Development of whole sporozoite malaria vaccines

Dendritic cell function and antigen presentation in malaria

(2016) Ian A Cockburn et al.   CURRENT OPINION IN IMMUNOLOGY

Optimizing Intradermal Administration of Cryopreserved Plasmodium falciparum Sporozoites in Controlled Human Malaria Infection

(2015) Kirsten E. Lyke et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Circumsporozoite protein as a potential target for antimalarials

(2015) Cristina Fernández-Arias et al.   Expert Review of Anti-Infective Therapy

Clinical development of RTS,S/AS malaria vaccine: a systematic review of clinical Phase I–III trials

(2015) Selidji T Agnandji et al.   Future Microbiology

Efficacy and safety of RTS,S/AS01 malaria vaccine with or without a booster dose in infants and children in Africa: final results of a phase 3, individually randomised, controlled trial

(2015)   LANCET

Immunogenicity of the RTS,S/AS01 malaria vaccine and implications for duration of vaccine efficacy: secondary analysis of data from a phase 3 randomised controlled trial

(2015) Michael T White et al.   LANCET INFECTIOUS DISEASES

Controlled human malaria infection by intramuscular and direct venous inoculation of cryopreserved Plasmodium falciparum sporozoites in malaria-naïve volunteers: effect of injection volume and dose on infectivity rates

(2015) Gloria P Gómez-Pérez et al.   MALARIA JOURNAL

Direct venous inoculation of Plasmodium falciparum sporozoites for controlled human malaria infection: a dose-finding trial in two centres

(2015) Benjamin Mordmüller et al.   MALARIA JOURNAL

Malaria Policy Advisory Committee to the WHO: conclusions and recommendations of seventh biannual meeting (March 2015)

(2015)   MALARIA JOURNAL

Heterologous Protection against Malaria after Immunization with Plasmodium falciparum Sporozoites

(2015) Remko Schats et al.   PLoS One

Discovery of Novel Plasmodium falciparum Pre-Erythrocytic Antigens for Vaccine Development

(2015) Joao C. Aguiar et al.   PLoS One

From the draining lymph node to the liver: the induction and effector mechanisms of malaria-specific CD8+ T cells

(2015) Andrea J. Radtke et al.   Seminars in Immunopathology

Cross-stage immunity for malaria vaccine development

(2015) Wiebke Nahrendorf et al.   VACCINE

Exploring immunological mechanisms of the whole sporozoite vaccination against P. falciparum malaria

(2015) Annie X.Y. Mo et al.   VACCINE

Vaccine approaches to malaria control and elimination: Insights from mathematical models

(2015) Michael T. White et al.   VACCINE

Progress with Plasmodium falciparum sporozoite (PfSPZ)-based malaria vaccines

(2015) Thomas L. Richie et al.   VACCINE

Novel approaches to whole sporozoite vaccination against malaria

(2015) Else M. Bijker et al.   VACCINE

Artemisinin-resistant Plasmodium falciparum clinical isolates can infect diverse mosquito vectors of Southeast Asia and Africa

(2015) Brandyce St. Laurent et al.   Nature Communications

Mechanisms of Stage-Transcending Protection Following Immunization of Mice with Late Liver Stage-Arresting Genetically Attenuated Malaria Parasites

(2015) Brandon K. Sack et al.   PLoS Pathogens

Lymph-Node Resident CD8α+ Dendritic Cells Capture Antigens from Migratory Malaria Sporozoites and Induce CD8+ T Cell Responses

(2015) Andrea J. Radtke et al.   PLoS Pathogens

Controlled Human Malaria Infection of Tanzanians by Intradermal Injection of Aseptic, Purified, Cryopreserved Plasmodium falciparum Sporozoites

(2014) Seif Shekalaghe et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Malaria Immunity in Man and Mosquito: Insights into Unsolved Mysteries of a Deadly Infectious Disease

(2014) Peter D. Crompton et al.   Annual Review of Immunology

A combined analysis of immunogenicity, antibody kinetics and vaccine efficacy from phase 2 trials of the RTS,S malaria vaccine

(2014) Michael T White et al.   BMC Medicine

CD8+T Cells Eliminate Liver-Stage Plasmodium berghei Parasites without Detectable Bystander Effect

