4.7 Article

A Short, Economical Synthesis of 2-Methoxyestradiol, an Anticancer Agent in Clinical Trials

期刊

JOURNAL OF ORGANIC CHEMISTRY
卷 74, 期 16, 页码 6362-6364

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AMER CHEMICAL SOC
DOI: 10.1021/jo901086s

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  1. Meyers Institute Fund, Southern Illinois University Carbondale
  2. Department of Chemistry and Biochemistry, Southern Illinois University Carbondale Summmer Research Program

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2-Methoxyestradiol, a natural metabolite of estradiol and potential therapeutic agent for many types of cancers, has been synthesized successfully in three steps, starting from estradiol and cumyl methyl peroxide.

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