Systemic manifestation and contribution of peripheral tissues to Huntington’s disease pathogenesis

Proteasome stress in skeletal muscle mounts a long-range protective response that delays retinal and brain aging

(2021) Mamta Rai et al.   Cell Metabolism

Hormesis and Ginkgo biloba (GB): Numerous biological effects of GB are mediated via hormesis

(2020) Edward J. Calabrese et al.   AGEING RESEARCH REVIEWS

Healthy Effects of Plant Polyphenols: Molecular Mechanisms

(2020) Manuela Leri et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Lysosomal Exocytosis, Exosome Release and Secretory Autophagy: The Autophagic- and Endo-Lysosomal Systems Go Extracellular

(2020) Sandra Buratta et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Healthspan Maintenance and Prevention of Parkinson’s-like Phenotypes with Hydroxytyrosol and Oleuropein Aglycone in C. elegans

(2020) Giovanni Brunetti et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hydroxytyrosol Inhibits Protein Oligomerization and Amyloid Aggregation in Human Insulin

(2020) Ivana Sirangelo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Healthspan Enhancement by Olive Polyphenols in C. elegans Wild Type and Parkinson’s Models

(2020) Gabriele Di Rosa et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Evidence for the spread of human-derived mutant huntingtin protein in mice and non-human primates

(2020) Philippe Gosset et al.   NEUROBIOLOGY OF DISEASE

Anti-inflammatory and Anti-oxidant Activity of Hidrox® in Rotenone-Induced Parkinson’s Disease in Mice

(2020) Rosalba Siracusa et al.   Antioxidants

Physical activity and muscle–brain crosstalk

(2019) Bente Klarlund Pedersen   Nature Reviews Endocrinology

Demonstration of prion-like properties of mutant huntingtin fibrils in both in vitro and in vivo paradigms

(2019) Maria Masnata et al.   ACTA NEUROPATHOLOGICA

Focused ultrasound-induced blood brain-barrier opening enhanced vascular permeability for GDNF delivery in Huntington's disease mouse model

(2019) Chung-Yin Lin et al.   Brain Stimulation

Rhes travels from cell to cell and transports Huntington disease protein via TNT-like protrusion

(2019) Manish Sharma et al.   JOURNAL OF CELL BIOLOGY

Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Models Parkinson’s Disease

(2019) Sangjune Kim et al.   NEURON

Peripheral Expression of Mutant Huntingtin is a Critical Determinant of Weight Loss and Metabolic Disturbances in Huntington’s Disease

(2019) Priya Lakra et al.   Scientific Reports

The microbiome: A target for Alzheimer disease?

(2019) Dong-oh Seo et al.   CELL RESEARCH

Cytotoxicity Models of Huntington's Disease and Relevance of Hormetic Mechanisms: A Critical Assessment of Experimental Approaches and Strategies

(2019) Edward J. Calabrese et al.   PHARMACOLOGICAL RESEARCH

Swim exercise in Caenorhabditis elegans extends neuromuscular and gut healthspan, enhances learning ability, and protects against neurodegeneration

(2019) Ricardo Laranjeiro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Muscle-derived Dpp regulates feeding initiation via endocrine modulation of brain dopamine biosynthesis

(2019) Maricela Robles-Murguia et al.   GENES & DEVELOPMENT

Leptin deficiency reverses high metabolic state and weight loss without affecting central pathology in the R6/2 mouse model of Huntington's disease

(2019) Marie Sjögren et al.   NEUROBIOLOGY OF DISEASE

Retinal dysfunction in a presymptomatic patient with Huntington’s disease

(2018) Jonelle Knapp et al.   DOCUMENTA OPHTHALMOLOGICA

A genetic modifier suggests that endurance exercise exacerbates Huntington's disease

(2018) Silvia Corrochano et al.   HUMAN MOLECULAR GENETICS

Generation of circadian rhythms in the suprachiasmatic nucleus

(2018) Michael H. Hastings et al.   NATURE REVIEWS NEUROSCIENCE

Neurofilament light protein in blood predicts regional atrophy in Huntington disease

(2018) Eileanoir B. Johnson et al.   NEUROLOGY

Cardiac mTORC1 Dysregulation Impacts Stress Adaptation and Survival in Huntington’s Disease

(2018) Daniel D. Child et al.   Cell Reports

Neuro-Cardio Mechanisms in Huntington’s Disease and Other Neurodegenerative Disorders

(2018) Bethan J. Critchley et al.   Frontiers in Physiology

Pathophysiology in the suprachiasmatic nucleus in mouse models of Huntington’s disease

(2018) Dika Kuljis et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Body Composition and Bone Mineral Density in Huntington's Disease (HD)

(2018) Renata Costa de Miranda et al.   NUTRITION

Evaluation of mutant huntingtin and neurofilament proteins as potential markers in Huntington’s disease

(2018) Lauren M. Byrne et al.   Science Translational Medicine

Endocrine Crosstalk Between Skeletal Muscle and the Brain

(2018) Julien Delezie et al.   Frontiers in Neurology

Increased oxidative stress and CaMKII activity contribute to electro-mechanical defects in cardiomyocytes from a murine model of Huntington's disease

(2018) Julliane Vasconcelos Joviano-Santos et al.   FEBS Journal

Platelet abnormalities in Huntington’s disease

(2018) Hélèna L Denis et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Degeneration of ipRGCs in mouse models of Huntington's Disease disrupts non-image forming behaviors prior to motor impairment

(2018) MengSyuan Lin et al.   JOURNAL OF NEUROSCIENCE

Peripheral immune system in aging and Alzheimer’s disease

(2018) Wei Cao et al.   Molecular Neurodegeneration

Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models

(2018) Mychael V. Lourenco et al.   NATURE MEDICINE

Muscle atrophy is associated with cervical spinal motoneuron loss in BACHD mouse model for Huntington's disease

(2017) Priscila Aparecida Costa Valadão et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Functional impairment of precerebral arteries in Huntington disease

(2017) Jan Kobal et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Treadmill exercise delays the onset of non-motor behaviors and striatal pathology in the CAG 140 knock-in mouse model of Huntington's disease

(2017) D.P. Stefanko et al.   NEUROBIOLOGY OF DISEASE

Circadian rhythm and autonomic dysfunction in presymptomatic and early Huntington's disease

(2017) Elena Bellosta Diago et al.   PARKINSONISM & RELATED DISORDERS

Huntington’s Disease iPSC-Derived Brain Microvascular Endothelial Cells Reveal WNT-Mediated Angiogenic and Blood-Brain Barrier Deficits

(2017) Ryan G. Lim et al.   Cell Reports

Cell-to-cell Transmission of Polyglutamine Aggregates in C. elegans

(2017) Dong-Kyu Kim et al.   Experimental Neurobiology

Impairment of blood-brain barrier is an early event in R6/2 mouse model of Huntington Disease

(2017) Alba Di Pardo et al.   Scientific Reports

Human-to-mouse prion-like propagation of mutant huntingtin protein

(2016) Iksoo Jeon et al.   ACTA NEUROPATHOLOGICA

Systemic Nutrient and Stress Signaling via Myokines and Myometabolites

(2016) Mamta Rai et al.   Annual Review of Physiology

Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease

(2016) Timothy R. Sampson et al.   CELL

HPA axis in major depression: cortisol, clinical symptomatology and genetic variation predict cognition

(2016) J Keller et al.   MOLECULAR PSYCHIATRY

Peripheral Synucleinopathy in Early Parkinson's Disease: Submandibular Gland Needle Biopsy Findings

(2016) Charles H. Adler et al.   MOVEMENT DISORDERS

The Biology of Huntingtin

(2016) Frédéric Saudou et al.   NEURON

Butyrate, neuroepigenetics and the gut microbiome: Can a high fiber diet improve brain health?

(2016) Megan W. Bourassa et al.   NEUROSCIENCE LETTERS

Common disease signatures from gene expression analysis in Huntington’s disease human blood and brain

(2016) Eleni Mina et al.   Orphanet Journal of Rare Diseases

A randomized, controlled trial of a multi-modal exercise intervention in Huntington’s disease

(2016) Lori Quinn et al.   PARKINSONISM & RELATED DISORDERS

Cardiac Dysfunction in the BACHD Mouse Model of Huntington’s Disease

(2016) Analyne M. Schroeder et al.   PLoS One

Cerebrovascular and blood-brain barrier impairments in Huntington's disease: Potential implications for its pathophysiology

(2015) Janelle Drouin-Ouellet et al.   ANNALS OF NEUROLOGY

Phosphorylated α-synuclein in skin nerve fibres differentiates Parkinson’s disease from multiple system atrophy

(2015) Leonora Zange et al.   BRAIN

The influence of the HPG axis on stress response and depressive-like behaviour in a transgenic mouse model of Huntington's disease

(2015) X. Du et al.   EXPERIMENTAL NEUROLOGY

Structure, production and signaling of leptin

(2015) Heike Münzberg et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Transcellular spreading of huntingtin aggregates in theDrosophilabrain

(2015) Daniel T. Babcock et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The regulation of muscle mass by endogenous glucocorticoids

(2015) Theodore P. Braun et al.   Frontiers in Physiology

Huntington disease

(2015) Gillian P. Bates et al.   Nature Reviews Disease Primers

Mutant huntingtin is present in neuronal grafts in huntington disease patients

(2014) Francesca Cicchetti et al.   ANNALS OF NEUROLOGY

The many faces of autophagy dysfunction in Huntington's disease: from mechanism to therapy

