标题
DNA methyltransferase inhibitors: an updated patent review (2012-2015)
作者
关键词
-
出版物
EXPERT OPINION ON THERAPEUTIC PATENTS
Volume 26, Issue 9, Pages 1017-1030
出版商
Informa UK Limited
发表日期
2016-07-04
DOI
10.1080/13543776.2016.1209488
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Structural basis for recognition of histone H3K36me3 nucleosome by human de novo DNA methyltransferases 3A and 3B
- (2016) Grégoire Rondelet et al. JOURNAL OF STRUCTURAL BIOLOGY
- Take two: Combining immunotherapy with epigenetic drugs to tackle cancer
- (2016) Karen Weintraub NATURE MEDICINE
- A phase I, pharmacokinetic, and pharmacodynamic evaluation of the DNA methyltransferase inhibitor 5-fluoro-2′-deoxycytidine, administered with tetrahydrouridine
- (2015) Edward M. Newman et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Discovery and development of DNA methyltransferase inhibitors using in silico approaches
- (2015) José L. Medina-Franco et al. DRUG DISCOVERY TODAY
- Selective inhibition of esophageal cancer cells by combination of HDAC inhibitors and Azacytidine
- (2015) Theresa D Ahrens et al. Epigenetics
- An Epigenetic Regulator: Methyl-CpG-Binding Domain Protein 1 (MBD1)
- (2015) Lu Li et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Evaluation of noncytotoxic DNMT1-depleting therapy in patients with myelodysplastic syndromes
- (2015) Yogen Saunthararajah et al. JOURNAL OF CLINICAL INVESTIGATION
- DNA methylation pathways and their crosstalk with histone methylation
- (2015) Jiamu Du et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Molecular mechanism for USP7-mediated DNMT1 stabilization by acetylation
- (2015) Jingdong Cheng et al. Nature Communications
- siRNA Versus miRNA as Therapeutics for Gene Silencing
- (2015) Jenny K W Lam et al. Molecular Therapy-Nucleic Acids
- Immune regulation by low doses of the DNA methyltransferase inhibitor 5-azacitidine in common human epithelial cancers
- (2015) Huili Li et al. Oncotarget
- Treatment of resistant metastatic melanoma using sequential epigenetic therapy (decitabine and panobinostat) combined with chemotherapy (temozolomide)
- (2014) Chang Xia et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Novel DNA methyltransferase-1 (DNMT1) depleting anticancer nucleosides, 4′-thio-2′-deoxycytidine and 5-aza-4′-thio-2′-deoxycytidine
- (2014) Jaideep V. Thottassery et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Interaction Between DNA/histone Methyltransferases and their Inhibitors
- (2014) J. Hu et al. CURRENT MEDICINAL CHEMISTRY
- Targeting DNA Methylation with Small Molecules: What’s Next?
- (2014) Alexandre Erdmann et al. JOURNAL OF MEDICINAL CHEMISTRY
- Identifying Novel Selective Non-Nucleoside DNA Methyltransferase 1 Inhibitors through Docking-Based Virtual Screening
- (2014) Shijie Chen et al. JOURNAL OF MEDICINAL CHEMISTRY
- Repair of methyl lesions in RNA by oxidative demethylation
- (2014) Fei Ye et al. MedChemComm
- Impact of Epigenetic Dietary Compounds on Transgenerational Prevention of Human Diseases
- (2013) Yuanyuan Li et al. AAPS Journal
- Identification of Novel Inhibitors of DNA Methylation by Screening of a Chemical Library
- (2013) Alexandre Ceccaldi et al. ACS Chemical Biology
- Interplay between the Cancer Genome and Epigenome
- (2013) Hui Shen et al. CELL
- Targeting the JAK-STAT pathway in lymphoma: a focus on pacritinib
- (2013) Enrico Derenzini et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- A phase I/II study of decitabine in combination with panitumumab in patients with wild-type (wt) KRAS metastatic colorectal cancer
- (2013) I. Garrido-Laguna et al. INVESTIGATIONAL NEW DRUGS
- Identification of DNMT1 Selective Antagonists Using a Novel Scintillation Proximity Assay
- (2013) Jessica A. Kilgore et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Laccaic Acid A Is a Direct, DNA-competitive Inhibitor of DNA Methyltransferase 1
- (2013) Rebecca L. Fagan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Phase I study of azacitidine and bortezomib in adults with relapsed or refractory acute myeloid leukemia
- (2013) Alison R. Walker et al. LEUKEMIA & LYMPHOMA
- Development of a universal radioactive DNA methyltransferase inhibition test for high-throughput screening and mechanistic studies
- (2013) Christina Gros et al. NUCLEIC ACIDS RESEARCH
- Molecular Modeling Studies of the Novel Inhibitors of DNA Methyltransferases SGI-1027 and CBC12: Implications for the Mechanism of Inhibition of DNMTs
- (2013) Jakyung Yoo et al. PLoS One
- An Ultrasensitive High Throughput Screen for DNA Methyltransferase 1-Targeted Molecular Probes
- (2013) Rebecca L. Fagan et al. PLoS One
- DNA methylation inhibitors in cancer: Recent and future approaches
- (2012) Christina Gros et al. BIOCHIMIE
- Clinical and pharmacodynamic activity of bortezomib and decitabine in acute myeloid leukemia
- (2012) W. Blum et al. BLOOD
- DNA methyltransferase inhibitors in cancer: a chemical and therapeutic patent overview and selected clinical studies
- (2012) Jacques Fahy et al. EXPERT OPINION ON THERAPEUTIC PATENTS
- Structure-Based Mechanistic Insights into DNMT1-Mediated Maintenance DNA Methylation
- (2012) J. Song et al. SCIENCE
- Quantitative measurement of genome-wide DNA methylation by a reliable and cost-efficient enzyme-linked immunosorbent assay technique
- (2011) D. Kremer et al. ANALYTICAL BIOCHEMISTRY
- C5-DNA Methyltransferase Inhibitors: From Screening to Effects on Zebrafish Embryo Development
- (2011) Alexandre Ceccaldi et al. CHEMBIOCHEM
- The impact of epigenomics on future drug design and new therapies
- (2011) Christopher A. Hamm et al. DRUG DISCOVERY TODAY
- Safety, efficacy and biological predictors of response to sequential azacitidine and lenalidomide for elderly patients with acute myeloid leukemia
- (2011) D A Pollyea et al. LEUKEMIA
- MPP8 mediates the interactions between DNA methyltransferase Dnmt3a and H3K9 methyltransferase GLP/G9a
- (2011) Yanqi Chang et al. Nature Communications
- Combination Epigenetic Therapy Has Efficacy in Patients with Refractory Advanced Non-Small Cell Lung Cancer
- (2011) R. A. Juergens et al. Cancer Discovery
- Hydralazine and magnesium valproate as epigenetic treatment for myelodysplastic syndrome. Preliminary results of a phase-II trial
- (2010) Myrna Candelaria et al. ANNALS OF HEMATOLOGY
- Anticancer Properties of Indole Compounds: Mechanism of Apoptosis Induction and Role in Chemotherapy
- (2010) Aamir Ahmad et al. CURRENT DRUG TARGETS
- Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons
- (2010) Jian Feng et al. NATURE NEUROSCIENCE
- What Is Epigenetics?
- (2010) Guy Riddihough et al. SCIENCE
- Structure of DNMT1-DNA Complex Reveals a Role for Autoinhibition in Maintenance DNA Methylation
- (2010) J. Song et al. SCIENCE
- Will DNA methylation inhibitors work in solid tumors? A review of the clinical experience with azacitidine and decitabine in solid tumors
- (2010) Lisa A Cowan et al. Epigenomics
- Constrained (l-)-S-adenosyl-l-homocysteine (SAH) analogues as DNA methyltransferase inhibitors
- (2009) Ljubomir Isakovic et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- A New Class of Quinoline-Based DNA Hypomethylating Agents Reactivates Tumor Suppressor Genes by Blocking DNA Methyltransferase 1 Activity and Inducing Its Degradation
- (2009) J. Datta et al. CANCER RESEARCH
- Phase I Study of MG98, an Oligonucleotide Antisense Inhibitor of Human DNA Methyltransferase 1, Given as a 7-Day Infusion in Patients with Advanced Solid Tumors
- (2009) R. Plummer et al. CLINICAL CANCER RESEARCH
- Total Synthesis of Vinblastine, Vincristine, Related Natural Products, and Key Structural Analogues
- (2009) Hayato Ishikawa et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Substrate specificity of new methyl-directed DNA endonuclease GlaI
- (2008) Galina V Tarasova et al. BMC MOLECULAR BIOLOGY
- Modes of action of the DNA methyltransferase inhibitors azacytidine and decitabine
- (2008) Carlo Stresemann et al. INTERNATIONAL JOURNAL OF CANCER
- Lenalidomide in the treatment of multiple myeloma: a review
- (2008) X. Armoiry et al. JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
- Epigenetics in Cancer
- (2008) Manel Esteller NEW ENGLAND JOURNAL OF MEDICINE
- Targeting Epigenetic Mechanisms: Potential of Natural Products in Cancer Chemoprevention
- (2008) Alexander-Thomas Hauser et al. PLANTA MEDICA
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreDiscover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversation