Article
Pharmacology & Pharmacy
Xiaoxian Huang, Lingfei Han, Ruyi Wang, Wanfang Zhu, Ning Zhang, Wei Qu, Wenyuan Liu, Fulei Liu, Feng Feng, Jingwei Xue
Summary: A dual-responsive prodrug micelle is designed to co-deliver a TGF-beta receptor inhibitor and a chemotherapy drug to remodel the tumor microenvironment and trigger immunogenic cell death, thereby inducing an antitumor immune response.
Article
Pharmacology & Pharmacy
Jiulong Zhang, Xiaoyan Sun, Xiufeng Zhao, Chunrong Yang, Menghao Shi, Benzhuo Zhang, Haiyang Hu, Mingxi Qiao, Dawei Chen, Xiuli Zhao
Summary: A versatile ICD amplifier was developed to enhance tumor immunotherapy by amplifying the eat me signal during tumor immunogenic cell death cascade. The amplifier enables chemotherapy-sensitized immuno-therapy and activates immune response against tumors.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Chemistry, Multidisciplinary
Zhiren Wang, Wenpan Li, Jonghan Park, Karina Marie Gonzalez, Aaron James Scott, Jianqin Lu
Summary: Camptothesome is an innovative nanovesicle therapeutic that has shown promising results in the treatment of colorectal cancer. It is taken up by cancer cells through a specific pathway and induces immunogenic cancer cell death. The use of Camptothesome-treated tumor cells as a vaccine has proven effective in preventing tumor growth. Furthermore, Camptothesome demonstrates superior anti-cancer efficacy and immune response compared to other treatments. It also enhances the effectiveness of immune checkpoint inhibitors in shrinking late-stage CRC tumors and prolonging survival.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Pharmacology & Pharmacy
Jeongjin Lee, Wooram Um, Hyungwon Moon, Hyeyeon Joo, Yeari Song, Minsung Park, Been Yoon, Hyun-Ryoung Kim, Jae Hyung Park
Summary: A combined therapy using ultrasound-responsive liposomal doxorubicin and focused ultrasound exposure has been developed to avoid off-target toxicity of doxorubicin and improve immunogenicity. The therapy showed potential clinical value for cancer treatment.
Article
Nanoscience & Nanotechnology
Junmei Zhang, Yuanyuan Zhang, Bingbing Zhao, Mengtong Lv, Enping Chen, Changshun Zhao, Linyang Jiang, Hongliang Qian, Dechun Huang, Yinan Zhong, Wei Chen
Summary: The study developed a cascade-responsive hierarchical nanosystem for spatially programed delivery of multiple drugs and simultaneously overcoming biological pathway barriers by releasing alpha PD-L1 and PTX in the tumor microenvironment, achieving enhanced chemoimmunotherapy.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Seong Dong Jeong, Bo-Kyeong Jung, Hyo Min Ahn, DaeYong Lee, JongHoon Ha, Ilkoo Noh, Chae-Ok Yun, Yeu-Chun Kim
Summary: The study demonstrates the potential of fluorinated mitochondria-disrupting helical polypeptides (MDHPs) in inducing immunogenic cell death (ICD) and activating antitumor immune responses. By destabilizing the mitochondrial outer membrane and triggering excessive ROS production and apoptosis, the helical polypeptide leads to ER stress-mediated ICD. The combination therapy of fluorinated MDHP and anti-PD-L1 antibodies shows promising results in regression of tumor growth and prevention of metastasis, suggesting a synergistic effect with immune checkpoint blockade therapy.
Article
Engineering, Biomedical
Jianqing Li, Jun Dai, Zeyan Zhuang, Zijuan Meng, Jing-Jing Hu, Xiaoding Lou, Fan Xia, Zujin Zhao, Ben Zhong Tang
Summary: This study presents a novel photosensitizer that can trigger endoplasmic reticulum stress and induce effective immunogenic cell death. Combining with immune checkpoint blockade, it can significantly inhibit tumor growth and provoke a systemic antitumor immune response.
Article
Chemistry, Multidisciplinary
Fan Zhang, Fangman Chen, Chao Yang, Lei Wang, Hanze Hu, Xuezhao Li, Xiao Zheng, Zheng Wang, Zhimin Chang, Tianyu Li, Li Li, Mingfeng Ge, Jinzhi Du, Wen Sun, Wen-Fei Dong, Dan Shao
Summary: The potential ICD nanoamplifier containing diselenide-bridged mesoporous organosilica nanoparticles (MONs) and chemotherapeutic ruthenium compound (KP1339) showed controlled drug release profiles and evoked robust antitumor immunological responses by amplifying ICD of KP1339.
Article
Engineering, Biomedical
Zhen Ya, Shifang Guo, Yan Li, Mingting Zhu, Lei Zhang, Yujin Zong, Mingxi Wan
Summary: This study explored the feasibility of focused acoustic vortex (FAV)-mediated sonochemotherapy combined with immune checkpoint blockade (ICB) to reshape the immunosuppressive tumor microenvironment (TME) and potentiate systemic anti-tumor immunity. FAV-activated sonochemotherapy significantly enriched immunogenic cell death (ICD) inducers in tumors and amplified ICD of cancer cells compared to conventional focused ultrasound (FUS)-activated sonochemotherapy. This research provides a multifunctional strategy for enriching ICD inducers in tumors, amplifying ICD, and improving the immunosuppressive TME to enhance systemic anti-tumor immunity.
Article
Chemistry, Physical
Xinyang Li, Yang Luo, Zhengjie Huang, Yi Wang, Jian Wu, Shaobing Zhou
Summary: A pH-responsive nanoliposome containing a small dendritic macromolecule loaded with doxorubicin, a toll-like receptor 7/8 agonist, and losartan was developed to overcome the barriers of cancer-associated fibroblasts in solid tumor treatment and enhance chemo-immunotherapy efficacy.
Article
Medicine, Research & Experimental
Weijing Yang, Jinmeng Yi, Rongrong Zhu, Yichen Guo, Kaixin Zhang, Yongjian Cao, Xinyan Li, Jinjie Zhang, Zhenzhong Zhang, Yongjuan Li, Xiaoyuan Chen
Summary: In this study, a new type of tumor microenvironment and reduction dual-responsive polymersomal prodrug (TRPP) nanoplatform was constructed for cancer immunotherapy. The nanoplatform achieved tumor microenvironment modulation, reactive oxygen species consumption, immune checkpoint blockade, and immunogenic cell death. In vivo experiments demonstrated the improved tumor accumulation, suppressed cancer-associated fibroblast formation, downregulated regulatory T cells, and promoted T lymphocyte infiltration by DPPA-TRPP/Tab, which resulted in a significant tumor regression and long-term immune memory response.
Article
Nanoscience & Nanotechnology
Hang Dong, Meng Gao, Lu Lu, Rong Gui, Yunfeng Fu
Summary: This study developed doxorubicin-loaded platelet decoys (PD@Dox) for chemotherapy and induction of tumor immunogenic cell death (ICD) in triple-negative breast cancer (TNBC). PD@Dox has the potential to enhance tumor therapy through chemoimmunotherapy by combining with PD-1 antibody in vivo.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Zili Gu, Candido G. Da Silva, Yang Hao, Timo Schomann, Marcel G. M. Camps, K. van der Maaden, Qi Liu, Ferry Ossendorp, Luis J. Cruz
Summary: Therapeutic cancer drug efficacy is often limited by factors such as insufficient tumor penetration, rapid clearance, systemic toxicity, and drug resistance. In this study, a liposomal platform was used to improve the therapeutic index by enhancing drug penetration and reducing clearance and toxicity. The combination of docetaxel and pemetrexed encapsulated in pH-sensitive liposomes showed strong cytotoxicity and induced immunogenic cell death in cellular experiments. In vivo, the liposome-based drug combination inhibited tumor development and stimulated immune responses, with significantly reduced systemic toxicity. When combined with anti-PD-L1 immunotherapy, tumor control was further enhanced in mouse models of colon cancer. These findings highlight the promising potential of liposome-mediated chemotherapy combined with immunotherapy for the treatment of colon cancers.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Oncology
X. M. Shao, J. Huang, N. Niknafs, A. Balan, C. Cherry, J. White, V. E. Velculescu, V Anagnostou, R. Karchin
Summary: The burden of HLA class II immunogenic mutations (IMMs) is associated with clinical responses to immune checkpoint blockade (ICB) in patients with melanoma and non-small-cell lung cancer (NSCLC). Patients with higher HLA class II IMM burden tend to have longer survival and show CD4+ T-cell infiltration and programmed death-ligand 1 expression. HLA class II IMMs play a distinct and complementary role in ICB responses compared to HLA class I.
