Article
Surgery
Akira Ikumi, Anne Gingery, Yoichi Toyoshima, Chunfeng Zhao, Steven L. Moran, Christopher Livia, Tyler Rolland, Timothy Peterson, Michael S. Sabbah, Soulmaz Boroumand, Tiam M. Saffari, Atta Behfar, Alexander Y. Shin, Peter C. Amadio
Summary: The study demonstrated improved functional motor recovery and nerve regeneration profiles in a rat sciatic nerve reverse autograft model with the local administration of purified exosome product. This suggests beneficial effects on nerve regeneration, gene profiles, and motor outcomes.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2021)
Article
Chemistry, Multidisciplinary
Bing Xia, Xue Gao, Jiaqi Qian, Shengyou Li, Beibei Yu, Yiming Hao, Bin Wei, Teng Ma, Haining Wu, Shijie Yang, Yi Zheng, Xueli Gao, Lingli Guo, Jianbo Gao, Yujie Yang, Yongfeng Zhang, Yitao Wei, Borui Xue, Yan Jin, Zhuojing Luo, Jin Zhang, Jinghui Huang
Summary: A superparamagnetic nanocomposite scaffold is developed to control the production of extracellular vesicles (EVs) by applying a rotating magnetic field. This non-invasive and remotely time-scheduled method accelerates tissue regeneration, including that of peripheral nerves.
ADVANCED MATERIALS
(2023)
Review
Neurosciences
Frederic A. A. Vallejo, Anthony Diaz, Emily L. L. Errante, Taylor Smartz, Aisha Khan, Risset Silvera, Adriana E. E. Brooks, Yee-Shuan Lee, Stephen Shelby Burks, Allan D. D. Levi
Summary: This study systematically evaluated the therapeutic use of Schwann cells (SC) in the repair of peripheral nerve injuries. The results showed that SCs have clear potential in improving morphological and functional outcomes in animal studies of long gap peripheral nerve injuries. However, the optimal nerve conduit or graft for delivering and retaining SCs for nerve regeneration has yet to be determined.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Marwa El Soury, Oscar Dario Garcia-Garcia, Matteo Moretti, Isabelle Perroteau, Stefania Raimondo, Arianna Barbara Lovati, Victor Carriel
Summary: This study investigates a novel nerve decellularization protocol that combines effective decellularization with good preservation of the extracellular matrix component in a short time compared to a specific nerve decellularization protocol. The results suggest that the novel protocol (DN-P1) may offer promising in vivo results, as it demonstrated better ultrastructure and ECM preservation compared to the specific nerve protocol (DN-P2), along with higher biocompatibility and support for viable cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Mar Bosch-Queralt, Robert Fledrich, Ruth M. Stassart
Summary: The Schwann cell (SC), a glial cell in the peripheral nervous system (PNS), is highly versatile in its functions. It plays a crucial role in ensuring the survival of neurons and guiding their axonal development. SCs also contribute to the structural organization of nerves, including blood vessels and various layers. They are involved in myelination of large axons and organization of non-myelinating bundles. SCs have diverse specialized functions in specific locations, such as the neuromuscular junction and cutaneous sensory end organs. They also interact closely with sensory and autonomic neurons. In response to nerve injuries, SCs exhibit remarkable plasticity and transform into repair cells that promote nerve regeneration. However, the molecular mechanisms underlying these functions are still not fully understood.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Engineering, Biomedical
Binghui Jin, Yunru Yu, Xiangxiang Chen, Yanhong Yang, Yushan Xiong, Young Jun Im, Yuanjin Zhao, Jian Xiao
Summary: The study proposes a novel microtube for sciatic nerve regeneration using gradient decellularized porcine sciatic nerve extracellular matrix hydrogel (pDScNM-gel). The pDScNM is shown to enhance cell proliferation and migration, improve axon growth, and these effects can also be achieved through coculture in a gradient pDScNM microtube. In vivo sciatic nerve regeneration and functional recovery are demonstrated by assembling the gradient pDScNM microtubes with a medical silicon tube.
BIOACTIVE MATERIALS
(2023)
Article
Cell & Tissue Engineering
Xinyang Zhou, Miaomei Yu, Daiyue Chen, Chunyan Deng, Qi Zhang, Xiaosong Gu, Fei Ding
Summary: This study demonstrates the potential of incorporating skin-derived precursor Schwann cell-derived extracellular vesicles (SKP-SC-EVs) into chitosan nerve conduits for the repair of long-distance sciatic nerve defects in rats. The results show that EV-NG significantly improves motor and sensory function recovery, promotes axonal regeneration and myelination, and alleviates muscle atrophy.
TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2023)
Article
Chemistry, Applied
Sergey O. Solomevich, Carlo M. Oranges, Daniel F. Kalbermatten, Anna Schwendeman, Srinivas Madduri
Summary: Peripheral nerve repair is a serious problem in neurosurgery, with poor clinical outcomes and significant socioeconomic burden. Biodegradable polysaccharides show great potential for improving nerve regeneration. This review focuses on the promising therapeutic strategies involving different types of polysaccharides and their composites for promoting nerve regeneration, highlighting their applications in nerve guidance conduits, hydrogels, nanofibers, and films. The ease of therapeutic implementation, drug release properties, therapeutic outcomes, and future research directions are also discussed.
CARBOHYDRATE POLYMERS
(2023)
Article
Neurosciences
Chang-Feng Lu, Bo Wang, Pei-Xun Zhang, Shuai Han, Wei Pi, Yu-Hui Kou, Bao-Guo Jiang
Summary: Nerve grafts constructed from chitin biological conduits combined with small autogenous nerves (SANs) and platelet-rich plasma (PRP) significantly improved the repair of 10-mm sciatic nerve defects in rats, showing potential for future therapeutic applications in repairing peripheral nerve defects.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Jose A. Gomez-Sanchez, Nikiben Patel, Fernanda Martirena, Shaline Fazal, Clara Mutschler, Hugo Cabedo
Summary: The peripheral nervous system (PNS) has superior regenerative capacity compared to the central nervous system (CNS). This regenerative ability is attributed to the reprogramming of Schwann cells (SC) into repair Schwann cells, which support axonal growth, myelin degradation, neurotrophic factor secretion, and axonal growth guidance. Epigenetic regulations, particularly histone acetylation and deacetylation, play a crucial role in SC reprogramming and nerve regeneration. This review focuses on Zn2+-dependent histone deacetylases (HDACs) and their importance in repair SC biology and remyelination after PNS injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Chen Liu, Fangzhen Shan, Feng Gao, Qingjie Ji, Yunfeng Chen, Changying Wang, Zihao Wang, Pengcheng Gao, Zhanyun Lv, Yuzhong Wang
Summary: The expression of DAP12 in Schwann cells and its roles in the peripheral nervous system (PNS) were investigated. DAP12-deficiency mice showed age-related motor deficits and thinner myelin, but faster clinical recovery after sciatic nerve crush injury. Proteomic analysis revealed differentially expressed proteins related to myelin loss and macrophage accumulation in DAP12 KO mice. DAP12 deletion promoted the phenotype conversion of macrophages from M1 to M2, suggesting dual roles of DAP12 in the PNS.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Emergency Medicine
Taotao Hu, Shusen Chang, Fang Qi, Zhonghui Zhang, Jiayin Chen, Lingli Jiang, Dali Wang, Chengliang Deng, Kaiyu Nie, Guangchao Xu, Zairong Wei
Summary: This study investigated the role of exosomes derived from Schwann cell-like cells (SCLCs) in peripheral nerve regeneration. SCLCs-exo significantly enhanced motor function recovery, attenuated muscle atrophy, and facilitated axonal regrowth, myelin formation, and angiogenesis. Furthermore, SCLCs-exo efficiently promoted proliferation and migration of Schwann cells and upregulated the expression of neurotrophic factors, myelin regulators, and myelin proteins.
Article
Neurosciences
Guoliang Wang, Zhihua Wang, Shuang Gao, Yang Wang, Qing Li
Summary: The study confirmed the reparative effect of curcumin on sciatic nerve injury, and discovered that its mechanism may be related to the regulation of Schwann cell proliferation and myelination by Runx2.
NEUROSCIENCE LETTERS
(2022)
Article
Neurosciences
Tarika Goncalves do Carmo Oliveira, Ana Claudia Moreira dos Santos, Alex Dias Assis, Raphael Teixeira Borges, Jessica Regina da Costa Silva, Carlos Ueira-Vieira, Gustavo Ferreira Simoes, Renata Graciele Zanon
Summary: The combination of BthTL glue and TNF mimetic peptide promoted axonal regrowth and remyelination, leading to better regeneration outcomes. The Tube + Glue + Pep group exhibited intense inflammatory infiltrate, higher expression of NGFRp75 receptor, increased myelin thickness and fiber diameter, as well as more type III collagen deposition.