(2014) Constanza J. Cortes et al.   DRUG DISCOVERY TODAY

Progressive hepatic mitochondrial dysfunction in premanifest Huntington's disease

(2014) Rainer Hoffmann et al.   MOVEMENT DISORDERS

Plasma melatonin is reduced in Huntington's disease

(2014) Eirini Kalliolia et al.   MOVEMENT DISORDERS

High stress hormone levels accelerate the onset of memory deficits in male Huntington's disease mice

(2014) Christina Mo et al.   NEUROBIOLOGY OF DISEASE

Effects of chronic stress on the onset and progression of Huntington's disease in transgenic mice

(2014) Christina Mo et al.   NEUROBIOLOGY OF DISEASE

Nitric Oxide Dysregulation in Platelets from Patients with Advanced Huntington Disease

(2014) Albino Carrizzo et al.   PLoS One

Intertissue Control of the Nucleolus via a Myokine-Dependent Longevity Pathway

(2014) Fabio Demontis et al.   Cell Reports

Dysfunction of the CNS-Heart Axis in Mouse Models of Huntington's Disease

(2014) Michal Mielcarek et al.   PLoS Genetics

The influence of skeletal muscle on systemic aging and lifespan

(2013) Fabio Demontis et al.   AGING CELL

Longitudinal analysis of the electroencephalogram and sleep phenotype in the R6/2 mouse model of Huntington’s disease

(2013) Simon P. Fisher et al.   BRAIN

What effect does a structured home-based exercise programme have on people with Huntington’s disease? A randomized, controlled pilot study

(2013) Hanan Khalil et al.   CLINICAL REHABILITATION

Mechanisms of muscle growth and atrophy in mammals andDrosophila

(2013) Rosanna Piccirillo et al.   DEVELOPMENTAL DYNAMICS

Exercise attenuates neuropathology and has greater benefit on cognitive than motor deficits in the R6/1 Huntington's disease mouse model

(2013) David J. Harrison et al.   EXPERIMENTAL NEUROLOGY

Mitochondrial respiratory chain complex activity and bioenergetic alterations in human platelets derived from pre-symptomatic and symptomatic Huntington's disease carriers

(2013) Ana C. Silva et al.   MITOCHONDRION

Hepatic mitochondrial dysfunction in manifest and premanifest Huntington disease

(2013) S. H. Stuwe et al.   NEUROLOGY

The Q175 Mouse Model of Huntington’s Disease Shows Gene Dosage- and Age-Related Decline in Circadian Rhythms of Activity and Sleep

(2013) Dawn H. Loh et al.   PLoS One

Huntington disease skeletal muscle is hyperexcitable owing to chloride and potassium channel dysfunction

(2013) C. W. Waters et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Huntington's disease: underlying molecular mechanisms and emerging concepts

(2013) John Labbadia et al.   TRENDS IN BIOCHEMICAL SCIENCES

A Randomized Feasibility Study of a 12-Week Community-Based Exercise Program for People With Huntingtonʼs Disease

(2013) Monica Busse et al.   Journal of Neurologic Physical Therapy

Bone Marrow Transplantation Confers Modest Benefits in Mouse Models of Huntington's Disease

(2012) W. Kwan et al.   JOURNAL OF NEUROSCIENCE

A Novel BACHD Transgenic Rat Exhibits Characteristic Neuropathological Features of Huntington Disease

(2012) L. Yu-Taeger et al.   JOURNAL OF NEUROSCIENCE

Neurocardiac dysregulation and neurogenic arrhythmias in a transgenic mouse model of Huntington's disease

(2012) Helen Kiriazis et al.   JOURNAL OF PHYSIOLOGY-LONDON

Oxidative stress and inflammation biomarkers in the blood of patients with Huntington’s disease

(2012) Fernando Sánchez-López et al.   NEUROLOGICAL RESEARCH

Comprehensive Behavioral and Molecular Characterization of a New Knock-In Mouse Model of Huntington’s Disease: zQ175

(2012) Liliana B. Menalled et al.   PLoS One

Environmental enrichment rescues female-specific hyperactivity of the hypothalamic-pituitary-adrenal axis in a model of Huntington's disease

(2012) X Du et al.   Translational Psychiatry

The dysfunction of hepatic transcriptional factors in mice with Huntington's Disease

(2011) Ming-Chang Chiang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Microcirculation response to local cooling in patients with Huntington’s disease

(2011) Ziva Melik et al.   JOURNAL OF NEUROLOGY

Gastrointestinal dysfunction contributes to weight loss in Huntington's disease mice

(2011) Jorien M.M. van der Burg et al.   NEUROBIOLOGY OF DISEASE

Retinal dysfunction, photoreceptor protein dysregulation and neuronal remodelling in the R6/1 mouse model of Huntington's disease