ANNALS OF ONCOLOGY
(2022)
Review
Medicine, Research & Experimental
Richard A. Lin, Jessica K. Lin, Shiaw-Yih Lin
Summary: ICD induces immunogenic cell death in cancer cells through chemotherapeutic drugs, creating an inflamed tumor environment; ICB targets immune checkpoints such as CTLA4 and PD-1 to enhance treatment responses.
KAOHSIUNG JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Materials Science, Biomaterials
Chang Xu, Xiuwen Guan, Lin Lin, Qing Wang, Bo Gao, Shuhua Zhang, Yanhui Li, Huayu Tian
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2018)
Article
Materials Science, Biomaterials
Chang Xu, Xiuwen Guan, Lin Lin, Qing Wang, Bo Gao, Shuhua Zhang, Yanhui Li, Huayu Tian
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2018)
Article
Engineering, Biomedical
Xiuwen Guan, Jie Chen, Yingying Hu, Lin Lin, Pingjie Sun, Huayu Tian, Xuesi Chen
Article
Chemistry, Multidisciplinary
Xiuwen Guan, Lin Lin, Jie Chen, Yingying Hu, Pingjie Sun, Huayu Tian, Atsushi Maruyama, Xuesi Chen
JOURNAL OF CONTROLLED RELEASE
(2019)
Article
Biotechnology & Applied Microbiology
Xiaoming Cui, Xiaoli Li, Zhilu Xu, Xiuwen Guan, Jinlong Ma, Dejun Ding, Weifen Zhang
Summary: NAT/CLZ@CTS/PLGA nanoparticles prepared using coaxial electrospray technology show obvious core-shell structures, uniform particle distribution, and sustained drug release; safety and efficiency evaluations demonstrate good biosafety and significant anti-candidiasis effect, providing a promising drug delivery system and new option for the treatment of FK.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Biophysics
Zhongying Gong, Xiaoying Liu, Baolong Zhou, Guohui Wang, Xiuwen Guan, Ying Xu, Juanjuan Zhang, Zexin Hong, Juanjuan Cao, Xirui Sun, Zhiqin Gao, Haozheng Lu, Xingliang Pan, Jingkun Bai
Summary: This study developed a strategy using peptide nanoparticles to release drugs in the acidic microenvironment of tumors, enhancing the effectiveness of anti-tumor drugs through targeted delivery.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Review
Nanoscience & Nanotechnology
Wenqiang Chen, Mingxia Jiang, Wenjing Yu, Zhiwei Xu, Xinyue Liu, Qingmiao Jia, Xiuwen Guan, Weifen Zhang
Summary: Nanoparticles used as carriers and/or adjuvants in tumor vaccines have shown significant therapeutic effects in cancer treatment. CpG ODN, a commonly used immune stimulant, can activate humoral and cellular immunity through Toll-like receptor 9 for cancer prevention or treatment.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Multidisciplinary Sciences
Mingxia Jiang, Liping Zhao, Xiaoming Cui, Xinghan Wu, Yuhan Zhang, Xiuwen Guan, Jinlong Ma, Weifen Zhang
Summary: This study aims to solve the dilemmas in cancer immunotherapy by combining minimalist nanovaccine with PD-1 blockade, resulting in satisfactory outcomes. The facile nanovaccine with minimal antigen and adjuvant in cooperation with PD-1 antibody showed enhanced delivery and improved therapeutic efficiency through the synergy of T cell induction and maintenance functions.
