An all-out assault on SARS-CoV-2 replication

Mechanism of SARS-CoV-2 polymerase stalling by remdesivir

(2021) Goran Kokic et al.   Nature Communications

Cryo-EM structures of the SARS-CoV-2 endoribonuclease Nsp15 reveal insight into nuclease specificity and dynamics

(2021) Monica C. Pillon et al.   Nature Communications

Structural basis for inhibition of the SARS-CoV-2 RNA polymerase by suramin

(2021) Wanchao Yin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp14/nsp10 exoribonuclease

(2021) Berta Canal et al.   BIOCHEMICAL JOURNAL

Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp5 main protease

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Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp12/7/8 RNA-dependent RNA polymerase

(2021) Agustina P. Bertolin et al.   BIOCHEMICAL JOURNAL

Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp3 papain-like protease

(2021) Chew Theng Lim et al.   BIOCHEMICAL JOURNAL

Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp14 RNA cap methyltransferase

(2021) Souradeep Basu et al.   BIOCHEMICAL JOURNAL

Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp13 helicase

(2021) Jingkun Zeng et al.   BIOCHEMICAL JOURNAL

Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp15 endoribonuclease

(2021) Berta Canal et al.   BIOCHEMICAL JOURNAL

Structural basis for RNA replication by the SARS-CoV-2 polymerase

(2020) Quan Wang et al.   CELL

A Mouse Model of SARS-CoV-2 Infection and Pathogenesis

(2020) Shi-Hui Sun et al.   Cell Host & Microbe

Structure of replicating SARS-CoV-2 polymerase

(2020) Hauke S. Hillen et al.   NATURE

Structure of the RNA-dependent RNA polymerase from COVID-19 virus

(2020) Yan Gao et al.   SCIENCE

Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors

(2020) Linlin Zhang et al.   SCIENCE

Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir

(2020) Wanchao Yin et al.   SCIENCE

Coronavirus RNA proofreading: molecular basis and therapeutic targeting

(2020) Fran Robson et al.   MOLECULAR CELL

Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity

(2020) Donghyuk Shin et al.   NATURE

Cryo-EM Structure of an Extended SARS-CoV-2 Replication and Transcription Complex Reveals an Intermediate State in Cap Synthesis

(2020) Liming Yan et al.   CELL

Approved Antiviral Drugs over the Past 50 Years

(2016) Erik De Clercq et al.   CLINICAL MICROBIOLOGY REVIEWS