Article
Agriculture, Multidisciplinary
Chenyu Xue, Hao Lv, Ying Li, Na Dong, Yanhui Wang, Jiale Zhou, Baoming Shi, Anshan Shan
Summary: This study investigated the effects of oleanolic acid on gut health, including gut microbiota and intestinal epithelial immunity, using Illumina MiSeq sequencing and Illumina HiSeq (RNA-seq) technology. The results showed that oleanolic acid can improve intestinal health by optimizing gut microbiota and altering the immune function of intestinal epithelial cells.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2022)
Review
Biochemistry & Molecular Biology
Mostafa H. Baky, Mostafa B. Elsaid, Mohamed A. Farag
Summary: This review focuses on the phytochemical and biological diversity of triterpenoid saponins in the Sapotaceae family. It highlights the rich content of protobassic acid, 16-alpha-hydroxyprotobassic acid, bayogenin, and oleanolic acid derivatives in Sapotaceae plants. These saponins have been found to exhibit various pharmacological effects and health benefits, including anti-inflammatory, antiulcer, antimicrobial, cytotoxic, anti-hypercholesterolemic, antioxidant, and immunomodulatory activities. The review aims to provide a comprehensive compilation of research on triterpenoid saponins from the Sapotaceae family and suggest future research perspectives.
Article
Chemistry, Applied
FanCheng Meng, XiaoDong Wei, Yan Sun, QingHong Zeng, Guowei Wang, XiaoZhong Lan, ZhiHua Liao, Min Chen
Summary: Two new cycloartane glycosides and a new oleanolic acid glycoside were isolated from Thalictrum atriplex and their structures were determined through extensive NMR and HR-ESI-MS analyses. One of the compounds exhibited cytotoxicity against human breast cancer cells MDA-MB-231.
NATURAL PRODUCT RESEARCH
(2021)
Article
Plant Sciences
Jianming Liu, Jiawei Liu, Chao Meng, Qi Gu, Chao Huang, Fanglan Liu, Chunhua Xia
Summary: This study found that the effect of oleanolic acid (OA) on cholestatic liver injury is closely related to the simultaneous activation of NRF2 and FXR dual signaling pathways, in which the NRF2 signaling pathway plays a more important role. The dual signaling pathways cooperatively regulate bile acid metabolic homeostasis through the interaction mechanism with β-catenin/P300.
Article
Food Science & Technology
Francesco Errichiello, Maria 'Amato, Angelita Gambuti, Luigi Moio, Arianna Pastore, Hekmat AL-Hmadi, Mariano Stornaiuolo, Elena Serino, Orazio Taglialatela-Scafati, Martino Forino
Summary: Grape pomace, a component of winery waste, contains various healthy compounds with bioactivities. In addition to polyphenols, an in-depth chemical analysis of Aglianico grape pomace revealed a remarkable concentration of oleanolic acid, a natural triterpenoid with multiple bioactivities. The study also assessed the influence of oleanolic acid on mitochondrial and glucose uptake activities, supporting its potential as an antidiabetic metabolite.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Biochemistry & Molecular Biology
Maria Narozna, Violetta Krajka-Kuzniak, Barbara Bednarczyk-Cwynar, Wanda Baer-Dubowska
Summary: Novel conjugates of Ibuprofen and Ketoprofen with oleanolic acid oximes derivatives were synthesized and their activity in modulating signaling pathways in liver cancer was evaluated. The results showed that the conjugates reduced cytotoxicity and activated different signaling pathways in normal and cancerous liver cells. These conjugates may be potential candidates for liver cancer prevention.
Article
Biochemistry & Molecular Biology
Shouping Wang, Kun Cao, Yuting Liao, Wei Zhang, Jihua Zheng, Xiaocui Li, Mengting Huang, Yonghao Zhong, Xiao Hu, De Chen, Yanjie Wang
Summary: CDCA2 is identified as a prognostic biomarker for HCC patients, with its amplification closely associated with HCC patient recurrence and survival. CDCA2 promotes HCC cell growth and inhibits apoptosis, while protecting HCC cells against oxidative damage through the BRCA1-NRF2 cascade.