JOURNAL OF ADVANCED RESEARCH
(2022)
Article
Chemistry, Physical
Liping Zhao, Mingxia Jiang, Zhilu Xu, Fengshuo Sun, Xinghan Wu, Mogen Zhang, Xiuwen Guan, Jinlong Ma, Weifen Zhang
Summary: A self-regulating photothermal conversion system based on self-assembling gold nanoparticles was designed for selective thermotherapy. The system demonstrated selective heating effect in both in vitro and in vivo models, achieving good tumor inhibition without damaging normal tissue. This work offers a novel validation protocol for tumor thermotherapy and provides an evaluation methodology for precise cancer therapy.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Review
Biotechnology & Applied Microbiology
Liping Zhao, Xu Zhang, Xiaoxia Wang, Xiuwen Guan, Weifeng Zhang, Jinlong Ma
Summary: Photothermal therapy (PTT) is a promising approach in cancer treatment, but challenges such as accurate laser exposure and potential side effects need to be addressed. Enhancing the selectivity of PTT involves increasing the accumulation of photothermal agents at tumor sites and giving them self-regulating photothermal conversion functions.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Materials Science, Multidisciplinary
Liping Zhao, Xiaoxia Wang, Mingxia Jiang, Xinghan Wu, Mogen Zhang, Xiuwen Guan, Jinlong Ma, Weifen Zhang
Summary: This research has successfully developed an effective and highly selective cancer treatment using CuET-ZIFCu@HA nano system, which has high biocompatibility, targets CD44 overexpressed cancer cells, and responds to acidic environments. Both in vivo and in vitro experiments have shown that CuET-ZIF(Cu)@HA has strong anti-tumor properties without evident side effects, providing a promising strategy for DSF nanosystems with simple preparation and high efficacy.
FRONTIERS OF MATERIALS SCIENCE
(2021)
Article
Chemistry, Physical
Liping Zhao, Xiaoxia Wang, Han Lou, Mingxia Jiang, Xinghan Wu, Jiamin Qin, Jingqi Zhang, Xiuwen Guan, Wentong Li, Weifen Zhang, Jinlong Ma
Summary: This study proposes a novel approach to enhance DSF-based cancer therapy by doping Cu2+ into hollow zeolitic imidazolate framework nanoparticles and equipping them with DSF, ICG, and FA as a targeted carrier. The strategy provides Cu2+ in a buffet-style, facilitating the transformation of DSF to CuET in the tumor. Furthermore, self-supplied Cu2+ can trigger a Fenton-like reaction for chemo-dynamic therapy and ICG enables photothermal therapy for tumor treatment.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Nanoscience & Nanotechnology
Jun Zeng, Yanju Sun, Shuo Sun, Mingxia Jiang, Daijuan Zhang, Wentong Li, Zhijun Liu, Hongcai Shang, Xiuwen Guan, Weifen Zhang
Summary: This study demonstrates the use of a nanodrug delivery system for targeting both tumor cells and M2 TAMs in colon cancer therapy. The system shows significant suppression efficacy and satisfactory biosafety in in vivo experiments.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Review
Chemistry, Multidisciplinary
Mingxia Jiang, Jun Zeng, Liping Zhao, Mogen Zhang, Jinlong Ma, Xiuwen Guan, Weifen Zhang
Summary: The article highlights the importance of inducing immunogenic cell death in tumor cells through chemotherapy drugs, and the promising future and potential of chemo-immunotherapy in cancer treatment.
