A Unified Catalytic Asymmetric (4+1) and (5+1) Annulation Strategy to Access Chiral Spirooxindole‐Fused Oxacycles

Use of α-trifluoromethyl carbanions for palladium-catalysed asymmetric cycloadditions

(2020) Barry M. Trost et al.   Nature Chemistry

Brønsted Acid Catalyzed Enantioselective Assembly of Spirochroman-3,3-oxindoles

(2020) Alavala Gopi Krishna Reddy et al.   ORGANIC LETTERS

General [4 + 1] Cyclization Approach To Access 2,2-Disubstituted Tetrahydrofurans Enabled by Electrophilic Bifunctional Peroxides

(2019) Min Gao et al.   ORGANIC LETTERS

Synthesis of α-Cyano and α-Sulfonyl Cyclic Ethers via Intramolecular Reactions of Peroxides with Sulfone- and Nitrile-Stabilized Carbanions

(2019) Alissa Horn et al.   JOURNAL OF ORGANIC CHEMISTRY

Forty Years after “Heterodiene Syntheses with α,β-Unsaturated Carbonyl Compounds”: Enantioselective Syntheses of 3,4-Dihydropyran Derivatives

(2018) Giovanni Desimoni et al.   CHEMICAL REVIEWS

From Oxiranes to Oligomers: Architectures of US FDA Approved Pharmaceuticals Containing Oxygen Heterocycles

(2018) Michael D. Delost et al.   JOURNAL OF MEDICINAL CHEMISTRY

Enantioselective α-Benzoyloxylation of β-Keto Esters by N-Oxide Phase-Transfer Catalysts

(2018) Yakun Wang et al.   JOURNAL OF ORGANIC CHEMISTRY

Enantioselective Palladium-Catalyzed [3+2] Cycloaddition of Trimethylenemethane and Fluorinated Ketones

(2018) Barry M. Trost et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

On the Origin of and a Solution for Uneven Efficiency by Cinchona Alkaloid-Derived, Pseudoenantiomeric Catalysts for Asymmetric Reactions

(2018) Bin Hu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catalytic Asymmetric [4+2]-Cycloaddition of Dienes with Aldehydes

(2017) Luping Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Amino Acid-Directed Strategy for Inducing the Marine-Derived Fungus Scedosporium apiospermum F41–1 to Maximize Alkaloid Diversity

(2017) Li-Hong Huang et al.   ORGANIC LETTERS

In Situ Electrophilic Activation of Hydrogen Peroxide for Catalytic Asymmetric α-Hydroxylation of 3-Substituted Oxindoles

(2017) Takashi Ooi et al.   SYNLETT

N-Heterocyclic carbene-catalyzed oxidative [3 + 2] annulation of dioxindoles and enals: cross coupling of homoenolate and enolate

(2017) Xiang-Yu Chen et al.   Chemical Science

Asymmetric α-Hydroxylation of β-Indanone Esters and β-Indanone Amides Catalyzed by C-2′ Substituted Cinchona Alkaloid Derivatives

(2016) Yakun Wang et al.   ADVANCED SYNTHESIS & CATALYSIS

Asymmetric Hydroxylation of 4-Substituted Pyrazolones Catalyzed by Natural Cinchona Alkaloids

(2016) Fuzhao Xue et al.   ADVANCED SYNTHESIS & CATALYSIS

Diastereo- and Enantioselective Construction of Dihydroisocoumarin-Based Spirooxindole Frameworks via Organocatalytic Tandem Reactions

(2016) Jia-Le Wu et al.   ADVANCED SYNTHESIS & CATALYSIS

Isatin Derived Spirocyclic Analogues with α-Methylene-γ-butyrolactone as Anticancer Agents: A Structure–Activity Relationship Study

(2016) Sandeep Rana et al.   JOURNAL OF MEDICINAL CHEMISTRY

Enantioselective α-Benzoyloxylation of Malonic Diesters by Phase-Transfer Catalysis

(2016) Takuya Kanemitsu et al.   ORGANIC LETTERS

Recent advances in the synthesis of tetrahydrofurans and applications in total synthesis

(2016) Aurélien de la Torre et al.   TETRAHEDRON

Formal [4+1] Annulation Reactions in the Synthesis of Carbocyclic and Heterocyclic Systems

(2015) Jia-Rong Chen et al.   CHEMICAL REVIEWS

Synthesis of Ethers via Reaction of Carbanions and Monoperoxyacetals

(2015) ShivaKumar Kyasa et al.   JOURNAL OF ORGANIC CHEMISTRY

Organocatalytic Asymmetric Michael/Cyclization Cascade Reactions of 3-Hydroxyoxindoles/3-Aminooxindoles with α,β-Unsaturated Acyl Phosphonates for the Construction of Spirocyclic Oxindole-γ-lactones/lactams

(2015) Lin Chen et al.   JOURNAL OF ORGANIC CHEMISTRY

Origin of Stereocontrol in Guanidine-Bisurea Bifunctional Organocatalyst That Promotes α-Hydroxylation of Tetralone-Derived β-Ketoesters: Asymmetric Synthesis of β- and γ-Substituted Tetralone Derivatives via Organocatalytic Oxidative Kinetic Resolution

(2015) Minami Odagi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Asymmetric α-Benzoyloxylation of β-Ketocarbonyls by a Chiral Primary Amine Catalyst

(2015) Dehong Wang et al.   ORGANIC LETTERS

Phase-Transfer-Catalyzed Enantioselective α-Hydroxylation of Acyclic and Cyclic Ketones with Oxygen

(2015) Sui-Boon Derek Sim et al.   ACS Catalysis

Conjugate Umpolung of β,β-Disubstituted Enals by Dual Catalysis with an N-Heterocyclic Carbene and a Brønsted Acid: Facile Construction of Contiguous Quaternary Stereocenters

(2014) Jun-Long Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Asymmetric Hetero-Diels-Alder Reaction in the Syntheses of Biologically Relevant Compounds

(2014) Vincent Eschenbrenner-Lux et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric Hetero-Diels-Alder Reaction of Danishefsky’s Diene with α-Ketoesters and Isatins Catalyzed by a ChiralN,N′-Dioxide/Magnesium(II) Complex

(2014) Jianfeng Zheng et al.   CHEMISTRY-A EUROPEAN JOURNAL

Oxacycle Synthesis via Intramolecular Reaction of Carbanions and Peroxides

(2014) Rachel Willand-Charnley et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of S,S,O-Orthoesters and 1,1-Difluoroalkyl Ethers via Reaction of Peroxides with Lithiated 1,3-Dithianes

(2014) ShivaKumar Kyasa et al.   ORGANIC LETTERS

Chiral Spirooxindole–Butenolide Synthesis through Asymmetric N-Heterocyclic Carbene-Catalyzed Formal (3 + 2) Annulation of 3-Bromoenals and Isatins

(2014) Chenguang Zheng et al.   ORGANIC LETTERS

Enantioselective Synthesis of 2,2-Disubstituted Tetrahydrofurans: Palladium-Catalyzed [3+2] Cycloadditions of Trimethylenemethane with Ketones

(2013) Barry M. Trost et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Recent Developments in Asymmetric Phase-Transfer Reactions

(2013) Seiji Shirakawa et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

An organocatalytic asymmetric sequential allylic alkylation–cyclization of Morita–Baylis–Hillman carbonates and 3-hydroxyoxindoles

(2013) Qi-Lin Wang et al.   CHEMICAL COMMUNICATIONS

Tetrahydrofuran-Containing Macrolides: A Fascinating Gift from the Deep Sea

(2013) Adriana Lorente et al.   CHEMICAL REVIEWS

Diastereo- and Enantioselective Construction of Oxindole-Fused Spirotetrahydrofuran Scaffolds through Palladium-Catalyzed Asymmetric [3+2] Cycloaddition of Vinyl Cyclopropanes and Isatins