(2014) Ian A. Cockburn et al.   INFECTION AND IMMUNITY

Independent Emergence of Artemisinin Resistance Mutations Among Plasmodium falciparum in Southeast Asia

(2014) Shannon Takala-Harrison et al.   JOURNAL OF INFECTIOUS DISEASES

Cytotoxic Markers Associate With Protection Against Malaria in Human Volunteers Immunized WithPlasmodium falciparumSporozoites

(2014) Else M. Bijker et al.   JOURNAL OF INFECTIOUS DISEASES

Controlled Human Malaria Infection

(2014) M. Spring et al.   JOURNAL OF INFECTIOUS DISEASES

A Next-generation Genetically Attenuated Plasmodium falciparum Parasite Created by Triple Gene Deletion

(2014) Sebastian A Mikolajczak et al.   MOLECULAR THERAPY

Sporozoite Immunization of Human Volunteers under Mefloquine Prophylaxis Is Safe, Immunogenic and Protective: A Double-Blind Randomized Controlled Clinical Trial

(2014) Else M. Bijker et al.   PLoS One

Protection against malaria by immunization with non-attenuated sporozoites under single-dose piperaquine-tetraphosphate chemoprophylaxis

(2014) Johannes Pfeil et al.   VACCINE

Immunization with genetically attenuated P. falciparum parasites induces long-lived antibodies that efficiently block hepatocyte invasion by sporozoites

(2014) Olivia C. Finney et al.   VACCINE

A genetically attenuated malaria vaccine candidate based on P. falciparum b9/slarp gene-deficient sporozoites

(2014) Ben C L van Schaijk et al.   eLife

Tissue signatures influence the activation of intrahepatic CD8+ T cells against malaria sporozoites

(2014) Alexandre Morrot et al.   Frontiers in Microbiology

Antibody and B cell responses to Plasmodium sporozoites

(2014) Johanna N. Dups et al.   Frontiers in Microbiology

Evaluating controlled human malaria infection in Kenyan adults with varying degrees of prior exposure to Plasmodium falciparum using sporozoites administered by intramuscular injection

(2014) Susanne H. Hodgson et al.   Frontiers in Microbiology

A Microscale Human Liver Platform that Supports the Hepatic Stages of Plasmodium falciparum and vivax

(2013) Sandra March et al.   Cell Host & Microbe

Unique transcriptional profile of liver-resident memory CD8+ T cells induced by immunization with malaria sporozoites

(2013) S-W Tse et al.   GENES AND IMMUNITY

Short-Lived Effector CD8 T Cells Induced by Genetically Attenuated Malaria Parasite Vaccination Express CD11c

(2013) Laura A. Cooney et al.   INFECTION AND IMMUNITY

The Survival of Memory CD8 T Cells That Is Mediated by IL-15 Correlates with Sustained Protection Against Malaria

(2013) S. Zarling et al.   JOURNAL OF IMMUNOLOGY

Malaria vaccine technology roadmap

(2013) Vasee S Moorthy et al.   LANCET

A molecular marker of artemisinin-resistant Plasmodium falciparum malaria

(2013) Frédéric Ariey et al.   NATURE

Imaging mosquito transmission of Plasmodium sporozoites into the mammalian host: Immunological implications

(2013) Jerome P. Vanderberg   PARASITOLOGY INTERNATIONAL

DNA Prime/Adenovirus Boost Malaria Vaccine Encoding P. falciparum CSP and AMA1 Induces Sterile Protection Associated with Cell-Mediated Immunity

(2013) Ilin Chuang et al.   PLoS One

Optimising Controlled Human Malaria Infection Studies Using Cryopreserved P. falciparum Parasites Administered by Needle and Syringe

(2013) Susanne H. Sheehy et al.   PLoS One

In vivo CD8+ T Cell Dynamics in the Liver of Plasmodium yoelii Immunized and Infected Mice

(2013) Mynthia Cabrera et al.   PLoS One

Protection against malaria after immunization by chloroquine prophylaxis and sporozoites is mediated by preerythrocytic immunity

(2013) E. M. Bijker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A T-cell response to a liver-stage Plasmodium antigen is not boosted by repeated sporozoite immunizations

(2013) S. C. Murphy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vivo imaging of CD8+ T cell-mediated elimination of malaria liver stages

(2013) I. A. Cockburn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protection Against Malaria by Intravenous Immunization with a Nonreplicating Sporozoite Vaccine

(2013) R. A. Seder et al.   SCIENCE

Intermittent preventive treatment: efficacy and safety of sulfadoxine-pyrimethamine and sulfadoxine-pyrimethamine plus piperaquine regimens in schoolchildren of the Democratic Republic of Congo: a study protocol for a randomized controlled trial

(2013) Joachim Doua et al.   Trials

First-in-human evaluation of genetically attenuated Plasmodium falciparum sporozoites administered by bite of Anopheles mosquitoes to adult volunteers

(2013) Michele Spring et al.   VACCINE

Controlled Human Malaria Infections by Intradermal Injection of Cryopreserved Plasmodium falciparum Sporozoites

(2012) Meta Roestenberg et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Protective CD8+ T lymphocytes in Primates Immunized with Malaria Sporozoites

(2012) Walter R. Weiss et al.   PLoS One

Long Term Protection after Immunization with P. berghei Sporozoites Correlates with Sustained IFNγ Responses of Hepatic CD8+ Memory T Cells

(2012) Krystelle Nganou-Makamdop et al.   PLoS One

Visualizing Non Infectious and Infectious Anopheles gambiae Blood Feedings in Naive and Saliva-Immunized Mice

(2012) Valerie Choumet et al.   PLoS One

Whole parasite vaccination approaches for prevention of malaria infection

(2012) Noah S. Butler et al.   TRENDS IN IMMUNOLOGY

Memory CD8 T Cells Specific for Plasmodia Liver-Stage Antigens Maintain Protracted Protection Against Malaria

(2012) Urszula Krzych et al.   Frontiers in Immunology

Superior Antimalarial Immunity after Vaccination with Late Liver Stage-Arresting Genetically Attenuated Parasites

(2011) Noah S. Butler et al.   Cell Host & Microbe

Long-term protection against malaria after experimental sporozoite inoculation: an open-label follow-up study

(2011) Meta Roestenberg et al.   LANCET

Live Attenuated Malaria Vaccine Designed to Protect Through Hepatic CD8+ T Cell Immunity

(2011) J. E. Epstein et al.   SCIENCE

Longevity and Composition of Cellular Immune Responses Following Experimental Plasmodium falciparum Malaria Infection in Humans

(2011) Anne C. Teirlinck et al.   PLoS Pathogens

Genetically engineered, attenuated whole-cell vaccine approaches for malaria

(2010) Ashley Vaughan et al.   Human vaccines & immunotherapeutics

Development of a metabolically active, non-replicating sporozoite vaccine to preventPlasmodium falciparummalaria

(2010) Stephen L. Hoffman et al.   Human vaccines & immunotherapeutics

From the circumsporozoite protein to the RTS,S/AS candidate vaccine

(2010) Joe Cohen et al.   Human vaccines & immunotherapeutics

Natural Immunization Against Malaria: Causal Prophylaxis with Antibiotics

(2010) J. Friesen et al.   Science Translational Medicine

The RTS,S malaria vaccine

(2010) Sofia Casares et al.   VACCINE

Prolonged Antigen Presentation Is Required for Optimal CD8+ T Cell Responses against Malaria Liver Stage Parasites

(2010) Ian A. Cockburn et al.   PLoS Pathogens

A retrospective evaluation of the role of T cells in the development of malaria vaccine

(2009) Moriya Tsuji   EXPERIMENTAL PARASITOLOGY

Protection against a Malaria Challenge by Sporozoite Inoculation

(2009) Meta Roestenberg et al.   NEW ENGLAND JOURNAL OF MEDICINE

Immunization with Radiation-Attenuated Plasmodium berghei Sporozoites Induces Liver cCD8α+DC that Activate CD8+T Cells against Liver-Stage Malaria

(2009) Ousman Jobe et al.   PLoS One

Preerythrocytic, live-attenuated Plasmodium falciparum vaccine candidates by design

(2009) K. M. VanBuskirk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA