Article
Biochemistry & Molecular Biology
Isis Salviano Soares de Amorim, Juliana Alves Rodrigues, Pedro Nicolau, Sandra Konig, Carolina Panis, Adenilson de Souza da Fonseca, Andre Luiz Mencalha
Summary: This study investigated the molecular effects of DNA methyltransferase inhibitor in response to treatment in normoxia and hypoxia in breast cancer model. It was found that the inhibitor upregulated proinflammatory pathways, with a greater effect observed in normoxia than hypoxia. Specifically, NF-kappa B expression increased only in normoxia after treatment with the inhibitor, suggesting a potential context-dependent impact on inflammatory response in the tumor microenvironment.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Agronomy
Shuo Liu, Yu Bao, Hui Deng, Guanqing Liu, Yangshuo Han, Yuechao Wu, Tao Zhang, Chen Chen
Summary: DNA methylation is a crucial epigenetic modification that regulates gene expression and genome stability. The methylation inhibitor, AzaD, can effectively reduce genome-wide hypomethylation and cause a series of epigenetic variations.
Article
Oncology
Yang-Jie Zhang, Ran Xie, Jie Jiang, Li Zhai, Cong-Hui Yang, Jing Zhang, Xi Wang, Dong-Xue Chen, Hua-Tao Niu, Long Chen
Summary: The study demonstrates the methylation modification of GAS5 in melanoma and the reversible effect of 5-Aza-dC on this modification. Treatment with 5-Aza-dC inhibits cell proliferation, increases apoptosis, and reduces migration and invasion in melanoma cells. The antitumor effect of 5-Aza-dC in melanoma is related to the methylation modification of GAS5.
Article
Biochemistry & Molecular Biology
Karolina Luczkowska, Piotr Kulig, Klaudia Rusinska, Bartlomiej Baumert, Boguslaw Machalinski
Summary: This study investigates the effects of a methylation inhibitor on the proliferation of multiple myeloma cells and the development of resistance to treatment, finding that alterations in DNA methylation are associated with drug resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Qinghua Wu, Li You, Eugenie Nepovimova, Zbynek Heger, Wenda Wu, Kamil Kuca, Vojtech Adam
Summary: Hypoxia in the tumor microenvironment weakens cytotoxic T cell function and promotes recruitment of regulatory T cells, thereby reducing tumor immunogenicity. Hypoxia-inducible factors (HIFs), especially HIF1A and HIF2A, play important roles in tumor immune escape through various mechanisms. Understanding these mechanisms can lead to the development of targeted therapies for tumor treatment.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2022)
Review
Cell Biology
Shivalika Khanduja, Jiah Kim, Jin Kook Kang, Cheng-Yuan Feng, Melissa Ann Vogelsong, Romergryko G. Geocadin, Glenn Whitman, Sung-Min Cho
Summary: Extracorporeal membrane oxygenation (ECMO) carries a significant risk of hypoxic-ischemic brain injury (HIBI), which is one of the most common types of acute brain injury in ECMO patients. Various risk factors have been associated with the development of HIBI in ECMO patients, and the pathogenic mechanisms are complex and multifactorial. Current therapeutics focus on targeting pathological mechanisms and optimizing cerebral oxygenation and perfusion to improve neurological outcomes in ECMO patients and minimize the morbidity of HIBI.
Article
Cell Biology
Jianhui Deng, Yanling Liao, Jianghu Chen, Andi Chen, Shuyan Wu, Yongxin Huang, Haitao Qian, Fei Gao, Guixi Wu, Yisheng Chen, Xiaohui Chen, Xiaochun Zheng
Summary: Hypoxic-ischemic brain damage (HIBD) can have deadly consequences for neonates or leave them with permanent neurological disabilities. This study found that HIBD increases m6A methylation of RNA in the brain and identified FTO demethylase as a key player in this abnormal modification. Additionally, transcripts with m6A modifications were found to be more highly expressed overall and overexpression of FTO led to hyperactivation of the Akt/mTOR pathway and inhibition of autophagy. Furthermore, overexpression of FTO in the hippocampus effectively reversed synaptic and neurocognitive disorders caused by HIBD.
CELL DEATH & DISEASE
(2023)
Article
Neurosciences
Shan Zhang, Wendong Li, Yiran Xu, Tao Li, Joakim Ek, Xiaoli Zhang, Yafeng Wang, Juan Song, Changlian Zhu, Xiaoyang Wang
Summary: The study found that alpha1-antitrypsin (AAT) has neuroprotective effects in preterm brain injury, reducing blood-brain barrier permeability, neuronal cell death, microglia activation, and improving motor function deficiencies. This effect is more pronounced in male mice.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Kazuki Hatayama, Sydney Riddick, Fares Awa, Xiaodi Chen, Daniela Virgintino, Barbara S. Stonestreet
Summary: Exposure to hypoxic-ischemic insults in newborns can lead to severe neurological sequelae. This study investigated the changes in the neurovascular unit (NVU) after hypoxic-ischemic injury in neonatal rats. The findings showed increased vascular density, neurovascular remodeling, and changes in pericyte coverage and claudin-5 expression in different brain regions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Gerhard P. Aigner, Pamela Nenning, Birgit Fiechtner, Maja Srut, Martina Hoeckner
Summary: This study found that the demethylating agent Aza inhibits gene activity while Cd induces MT2 gene expression, but neither has an effect on global DNA methylation levels. Thus, Cd detoxification based on MT2 induction is not related to changes in DNA methylation.
Article
Neurosciences
Han Qiu, Tianyang Qian, Tong Wu, Ting Gao, Qinghe Xing, Laishuan Wang
Summary: This study identified the pattern of p-Src expression after HI brain injury in immature rats and demonstrated its relationship with activated NMDA receptors. Inhibiting p-Src can ameliorate neuropathological changes and damage to neurological functions induced by HI injury.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Nanoscience & Nanotechnology
Wen-Sheng Tzeng, Wei-Lin Teng, Pao-Hsien Huang, Tzu-Ching Lin, Feng-Lin Yen, Yow-Ling Shiue
Summary: The study demonstrated that the prepared PTS nanoparticles (PSN) showed better antihepatoma activities in HepG2 cells, especially under hypoxic conditions, and effectively improved the water solubility and drug release of PTS.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Review
Cell Biology
Elena V. Mitroshina, Maria O. Savyuk, Evgeni Ponimaskin, Maria V. Vedunova
Summary: Hypoxia is a common pathological condition induced by various events, with the body's adaptation to it being crucial for health and disease. HIFs, a family of transcription factors, play a key role in cellular responses to hypoxia and are increasingly viewed as potential targets for treating a range of hypoxia-associated diseases. The role of HIFs in adaptation to hypoxia is universal across tissue types, including the CNS, where they are involved in regulating neurogenesis, nerve cell differentiation, and neuronal apoptosis, potentially offering new therapeutic opportunities.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Jose Martinez-Orgado, Maria Villa, Aaron del Pozo
Summary: CBD shows neuroprotective effects in newborn pigs and rodents with HIBI, modulating the major components of HIBI pathophysiology. It has the potential to be an effective treatment for neonatal HIBI.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Obstetrics & Gynecology
Christopher A. Lear, Jenny A. Westgate, Laura Bennet, Austin Ugwumadu, Peter R. Stone, Alexane Tournier, Alistair J. Gunn
Summary: During labor, uterine contractions and fetal engagement can compress the fetal head, but the impact on the fetus remains uncertain and controversial. This review highlights the rarity of fetal head compression associated with decelerations, and the ability of the fetus to adapt to increased intracranial pressure through the intracranial baroreflex. Fetal head compression does not seem to be a common cause of intrapartum decelerations, but may work synergistically with the peripheral chemoreflex to promote fetal adaptation to labor.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Rui Song, Xiang-Qun Hu, Monica Romero, Mark A. Holguin, Whitney Kagabo, Daliao Xiao, Sean M. Wilson, Lubo Zhang
Summary: Pregnancy increases the association of BKCa channel subunits and alters the localization of RyR subtypes in uterine arteries. Knockdown of RyR1 or RyR2 decreases Ca2+ sparks and STOCs frequency, increases myogenic tone, while RyR3 knockdown has no significant effect. This study provides new insights into the mechanisms of uterine vascular adaptation to pregnancy through RyR subtypes.
