Specialized Proresolving Mediators for Therapeutic Interventions Targeting Metabolic and Inflammatory Disorders

Maresin 1 protects the liver against ischemia/reperfusion injury via the ALXR/Akt signaling pathway

(2021) Da Tang et al.   MOLECULAR MEDICINE

Therapeutic landscape for NAFLD in 2020

(2020) Brent A. Neuschwander-Tetri   GASTROENTEROLOGY

The Presence of Active Brown Adipose Tissue Determines Cold-Induced Energy Expenditure and Oxylipin Profiles in Humans

(2020) Oana C Kulterer et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Resolvin E1 derived from eicosapentaenoic acid prevents hyperinsulinemia and hyperglycemia in a host genetic manner

(2020) Anandita Pal et al.   FASEB JOURNAL

Deficit of resolution receptor magnifies inflammatory leukocyte directed cardiorenal and endothelial dysfunction with signs of cardiomyopathy of obesity

(2020) Bochra Tourki et al.   FASEB JOURNAL

Effects of Maresin 1 (MaR1) on Colonic Inflammation and Gut Dysbiosis in Diet-Induced Obese Mice

(2020) Irene C. León et al.   Microorganisms

Maresin 1 regulates insulin signaling in human adipocytes as well as in adipose tissue and muscle of lean and obese mice

(2020) L. Martínez-Fernández et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Pro-resolving lipid mediator ameliorates obesity induced osteoarthritis by regulating synovial macrophage polarisation

(2019) Antonia Rujia Sun et al.   Scientific Reports

A maresin 1/RORα/12-lipoxygenase autoregulatory circuit prevents inflammation and progression of nonalcoholic steatohepatitis

(2019) Yong-Hyun Han et al.   JOURNAL OF CLINICAL INVESTIGATION

Maresin 1 activates LGR6 receptor promoting phagocyte immunoresolvent functions

(2019) Nan Chiang et al.   JOURNAL OF CLINICAL INVESTIGATION

Maresin 1 Regulates Hepatic FGF21 in Diet‐Induced Obese Mice and in Cultured Hepatocytes

(2019) L. Martínez‐Fernández et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Protectin DX attenuates IL-1β-induced inflammation via the AMPK/NF-κB pathway in chondrocytes and ameliorates osteoarthritis progression in a rat model

(2019) Shang Piao et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The Eicosanoids, Redox-Regulated Lipid Mediators in Immunometabolic Disorders

(2018) Ana Carolina Araújo et al.   ANTIOXIDANTS & REDOX SIGNALING

Maresin 1 attenuates NAFLD by suppression of endoplasmic reticulum stress via AMPK–SERCA2b pathway

(2018) Tae Woo Jung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GPR37 regulates macrophage phagocytosis and resolution of inflammatory pain

(2018) Sangsu Bang et al.   JOURNAL OF CLINICAL INVESTIGATION

Impact of dietary ω3 polyunsaturated fatty acid supplementation on brown and brite adipocyte function

(2018) Rayane A. Ghandour et al.   JOURNAL OF LIPID RESEARCH

Author Correction: ERV1 Overexpression in Myeloid Cells Protects against High Fat Diet Induced Obesity and Glucose Intolerance

(2018) Corneliu Sima et al.   Scientific Reports

Maresin 1 improves insulin sensitivity and attenuates adipose tissue inflammation in ob/ob and diet-induced obese mice

(2017) Leyre Martínez-Fernández et al.   FASEB JOURNAL

The specialized proresolving lipid mediator maresin 1 protects hepatocytes from lipotoxic and hypoxia-induced endoplasmic reticulum stress

(2017) Bibiana Rius et al.   FASEB JOURNAL

Maresin 1 mitigates liver steatosis in ob/ob and diet-induced obese mice

(2017) L M Laiglesia et al.   INTERNATIONAL JOURNAL OF OBESITY

Maresin 1 inhibits TNF-alpha-induced lipolysis and autophagy in 3T3-L1 adipocytes

(2017) Laura M Laiglesia et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Liver inflammation and fibrosis

(2017) Yukinori Koyama et al.   JOURNAL OF CLINICAL INVESTIGATION

Resolvin RvD2 reduces hypothalamic inflammation and rescues mice from diet-induced obesity

(2017) Livia B. Pascoal et al.   Journal of Neuroinflammation

Discovery of specialized pro-resolving mediators marks the dawn of resolution physiology and pharmacology

(2017) Charles N. Serhan   MOLECULAR ASPECTS OF MEDICINE

Structural elucidation and physiologic functions of specialized pro-resolving mediators and their receptors

(2017) Nan Chiang et al.   MOLECULAR ASPECTS OF MEDICINE

RORα Induces KLF4-Mediated M2 Polarization in the Liver Macrophages that Protect against Nonalcoholic Steatohepatitis

(2017) Yong-Hyun Han et al.   Cell Reports

Biomarker-guided clinical development of the first-in-class anti-inflammatory FPR2/ALX agonist ACT-389949

(2016) Anna K. Stalder et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Resolving Lipid Mediators Maresin 1 and Resolvin D2 Prevent Atheroprogression in Mice

(2016) Joana Viola et al.   CIRCULATION RESEARCH

Signaling and Immunoresolving Actions of Resolvin D1 in Inflamed Human Visceral Adipose Tissue

(2016) Esther Titos et al.   JOURNAL OF IMMUNOLOGY

Resolvin D1 Polarizes Primary Human Macrophages toward a Proresolution Phenotype through GPR32

(2016) Mattia Schmid et al.   JOURNAL OF IMMUNOLOGY

An imbalance between specialized pro-resolving lipid mediators and pro-inflammatory leukotrienes promotes instability of atherosclerotic plaques

(2016) Gabrielle Fredman et al.   Nature Communications

Proresolving actions of a new resolvin D1 analog mimetic qualifies as an immunoresolvent

(2015) Sarah K. Orr et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

NPD1-mediated stereoselective regulation of BIRC3 expression through cREL is decisive for neural cell survival

(2015) J M Calandria et al.   CELL DEATH AND DIFFERENTIATION

Lipoxin A4 Attenuates Obesity-Induced Adipose Inflammation and Associated Liver and Kidney Disease

(2015) Emma Börgeson et al.   Cell Metabolism

The Docosanoid Neuroprotectin D1 Induces TH-Positive Neuronal Survival in a Cellular Model of Parkinson’s Disease

(2015) Jorgelina M. Calandria et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

The role of parkinson's disease-associated receptor GPR37 in the hippocampus: functional interplay with the adenosinergic system

(2015) João P. Lopes et al.   JOURNAL OF NEUROCHEMISTRY

Pro-Resolving Lipid Mediators Improve Neuronal Survival and Increase Aβ42 Phagocytosis

(2015) Mingqin Zhu et al.   MOLECULAR NEUROBIOLOGY

Resolvin D1 and E1 alleviate the progress of hepatitis toward liver cancer in long-term concanavalin A-induced mice through inhibition of NF-κB activity

(2015) HAOYU KUANG et al.   ONCOLOGY REPORTS

Proresolving Lipid Mediators and Mechanisms in the Resolution of Acute Inflammation

(2014) Christopher D. Buckley et al.   IMMUNITY

Diversity of lipid mediators in human adipose tissue depots

(2013) Joan Clària et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Resolvins, Specialized Proresolving Lipid Mediators, and Their Potential Roles in Metabolic Diseases

(2013) Matthew Spite et al.   Cell Metabolism

Impaired Local Production of Proresolving Lipid Mediators in Obesity and 17-HDHA as a Potential Treatment for Obesity-Associated Inflammation

(2013) A. Neuhofer et al.   DIABETES

Resolvin D1 primes the resolution process initiated by calorie restriction in obesity-induced steatohepatitis

(2013) Bibiana Rius et al.   FASEB JOURNAL

Resolvin D1 Receptor Stereoselectivity and Regulation of Inflammation and Proresolving MicroRNAs

(2012) Sriram Krishnamoorthy et al.   AMERICAN JOURNAL OF PATHOLOGY

Specific lipid mediator signatures of human phagocytes: microparticles stimulate macrophage efferocytosis and pro-resolving mediators

(2012) J. Dalli et al.   BLOOD

Lipoxin A4 attenuates adipose inflammation

(2012) Emma Börgeson et al.   FASEB JOURNAL

Resolvin D1 and Resolvin D2 Govern Local Inflammatory Tone in Obese Fat

(2012) J. Claria et al.   JOURNAL OF IMMUNOLOGY

Resolvin D1 attenuates inflammation in lipopolysaccharide-induced acute lung injury through a process involving the PPARγ/NF-κB pathway

(2012) Zenglin Liao et al.   RESPIRATORY RESEARCH

Resolvin D1 decreases adipose tissue macrophage accumulation and improves insulin sensitivity in obese-diabetic mice

(2011) Jason Hellmann et al.   FASEB JOURNAL

Inflammatory links between obesity and metabolic disease

(2011) Carey N. Lumeng et al.   JOURNAL OF CLINICAL INVESTIGATION

Resolvin D1 and Its Precursor Docosahexaenoic Acid Promote Resolution of Adipose Tissue Inflammation by Eliciting Macrophage Polarization toward an M2-Like Phenotype

(2011) Esther Titos et al.   JOURNAL OF IMMUNOLOGY

Neuroprotectin D1 Induces Neuronal Survival and Downregulation of Amyloidogenic Processing in Alzheimer’s Disease Cellular Models

(2011) David T. Stark et al.   MOLECULAR NEUROBIOLOGY

Docosahexaenoic Acid-Derived Neuroprotectin D1 Induces Neuronal Survival via Secretase- and PPARγ-Mediated Mechanisms in Alzheimer's Disease Models

(2011) Yuhai Zhao et al.   PLoS One

GPR120 Is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-inflammatory and Insulin-Sensitizing Effects

(2010) Da Young Oh et al.   CELL

5-Lipoxygenase Activating Protein Signals Adipose Tissue Inflammation and Lipid Dysfunction in Experimental Obesity

(2010) R. Horrillo et al.   JOURNAL OF IMMUNOLOGY

Obesity-induced insulin resistance and hepatic steatosis are alleviated by ω-3 fatty acids: a role for resolvins and protectins

(2009) Ana González-Périz et al.   FASEB JOURNAL

The plasma lipidomic signature of nonalcoholic steatohepatitis

(2009) Puneet Puri et al.   HEPATOLOGY

5-lipoxygenase deficiency reduces hepatic inflammation and tumor necrosis factor α-induced hepatocyte damage in hyperlipidemia-prone ApoE-null mice

(2009) Marcos Martínez-Clemente et al.   HEPATOLOGY