The influence of skeletal muscle on systemic aging and lifespan

Skeletal muscle uncoupling-induced longevity in mice is linked to increased substrate metabolism and induction of the endogenous antioxidant defense system

(2013) S. Keipert et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Adenosine Nucleotide Biosynthesis and AMPK Regulate Adult Life Span and Mediate the Longevity Benefit of Caloric Restriction in Flies

(2013) Drew Stenesen et al.   Cell Metabolism

Muscle-derived expression of the chemokine CXCL1 attenuates diet-induced obesity and improves fatty acid oxidation in the muscle

(2012) Line Pedersen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human

(2012) Jun Wu et al.   CELL

Intramyocellular Fatty-Acid Metabolism Plays a Critical Role in Mediating Responses to Dietary Restriction in Drosophila melanogaster

(2012) Subhash D. Katewa et al.   Cell Metabolism

IL-15 Overexpression Promotes Endurance, Oxidative Energy Metabolism, and Muscle PPARδ, SIRT1, PGC-1α, and PGC-1β Expression in Male Mice

(2012) LeBris S. Quinn et al.   ENDOCRINOLOGY

A novel myokine, secreted protein acidic and rich in cysteine (SPARC), suppresses colon tumorigenesis via regular exercise

(2012) Wataru Aoi et al.   GUT

Myonectin (CTRP15), a Novel Myokine That Links Skeletal Muscle to Systemic Lipid Homeostasis

(2012) Marcus M. Seldin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Myostatin inhibition induces muscle fibre hypertrophy prior to satellite cell activation

(2012) Qian Wang et al.   JOURNAL OF PHYSIOLOGY-LONDON

Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis

(2012) Congcong He et al.   NATURE

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

(2012) Pontus Boström et al.   NATURE

Muscles, exercise and obesity: skeletal muscle as a secretory organ

(2012) Bente K. Pedersen et al.   Nature Reviews Endocrinology

E-Peptides Control Bioavailability of IGF-1

(2012) Marianne Smedegaard Hede et al.   PLoS One

Muscle-derived stem/progenitor cell dysfunction limits healthspan and lifespan in a murine progeria model

(2012) Mitra Lavasani et al.   Nature Communications

Proteomic identification of secreted proteins from human skeletal muscle cells and expression in response to strength training

(2011) Frode Norheim et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Exercise-induced muscle-derived cytokines inhibit mammary cancer cell growth

(2011) Pernille Hojman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Physical exercise stimulates autophagy in normal skeletal muscles but is detrimental for collagen VI-deficient muscles

(2011) Paolo Grumati et al.   Autophagy

A Muscle-Specific p38 MAPK/Mef2/MnSOD Pathway Regulates Stress, Motor Function, and Life Span in Drosophila

(2011) Alysia Vrailas-Mortimer et al.   DEVELOPMENTAL CELL

Interleukin-15 treatment improves glucose homeostasis and insulin sensitivity in obese mice

(2011) N. G. Barra et al.   DIABETES OBESITY & METABOLISM

LIF is a contraction-induced myokine stimulating human myocyte proliferation

(2011) Christa Broholm et al.   JOURNAL OF APPLIED PHYSIOLOGY

Flight restriction prevents associative learning deficits but not changes in brain protein-adduct formation during honeybee ageing

(2011) C. C. Tolfsen et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells

(2011) Helga Ellingsgaard et al.   NATURE MEDICINE

Beneficial effects of exercise in a transgenic mouse model of Alzheimer's disease-like Tau pathology

(2011) Karim Belarbi et al.   NEUROBIOLOGY OF DISEASE

Endurance exercise rescues progeroid aging and induces systemic mitochondrial rejuvenation in mtDNA mutator mice

(2011) A. Safdar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dietary effects on body composition, glucose metabolism, and longevity are modulated by skeletal muscle mitochondrial uncoupling in mice

(2010) Susanne Keipert et al.   AGING CELL

A critical role of SNF1A/dAMPKα (Drosophila AMP-activated protein kinase α) in muscle on longevity and stress resistance in Drosophila melanogaster