(2011) Abrez Hussain Batcha et al.   NEUROBIOLOGY OF DISEASE

A Genetic Screening Strategy Identifies Novel Regulators of the Proteostasis Network

(2011) M. Catarina Silva et al.   PLoS Genetics

Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network

(2010) Richard C. Scarpulla   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

FOXO/4E-BP Signaling in Drosophila Muscles Regulates Organism-wide Proteostasis during Aging

(2010) Fabio Demontis et al.   CELL

Diabetes mellitus in Huntington disease

(2010) Lindsay A. Farrer   CLINICAL GENETICS

Dysfunctions in circadian behavior and physiology in mouse models of Huntington's disease

(2010) Takashi Kudo et al.   EXPERIMENTAL NEUROLOGY

Impairment of PGC-1alpha expression, neuropathology and hepatic steatosis in a transgenic mouse model of Huntington's disease following chronic energy deprivation

(2010) R. K. Chaturvedi et al.   HUMAN MOLECULAR GENETICS

Puromycin-sensitive aminopeptidase protects against aggregation-prone proteins via autophagy

(2010) Fiona M. Menzies et al.   HUMAN MOLECULAR GENETICS

Protein homeostasis and aging in neurodegeneration

(2010) Peter M. Douglas et al.   JOURNAL OF CELL BIOLOGY

Challenges assessing clinical endpoints in early Huntington disease

(2010) Jane S. Paulsen et al.   MOVEMENT DISORDERS

Cell-to-cell transmission of non-prion protein aggregates

(2010) Seung-Jae Lee et al.   Nature Reviews Neurology

Reduced gluconeogenesis and lactate clearance in Huntington's disease

(2010) Knud Josefsen et al.   NEUROBIOLOGY OF DISEASE

Autonomic dysfunction in presymptomatic and early symptomatic Huntington’s disease

(2009) J. Kobal et al.   ACTA NEUROLOGICA SCANDINAVICA

Reduced IGF-1 Signaling Delays Age-Associated Proteotoxicity in Mice

(2009) Ehud Cohen et al.   CELL

Huntington's disease: The current state of research with peripheral tissues

(2009) Jenny Sassone et al.   EXPERIMENTAL NEUROLOGY

Adipose tissue dysfunction tracks disease progression in two Huntington's disease mouse models

(2009) Jack Phan et al.   HUMAN MOLECULAR GENETICS

Increased Hypothalamic-Pituitary-Adrenal Axis Activity in Huntington’s Disease

(2009) N. Ahmad Aziz et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Abnormal morphology of peripheral cell tissues from patients with Huntington disease

(2009) Ferdinando Squitieri et al.   JOURNAL OF NEURAL TRANSMISSION

Delayed onset of the diurnal melatonin rise in patients with Huntington’s disease

(2009) N. Ahmad Aziz et al.   JOURNAL OF NEUROLOGY

Cytoplasmic penetration and persistent infection of mammalian cells by polyglutamine aggregates

(2009) Pei-Hsien Ren et al.   NATURE CELL BIOLOGY

Formation of Polyglutamine Inclusions in a Wide Range of Non-CNS Tissues in the HdhQ150 Knock-In Mouse Model of Huntington's Disease

(2009) Hilary Moffitt et al.   PLoS One

Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites

(2009) W. R. Wikoff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wheel running from a juvenile age delays onset of specific motor deficits but does not alter protein aggregate density in a mouse model of Huntington's disease

(2008) Anton van Dellen et al.   BMC NEUROSCIENCE

Exendin-4 Improves Glycemic Control, Ameliorates Brain and Pancreatic Pathologies, and Extends Survival in a Mouse Model of Huntington's Disease

(2008) B. Martin et al.   DIABETES

Cardiovagal modulation upon postural change is altered in Huntingtons disease

(2008) K. J. Br et al.   EUROPEAN JOURNAL OF NEUROLOGY

Huntington’s disease: revisiting the aggregation hypothesis in polyglutamine neurodegenerative diseases

(2008) Ray Truant et al.   FEBS Journal

Sex differences in a transgenic rat model of Huntington's disease: decreased 17β-estradiol levels correlate with reduced numbers of DARPP32+ neurons in males

(2008) Felix J. Bode et al.   HUMAN MOLECULAR GENETICS

Use of hand-held dynamometry in the evaluation of lower limb muscle strength in people with Huntington’s disease

(2008) M. E. Busse et al.   JOURNAL OF NEUROLOGY

Full-Length Human Mutant Huntingtin with a Stable Polyglutamine Repeat Can Elicit Progressive and Selective Neuropathogenesis in BACHD Mice

(2008) M. Gray et al.   JOURNAL OF NEUROSCIENCE