipid metabolites with endoplasmic reticulum (ER) stress and impaired protein trafficking

(2011) Ebru Boslem et al.   BIOCHEMICAL JOURNAL

Liver-specific deletion of protein tyrosine phosphatase (PTP) 1B improves obesity- and pharmacologically induced endoplasmic reticulum stress

(2011) Abdelali Agouni et al.   BIOCHEMICAL JOURNAL

Endoplasmic Reticulum Calcium Depletion Impacts Chaperone Secretion, Innate Immunity, and Phagocytic Uptake of Cells

(2011) L. R. Peters et al.   JOURNAL OF IMMUNOLOGY

Transmission of endoplasmic reticulum stress and pro-inflammation from tumor cells to myeloid cells

(2011) N. R. Mahadevan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

H2S-Induced Sulfhydration of the Phosphatase PTP1B and Its Role in the Endoplasmic Reticulum Stress Response

(2011) N. Krishnan et al.   Science Signaling

Different effects of oleate vs. palmitate on mitochondrial function, apoptosis, and insulin signaling in L6 skeletal muscle cells: role of oxidative stress

(2010) Larysa Yuzefovych et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Linking endoplasmic reticulum stress to cell death in hepatocytes: roles of C/EBP homologous protein and chemical chaperones in palmitate-mediated cell death

(2010) Kyle T. Pfaffenbach et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Peroxisome-Generated Hydrogen Peroxide as Important Mediator of Lipotoxicity in Insulin-Producing Cells

(2010) M. Elsner et al.   DIABETES

Role of metabolically generated reactive oxygen species for lipotoxicity in pancreatic β-cells

(2010) W. Gehrmann et al.   DIABETES OBESITY & METABOLISM

Causes and cures for endoplasmic reticulum stress in lipotoxic β-cell dysfunction

(2010) M. Cnop et al.   DIABETES OBESITY & METABOLISM

Palmitate induces a pro-inflammatory response in human pancreatic islets that mimics CCL2 expression by beta cells in type 2 diabetes

(2010) M. Igoillo-Esteve et al.   DIABETOLOGIA

Mammalian ER stress sensor IRE1β specifically down-regulates the synthesis of secretory pathway proteins

(2010) Daisuke Nakamura et al.   FEBS LETTERS

Lipid-induced ER stress in yeast and β cells: parallel trails to a common fate

(2010) Ludovic Pineau et al.   FEMS YEAST RESEARCH

Effects of palmitic acid on lipid metabolism homeostasis and apoptosis in goose primary hepatocytes

(2010) Zhixiong Pan et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

IRE1α Disruption Causes Histological Abnormality of Exocrine Tissues, Increase of Blood Glucose Level, and Decrease of Serum Immunoglobulin Level

(2010) Takao Iwawaki et al.   PLoS One

Endoplasmic reticulum stress-induced transcription factor, CHOP, is crucial for dendritic cell IL-23 expression

(2010) Jane C. Goodall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of palmitate on ER and cytosolic Ca2+ homeostasis in β-cells

(2009) Kamila S. Gwiazda et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Long-term high glucose concentration influences Akt, ERK1/2, and PTP1B protein expression in human aortic smooth muscle cells

(2009) Doina Popov et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

IRE1α Kinase Activation Modes Control Alternate Endoribonuclease Outputs to Determine Divergent Cell Fates

(2009) Dan Han et al.   CELL

Glucagon-Like Peptide-1 Agonists Protect Pancreatic β-Cells From Lipotoxic Endoplasmic Reticulum Stress Through Upregulation of BiP and JunB

(2009) Daniel A. Cunha et al.   DIABETES

Palmitate Induces Insulin Resistance in H4IIEC3 Hepatocytes through Reactive Oxygen Species Produced by Mitochondria

(2009) Seiji Nakamura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential effect of oleic and palmitic acid on lipid accumulation and apoptosis in cultured hepatocytes

(2009) Matteo Ricchi et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Glucose Amplifies Fatty Acid-Induced Endoplasmic Reticulum Stress in Pancreatic β-Cells via Activation of mTORC1

(2009) Etti Bachar et al.   PLoS One

Susceptibility of Pancreatic Beta Cells to Fatty Acids Is Regulated by LXR/PPARα-Dependent Stearoyl-Coenzyme A Desaturase

(2009) Karine H. Hellemans et al.   PLoS One

Redox Regulation of Cell Survival

(2008) Dunyaporn Trachootham et al.   ANTIOXIDANTS & REDOX SIGNALING

ATF6 Is a Transcription Factor Specializing in the Regulation of Quality Control Proteins in the Endoplasmic Reticulum

(2008) Yusuke Adachi et al.   CELL STRUCTURE AND FUNCTION

Inhibition of Foxo1 Protects Pancreatic Islet  -Cells Against Fatty Acid and Endoplasmic Reticulum Stress-Induced Apoptosis

(2008) S. C. Martinez et al.   DIABETES

Liver-Specific Deletion of Protein-Tyrosine Phosphatase 1B (PTP1B) Improves Metabolic Syndrome and Attenuates Diet-Induced Endoplasmic Reticulum Stress

(2008) M. Delibegovic et al.   DIABETES

The Role for Endoplasmic Reticulum Stress in Diabetes Mellitus

(2008) Décio L. Eizirik et al.   ENDOCRINE REVIEWS

Differentiated Murine Airway Epithelial Cells Synthesize a Leukocyte-adhesive Hyaluronan Matrix in Response to Endoplasmic Reticulum Stress

(2008) Mark E. Lauer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Initiation and execution of lipotoxic ER stress in pancreatic  -cells

(2008) D. A. Cunha et al.   JOURNAL OF CELL SCIENCE

Palmitate increases superoxide production through mitochondrial electron transport chain and NADPH oxidase activity in skeletal muscle cells

(2008) Rafael Herling Lambertucci et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Chop deletion reduces oxidative stress, improves β cell function, and promotes cell survival in multiple mouse models of diabetes

(2008) Benbo Song et al.   JOURNAL OF CLINICAL INVESTIGATION