(2010) Daisuke Tohyama et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Strenuous endurance exercise improves life expectancy: it's in our genes

(2010) J. R. Ruiz et al.   BRITISH JOURNAL OF SPORTS MEDICINE

Reversal of Cancer Cachexia and Muscle Wasting by ActRIIB Antagonism Leads to Prolonged Survival

(2010) Xiaolan Zhou et al.   CELL

FOXO/4E-BP Signaling in Drosophila Muscles Regulates Organism-wide Proteostasis during Aging

(2010) Fabio Demontis et al.   CELL

The Transcriptional Coregulators TIF2 and SRC-1 Regulate Energy Homeostasis by Modulating Mitochondrial Respiration in Skeletal Muscles

(2010) Delphine Duteil et al.   Cell Metabolism

PGC-1α and Myokines in the Aging Muscle – A Mini-Review

(2010) Anne-Sophie Arnold et al.   GERONTOLOGY

Insulin-like 6 Is Induced by Muscle Injury and Functions as a Regenerative Factor

(2010) Ling Zeng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Peroxisome Proliferator-activated Receptor γ Coactivator 1α or 1β Overexpression Inhibits Muscle Protein Degradation, Induction of Ubiquitin Ligases, and Disuse Atrophy

(2010) Jeffrey J. Brault et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Age- and tissue-specific changes in mitochondrial and nuclear DNA base excision repair activity in mice: Susceptibility of skeletal muscles to oxidative injury

(2010) Bartosz Szczesny et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Dynamics of the Skeletal Muscle Secretome during Myoblast Differentiation

(2010) Jeanette Henningsen et al.   MOLECULAR & CELLULAR PROTEOMICS

Age- and Temperature-Dependent Somatic Mutation Accumulation in Drosophila melanogaster

(2010) Ana Maria Garcia et al.   PLoS Genetics

Effects of myostatin deletion in aging mice

(2009) Michael R. Morissette et al.   AGING CELL

Smad2 and 3 transcription factors control muscle mass in adulthood

(2009) Roberta Sartori et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Sod2 knockdown in the musculature has whole-organism consequences in Drosophila

(2009) Ian Martin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Myostatin Inhibition Enhances the Effects of Exercise on Performance and Metabolic Outcomes in Aged Mice

(2009) N. K. LeBrasseur et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Triggering endogenous neuroprotective processes through exercise in models of dopamine deficiency

(2009) Michael J. Zigmond et al.   PARKINSONISM & RELATED DISORDERS

Myostatin Inhibition in Muscle, but Not Adipose Tissue, Decreases Fat Mass and Improves Insulin Sensitivity

(2009) Tingqing Guo et al.   PLoS One

Exercise-Training in Young Drosophila melanogaster Reduces Age-Related Decline in Mobility and Cardiac Performance

(2009) Nicole Piazza et al.   PLoS One

Increased muscle PGC-1  expression protects from sarcopenia and metabolic disease during aging

(2009) T. Wenz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Signals of youth: endocrine regulation of aging in Caenorhabditis elegans

(2009) Siler H. Panowski et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Born to run; the story of the PEPCK-Cmus mouse

(2008) Richard W. Hanson et al.   BIOCHIMIE

Muscle-Derived Angiopoietin-Like Protein 4 Is Induced by Fatty Acids via Peroxisome Proliferator-Activated Receptor (PPAR)-  and Is of Metabolic Relevance in Humans

(2008) H. Staiger et al.   DIABETES

FGF21 is an Akt-regulated myokine

(2008) Yasuhiro Izumiya et al.   FEBS LETTERS

Follistatin-like 1, a Secreted Muscle Protein, Promotes Endothelial Cell Function and Revascularization in Ischemic Tissue through a Nitric-oxide Synthase-dependent Mechanism

(2008) Noriyuki Ouchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1α

(2008) Zoltan Arany et al.   NATURE

Long-term enhancement of skeletal muscle mass and strength by single gene administration of myostatin inhibitors

(2008) A. M. Haidet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA