Trim21-mediated HIF-1α degradation attenuates aerobic glycolysis to inhibit renal cancer tumorigenesis and metastasis

Stabilization of FASN by ACAT1-mediated GNPAT acetylation promotes lipid metabolism and hepatocarcinogenesis

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The nuclear translocation of transketolase inhibits the farnesoid receptor expression by promoting the binding of HDAC3 to FXR promoter in hepatocellular carcinoma cell lines

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Methylation of EZH2 by PRMT1 regulates its stability and promotes breast cancer metastasis

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The Metabolic Basis of Kidney Cancer

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PTBP3 contributes to colorectal cancer growth and metastasis via translational activation of HIF-1α

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TRIM 21‐mediated proteasomal degradation of SAMHD 1 regulates its antiviral activity

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TRIM21 controls Toll‐like receptor 2 responses in bone‐marrow‐derived macrophages

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KIF4A facilitates cell proliferation via induction of p21-mediated cell cycle progression and promotes metastasis in colorectal cancer

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Metabolic Maturation of Human Pluripotent Stem Cell-Derived Cardiomyocytes by Inhibition of HIF1α and LDHA

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TRIM21 mediates ubiquitination of Snail and modulates epithelial to mesenchymal transition in breast cancer cells

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Metabolic reprogramming ensures cancer cell survival despite oncogenic signaling blockade

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XIAP upregulates expression of HIF target genes by targeting HIF1α for Lys63-linked polyubiquitination

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Parkin targets HIF-1α for ubiquitination and degradation to inhibit breast tumor progression

(2017) Juan Liu et al.   Nature Communications

Energy stress-induced lncRNA FILNC1 represses c-Myc-mediated energy metabolism and inhibits renal tumor development

(2017) Zhen-Dong Xiao et al.   Nature Communications

PKCα–GSK3β–NF-κB signaling pathway and the possible involvement of TRIM21 in TRAIL-induced apoptosis

(2016) Xuejuan Gao et al.   Biochemistry and Cell Biology

Immunoregulatory Protein B7-H3 Reprograms Glucose Metabolism in Cancer Cells by ROS-Mediated Stabilization of HIF1α

(2016) Sangbin Lim et al.   CANCER RESEARCH

The degradation of EZH2 mediated by lncRNA ANCR attenuated the invasion and metastasis of breast cancer

(2016) Zhongwei Li et al.   CELL DEATH AND DIFFERENTIATION

Regulation of ATP13A2 via PHD2-HIF1  Signaling Is Critical for Cellular Iron Homeostasis: Implications for Parkinson's Disease

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The Nephrologists Tumor: Basic Biology and Management of Renal Cell Carcinoma

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Hypoxic control of metastasis

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Reduced expression of TRIM21/Ro52 predicts poor prognosis in diffuse large B-cell lymphoma patients with and without rheumatic disease

(2015) S. Brauner et al.   JOURNAL OF INTERNAL MEDICINE

Metabolic pathways promoting cancer cell survival and growth

(2015) Lindsey K. Boroughs et al.   NATURE CELL BIOLOGY

Downregulation of TRIM21 contributes to hepatocellular carcinoma carcinogenesis and indicates poor prognosis of cancers

(2015) Qianshan Ding et al.   TUMOR BIOLOGY

Hypertension and Obesity and the Risk of Kidney Cancer in 2 Large Cohorts of US Men and Women

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Fructose-1,6-bisphosphatase opposes renal carcinoma progression

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Overall Survival in Renal-Cell Carcinoma with Pazopanib versus Sunitinib

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LincRNA-ROR induces epithelial-to-mesenchymal transition and contributes to breast cancer tumorigenesis and metastasis

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HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations

(2013) Gregg L. Semenza   JOURNAL OF CLINICAL INVESTIGATION

Treatment selection in metastatic renal cell carcinoma: expert consensus

(2012) Bernard Escudier et al.   Nature Reviews Clinical Oncology

SS-A/Ro52 promotes apoptosis by regulating Bcl-2 production

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(2009) Mark Hochstrasser   NATURE

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Regulation of gene expression by hypoxia

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The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

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