An Integrated Nanoaircraft Carrier Modulating Antitumor Immunity to Enhance Immune Checkpoint Blockade Therapy

Boosting anti-PD-1 therapy with metformin-loaded macrophage-derived microparticles

(2021) Zhaohan Wei et al.   Nature Communications

Precise Depletion of Tumor Seed and Growing Soil with Shrinkable Nanocarrier for Potentiated Cancer Chemoimmunotherapy

(2021) Junxia Wang et al.   ACS Nano

Cancer-activated doxorubicin prodrug nanoparticles induce preferential immune response with minimal doxorubicin-related toxicity

(2021) Suah Yang et al.   BIOMATERIALS

Targeting Treg cells with GITR activation alleviates resistance to immunotherapy in murine glioblastomas

(2021) Zohreh Amoozgar et al.   Nature Communications

Recent Advances in Engineered Materials for Immunotherapy‐Involved Combination Cancer Therapy

(2021) Jun‐Long Liang et al.   ADVANCED MATERIALS

Dual‐Targeting to Cancer Cells and M2 Macrophages via Biomimetic Delivery of Mannosylated Albumin Nanoparticles for Drug‐Resistant Cancer Therapy

(2020) Pengfei Zhao et al.   ADVANCED FUNCTIONAL MATERIALS

Irradiated tumor cell–derived microparticles mediate tumor eradication via cell killing and immune reprogramming

(2020) Chao Wan et al.   Science Advances

Small Morph Nanoparticles for Deep Tumor Penetration via Caveolae-Mediated Transcytosis

(2020) Zipeng Zhang et al.   ACS Applied Materials & Interfaces

Cancer Therapy: Biomimetic Diselenide‐Bridged Mesoporous Organosilica Nanoparticles as an X‐ray‐Responsive Biodegradable Carrier for Chemo‐Immunotherapy (Adv. Mater. 50/2020)

(2020) Dan Shao et al.   ADVANCED MATERIALS

Metabolic rewiring of macrophages by CpG potentiates clearance of cancer cells and overcomes tumor-expressed CD47−mediated ‘don’t-eat-me’ signal

(2019) Mingen Liu et al.   NATURE IMMUNOLOGY

Antigens reversibly conjugated to a polymeric glyco-adjuvant induce protective humoral and cellular immunity

(2019) D. Scott Wilson et al.   NATURE MATERIALS

Tumors and Their Microenvironment Dual‐Targeting Chemotherapy with Local Immune Adjuvant Therapy for Effective Antitumor Immunity against Breast Cancer

(2019) Caifeng Deng et al.   Advanced Science

Photothermal Therapy Promotes Tumor Infiltration and Antitumor Activity of CAR T Cells

(2019) Qian Chen et al.   ADVANCED MATERIALS

Nanoengineered Immune Niches for Reprogramming the Immunosuppressive Tumor Microenvironment and Enhancing Cancer Immunotherapy

(2019) Hathaichanok Phuengkham et al.   ADVANCED MATERIALS

In Situ Nanoadjuvant-Assembled Tumor Vaccine for Preventing Long-Term Recurrence

(2019) Quoc-Viet Le et al.   ACS Nano

TRAIL-based gene delivery and therapeutic strategies

(2019) Hui-hai Zhong et al.   ACTA PHARMACOLOGICA SINICA

Self‐Amplified Drug Delivery with Light‐Inducible Nanocargoes to Enhance Cancer Immunotherapy

(2019) Bing Feng et al.   ADVANCED MATERIALS

Immunization with mannosylated nanovaccines and inhibition of the immune-suppressing microenvironment sensitizes melanoma to immune checkpoint modulators

(2019) João Conniot et al.   Nature Nanotechnology

Recent Advances in Nanostrategies Capable of Overcoming Biological Barriers for Tumor Management

(2019) Da Huo et al.   ADVANCED MATERIALS

Tumor‐Targeted Drug and CpG Delivery System for Phototherapy and Docetaxel‐Enhanced Immunotherapy with Polarization toward M1‐Type Macrophages on Triple Negative Breast Cancers

(2019) Lv Chen et al.   ADVANCED MATERIALS

Triggered All-Active Metal Organic Framework: Ferroptosis Machinery Contributes to the Apoptotic Photodynamic Antitumor Therapy

(2019) Xuan Meng et al.   NANO LETTERS

Genetic programming of macrophages to perform anti-tumor functions using targeted mRNA nanocarriers

(2019) F. Zhang et al.   Nature Communications

Melanocortin-1 Receptor-Targeting Ultrasmall Silica Nanoparticles for Dual-Modality Human Melanoma Imaging

