DNA methyltransferase inhibitors in cancer: a chemical and therapeutic patent overview and selected clinical studies

Defining the Mechanism of Action and Enzymatic Selectivity of Psammaplin A against Its Epigenetic Targets

(2012) Matthias G. J. Baud et al.   JOURNAL OF MEDICINAL CHEMISTRY

Fluorocyclopentenyl-cytosine with Broad Spectrum and Potent Antitumor Activity

(2012) Won Jun Choi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Role of Human Nucleoside Transporters in the Uptake and Cytotoxicity of Azacitidine and Decitabine

(2012) Vijaya L. Damaraju et al.   NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS

Structure-Based Mechanistic Insights into DNMT1-Mediated Maintenance DNA Methylation

(2012) J. Song et al.   SCIENCE

The role of methyl-binding proteins in chromatin organization and epigenome maintenance

(2011) A. Fournier et al.   Briefings in Functional Genomics

Rapid Synthesis of New DNMT Inhibitors Derivatives of Procainamide

(2011) Ludovic Halby et al.   CHEMBIOCHEM

Combination Epigenetic Therapy Has Efficacy in Patients with Refractory Advanced Non-Small Cell Lung Cancer

(2011) R. A. Juergens et al.   Cancer Discovery

Structure and Function of Mammalian DNA Methyltransferases

(2010) Renata Zofia Jurkowska et al.   CHEMBIOCHEM

Delivery of 5-Azacytidine to Human Cancer Cells by Elaidic Acid Esterification Increases Therapeutic Drug Efficacy

(2010) B. Brueckner et al.   MOLECULAR CANCER THERAPEUTICS

S110, a 5-Aza-2'-Deoxycytidine-Containing Dinucleotide, Is an Effective DNA Methylation Inhibitor In vivo and Can Reduce Tumor Growth

(2010) J. C. Chuang et al.   MOLECULAR CANCER THERAPEUTICS

Comprehensive methylome map of lineage commitment from haematopoietic progenitors

(2010) Hong Ji et al.   NATURE

Chromatin structure and the inheritance of epigenetic information

(2010) Raphaël Margueron et al.   NATURE REVIEWS GENETICS

Disulfiram is a DNA demethylating agent and inhibits prostate cancer cell growth

(2010) Jianqing Lin et al.   PROSTATE

Structure of DNMT1-DNA Complex Reveals a Role for Autoinhibition in Maintenance DNA Methylation

(2010) J. Song et al.   SCIENCE

Molecular Signals of Epigenetic States

(2010) Roberto Bonasio et al.   SCIENCE

Epigenetic Reprogramming in Plant and Animal Development

(2010) Suhua Feng et al.   SCIENCE

Design, synthesis, inhibitory activity, and binding mode study of novel DNA methyltransferase 1 inhibitors

(2009) Takayoshi Suzuki et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A New Class of Quinoline-Based DNA Hypomethylating Agents Reactivates Tumor Suppressor Genes by Blocking DNA Methyltransferase 1 Activity and Inducing Its Degradation

(2009) J. Datta et al.   CANCER RESEARCH

Epigenetics in cancer

(2009) S. Sharma et al.   CARCINOGENESIS

Targeting DNA Methylation

(2009) J.-P. J. Issa et al.   CLINICAL CANCER RESEARCH

Phase I Study of MG98, an Oligonucleotide Antisense Inhibitor of Human DNA Methyltransferase 1, Given as a 7-Day Infusion in Patients with Advanced Solid Tumors

(2009) R. Plummer et al.   CLINICAL CANCER RESEARCH

An operational definition of epigenetics

(2009) S. L. Berger et al.   GENES & DEVELOPMENT

Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts

(2009) Akiko Doi et al.   NATURE GENETICS

The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores

(2009) Rafael A Irizarry et al.   NATURE GENETICS

Curcumin is a potent DNA hypomethylation agent

(2008) Zhongfa Liu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

2′-Deoxy-N4-[2-(4-nitrophenyl)ethoxycarbonyl]-5-azacytidine: A novel inhibitor of DNA methyltransferase that requires activation by human carboxylesterase 1

(2008) Hyang-Min Byun et al.   CANCER LETTERS

Epi-drugs to fight cancer: From chemistry to cancer treatment, the road ahead

(2008) Antonello Mai et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Epigenetics in Cancer

(2008) Manel Esteller   NEW ENGLAND JOURNAL OF MEDICINE