Polyunsaturated fatty acids, specialized pro-resolving mediators, and targeting inflammation resolution in the age of precision nutrition

The gut microbiome modulates the protective association between a Mediterranean diet and cardiometabolic disease risk

(2021) Dong D. Wang et al.   NATURE MEDICINE

Metabolic and functional impairment of CD8 + T cells from the lungs of influenza‐infected obese mice

(2021) William D. Green et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Synergizing Mouse and Human Studies to Understand the Heterogeneity of Obesity

(2021) Penny Gordon-Larsen et al.   Advances in Nutrition

Precision (Personalized) Nutrition: Understanding Metabolic Heterogeneity

(2020) Steven H. Zeisel   Annual Review of Food Science and Technology

Metabolically Healthy Obesity—Heterogeneity in Definitions and Unconventional Factors

(2020) Inês Brandão et al.   Metabolites

Decreased Plasma Maresin 1 Concentration Is Associated with Diabetic Foot Ulcer

(2020) Tian Miao et al.   MEDIATORS OF INFLAMMATION

Resolvin E1 derived from eicosapentaenoic acid prevents hyperinsulinemia and hyperglycemia in a host genetic manner

(2020) Anandita Pal et al.   FASEB JOURNAL

Myeloid ALX/FPR2 regulates vascularization following tissue injury

(2020) Brian E. Sansbury et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting T-cell oxidative metabolism to improve influenza survival in a mouse model of obesity

(2020) Yazan Alwarawrah et al.   INTERNATIONAL JOURNAL OF OBESITY

Individuals with obesity and COVID‐19: A global perspective on the epidemiology and biological relationships

(2020) Barry M. Popkin et al.   Obesity Reviews

Do Eicosapentaenoic Acid and Docosahexaenoic Acid Have the Potential to Compete against Each Other?

(2020) Anandita Pal et al.   Nutrients

Leukocytes from obese individuals exhibit an impaired SPM signature

(2019) Cristina López-Vicario et al.   FASEB JOURNAL

Linoleic acid rescues microglia inflammation triggered by saturated fatty acid

(2019) Thai Hien Tu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Resolvin D4 attenuates the severity of pathological thrombosis in mice

(2019) Deya Cherpokova et al.   BLOOD

Linoleic acid esters of hydroxy linoleic acids are anti-inflammatory lipids found in plants and mammals

(2019) Matthew J. Kolar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Immunity to influenza: Impact of obesity

(2019) Sandra Angélica Rojas-Osornio et al.   Obesity Research & Clinical Practice

Omega-3, omega-6, and total dietary polyunsaturated fat for prevention and treatment of type 2 diabetes mellitus: systematic review and meta-analysis of randomised controlled trials

(2019) Tracey J Brown et al.   BMJ-British Medical Journal

High-fat diet exacerbates SIV pathogenesis and accelerates disease progression

(2019) Tianyu He et al.   JOURNAL OF CLINICAL INVESTIGATION

From the Table to the Tumor: The Role of Mediterranean and Western Dietary Patterns in Shifting Microbial-Mediated Signaling to Impact Breast Cancer Risk

(2019) Tiffany M. Newman et al.   Nutrients

Viral Infections and Interferons in the Development of Obesity

(2019) Yun Tian et al.   Biomolecules

Enriched Marine Oil Supplements Increase Peripheral Blood Specialized Pro-Resolving Mediators Concentrations and Reprogram Host Immune Responses

(2019) Patricia R. Souza et al.   CIRCULATION RESEARCH

Interactive effects of maternal and weaning high linoleic acid intake on hepatic lipid metabolism, oxylipins profile and hepatic steatosis in offspring

(2019) Justine Marchix et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming

(2018) Anette Christ et al.   CELL

Resolvins in inflammation: emergence of the pro-resolving superfamily of mediators

(2018) Charles N. Serhan et al.   JOURNAL OF CLINICAL INVESTIGATION

ExacerbatedStaphylococcus aureusFoot Infections in Obese/Diabetic Mice Are Associated with Impaired Germinal Center Reactions, Ig Class Switching, and Humoral Immunity

(2018) Christopher W. Farnsworth et al.   JOURNAL OF IMMUNOLOGY

Dietary DHA amplifies LXA4 circuits in tissues and lymph node PMN and is protective in immune-driven dry eye disease

(2018) Yuan Gao et al.   Mucosal Immunology

Genetic variant in the 3′-untranslated region of the COX2 gene is associated with type 2 diabetes: A hospital-based case-control study

(2018) Cansu Ozbayer et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Obesity-Induced Changes in T-Cell Metabolism Are Associated With Impaired Memory T-Cell Response to Influenza and Are Not Reversed With Weight Loss

(2018) Jennifer Rebeles et al.   JOURNAL OF INFECTIOUS DISEASES

Frontline Science: A reduction in DHA-derived mediators in male obesity contributes toward defects in select B cell subsets and circulating antibody

(2018) Miranda J. Crouch et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Dietary fat: From foe to friend?

(2018) David S. Ludwig et al.   SCIENCE

Identification of specialized pro-resolving mediator clusters from healthy adults after intravenous low-dose endotoxin and omega-3 supplementation: a methodological validation

(2018) Paul C. Norris et al.   Scientific Reports

Adipose tissue B2 cells promote insulin resistance through leukotriene LTB4/LTB4R1 signaling

(2017) Wei Ying et al.   JOURNAL OF CLINICAL INVESTIGATION

Inflammatory mechanisms linking obesity and metabolic disease

(2017) Alan R. Saltiel et al.   JOURNAL OF CLINICAL INVESTIGATION

B Cell Activity Is Impaired in Human and Mouse Obesity and Is Responsive to an Essential Fatty Acid upon Murine Influenza Infection

(2017) Rasagna Kosaraju et al.   JOURNAL OF IMMUNOLOGY

New pro-resolving n-3 mediators bridge resolution of infectious inflammation to tissue regeneration

(2017) Charles N. Serhan et al.   MOLECULAR ASPECTS OF MEDICINE

Identification and Profiling of Specialized Pro-Resolving Mediators in Human Tears by Lipid Mediator Metabolomics

(2017) Justin T. English et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Precision Nutrition and Omega-3 Polyunsaturated Fatty Acids: A Case for Personalized Supplementation Approaches for the Prevention and Management of Human Diseases

(2017) Floyd Chilton et al.   Nutrients

Association of a variant in the gene encoding for ERV1/ChemR23 with reduced inflammation in visceral adipose tissue from morbidly obese individuals

(2017) Cristina López-Vicario et al.   Scientific Reports

ERV1 Overexpression in Myeloid Cells Protects against High Fat Diet Induced Obesity and Glucose Intolerance

(2017) Corneliu Sima et al.   Scientific Reports

Omega-3 fatty acid supplementation influences the whole blood transcriptome in women with obesity, associated with pro-resolving lipid mediator production

(2016) Anna Polus et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Hydroxyoctadecadienoic acids: Oxidised derivatives of linoleic acid and their role in inflammation associated with metabolic syndrome and cancer

(2016) Venkat N. Vangaveti et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Specialized proresolving lipid mediators in patients with coronary artery disease and their potential for clot remodeling

(2016) Tarec K. Elajami et al.   FASEB JOURNAL

Divergent shifts in lipid mediator profile following supplementation with n-3 docosapentaenoic acid and eicosapentaenoic acid

(2016) James F. Markworth et al.   FASEB JOURNAL

Signaling and Immunoresolving Actions of Resolvin D1 in Inflamed Human Visceral Adipose Tissue

(2016) Esther Titos et al.   JOURNAL OF IMMUNOLOGY

Arachidonate 5-lipoxygenase (ALOX5) gene polymorphism is associated with Alzheimer's disease and body mass index

(2016) Omar Šerý et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Dihydroxylated E,E,Z-docosatrienes. An overview of their synthesis and biological significance

(2016) Laurence Balas et al.   PROGRESS IN LIPID RESEARCH

Global survey of the omega-3 fatty acids, docosahexaenoic acid and eicosapentaenoic acid in the blood stream of healthy adults

(2016) Ken D. Stark et al.   PROGRESS IN LIPID RESEARCH

Linoleic acid and the pathogenesis of obesity

(2016) Shaan S. Naughton et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

An Increase in the Omega-6/Omega-3 Fatty Acid Ratio Increases the Risk for Obesity

(2016) Artemis Simopoulos   Nutrients

Resolvin D4 stereoassignment and its novel actions in host protection and bacterial clearance

(2016) Jeremy W. Winkler et al.   Scientific Reports

Impact of Obesity and Metabolic Syndrome on Immunity

(2016) Catherine J Andersen et al.   Advances in Nutrition

Association of Specific Dietary Fats With Total and Cause-Specific Mortality

(2016) Dong D. Wang et al.   JAMA Internal Medicine

Dietary inflammatory index and telomere length in subjects with a high cardiovascular disease risk from the PREDIMED-NAVARRA study: cross-sectional and longitudinal analyses over 5 y

(2015) Sonia García-Calzón et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Marine omega-3 fatty acids and inflammatory processes: Effects, mechanisms and clinical relevance

(2015) Philip C. Calder   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Lipoxin A4 Attenuates Obesity-Induced Adipose Inflammation and Associated Liver and Kidney Disease

(2015) Emma Börgeson et al.   Cell Metabolism

Identification of resolvin D2 receptor mediating resolution of infections and organ protection

(2015) Nan Chiang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

ChemR23, the Receptor for Chemerin and Resolvin E1, Is Expressed and Functional on M1 but Not on M2 Macrophages

(2015) Magdalena Herová et al.   JOURNAL OF IMMUNOLOGY

How Can Linoleic Acid Be the Preferential Substrate of the Enzyme 15-Lipoxygenase-1? A QM/MM Approach

(2015) Jordi Soler et al.   JOURNAL OF PHYSICAL CHEMISTRY B

The resolution code of acute inflammation: Novel pro-resolving lipid mediators in resolution

(2015) Charles N. Serhan et al.   SEMINARS IN IMMUNOLOGY

Inflammation as a link between obesity, metabolic syndrome and type 2 diabetes

(2014) Nathalie Esser et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

CYP4F2 genetic polymorphisms are associated with coronary heart disease in a Chinese population

(2014) Changqing Yu et al.   Lipids in Health and Disease

Pro-resolving lipid mediators are leads for resolution physiology

(2014) Charles N. Serhan   NATURE

Diet-Gene Interactions and PUFA Metabolism: A Potential Contributor to Health Disparities and Human Diseases

(2014) Floyd Chilton et al.   Nutrients

Gender Differences in the Long-Chain Polyunsaturated Fatty Acid Status: Systematic Review of 51 Publications

(2013) Szimonetta Lohner et al.   ANNALS OF NUTRITION AND METABOLISM

Linoleic acid: Between doubts and certainties

(2013) Benjamin Choque et al.   BIOCHIMIE

Resolution phase lipid mediators of inflammation: agonists of resolution

(2013) Charles N. Serhan et al.   CURRENT OPINION IN PHARMACOLOGY

Impaired Local Production of Proresolving Lipid Mediators in Obesity and 17-HDHA as a Potential Treatment for Obesity-Associated Inflammation

(2013) A. Neuhofer et al.   DIABETES

Dyslipidemia in Obesity: Mechanisms and Potential Targets

(2013) Boudewijn Klop et al.   Nutrients

Linoleic Acid

(2013) Jay Whelan et al.   Advances in Nutrition

Omega-3 polyunsaturated fatty acids and inflammatory processes: nutrition or pharmacology?

(2012) Philip C. Calder   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Proresolution Therapy for the Treatment of Delayed Healing of Diabetic Wounds

(2012) Y. Tang et al.   DIABETES

Macrophage proresolving mediator maresin 1 stimulates tissue regeneration and controls pain

(2012) Charles N. Serhan et al.   FASEB JOURNAL

Identification and Structure Determination of Novel Anti-inflammatory Mediator Resolvin E3, 17,18-Dihydroxyeicosapentaenoic Acid

(2012) Yosuke Isobe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Resolvin D1 and Resolvin D2 Govern Local Inflammatory Tone in Obese Fat

(2012) J. Claria et al.   JOURNAL OF IMMUNOLOGY

Dietary fats and coronary heart disease

(2012) W. C. Willett   JOURNAL OF INTERNAL MEDICINE

Association of ALOX15 Gene Polymorphism with Ischemic Stroke in Northern Chinese Han Population

(2012) Jie Zhao et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

The role of marine omega-3 (n-3) fatty acids in inflammatory processes, atherosclerosis and plaque stability

(2012) Philip C. Calder   MOLECULAR NUTRITION & FOOD RESEARCH

Infection regulates pro-resolving mediators that lower antibiotic requirements

(2012) Nan Chiang et al.   NATURE

Resolvin E1 promotes phagocytosis-induced neutrophil apoptosis and accelerates resolution of pulmonary inflammation

(2012) D. El Kebir et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Changes in consumption of omega-3 and omega-6 fatty acids in the United States during the 20th century

(2011) Tanya L Blasbalg et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Pro-resolving actions and stereoselective biosynthesis of 18S E-series resolvins in human leukocytes and murine inflammation

(2011) Sungwhan F. Oh et al.   JOURNAL OF CLINICAL INVESTIGATION

Obesity-mediated inflammation may damage the brain circuit that regulates food intake

(2010) Fanny Cazettes et al.   BRAIN RESEARCH

ALOX12 polymorphisms are associated with fat mass but not peak bone mineral density in Chinese nuclear families

(2010) W-J Xiao et al.   INTERNATIONAL JOURNAL OF OBESITY

Resolvin D1 binds human phagocytes with evidence for proresolving receptors

(2010) S. Krishnamoorthy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic effects in the leukotriene biosynthesis pathway and association with atherosclerosis

(2009) David R. Crosslin et al.   HUMAN GENETICS

Effect of Dietary Fatty Acids on Inflammatory Gene Expression in Healthy Humans

(2009) Kelly L. Weaver et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Association of polymorphisms in cyclooxygenase (COX)-2 with coronary and carotid calcium in the Diabetes Heart Study

(2008) Megan E. Rudock et al.   ATHEROSCLEROSIS

Common polymorphisms of ALOX5 and ALOX5AP and risk of coronary artery disease

(2008) Themistocles L. Assimes et al.   HUMAN GENETICS

Increased risk of incident stroke associated with the cyclooxygenase 2 (COX-2) G−765C polymorphism in African-Americans: The Atherosclerosis Risk in Communities Study

(2007) Shun Kohsaka et al.   ATHEROSCLEROSIS