(2018) Feng Chen et al.   ACS Applied Materials & Interfaces

Nanoparticles for Immune Cytokine TRAIL-Based Cancer Therapy

(2018) Pedro P.G. Guimarães et al.   ACS Nano

Quantifying the Ligand-Coated Nanoparticle Delivery to Cancer Cells in Solid Tumours

(2018) Qin Dai et al.   ACS Nano

Enzyme-triggered size shrink and laser-enhanced NO release nanoparticles for deep tumor penetration and combination therapy

(2018) Chuan Hu et al.   BIOMATERIALS

Size shrinkable drug delivery nanosystems and priming the tumor microenvironment for deep intratumoral penetration of nanoparticles

(2018) Yimin Niu et al.   JOURNAL OF CONTROLLED RELEASE

Bioreduction-ruptured nanogel for switch on/off release of Bcl2 siRNA in breast tumor therapy

(2018) Huipeng Li et al.   JOURNAL OF CONTROLLED RELEASE

Chloroquine modulates antitumor immune response by resetting tumor-associated macrophages toward M1 phenotype

(2018) Degao Chen et al.   Nature Communications

A designer self-assembled supramolecule amplifies macrophage immune responses against aggressive cancer

(2018) Ashish Kulkarni et al.   Nature Biomedical Engineering

Binary Cooperative Prodrug Nanoparticles Improve Immunotherapy by Synergistically Modulating Immune Tumor Microenvironment

(2018) Bing Feng et al.   ADVANCED MATERIALS

Near-Infrared Laser-Driven in Situ Self-Assembly as a General Strategy for Deep Tumor Therapy

(2018) Fu-Hua Liu et al.   NANO LETTERS

Carboplatin Loaded SMND to Reduce GSH Mediated Platinum Resistance for Prostate Cancer Therapy

(2018) Na Zhang et al.   Journal of Materials Chemistry B

Cancer immunoediting and resistance to T cell-based immunotherapy

(2018) Jake S. O’Donnell et al.   Nature Reviews Clinical Oncology

Targeting macrophages: therapeutic approaches in cancer

(2018) Luca Cassetta et al.   NATURE REVIEWS DRUG DISCOVERY

Intratumoral injection of gels containing losartan microspheres and (PLG-g-mPEG)-cisplatin nanoparticles improves drug penetration, retention and anti-tumor activity

(2018) Meiling Yu et al.   CANCER LETTERS

Combination therapy strategies for improving PD-1 blockade efficacy: a new era in cancer immunotherapy

(2017) P. S. Chowdhury et al.   JOURNAL OF INTERNAL MEDICINE

Nano-enabled pancreas cancer immunotherapy using immunogenic cell death and reversing immunosuppression

(2017) Jianqin Lu et al.   Nature Communications

Albumin/vaccine nanocomplexes that assemble in vivo for combination cancer immunotherapy

(2017) Guizhi Zhu et al.   Nature Communications

Current Multistage Drug Delivery Systems Based on the Tumor Microenvironment

(2017) Binlong Chen et al.   Theranostics

PI3Kγ Activates Integrin α 4 and Promotes Immune Suppressive Myeloid Cell Polarization during Tumor Progression

(2017) Philippe Foubert et al.   Cancer Immunology Research

Development and evaluation of oxaliplatin and irinotecan co-loaded liposomes for enhanced colorectal cancer therapy

(2016) Bo Zhang et al.   JOURNAL OF CONTROLLED RELEASE

Carboplatin and pemetrexed with or without pembrolizumab for advanced, non-squamous non-small-cell lung cancer: a randomised, phase 2 cohort of the open-label KEYNOTE-021 study

(2016) Corey J Langer et al.   LANCET ONCOLOGY

Photothermal therapy with immune-adjuvant nanoparticles together with checkpoint blockade for effective cancer immunotherapy

(2016) Qian Chen et al.   Nature Communications

Current clinical trials testing the combination of immunotherapy with radiotherapy

(2016) Josephine Kang et al.   Journal for ImmunoTherapy of Cancer

Bioconjugated Manganese Dioxide Nanoparticles Enhance Chemotherapy Response by Priming Tumor-Associated Macrophages toward M1-like Phenotype and Attenuating Tumor Hypoxia

(2015) Manli Song et al.   ACS Nano

Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer

(2015) Christina Twyman-Saint Victor et al.   NATURE

Control of adaptive immunity by the innate immune system

(2015) Akiko Iwasaki et al.   NATURE IMMUNOLOGY

Oxaliplatin-chitosan nanoparticles induced intrinsic apoptotic signaling pathway: A “smart” drug delivery system to breast cancer cell therapy

(2014) Raju Vivek et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Subcellular trafficking and transfection efficacy of polyethylenimine–polyethylene glycol polyplex nanoparticles with a ligand to melanocortin receptor-1

(2012) Mikhail O. Durymanov et al.   JOURNAL OF CONTROLLED RELEASE