Article
Biochemistry & Molecular Biology
Pengfei Fan, Huali Meng, Wenhao Hao, Yan Zheng, Hui Li, Zhiyue Zhang, Lei Du, Xin Guo, Dongliang Wang, Yunyan Wang, Hao Wu
Summary: This study found that cardamonin has significant effects on atherosclerosis, which can prevent its formation, reduce necrotic areas, and inhibit inflammation and oxidative stress. Additionally, cardamonin can also suppress inflammation and oxidative stress in endothelial cells. Cardamonin activates the NRF2/HO1 signaling pathway, independent of the aryl hydrocarbon receptor.
Article
Cell Biology
Yingying Lu, Lingling An, Matthew R. G. Taylor, Qin M. Chen
Summary: Increased Nrf2 gene expression in failing hearts of patients with heart failure is not accompanied by corresponding increases in antioxidant and detoxification genes, indicating impaired Nrf2 signaling. Decreased expression of multiple antioxidant and detoxification genes is consistent with elevated oxidative stress in failing hearts.
PHYSIOLOGICAL GENOMICS
(2022)
Article
Chemistry, Medicinal
Maria Narozna, Violetta Krajka-Kuzniak, Barbara Bednarczyk-Cwynar, Robert Kleszcz, Wanda Baer-Dubowska
Summary: The synthesis of OAO-IND conjugates showed potential in downregulating Nrf2 and NF-kappaB activation in HepG2 hepatoma cells and increasing Nrf2 activation in normal hepatocytes. Different effects were observed in THLE-2 cells compared to HepG2 cells after treatment with these compounds.
Article
Medicine, Research & Experimental
Xianming Chen, Yulin Zhang, Sen Zhang, Aiming Wang, Quanyin Du, Ziming Wang
Summary: Oleanolic acid inhibits osteosarcoma cell proliferation, migration, and invasion, and reduces cell viability by modulating the SOX9/Wnt1 signaling pathway.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Medicine, Research & Experimental
Chang Hyeon Kong, Kyungnam Cho, Ji Won Min, Jae Youn Kim, Keontae Park, Do Yeon Kim, Mijin Jeon, Woo Chang Kang, Seo Yun Jung, Jae Yeol Lee, Jong Hoon Ryu
Summary: This study aimed to investigate whether oleanolic acid (OA) could ameliorate extrapyramidal symptoms (EPS) or cognitive impairment induced by haloperidol. The results showed that OA significantly attenuated EPS and cognitive impairment induced by haloperidol without affecting its antipsychotic properties.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Pharmacology & Pharmacy
Songjie Liao, Xiaolong Fu, Jianxiang Huang, Yi Wang, Yuanfu Lu, Shaoyu Zhou
Summary: Oleanolic acid (OA) causes hepatotoxicity by suppressing the expression of FXR signaling pathway, leading to bile acid imbalance. Activation of SIRT1/FXR pathway can alleviate the hepatotoxicity.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2023)
Article
Genetics & Heredity
Prajitha Mohandas Edathara, Shivakanth Chintalapally, Venkata Krishna Kanth Makani, Chitrakshi Pant, Suresh Yerramsetty, Manohar D. Rao, Manika Pal Bhadra
Summary: Cervical cancer burden is increasing in low and middle-income groups, emphasizing the importance of early screening and diagnosis for prevention. Plant-derived compounds like oleanolic acid and esculetin show promise as therapeutic agents for cancer treatment. Studies demonstrate their potential effects on inhibiting proliferation, reducing migration, and affecting gene expression in cervical carcinoma cells, highlighting their therapeutic potential.
Article
Biochemistry & Molecular Biology
Jiang Xiaofei, Shi Mingqing, Sui Miao, Yuan Yizhen, Zhang Shuang, Xia Qinhua, Zhao Kai
Summary: OA activates ferroptosis in Hela cells by promoting ACSL4 expression, reducing cell survival rate, which may be a potential approach for the treatment of cervical cancer.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Toxicology
Chengjie Chen, Xue Han, Gang Wang, Dan Liu, Lina Bao, Congcong Jiao, Junjun Luan, Yongyong Hou, Yuanyuan Xu, Huihui Wang, Qiang Zhang, Hua Zhou, Jingqi Fu, Jingbo Pi
Summary: Nrf2 gene plays an important role in kidney injury induced by subacute cadmium exposure, with Nrf2-deficient mice showing increased sensitivity to kidney damage due to a weakened antioxidant response and likely decreased production of specific Cd detoxification metallothioneins.
ARCHIVES OF TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zhendi Wang, Yongyong Hou, Suping Ren, Zhiyuan Liu, Zhuo Zuo, Sicui Huang, Wanqi Wang, Huihui Wang, Yanyan Chen, Yuanyuan Xu, Masayuki Yamamoto, Qiang Zhang, Jingqi Fu, Jingbo Pi
Summary: NFE2L1 plays a crucial role in regulating adipose inflammation and metabolism, impacting fat cell hypertrophy and macrophage infiltration. Knockout of Nfe2l1 leads to reduced lipolytic gene expression, while treatment with CL316243 can alleviate adipose inflammation and related gene expression.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Environmental Sciences
Yihui Ruan, Xin Fang, Tingyue Guo, Yiting Liu, Yu Hu, Xuening Wang, Yuxin Hu, Lanyue Gao, Yongfang Li, Jingbo Pi, Yuanyuan Xu
Summary: Chronic exposure to arsenic is associated with various cancers, with metabolic reprogramming being a key mechanism. Research has primarily focused on glucose reprogramming induced by arsenic exposure. Apart from enhanced glycolysis, arsenic may also disrupt lipid deposition and induce one-carbon metabolism pathway.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Correction
Biochemistry & Molecular Biology
Lijuan Zhan, Hao Zhang, Qiang Zhang, Courtney G. Woods, Yanyan Chen, Peng Xue, Jian Dong, Erik J. Tokar, Yuanyuan Xu, Yongyong Hou, Jingqi Fu, Kathy Yarborough, Aiping Wang, Weidong Qu, Michael P. Waalkes, Melvin E. Andersen, Jingbo Pi
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Correction
Pharmacology & Pharmacy
Zhiyuan Liu, Yongyong Hou, Lu Li, Yang Yang, Jingkun Jia, Zhixuan Hong, Tingfeng Li, Yuanyuan Xu, Jingqi Fu, Yongxin Sun, Masayuki Yamamoto, Huihui Wang, Jingbo Pi
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Article
Physiology
Yan Wu, Junjun Luan, Congcong Jiao, Shiwen Zhang, Cong Ma, Yixiao Zhang, Jingqi Fu, En Yin Lai, Jeffrey B. Kopp, Jingbo Pi, Hua Zhou
Summary: This study aimed to investigate the involvement of circHIPK3 in the pathogenesis of renal fibrosis. The results showed that circHIPK3 promoted renal fibrosis by sponging miR-30a and a feed-forward cycle existed among circHIPK3, miR-30a, and TGF-beta 1. This study provides important evidence for the identification of a novel therapeutic target for slowing the progression of chronic kidney disease.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Toxicology
Chenlu Fan, Zaihong Zhan, Xin Zhang, Qun Lou, Ning Guo, Mengyao Su, Yue Gao, Ming Qin, Liaowei Wu, Wei Huang, Meichen Zhang, Fanshuo Yin, Yanhui Wu, Jingbo Pi, Yuanyuan Xu, Yanmei Yang, Yanhui Gao
Summary: Type 2 diabetes mellitus (T2DM) is a major global public health problem. This study found that low-to-moderate level arsenic exposure may be a risk factor for T2DM, while the KEAP1 rs11545829 SNP mutation homozygote AA genotype may be protective against the risk of T2DM.
ARCHIVES OF TOXICOLOGY
(2022)
Article
Environmental Sciences
Yongfang Li, Ru Sun, Xin Fang, Yihui Ruan, Yuxin Hu, Kemu Wang, Jiao Liu, Huihui Wang, Jingbo Pi, Yanyan Chen, Yuanyuan Xu
Summary: This study demonstrates that chronic arsenic exposure induces EMT and malignant transformation in human bronchial epithelial cells. The long isoforms of NFE2L1 (NFE2L1-L) are upregulated during the process of malignant transformation. Silencing of NFE2L1-L gene inhibits EMT and malignant transformation induced by arsenic by regulating SNAIL1 transcription.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Correction
Food Science & Technology
Suping Ren, Yongyong Hou, Zhuo Zuo, Zhiyuan Liu, Huihui Wang, Yuanyuan Xu, Masayuki Yamamoto, Qiang Zhang, Jingqi Fu, Jingbo Pi
FOOD AND CHEMICAL TOXICOLOGY
(2022)
News Item
Oncology
Margaret R. Karagas, Amy Wang, David C. Dorman, Amy L. Hall, Jingbo Pi, Consolato M. Sergi, Elaine Symanski, Elizabeth M. Ward, Victoria H. Arrandale, Kenichi Azuma, Eduardo Brambila, Gloria M. Calaf, Jason M. Fritz, Shoji Fukushima, Joanna M. Gaitens, Tom K. Grimsrud, Lei Guo, Elsebeth Lynge, Amelia P. Marinho-Reis, Melissa A. McDiarmid, Daniel R. S. Middleton, Thomas P. Ong, David A. Polya, Betzabet Quintanilla-Vega, Georgia K. Roberts, Tiina Santonen, Riitta Sauni, Maria J. Silva, Pascal Wild, Changwen W. Zhang, Qunwei Zhang, Yann Grosse, Lamia Benbrahim-Tallaa, Aline de Conti, Nathan L. DeBono, Fatiha El Ghissassi, Federica Madia, Bradley Reisfeld, Leslie T. Stayner, Eero Suonio, Susana Viegas, Roland Wedekind, Shukrullah Ahmadi, Heidi Mattock, William M. Gwinn, Mary K. Schubauer-Berigan
Article
Biochemistry & Molecular Biology
Qiushuo Jin, Chunyang Yao, Yiying Bian, Jingbo Pi
Summary: Lead exposure can lead to procoagulant activity in erythroid cells, resulting in thrombosis before hemolysis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Xiangnan Hao, Junjun Luan, Congcong Jiao, Cong Ma, Zixuan Feng, Lingzi Zhu, Yixiao Zhang, Jingqi Fu, Enyin Lai, Beiru Zhang, Yanqiu Wang, Jeffrey B. Kopp, Jingbo Pi, Hua Zhou
Summary: Renal interstitial fibrosis (RIF) is a common pathological feature in chronic kidney injury, and there is currently no effective therapy for it. This study showed that locked nuclear acid (LNA)-anti-miR-150 can alleviate RIF in folic acid-induced RIF mice by regulating the SOCS1/JAK1/STAT1 pathway and reducing pro-inflammatory M1 and M2 macrophage polarization.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Environmental Sciences
Ruirui Wu, Xin Chen, Hengchao Wu, Yuxin Hu, Gang Wang, Huihui Wang, Bei Yang, Jingqi Fu, Yanhui Gao, Jingbo Pi, Yuanyuan Xu
Summary: Our study reveals that developmental arsenic exposure enhances DEN-induced hepatic tumorigenesis through Nrf2 activation, which may be related to the role of Nrf2 in DEN metabolic activation.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Review
Biochemistry & Molecular Biology
Zihang Liu, Panpan Deng, Shengnan Liu, Yiying Bian, Yuanyuan Xu, Qiang Zhang, Huihui Wang, Jingbo Pi
Summary: Cytokine storm refers to a state of the immune system characterized by excessive release of cytokines, leading to inflammation, organ failure, and disease outcomes. NRF2, a transcription factor involved in cellular redox homeostasis, has emerged as a potential therapeutic target in preventing and treating cytokine storms. This review summarizes the causes of cytokine storms and the rationale for targeting NRF2 as a therapeutic intervention.
Article
Ophthalmology
Yida Jiang, Li-Juan Duan, Jingbo Pi, Yun-Zheng Le, Guo-Hua Fong
Summary: The NRF2-HO1 axis protects TJ integrity and RPE barrier functions by driving heme degradation. Oxidant exposure and NRF2 deficiency compromise TJ structures and RPE barrier functions, but can be rescued by HO1 inducer. In contrast, treatment with HO1 inhibitor or heme precursor is destructive to TJ structures and RPE barrier properties.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Paola Orlandi, Marta Banchi, Francesca Vaglini, Marco Carli, Stefano Aringhieri, Arianna Bandini, Carla Pardini, Cristina Viaggi, Michele Lai, Greta Ali, Alessandra Ottani, Eleonora Vandini, Patrizia Guidi, Margherita Bernardeschi, Veronica La Rocca, Giulio Francia, Gabriella Fontanini, Mauro Pistello, Giada Frenzilli, Daniela Giuliani, Marco Scarselli, Guido Bocci
Summary: This study investigates the role of MC4R in melanoma and the use of the selective antagonist ML in combination with vemurafenib. The results show that ML can inhibit melanoma cell proliferation and induce apoptosis through the inhibition of ERK1/2 phosphorylation and reduction of BCL-XL expression. The combination of vemurafenib and ML exhibits a synergistic effect in vitro and inhibits tumor growth in vivo without causing adverse effects.
BIOCHEMICAL PHARMACOLOGY
(2024)
Article
Pharmacology & Pharmacy
Conor J. Bloxham, Katina D. Hulme, Fabrizio Fierro, Christian Fercher, Cassandra L. Pegg, Shannon L. O'Brien, Simon R. Foster, Kirsty R. Short, Sebastian G. B. Furness, Melissa E. Reichelt, Masha Y. Niv, Walter G. Thomas
Summary: Bitter taste receptors (T2Rs) are a type of G protein-coupled receptors that allow humans to detect aversive and toxic substances. This study characterized the functional properties of previously identified T2Rs in human cardiac tissues and their naturally occurring polymorphisms. The results showed differences in signaling among different T2R variants, and revealed a potential association between the T2R50 Tyr203 variant and cardiovascular disease.
BIOCHEMICAL PHARMACOLOGY
(2024)
Article
Pharmacology & Pharmacy
Lu Chen, Huanying Shi, Wenxin Zhang, Yongjun Zhu, Haifei Chen, Zimei Wu, Huijie Qi, Jiafeng Liu, Mingkang Zhong, Xiaojin Shi, Tianxiao Wang, Qunyi Li
Summary: This study demonstrates that Carfilzomib exhibits potent anti-tumor activity against esophageal squamous cell carcinoma (ESCC) by triggering mitochondrial apoptosis and reprogramming cellular metabolism. It has been identified that activating transcription factor 3 (ATF3) plays a crucial role as a cellular target in ESCC cells treated with Carfilzomib. Overexpression of ATF3 effectively counteracts the effects of Carfilzomib on ESCC cell proliferation, apoptosis, and metabolic reprogramming. Furthermore, ATF3 mediates the anti-tumor activity of Carfilzomib, suggesting its potential as a therapeutic agent for ESCC.
BIOCHEMICAL PHARMACOLOGY
(2024)
Review
Pharmacology & Pharmacy
Xing Zhang, Xiang Li, Ran Xia, Hong-Sheng Zhang
Summary: This review summarizes recent progress on the mechanisms of ferroptosis resistance in cancer and highlights the role of redox status and metabolism. Combination therapy for ferroptosis has great potential in treating resistant malignant tumors.
BIOCHEMICAL PHARMACOLOGY
(2024)