Article
Cell Biology
Prathyusha Bagam, Gagandeep Kaur, Dhirendra Pratap Singh, Sanjay Batra
Summary: Cigarette smoking is the primary cause of chronic obstructive pulmonary disease. Oxidative stress induced by cigarette smoke leads to abnormal autophagy, resulting in acute lung injury. The study highlights the crucial role of FOXO1 and FOXO3a in regulating autophagy in response to cigarette smoke exposure.
CELL BIOLOGY AND TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Bin-feng He, Yi-xing Wu, Wei-ping Hu, Jian-lan Hua, Yaoping Han, Jing Zhang
Summary: Cigarette smoking-induced airway inflammatory responses play a crucial role in the development of emphysema and COPD. This study reveals that CS exposure and ROS suppress the expression of Rab26 and increase the expression of DNMT3b. Further analysis shows that DNA methylation inhibits the promoter activity of Rab26, and NAC can alleviate this inhibitory effect. Restoring the expression of Rab26 in the airway epithelium may be a potential strategy for treating airway inflammation and COPD.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Cell Biology
Patricia Gonzalez-Rodriguez, Mathilde Cheray, Jens Fullgrabe, Maria Salli, Pinelopi Engskog-Vlachos, Lily Keane, Virginia Cunha, Agata Lupa, Wenbo Li, Qi Ma, Kristian Dreij, Michael G. Rosenfeld, Bertrand Joseph
Summary: Autophagy is a catabolic pathway that maintains cellular homeostasis and can be stimulated under cellular stress. The persistent downregulation of MAP1LC3 expression upon autophagy induction indicates an epigenetic memory of autophagy, offering insights into its long-term effects.
Article
Biochemistry & Molecular Biology
Cheol Park, Hee-Jae Cha, Min Yeong Kim, EunJin Bang, Sung-Kwon Moon, Seok Joong Yun, Wun-Jae Kim, Jeong Sook Noh, Gi-Young Kim, Suengmok Cho, Hyesook Lee, Yung Hyun Choi
Summary: The study found that phloroglucinol can protect human retinal pigment epithelium cells from oxidative damage, reduce apoptosis, and improve cell function by decreasing ROS production.
Review
Nutrition & Dietetics
Krzysztof Halczuk, Julia Kazmierczak-Baranska, Boleslaw T. Karwowski, Aleksandra Karmanska, Marcin Cieslak
Summary: Vitamin B12 plays a crucial role in DNA stability by acting as a cofactor for enzymes involved in nucleotide synthesis and DNA methylation. It also has antioxidant properties that protect DNA from oxidative damage. Additionally, it can generate DNA-damaging radicals and has potential applications in drug delivery.
Review
Biochemistry & Molecular Biology
Xiaochen Xie, Ye Zhang, Zhuo Wang, Shanshan Wang, Xiaoyou Jiang, Hongyan Cui, Tingting Zhou, Zheng He, Hao Feng, Qiqiang Guo, Xiaoyu Song, Liu Cao
Summary: ROS, initially considered pathological, are now recognized as signaling intermediates that promote cellular adaptation to stress through autophagy regulation. ATM protein, activated by ROS, is involved in autophagy regulation, maintaining genome stability and triggering cytoplasmic autophagy as a ROS sensor.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Ralph C. Budd, Christopher D. Scharer, Ramiro Barrantes-Reynolds, Scott Legunn, Karen A. Fortner
Summary: The abnormalities in T cells of SLE patients involve various epigenetic and metabolic changes, with accelerated homeostatic proliferation of T cells being a key factor. Research in SLE patients has shown that increased mitochondrial size and ROS production induce type I interferon production, all of which occur during homeostatic proliferation of T cells.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Article
Biochemistry & Molecular Biology
Biqi He, Siyuan Dong, Qun Chen, Zhaoheng Dong, Chen Chen
Summary: This study found that DNA methylation levels were higher in fluorosis patients, while serum estradiol levels were lower. Hormone levels in women in the High F group were significantly altered, and the DNA methylation sequences of KGN cells were affected by sodium fluoride treatment.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Article
Environmental Sciences
Zainab Awada, Vincent Cahais, Cyrille Cuenin, Reem Akika, Anna Luiza Silva Almeida Vicente, Maha Makki, Hani Tamim, Zdenko Herceg, Nathalie Khoueiry Zgheib, Akram Ghantous
Summary: Waterpipe smoking is common in the Middle East and Africa, and this study investigates the epigenetic markers of waterpipe smokers and their role in addiction. The researchers found distinct epigenetic markers in waterpipe smokers compared to cigarette smokers and were able to accurately predict the type of smoking based on DNA methylation patterns. These markers offer potential targets for reversing the epigenetic memory of addiction and guiding prevention strategies for tobacco smoking.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Cardiac & Cardiovascular Systems
Yohannes Getiye, Matthew R. Peterson, Brandon D. Phillips, Daniel Carrillo, Bledar Bisha, Guanglong He
Summary: This study found that vaping electronic cigarettes may cause cardiopulmonary injury and inflammation, with more severe effects when heating is involved. The roles of CARD9 and NLRP3 in this process were identified.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2022)
Article
Biology
Cheol Park, Hyesook Lee, Soojung Jin, Jung-Ha Park, Min Ho Han, Jin-Woo Jeong, Hyun Ju Kwon, Byung Woo Kim, Shin-Hyung Park, Su Hyun Hong, Gi-Young Kim, Yung Hyun Choi
Summary: Loganin protects human keratinocytes from oxidative stress-induced cellular damage by inhibiting mitochondrial dysfunction, autophagy, and apoptosis.
Article
Cell Biology
Meng-Hao Pan, Cheng-Cheng Zhu, Jia-Qian Ju, Yi Xu, Shi-Ming Luo, Shao-Chen Sun, Xiang-Hong Ou
Summary: The study suggests that obesity affects early embryonic development in mice by inducing DNA damage, aberrant histone methylation, and changes in autophagy levels.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Environmental Sciences
Na Li, Jinhan Wang, Kejun Li, Ping Yang, Yan Wang, Chang Xu, Ningning He, Kaihua Ji, Huijuan Song, Manman Zhang, Liqing Du, Qiang Liu
Summary: This study found that long-term exposure to e-waste can lead to changes in DNA methylation levels, which can further impact health. By testing the blood samples of e-waste recycling workers and a control group, it was discovered that the concentration of 28 PCB congeners in the blood samples of e-waste recycling workers was higher, and DNA damage levels were significantly higher compared to the control group. Additionally, it was also found that exposure to e-waste potentially changes the methylation levels of 1233 gene loci, which could have negative effects on health.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Hunter T. Snoderly, Timothy R. Nurkiewicz, Elizabeth C. Bowdridge, Margaret F. Bennewitz
Summary: Electronic cigarettes are not necessarily a safer alternative to conventional cigarettes, as they can lead to acute lung injury and dysfunction in the lung and vasculature. E-cigarettes alter vascular dynamics, affect immune response, impair pulmonary function, and promote pre-oncogenic phenomena.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Anning Yang, Wen Zeng, Hongwen Zhang, Yinju Hao, Qingqing Wang, Yue Sun, Shangkun Quan, Ning Ding, Xiaoling Yang, Jianmin Sun, Huiping Zhang, Bin Liu, Yun Jiao, Kai Wu, Yideng Jiang
Summary: This study reveals that homocysteine (Hcy) can activate autophagy in hepatocytes by upregulating the expression of nuclear transcription factor EB (TFEB). The effect of Hcy on TFEB expression is regulated by hypomethylation of the TFEB promoter catalyzed by DNMT3b.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2023)
Article
Cardiac & Cardiovascular Systems
Rui Song, Xiang-Qun Hu, Monica Romero, Mark A. Holguin, Whitney Kagabo, Daliao Xiao, Sean M. Wilson, Lubo Zhang
Summary: Pregnancy increases the association of BKCa channel subunits and alters the localization of RyR subtypes in uterine arteries. Knockdown of RyR1 or RyR2 decreases Ca2+ sparks and STOCs frequency, increases myogenic tone, while RyR3 knockdown has no significant effect. This study provides new insights into the mechanisms of uterine vascular adaptation to pregnancy through RyR subtypes.
CARDIOVASCULAR RESEARCH
(2021)
Meeting Abstract
Biochemistry & Molecular Biology
Bailin Liu, Xia Liang, Jian Jie, Yong Li, Chiranjib Dasgupta, Xiaohui Huang, Lubo Zhang, Xuesi Shao, DaLiao Xiao
Meeting Abstract
Biochemistry & Molecular Biology
Jie Jian, Peng Zhang, Yong Li, Bailin Liu, Daliao Xiao
Article
Peripheral Vascular Disease
Xiang-Qun Hu, Rui Song, Monica Romero, Chiranjib Dasgupta, Joseph Min, Daisy Hatcher, Daliao Xiao, Arlin Blood, Sean M. Wilson, Lubo Zhang
Article
Reproductive Biology
Yanyan Zhang, Meizi Yang, Yong Li, Bailin Liu, Lubo Zhang, Daliao Xiao
Summary: The study revealed that DNA methylation deficiency in neonatal stage could affect the development of cardiovascular diseases in adulthood, leading to differential reprogramming of gene expression patterns and development of a heart ischemia-sensitive phenotype in late life.
REPRODUCTIVE TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yong Li, Yanyan Zhang, Andrew Walayat, Yingjie Fu, Bailin Liu, Lubo Zhang, Daliao Xiao
Summary: Nicotine exposure during the perinatal period can induce a sensitive phenotype to neonatal brain hypoxic-ischemic injury in offspring. The H19/miR-181a/ATG5 signaling pathway plays a regulatory role in this process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Zhong Chen, Wanqiu Chen, Yong Li, Malcolm Moos, Daliao Xiao, Charles Wang
Summary: Studies have shown that maternal vaping can negatively affect the brain development of offspring by disrupting calcium homeostasis, inducing microglia cell death, and increasing susceptibility to cerebral ischemic injury. These abnormalities distort neuronal lineage differentiation in the neonatal brain, impairing brain development.
Article
Clinical Neurology
Yong Li, Rui Song, Guofang Shen, Lei Huang, DaLiao Xiao, Qingyi Ma, Lubo Zhang
Summary: In this study, it was discovered that miR210 regulates neuroinflammatory response induced by ischemic stroke through repression of TET2 in the adult mouse brain. Inhibition of miR210 reduced ischemic stroke-induced neuroinflammatory response, suggesting that miR210 is a potential treatment target for acute brain injury after ischemic stroke.
Review
Cell Biology
Robert Tarran, R. Graham Barr, Neal L. Benowitz, Aruni Bhatnagar, Hong W. Chu, Pamela Dalton, Claire M. Doerschuk, M. Bradley Drummond, Diane R. Gold, Maciej L. Goniewicz, Eric R. Gross, Nadia N. Hansel, Philip K. Hopke, Robert A. Kloner, Vladimir B. Mikheev, Evan W. Neczypor, Kent E. Pinkerton, Lisa Postow, Irfan Rahman, Jonathan M. Samet, Matthias Salathe, Catherine M. Stoney, Philip S. Tsao, Rachel Widome, Tian Xia, DaLiao Xiao, Loren E. Wold
Summary: E-cigarettes have become increasingly popular, particularly among young people, in recent years. Research on the health effects of e-cigarettes is still in its early stages, with some suggesting that they may pose less of a health risk compared to traditional combustible cigarettes.
Meeting Abstract
Obstetrics & Gynecology
Andrew Walayat, Yanyan Zhang, Yong Li, Asanjan Hosseini Maryam, Daliao Xiao
REPRODUCTIVE SCIENCES
(2021)
Article
Medicine, Research & Experimental
Maryam Hosseini, Wanqiu Chen, Daliao Xiao, Charles Wang
Summary: The COVID-19 pandemic has spread worldwide, highlighting the urgent need for effective drugs and vaccines. Computational studies have identified potential inhibitors against SARS-CoV-2, with promising candidates for further clinical studies.
PRECISION CLINICAL MEDICINE
(2021)
Article
Medicine, Research & Experimental
Jie Jian, Peng Zhang, Yong Li, Bailin Liu, Yanyan Zhang, Lubo Zhang, Xuesi M. Shao, Jian Zhuang, Daliao Xiao
Article
Medicine, General & Internal
Andrew J. Patterson, Minwoo A. Song, David Choe, Daliao Xiao, Gary Foster, Lubo Zhang
Article
Biochemistry & Molecular Biology
Peng Zhang, Yong Li, Yingjie Fu, Lei Huang, Bailin Liu, Lubo Zhang, Xuesi M. Shao, Daliao Xiao
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2020)
