Involvement of Akt/mTOR in the Neurotoxicity of Rotenone-Induced Parkinson’s Disease Models

Influence of Normal Aging on Brain Autophagy: A Complex Scenario

(2019) David A. Loeffler   Frontiers in Aging Neuroscience

SC79, a novel Akt activator, protects dopaminergic neuronal cells from MPP+ and rotenone

(2019) Jian-liang Zhu et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Activation of the immunoproteasome protects SH-SY5Y cells from the toxicity of rotenone

(2019) Congcong Sun et al.   NEUROTOXICOLOGY

Resveratrol Suppresses Rotenone-induced Neurotoxicity Through Activation of SIRT1/Akt1 Signaling Pathway

(2018) Hui Wang et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Novel biomolecular information in rotenone-induced cellular model of Parkinson's disease

(2018) D. Lin et al.   GENE

AMBRA1-Mediated Mitophagy Counteracts Oxidative Stress and Apoptosis Induced by Neurotoxicity in Human Neuroblastoma SH-SY5Y Cells

(2018) Anthea Di Rita et al.   Frontiers in Cellular Neuroscience

Mitochondrial regulation by pyrroloquinoline quinone prevents rotenone-induced neurotoxicity in Parkinson’s disease models

(2018) Jinli Lu et al.   NEUROSCIENCE LETTERS

The role of posttranslational modifications of α-synuclein and LRRK2 in Parkinson's disease: Potential contributions of environmental factors

(2018) Edward Pajarillo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

T-type Calcium Channels Determine the Vulnerability of Dopaminergic Neurons to Mitochondrial Stress in Familial Parkinson Disease

(2018) Yoshikuni Tabata et al.   Stem Cell Reports

Rifampicin inhibits rotenone-induced microglial inflammation via enhancement of autophagy

(2017) Yanran Liang et al.   NEUROTOXICOLOGY

Neuroprotective Role of the PI3 Kinase/Akt Signaling Pathway in Zebrafish

(2017) Shuang Chen et al.   Frontiers in Endocrinology

Proliferation, survival and metabolism: the role of PI3K/AKT/mTOR signalling in pluripotency and cell fate determination

(2016) Jason S. L. Yu et al.   DEVELOPMENT

The novel mechanism of rotenone-induced α-synuclein phosphorylation via reduced protein phosphatase 2A activity

(2016) Yi Wang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Neuroprotective Effect of the LRRK2 Kinase Inhibitor PF-06447475 in Human Nerve-Like Differentiated Cells Exposed to Oxidative Stress Stimuli: Implications for Parkinson’s Disease

(2016) Miguel Mendivil-Perez et al.   NEUROCHEMICAL RESEARCH

Neuroprotective effects of pyrroloquinoline quinone against rotenone injury in primary cultured midbrain neurons and in a rat model of Parkinson's disease

(2016) Qi Zhang et al.   NEUROPHARMACOLOGY

SC79 protects retinal pigment epithelium cells from UV radiation via activating Akt-Nrf2 signaling

(2016) Yi-qing Gong et al.   Oncotarget

An update on the rotenone models of Parkinson's disease: Their ability to reproduce the features of clinical disease and model gene–environment interactions

(2015) Michaela E. Johnson et al.   NEUROTOXICOLOGY

Systems genomics evaluation of the SH-SY5Y neuroblastoma cell line as a model for Parkinson’s disease

(2015) Abhimanyu Krishna et al.   BMC GENOMICS

Tetranectin Knockout Mice Develop Features of Parkinson Disease

(2014) Er-song Wang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

The role of PI3K/AKT/mTOR pathway in the modulation of autophagy and the clearance of protein aggregates in neurodegeneration

(2014) David Heras-Sandoval et al.   CELLULAR SIGNALLING

The role of autophagy in Parkinson's disease: rotenone-based modeling

(2013) Nian Xiong et al.   Behavioral and Brain Functions

Rotenone induces neuronal death by microglial phagocytosis of neurons

(2013) Julius V. Emmrich et al.   FEBS Journal

Quantitative Profiling of DNA Damage and Apoptotic Pathways in UV Damaged Cells Using PTMScan Direct

(2012) Matthew Stokes et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mitochondrial Dysfunction and Oxidative Stress Promote Apoptotic Cell Death in the Striatum via Cytochrome c/ Caspase-3 Signaling Cascade Following Chronic Rotenone Intoxication in Rats

(2012) Tsu-Kung Lin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

PTMScan Direct: Identification and Quantification of Peptides from Critical Signaling Proteins by Immunoaffinity Enrichment Coupled with LC-MS/MS

(2012) Matthew P. Stokes et al.   MOLECULAR & CELLULAR PROTEOMICS

Structure of the human ATG12~ATG5 conjugate required for LC3 lipidation in autophagy

(2012) Chinatsu Otomo et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Lack of CCR5 modifies glial phenotypes and population of the nigral dopaminergic neurons, but not MPTP-induced dopaminergic neurodegeneration

(2012) Dong-Young Choi et al.   NEUROBIOLOGY OF DISEASE

Small molecule-induced cytosolic activation of protein kinase Akt rescues ischemia-elicited neuronal death

(2012) H. Jo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Shedding new light on neurodegenerative diseases through the mammalian target of rapamycin

(2012) Zhao Zhong Chong et al.   PROGRESS IN NEUROBIOLOGY

Rotenone, Paraquat, and Parkinson’s Disease

(2011) Caroline M. Tanner et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Neuroprotection of kaempferol by autophagy in models of rotenone-mediated acute toxicity: possible implications for Parkinson's disease

(2010) Giuseppe Filomeni et al.   NEUROBIOLOGY OF AGING

A highly reproducible rotenone model of Parkinson's disease

(2009) Jason R. Cannon et al.   NEUROBIOLOGY OF DISEASE