Oleanolic acid derivatives for pharmaceutical use: a patent review

Plurality of anxiety and depression alteration mechanism by oleanolic acid

(2014) James O Fajemiroye et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Sofosbuvir (Sovaldi) for the treatment of hepatitis C

(2014) Brian Lam et al.   Expert Review of Clinical Pharmacology

Inhibitory effect of oleanolic acid on hepatocellular carcinoma via ERK–p53-mediated cell cycle arrest and mitochondrial-dependent apoptosis

(2013) Xin Wang et al.   CARCINOGENESIS

The Identification of Nitric Oxide as Endothelium-Derived Relaxing Factor

(2013) Joseph Loscalzo   CIRCULATION RESEARCH

Oleanolic acid increases plasma ANP levels via an accentuation of cardiac ANP synthesis and secretion in rats

(2013) Hye Yoom Kim et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Inhibition of Telomerase Activity by Oleanane Triterpenoid CDDO-Me in Pancreatic Cancer Cells is ROS-Dependent

(2013) Dorrah Deeb et al.   MOLECULES

Bardoxolone Methyl in Type 2 Diabetes and Stage 4 Chronic Kidney Disease

(2013) Dick de Zeeuw et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inhibition of cell proliferation and induction of apoptosis by oleanane triterpenoid (CDDO-Me) in pancreatic cancer cells is associated with the suppression of hTERT gene expression and its telomerase activity

(2012) Dorrah Deeb et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A Phase I First-in-Human Trial of Bardoxolone Methyl in Patients with Advanced Solid Tumors and Lymphomas

(2012) D. S. Hong et al.   CLINICAL CANCER RESEARCH

Oleanolic acid arrests cell cycle and induces apoptosis via ROS-mediated mitochondrial depolarization and lysosomal membrane permeabilization in human pancreatic cancer cells

(2012) Jianteng Wei et al.   JOURNAL OF APPLIED TOXICOLOGY

Evaluation of in Vivo Antioxidant and Immunity Enhancing Activities of Sodium Aescinate Injection Liquid

(2012) Yong-Kun Wang et al.   MOLECULES

Oleanolic acid

(2012) Jacob Pollier et al.   PHYTOCHEMISTRY

Pachastrissamine fromPachastrissa sp. Inhibits Melanoma Cell Growth by Dual Inhibition of Cdk2 and ERK-mediated FOXO3 Downregulation

(2012) Hyun Yoo et al.   PHYTOTHERAPY RESEARCH

Insulin stimulation of SREBP-1c processing in transgenic rat hepatocytes requires p70 S6-kinase

(2012) J. L. Owen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nrf2 activation prevents cadmium-induced acute liver injury

(2012) Kai C. Wu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Inhibition of SREBP by a Small Molecule, Betulin, Improves Hyperlipidemia and Insulin Resistance and Reduces Atherosclerotic Plaques

(2011) Jing-Jie Tang et al.   Cell Metabolism

Regulation of LXR by fatty acids, insulin, growth hormone and tumor necrosis factor-α in rainbow trout myocytes

(2011) Lourdes Cruz-Garcia et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY

Antidiabetic activity of some pentacyclic acid triterpenoids, role of PTP–1B: In vitro, in silico, and in vivo approaches

(2011) Juan José Ramírez-Espinosa et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Oleanen Induces Apoptosis of Cervical Cancer Cells by Up-Regulation of Bim

(2011) Ningyue Gan et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

Quinoxaline derivative of oleanolic acid inhibits osteoclastic bone resorption and prevents ovariectomy-induced bone loss

(2011) Yu Zhao et al.   MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY

Oleanolic acid exerts an osteoprotective effect in ovariectomy-induced osteoporotic rats and stimulates the osteoblastic differentiation of bone mesenchymal stem cells in vitro

(2011) Qin Bian et al.   MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY

Synthesis, biology and clinical significance of pentacyclic triterpenes: a multi-target approach to prevention and treatment of metabolic and vascular diseases

(2011) Huaming Sheng et al.   NATURAL PRODUCT REPORTS

Cancer Chemoprevention Mechanisms Mediated Through the Keap1–Nrf2 Pathway

(2010) John D. Hayes et al.   ANTIOXIDANTS & REDOX SIGNALING

Oleanolic acid, a natural triterpenoid improves blood glucose tolerance in normal mice and ameliorates visceral obesity in mice fed a high-fat diet

(2010) Célio L. de Melo et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis

(2010) Shijie Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pharmacokinetics and Pharmacodynamics of LCZ696, a Novel Dual-Acting Angiotensin Receptor-Neprilysin Inhibitor (ARNi)

(2009) Jessie Gu et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Achyranthoside H methyl ester, a novel oleanolic acid saponin derivative from Achyranthes fauriei roots, induces apoptosis in human breast cancer MCF-7 and MDA-MB-453 cells via a caspase activation pathway

(2009) Motonori Fukumura et al.   Journal of Natural Medicines

Antidiabetic and antioxidant effects of oleanolic acid fromLigustrum lucidumAit in alloxan-induced diabetic rats

(2009) Dawei Gao et al.   PHYTOTHERAPY RESEARCH

Oleanolic acid derivative NPLC441 potently stimulates glucose transport in 3T3-L1 adipocytes via a multi-target mechanism

(2008) Zhonghui Lin et al.   BIOCHEMICAL PHARMACOLOGY

New insights into generalized hepatoprotective effects of oleanolic acid: Key roles of metallothionein and Nrf2 induction

(2008) Jie Liu et al.   BIOCHEMICAL PHARMACOLOGY

Apoptotic Activity and Mechanism of 2-Cyano-3,12-Dioxoolean-1,9-Dien-28-Oic-Acid and Related Synthetic Triterpenoids in Prostate Cancer

(2008) M. L. Hyer et al.   CANCER RESEARCH

Naturally Occurring Pentacyclic Triterpenes as Inhibitors of Glycogen Phosphorylase: Synthesis, Structure−Activity Relationships, and X-ray Crystallographic Studies†

(2008) Xiaoan Wen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Chemoprevention of Colon Carcinogenesis by Oleanolic Acid and Its Analog in Male F344 Rats and Modulation of COX-2 and Apoptosis in Human Colon HT-29 Cancer Cells

(2008) Naveena B. Janakiram et al.   PHARMACEUTICAL RESEARCH

Ursolic Acid and Oleanolic Acid Suppress Preneoplastic Lesions Induced by 1,2-Dimethylhydrazine in Rat Colon

(2008) Ricardo A. Furtado et al.   TOXICOLOGIC PATHOLOGY