BRAIN RESEARCH BULLETIN
(2021)
Article
Medicine, Research & Experimental
Wei Chen, Shusen Chang, Chenglan Yang, Jian Zhou, Huizhong Zhang, Kaiyu Nie, Zairong Wei
Summary: This study investigated the mechanism underlying sensory function reconstruction using Schwann cells (SCs). The researchers found that the SOX2/FN1 axis and exosomes secreted by SCs promoted nerve regeneration and recovery.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2022)
Article
Toxicology
Jiaojiao Qin, Meilong Wu, Shu Yu, Xiaorong Gao, Jingjing Zhang, Xingyue Dong, Jinyan Ji, Yuxi Zhang, Lin Zhou, Qi Zhang, Fei Ding
TOXICOLOGY LETTERS
(2015)
Article
Neurosciences
Qi Zhang, Shuhua Chen, Shu Yu, Jiaojiao Qin, Jingjing Zhang, Qiong Cheng, Kaifu Ke, Fei Ding
Article
Neurosciences
Q. Zhang, J. Zhang, C. Jiang, J. Qin, K. Ke, F. Ding
Article
Neurosciences
Jinli Lu, Shuhua Chen, Mi Shen, Qianru He, Yu Zhang, Yue Shi, Fei Ding, Qi Zhang
NEUROSCIENCE LETTERS
(2018)
Article
Clinical Neurology
Yi-Wu Shi, Qi Zhang, Kefu Cai, Sarah Poliquin, Wangzhen Shen, Nathan Winters, Yong-Hong Yi, Jie Wang, Ningning Hu, Robert L. Macdonald, Wei-Ping Liao, Jing-Qiong Kang
Article
Environmental Sciences
Yu Zhang, Hui Guo, Xinyu Guo, Denfeng Ge, Yue Shi, Xiyu Lu, Jinli Lu, Juan Chen, Fei Ding, Qi Zhang
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2019)
Article
Chemistry, Multidisciplinary
Qiong Cheng, Juan Chen, Hui Guo, Jin-li Lu, Jing Zhou, Xin-yu Guo, Yue Shi, Yu Zhang, Shu Yu, Qi Zhang, Fei Ding
Summary: The study demonstrates that PQQ can alleviate locomotor deficits and dopaminergic neuron loss in a mouse PD model by promoting mitochondrial biogenesis through the activation of the AMPK signaling pathway.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Biochemistry & Molecular Biology
Qi Zhang, Jing Zhou, Mi Shen, Hui Xu, Shu Yu, Qiong Cheng, Fei Ding
Article
Oncology
Dingding Shen, Juan Chen, Dong Liu, Mi Shen, Xin Wang, Youjia Wu, Shuan Ke, Robert L. Macdonald, Qi Zhang
ANNALS OF TRANSLATIONAL MEDICINE
(2020)
Article
Behavioral Sciences
Guihai Suo, Xing Cao, Yuqin Zheng, Haiying Li, Qi Zhang, Jihong Tang, Youjia Wu
Summary: Mutations in STXBP1 gene are associated with neurodevelopmental disorders and early-onset epileptic encephalopathies. Using a zebrafish model with mutant STXBP1, researchers demonstrated clinical phenotypes related to human STXBP1 mutation and evaluated antiepileptic drugs effects on seizures.
EPILEPSY & BEHAVIOR
(2021)
Article
Biochemistry & Molecular Biology
Jing Zhou, Wenpeng Liang, Jie Wang, Juan Chen, Dong Liu, Xin Wang, Youjia Wu, Qi Zhang, Dingding Shen
Summary: Mutations in the GABRG2 gene have been linked to epilepsy syndromes. Using a zebrafish model, this study demonstrates that the mutant GABRG2 gene can cause seizures, altered locomotor activity, and synaptic abnormalities.
HUMAN MOLECULAR GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Wei Wang, Dingding Shen, Lilei Zhang, Yanan Ji, Lai Xu, Zehao Chen, Yuntian Shen, Leilei Gong, Qi Zhang, Mi Shen, Xiaosong Gu, Hualin Sun
Summary: The study found that SKP-SC-EVs can alleviate denervated muscle atrophy by inhibiting oxidative stress and inflammation, promoting proliferation and differentiation of myoblasts, improving muscle blood perfusion, and reducing mitochondrial vacuolar degeneration and autophagy.
Review
Biochemistry & Molecular Biology
Jie Wang, Feng Yun, Jiahui Sui, Wenpeng Liang, Dingding Shen, Qi Zhang
Summary: Epilepsy, a common and severe chronic neurological disorder, has been the subject of extensive research on post-translational modification (PTM) mechanisms, particularly protein acetylation modifications. Histone acetyltransferases (HATs) and histone deacetylases (HDACs) regulate acetylation, with HATs transferring acetyl groups to lysine residues and HDACs removing acetyl groups. Epilepsy is associated with the regulation of gene expression through histone acetylation and deacetylation, as well as the acetylation modification of non-histone substrates. HDAC inhibitors (HDACi) have been developed as potential antiepileptic drugs. This review summarizes the changes in acetylation modification during epileptogenesis, the application of HDACi in epilepsy treatment, and the underlying mechanisms. Further understanding of acetylation regulation will provide insights into the pathological mechanism of epilepsy and novel therapeutic ideas.
Article
Immunology
Wenpeng Liang, Jie Wang, Jiahui Sui, Feng Yun, Yuntian Shen, Jing Zhou, Youjia Wu, Dingding Shen, Qi Zhang
Summary: This study established an in vivo model of hyperthermia-induced seizures in zebrafish larvae, and found that hyperthermia increased the susceptibility to seizure and the production of pro-inflammatory factors. The study also showed that inflammation played an important role in fever-associated epilepsy. The results suggested that there is a vicious cycle between fever and inflammation, and anti-inflammatory strategies might be a potential treatment for fever-associated epilepsy.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)