CARDIOVASCULAR RESEARCH
(2021)
Article
Immunology
Qingyi Ma, Chiranjib Dasgupta, Guofang Shen, Yong Li, Lubo Zhang
Summary: The miR-210-TET2 axis plays a crucial role in regulating pro-inflammatory cytokine expression in neonatal hypoxic-ischemic brain injury.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Immunology
Angeliki Maria Nikolakopoulou, Yaoming Wang, Qingyi Ma, Abhay P. Sagare, Axel Montagne, Mikko T. Huuskonen, Sanket V. Rege, Kassandra Kisler, Zhonghua Dai, Jakob Korbelin, Joachim Herz, Zhen Zhao, Berislav V. Zlokovic
Summary: Loss of LRP1 in endothelial cells leads to blood-brain barrier breakdown, neuronal loss, and cognitive deficits, which can be reversed by endothelial-specific LRP1 gene therapy. This effect is mediated by inhibiting cyclophilin A.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Physiology
Andrew Walayat, Yong Li, Yanyan Zhang, Yingjie Fu, Bailin Liu, Xuesi M. Shao, Lubo Zhang, Daliao Xiao
Summary: The study demonstrates that maternal e-cigarette exposure can reduce body weight and brain weight in neonates, but increase the brain-to-body weight ratio. Additionally, e-cigarette exposure can increase the sensitivity of male neonates to hypoxic-ischemic brain injury and regulate autophagy-related gene expression through DNA methylation.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yong Li, Yanyan Zhang, Andrew Walayat, Yingjie Fu, Bailin Liu, Lubo Zhang, Daliao Xiao
Summary: Nicotine exposure during the perinatal period can induce a sensitive phenotype to neonatal brain hypoxic-ischemic injury in offspring. The H19/miR-181a/ATG5 signaling pathway plays a regulatory role in this process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Zhong Chen, Wanqiu Chen, Yong Li, Malcolm Moos, Daliao Xiao, Charles Wang
Summary: Studies have shown that maternal vaping can negatively affect the brain development of offspring by disrupting calcium homeostasis, inducing microglia cell death, and increasing susceptibility to cerebral ischemic injury. These abnormalities distort neuronal lineage differentiation in the neonatal brain, impairing brain development.
Article
Biochemistry & Molecular Biology
Taiming Liu, Meijuan Zhang, Avoumia Mourkus, Hobe Schroeder, Lubo Zhang, Gordon G. Power, Arlin B. Blood
Summary: Chronic hypoxia at high altitude alters iron homeostasis and bioactive nitric oxide metabolites (NOx) levels in the fetal circulation. The fetus utilizes iron from non-hematopoietic tissues for erythropoiesis and shows increased bioavailability of NO in response to hypoxic stress at high altitude during gestation.
Article
Clinical Neurology
Yong Li, Rui Song, Guofang Shen, Lei Huang, DaLiao Xiao, Qingyi Ma, Lubo Zhang
Summary: In this study, it was discovered that miR210 regulates neuroinflammatory response induced by ischemic stroke through repression of TET2 in the adult mouse brain. Inhibition of miR210 reduced ischemic stroke-induced neuroinflammatory response, suggesting that miR210 is a potential treatment target for acute brain injury after ischemic stroke.
Article
Biochemistry & Molecular Biology
Eugenia Mata-Greenwood, Hans C. A. Westenburg, Stacy Zamudio, Nicholas P. Illsley, Lubo Zhang
Summary: High-altitude residence negatively impacts vitamin D levels, with Andeans having the lowest 25-OH-D levels and Europeans having the lowest 1 alpha,25-(OH)(2)-D levels. The ratio of 1 alpha,25-(OH)(2)-D to 25-OH-D is significantly lower in Europeans compared to Andeans. Placental gene expression plays a major role in circulating vitamin D levels, and high-altitude residents have a stronger correlation between vitamin D levels and placental gene expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Guofang Shen, Kayla Sanchez, Shirley Hu, Zhen Zhao, Lubo Zhang, Qingyi Ma
Summary: This study used a non-invasive 3D ultrasound imaging approach to evaluate the changes of cerebral blood flow (CBF) after hypoxic-ischemic encephalopathy (HIE) and explored its correlation with HI-induced brain infarct in mice. The results showed that CBF reduction is an indicator for neonatal HI brain injury, and 3D ultrasound imaging is a useful non-invasive approach for assessing HI brain injury in mice.
Review
Cell Biology
Robert Tarran, R. Graham Barr, Neal L. Benowitz, Aruni Bhatnagar, Hong W. Chu, Pamela Dalton, Claire M. Doerschuk, M. Bradley Drummond, Diane R. Gold, Maciej L. Goniewicz, Eric R. Gross, Nadia N. Hansel, Philip K. Hopke, Robert A. Kloner, Vladimir B. Mikheev, Evan W. Neczypor, Kent E. Pinkerton, Lisa Postow, Irfan Rahman, Jonathan M. Samet, Matthias Salathe, Catherine M. Stoney, Philip S. Tsao, Rachel Widome, Tian Xia, DaLiao Xiao, Loren E. Wold
Summary: E-cigarettes have become increasingly popular, particularly among young people, in recent years. Research on the health effects of e-cigarettes is still in its early stages, with some suggesting that they may pose less of a health risk compared to traditional combustible cigarettes.
Meeting Abstract
Obstetrics & Gynecology
Andrew Walayat, Yanyan Zhang, Yong Li, Asanjan Hosseini Maryam, Daliao Xiao
REPRODUCTIVE SCIENCES
(2021)
Article
Medicine, Research & Experimental
Maryam Hosseini, Wanqiu Chen, Daliao Xiao, Charles Wang
Summary: The COVID-19 pandemic has spread worldwide, highlighting the urgent need for effective drugs and vaccines. Computational studies have identified potential inhibitors against SARS-CoV-2, with promising candidates for further clinical studies.
PRECISION CLINICAL MEDICINE
(2021)
Article
Neurosciences
Wenzhu Wang, Zihan Li, Yitong Yan, Shuo Wu, Xinyu Yao, Chen Gao, Lanxiang Liu, Yan Yu
Summary: This study investigated the reparative mechanisms of low-intensity pulsed ultrasound (LIPUS) in traumatic brain injury (TBI) and found that LIPUS promotes hippocampal neurogenesis, enhances neural electrical activity and neural plasticity, ultimately restoring neuronal function and cognitive capabilities in TBI mice.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Wenmin Yi, Fei Chen, Minghao Yuan, Chuanling Wang, Shengyuan Wang, Jie Wen, Qian Zou, Yinshuang Pu, Zhiyou Cai
Summary: The study suggests that a high-fat diet may lead to tau hyperphosphorylation and synaptic dysfunction by inhibiting the SIRT1/AMPK pathway and disrupting autophagy flux, ultimately resulting in cognitive decline.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Kim M. Hemsley, Helen Beard, Glyn Chidlow, Teresa Mammone, Leanne K. Winner, Daniel Neumann, Barbara King, Marten F. Snel, Paul J. Trim, Robert J. Casson
Summary: Optical coherence tomography (OCT) is a non-invasive method that can be used to rapidly and quantitatively examine the integrity of the neuroretina. It has been shown that OCT can be used to observe retinal thinning in patients with childhood dementia, and to assess the improvement of retinal structure after treatment. Furthermore, OCT can provide insights into other childhood dementias based on the correlation between retinal and brain degeneration in Sanfilippo syndrome.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Qianling Jiang, Xin Ma, Gaochen Zhu, Wen Si, Lingyu He, Guan Yang
Summary: This study investigated the effects of EAE induction on thymopoiesis and T cell development, revealing changes such as increased apoptosis, decreased proliferation, and a blockade in the transition from double-negative thymocytes to double-positive cells. It was also found that positive selection was disrupted in the thymus of EAE mice, along with an increased production of regulatory T cells.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Alice McDouall, Guido Wassink, Sumudu Ranasinghe, Kelly Q. Zhou, Rashika N. Karunasinghe, Justin M. Dean, Joanne O. Davidson
Summary: This study found that blocking connexin 43 hemichannels can attenuate brain injury and promote neurodevelopment in infants with mild hypoxic-ischemic encephalopathy, without causing hypothermia.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Hannah Sweetman, Mahmudur Rahman, Aditya Vedantam, Kajana Satkunendrarajah
Summary: Degenerative cervical myelopathy (DCM) is a neurological condition characterized by chronic compression of the cervical spinal cord, leading to impaired limb function. While respiratory dysfunction is not a common symptom of DCM, it can affect the ventilatory response to respiratory challenges. Surgical decompression improves sensorimotor function in DCM, but its impact on respiratory function is unclear. This study evaluates respiratory function and adaptive ventilation in a DCM model, showing that DCM impairs acute adaptive ventilatory ability and surgical decompression does not fully restore it.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Chengmei Sun, Muhammad Saif Ur Rahman, Budbazar Enkhjargal, Jianhua Peng, Keren Zhou, Zhiyi Xie, Lingyun Wu, Tongyu Zhang, Qiquan Zhu, Jiping Tang, Yujia Zeng, John H. Zhang, Shanshan Xu
Summary: This study found that Osteopontin (OPN) can attenuate inflammatory responses after subarachnoid hemorrhage (SAH) by promoting an anti-inflammatory microglial state. This effect may be mediated through the integrin-FAK-STAT3 and NF-kappa B signaling pathways.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Yang Yang, Xuezhu Chen, Chuanyan Yang, Mei Liu, Qianying Huang, Likun Yang, Yuhai Wang, Hua Feng, Zhongyang Gao, Tunan Chen
Summary: The study explores the effects of specific chemogenetic stimulation of intact corticospinal tract on functional recovery after stroke in mice. The findings demonstrate that combining chemogenetic activation with rehabilitation training leads to significant motor functional recovery by promoting axon sprouting and rewiring new functional circuits.
EXPERIMENTAL NEUROLOGY
(2024)
