期刊
SMALL
卷 17, 期 26, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.202100006
关键词
chemoimmunotherapy; coordination-responsive drug release; diselenide bond; immunogenic cell-death; mesoporous organosilica nanoparticles
类别
资金
- National Natural Science Foundation of China [81771982, 82072049, 81902166, 61535010, 21803075, 91959112]
- National Key R&D Program of China [2017YFF0108600, 2017YFC0211900, 2020YFC2004500, 2020YFC2004600]
- Natural Science Foundation of Jiangsu Province [BK20181236, BK20170389]
- Primary Research & Development Plan of Jiangsu Province [BE2019683]
- Science and Technology Department of Jinan City [2018GXRC016]
The potential ICD nanoamplifier containing diselenide-bridged mesoporous organosilica nanoparticles (MONs) and chemotherapeutic ruthenium compound (KP1339) showed controlled drug release profiles and evoked robust antitumor immunological responses by amplifying ICD of KP1339.
Amplifying the chemotherapy-driven immunogenic cell death (ICD) for efficient and safe cancer chemoimmunotherapy remains a challenge. Here, a potential ICD nanoamplifier containing diselenide-bridged mesoporous organosilica nanoparticles (MONs) and chemotherapeutic ruthenium compound (KP1339) to achieve cancer chemoimmunotherapy is tailored. KP1339-loaded MONs show controlled drug release profiles via glutathione (GSH)-responsive competitive coordination and matrix degradation. High concentration of MONs selectively evoked reactive oxygen species production, GSH depletion, and endoplasmic reticulum stress in cancer cells, thus amplifying the ICD of KP1339 and boosting robust antitumor immunological responses. After the combination of PD-L1 checkpoint blockade, cancer cell membrane-cloaked KP1339-loaded MONs not only regress primary tumor growth with low systemic toxicity, but also inhibit distant tumor growth and pulmonary metastasis of breast cancer. The results have shown the potential of coordination and redox dual-responsive MONs boosting amplified ICD for cancer chemoimmunotherapy.
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