(2013) Liang-yong Mei et al.   ORGANOMETALLICS

Highly Enantioselective Synthesis of Multifunctionalized Dihydrofurans by Copper-Catalyzed Asymmetric [4 + 1] Cycloadditions of α-Benzylidene-β-ketoester with Diazo Compound

(2013) Jiao-Long Zhou et al.   ACS Catalysis

An N-Heterocyclic Carbene/Lewis Acid Strategy for the Stereoselective Synthesis of Spirooxindole Lactones

(2012) Julien Dugal-Tessier et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Isatins As Privileged Molecules in Design and Synthesis of Spiro-Fused Cyclic Frameworks

(2012) Girija S. Singh et al.   CHEMICAL REVIEWS

Enantioselective α-Benzoyloxylation of Ketones Promoted by Primary Amine Catalyst

(2012) Milind S. Jadhav et al.   JOURNAL OF ORGANIC CHEMISTRY

Enantioselective α-hydroxylation of β-ketoamides

(2012) Claudia De Fusco et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Pentanidium–Catalyzed Enantioselective α-Hydroxylation of Oxindoles Using Molecular Oxygen

(2012) Yuanyong Yang et al.   ORGANIC LETTERS

Direct Asymmetric α Benzoyloxylation of Cyclic Ketones

(2011) Olga Lifchits et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structural Study-Guided Development of Versatile Phase-Transfer Catalysts for Asymmetric Conjugate Additions of Cyanide

(2011) Brian A. Provencher et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Asymmetric [3+2] Annulation of Allylsilanes with Isatins: Synthesis of Spirooxindoles

(2011) Nadine V. Hanhan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric Synthesis of Methylenetetrahydrofurans by Palladium-Catalyzed [3 + 2] Cycloaddition of Trimethylenemethane with Aldehydes – A Novel Ligand Design

(2011) Barry M. Trost et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Highly Enantioselective Catalytic Benzoyloxylation of 3-Aryloxindoles Using Chiral VAPOL Calcium Phosphate

(2010) Zuhui Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Organocatalytic synthesis of spiro compounds via a cascade Michael–Michael-aldol reaction

(2010) Xavier Companyó et al.   CHEMICAL COMMUNICATIONS

Asymmetric Direct α-Hydroxylation of β-Oxo Esters by Phase-Transfer Catalysis Using Chiral Quaternary Ammonium Salts

(2010) Mingming Lian et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Diphenylprolinol silyl ether as a catalyst in an asymmetric, catalytic and direct α-benzoyloxylation of aldehydes

(2009) Hiroaki Gotoh et al.   CHEMICAL COMMUNICATIONS

A Short, Economical Synthesis of 2-Methoxyestradiol, an Anticancer Agent in Clinical†

(2009) Yuqing Hou et al.   JOURNAL OF ORGANIC CHEMISTRY

Catalytic Enantioselective Synthesis of Tetrahydrofurans: A Dynamic Kinetic Asymmetric [3 + 2] Cycloaddition of Racemic Cyclopropanes and Aldehydes

(2009) Andrew T. Parsons et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chiral Phosphoric Acid-Governed Anti-Diastereoselective and Enantioselective Hetero-Diels−Alder Reaction of Glyoxylate

(2009) Norie Momiyama et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Direct Asymmetric Benzoyloxylation of Aldehydes Catalyzed by 2-Tritylpyrrolidine

(2009) Taichi Kano et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Synthesis of Spirocyclic Benzopyranones by Rhodium‐Catalyzed Intermolecular [4+2] Annulation

(2008) Daiki Hojo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Asymmetric Hydroxylation of Oxindoles by Molecular Oxygen Using a Phase-Transfer Catalyst

(2008) Daisuke Sano et al.   ORGANIC LETTERS